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Search results for: Anti-human Apolipoprotein-H (β2-Glycoprotein-I ) Antibody

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#33625289   // To Up

Monoclonal Antibody JMAM-1 (Mouse Antihuman CD10) Against Malignant Mesothelioma.


1374 related Products with: Monoclonal Antibody JMAM-1 (Mouse Antihuman CD10) Against Malignant Mesothelioma.

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#33433412   // To Up

Glomerular C4d deposition in proliferative glomerular diseases.

The aim of this study was to evaluate the immunohistochemical expression of C4d in native renal biopsies of proliferative glomerular diseases, complement pathways in these diseases, and assess the relationship of C4d with histological and clinicopathological parameters, other complement proteins, and immunoglobulin markers.
Sarojini Raman, Pallavi Mishra, Ansuman Panigrahi, Nikunj K Rout, Kanakalata Dash

2613 related Products with: Glomerular C4d deposition in proliferative glomerular diseases.

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#33374617   2020/12/23 To Up

Characteristics of Immunoglobulin M Type Antibodies of Different Origins from the Immunologic and Clinical Viewpoints and Their Application in Controlling Antibody-Mediated Allograft Rejection.

Antibody-mediated allograft rejection (AMR) hinders patient prognosis after organ transplantation. Current studies concerning AMR have mainly focused on the diagnostic value of immunoglobulin G (IgG)-type donor-specific antihuman leukocyte antigen antibodies (DSAs), primarily because of their antigen specificity, whereas the clinical significance of immunoglobulin M (IgM)-type DSAs has not been thoroughly investigated in the context of organ transplantation because of their nonspecificity against antigens. Although consensus regarding the clinical significance and role of IgM antibodies is not clear, as discussed in this review, recent findings strongly suggest that they also have a huge potential in novel diagnostic as well as therapeutic application for the prevention of AMR. Most serum IgM antibodies are known to comprise natural antibodies with low affinity toward antigens, and this is derived from B-1 cells (innate B cells). However, some of the serum IgM-type antibodies reportedly also produced by B-2 cells (conventional B cells). The latter are known to have a high affinity for donor-specific antigens. In this review, we initially discuss how IgM-type antibodies of different origins participate in the pathology of various diseases, directly or through cell surface receptors, complement activation, or cytokine production. Then, we discuss the clinical applicability of B-1 and B-2 cell-derived IgM-type antibodies for controlling AMR with reference to the involvement of IgM antibodies in various pathological conditions.
Yoshiko Matsuda, Takahisa Hiramitsu, Xiao-Kang Li, Takeshi Watanabe

2312 related Products with: Characteristics of Immunoglobulin M Type Antibodies of Different Origins from the Immunologic and Clinical Viewpoints and Their Application in Controlling Antibody-Mediated Allograft Rejection.

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#33237536   // To Up

Phenotyping of Myeloid-Derived Suppressor Cells in Nonhuman Primates.

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Ang Lin, Karin Loré

2036 related Products with: Phenotyping of Myeloid-Derived Suppressor Cells in Nonhuman Primates.

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#33210724   2020/10/30 To Up

Expression of trefoil factor 3 is decreased in colorectal cancer.

In colorectal cancer (CRC), high expression of trefoil factor 3 (TFF3) is associated with tumor progression and reduced patient survival; however, bioinformatics analyses of public 'omics' databases show low TFF3 expression in CRCs as compared to normal tissues. Thus, we examined TFF3 expression in CRCs and matching normal tissues to evaluate its role in CRC progression. TFF3 gene expression was characterized using the bioinformatics portal UALCAN (http://ualcan.path.uab.edu). Tissue microarrays (TMAs) of archival CRC specimens (n=96) were immunostained with anti‑human TFF3 antibodies. Immunohistochemical (IHC) staining intensity was semi‑quantitatively scored. For this cohort, the median follow‑up was 5.4 years. Associations between clinical and pathological variables were determined using Chi‑square or Fisher's exact tests. Univariate disease‑free survival was estimated by the Kaplan‑Meier method. Omics data analyses by UALCAN showed downregulation of TFF3 expression in CRC relative to normal tissue at protein (χ2, P<0.0001) levels. There was a similar decreasing trend of TFF3 expression in the pathologic stages of the CRCs (RNA, χ2, P=0.88 and protein, χ2 P<0.0001). UALCAN data analysis showed that TFF3 exhibited 27% lower mRNA expression in tumors with mutant TP53 (P=0.007). Confirming the findings of omics analyses, IHC analysis of TMAs exhibited lower TFF3 expression in 95.6% (65 of 68) of the available normal‑tumor matching pairs (χ2, P<0.0001). There was no statistically significant association of tumor TFF3 expression with patient sex, race/ethnicity, tumor location within the colorectum, Tumor, Node, Metastasis (TNM) stage, lymph node metastasis, or surgical margins. However, low TFF3 IHC staining in tumor tissue was associated with histological grade (P=0.026). Kaplan‑Meier survival analysis showed no prognostic value of low TFF3 expression relative to those with high expression (log‑rank, P=0.605). Our findings demonstrate low expression of TFF3 in CRCs. Association between low TFF3 and histopathological features suggests involvement of this molecule in progression of CRC.
Ingrid Espinoza, Sumit Agarwal, Amit Reddy, Veena Shenoy, Charulochana Subramony, Marcelo Sakiyama, Logan Fair, Teja Poosarla, Xinchun Zhou, W Shannon Orr, Christopher Lahr, Sejong Bae, Sameer Al Diffalha, Upender Manne, Christian R Gomez

2306 related Products with: Expression of trefoil factor 3 is decreased in colorectal cancer.

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#33175401   2020/11/23 To Up

Urgent desensitization in patients bridged to heart transplantation under extracorporeal membrane oxygenation support: A preliminary experience.

Antihuman leukocyte antigen (HLA) antibodies restrict the access to cardiac allografts. Desensitization therapy is a major challenge in patients with cardiogenic shock waiting for urgent heart transplantation (HT). We retrospectively reviewed six patients (mean age of 37.5 years [16-70]) who underwent plasmapheresis (PP) under extracorporeal membrane oxygenation (ECMO) before transplant between January 2017 and September 2018. The average duration of follow-up was 25 months [20-32]. Mean fluorescence intensity (MFI) of HLA-specific antibodies was reported as follows: score 4 for MFI < 1000, score 6 for 1000 < MFI < 3000 and score 8 for MFI > 3000. The mean duration of ECMO support was 29 days [1-74] and 6.8 [1-29] PP sessions were performed per patient before transplant. The mean number of HLA-specific antibodies before HT was 9.6 for score 6 [4-13] and 5.8 for score 8 [1-12]. Four patients had major complications after transplantation (2 hemorrhagic shocks, 5 infectious events). Mean MFI reduction rate was 94% [79-100] for Class I and 44.2% for Class II [0-83]. Hospital survival was 100%, and early antibody-mediated rejection was diagnosed in one patient at 7 days after HT. Plasmapheresis under ECMO support was associated with favorable early outcomes in highly sensitized candidates for urgent heart transplantation.
Julien Guihaire, Serena D'Avino, Francois Stephan, Martin Kloeckner, Ngoc Tram To, Agathe Potier, Maïra Gaillard, Ramzi Ramadan, Jean-Luc Taupin, Jerome Le Pavec, Philippe Deleuze

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#33121367   2020/10/29 To Up

Highly Specific Mouse Anti-Joining Chain of Human Immunoglobulin A.

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Monir Ejemel, Melissa A Gawron, Matthew I Schneider, Aaron Wallace, Zachary A Schiller, Ryan Schneider, Joseph C Martin Iii, Mark S Klempner, Yang Wang, Lisa A Cavacini

2082 related Products with: Highly Specific Mouse Anti-Joining Chain of Human Immunoglobulin A.

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#32969848   // To Up

Efficacy of Rabbit Antithymocyte Globulin as a First-line Therapy in Children With Aplastic Anemia.

The efficacy, safety, and outcome of rabbit antihuman thymocyte globulin (rATG) as initial therapy for children aplastic anemia (AA) were evaluated.
Fuxing Li, Wei He, Wei Shi, Xiaotian Xie

1300 related Products with: Efficacy of Rabbit Antithymocyte Globulin as a First-line Therapy in Children With Aplastic Anemia.

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#32954173   2020/08/31 To Up

Highly Sensitive Fluorescence-Linked Immunosorbent Assay for the Determination of Human IgG in Serum Using Quantum Dot Nanobeads and Magnetic FeO Nanospheres.

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Jiaping Guo, Yameng Wang, Shanshan Niu, Hongping Li, Yongmei Tian, Songcheng Yu, Fei Yu, Yongjun Wu, Li-E Liu

1804 related Products with: Highly Sensitive Fluorescence-Linked Immunosorbent Assay for the Determination of Human IgG in Serum Using Quantum Dot Nanobeads and Magnetic FeO Nanospheres.

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