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Search results for: ANG4 Antibody

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#29915298   2018/06/18 To Up

Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T cells through modification of the intestinal microbiota.

The cytokines IL-17A and IL-17F have 50% amino-acid identity and bind the same receptor; however, their functional differences have remained obscure. Here we found that Il17f mice resisted chemically induced colitis, but Il17a mice did not, and that Il17f CD45RBCD4 T cells induced milder colitis in lymphocyte-deficient Rag2 mice, accompanied by an increase in intestinal regulatory T cells (T cells). Clostridium cluster XIVa in colonic microbiota capable of inducing T cells was increased in both Il17f mice and mice given transfer Il17f T cells, due to decreased expression of a group of antimicrobial proteins. There was substantial production of IL-17F, but not of IL-17A, not only by naive T cells but also by various colon-resident cells under physiological conditions. Furthermore, antibody to IL-17F suppressed the development of colitis, but antibody to IL-17A did not. These observations suggest that IL-17F is an effective target for the treatment of colitis.
Ce Tang, Shigeru Kakuta, Kenji Shimizu, Motohiko Kadoki, Tomonori Kamiya, Tomoyuki Shimazu, Sachiko Kubo, Shinobu Saijo, Harumichi Ishigame, Susumu Nakae, Yoichiro Iwakura

2490 related Products with: Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T cells through modification of the intestinal microbiota.

5 G1 mg100.00 ug5 mg1 mg5 mg 5 G1 ml10 mg100 ug1.5 x 10^6 cells1 mg

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#25399934   // To Up

The role of Gr-1(+) cells and tumour necrosis factor-α signalling during Clostridium difficile colitis in mice.

The host response to Clostridium difficile infection in antibiotic-treated mice is characterized by robust recruitment of Gr-1(+) cells, increased expression of inflammatory cytokines including tumour necrosis factor-α (TNF-α), and the development of severe epithelial damage. To investigate the role of Gr-1(+) cells and TNF-α during C. difficile colitis, we treated infected mice with monoclonal antibodies against Gr-1 or TNF-α. Mice were challenged with vegetative cells of C. difficile strain VPI 10463 following treatment with the third-generation cephalosporin ceftriaxone. Ceftriaxone treatment alone was associated with significant changes in cytokine expression within the colonic mucosa but not overt inflammatory histopathological changes. In comparison, C. difficile infection following ceftriaxone treatment was associated with increased expression of inflammatory cytokines and chemokines including Cxcl1, Cxcl2, Il1b, Il17f and Tnfa, as well as robust recruitment of Ly6C(Mid)  Gr-1(High) neutrophils and Ly6C(High) Gr-1(Mid) monocytes and the development of severe colonic histopathology. Anti-Gr-1 antibody treatment resulted in effective depletion of both Ly6C(Mid) Gr-1(High) neutrophils and Ly6C(High) Gr-1(Mid) monocytes: however, we observed no protection from the development of severe pathology or reduction in expression of the pro-inflammatory cytokines Il1b, Il6, Il33 and Tnfa following anti-Gr-1 treatment. By contrast, anti-TNF-α treatment did not affect Gr-1(+) cell recruitment, but was associated with increased expression of Il6 and Il1b. Additionally, Ffar2, Ffar3, Tslp, Tff and Ang4 expression was significantly reduced in anti-TNF-α-treated animals, in association with marked intestinal histopathology. These studies raise the possibility that TNF-α may play a role in restraining inflammation and protecting the epithelium during C. difficile infection.
Andrew J McDermott, Kathryn E Higdon, Ryan Muraglia, John R Erb-Downward, Nicole R Falkowski, Roderick A McDonald, Vincent B Young, Gary B Huffnagle

1757 related Products with: The role of Gr-1(+) cells and tumour necrosis factor-α signalling during Clostridium difficile colitis in mice.

1 mg5 x 50 ug10 ug50 ug96 tests100 μg2 ml0.1 mg10ug1.00 flask

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#23937122   2013/08/12 To Up

Effect of intracavernous administration of angiopoietin-4 on erectile function in the streptozotocin-induced diabetic mouse.

Erectile dysfunction (ED) is a highly prevalent complication of diabetes, and the severity of endothelial dysfunction is one of the most important factors in reduced responsiveness to oral phosphodiesterase type 5 inhibitors.
Mi-Hye Kwon, Ji-Kan Ryu, Woo Jean Kim, Hai-Rong Jin, Kang-Moon Song, Ki-Dong Kwon, Dulguun Batbold, Guo Nan Yin, Gou Young Koh, Jun-Kyu Suh

1755 related Products with: Effect of intracavernous administration of angiopoietin-4 on erectile function in the streptozotocin-induced diabetic mouse.

100 ul100 ul50 ul2ug100 ul100ug Lyophilized100ug100.00 ug4 Arrays/Slide100 μg1-8 Sample Kit1 mg

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#23817541   // To Up

Serum levels of angiopoietin-2, but not angiopoietin-1, are elevated in patients with erythrodermic cutaneous T-cell lymphoma.

Angiogenesis is a crucial process in the growth and progression of cancer, correlating with the metastatic potential of tumour cells. Angiopoietins are ligands for the endothelium-specific tyrosine kinase Tie2 receptor, which comprise 4 structurally related proteins, termed angiopoietin (Ang)-1, Ang-2, Ang-3 and Ang-4. The roles of Ang-1 and Ang-2 have recently been clarified as crucial in angiogenesis. In this report, we measured serum Ang-1 and Ang-2 levels in patients with cutaneous T-cell lymphoma (CTCL). Serum levels of Ang-2, but not Ang-1, in patients with Sézary syndrome were significantly higher than those in patch mycosis fungoides (MF), plaque/tumour MF, and healthy controls. In patients with CTCL, serum Ang-2 correlated with disease activity. Moreover, the numbers of Ang-2+ cells in lesional skin of CTCL were significantly larger than those in normal skin. These results suggest that Ang-2 may have important roles in the development of CTCL.
Makiko Kawaguchi, Makoto Sugaya, Hiraku Suga, Tomomitsu Miyagaki, Hanako Ohmatsu, Hideki Fujita, Yoshihide Asano, Yayoi Tada, Takafumi Kadono, Shinichi Sato

1049 related Products with: Serum levels of angiopoietin-2, but not angiopoietin-1, are elevated in patients with erythrodermic cutaneous T-cell lymphoma.

1 L.casecase100 μg100ug500 ml500 ml96T100ug Lyophilized96 tests100 µg

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#21669204   2011/05/05 To Up

The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice.

Epithelial cells that cover the intestinal mucosal surface maintain immune homeostasis and tolerance in the gastrointestinal tract. However, little is known about the molecular mechanisms that regulate epithelial immune functions. Epithelial cells are distinct in that they are highly polarized; this polarity is, at least in part, established by the epithelium-specific polarized sorting factor adaptor protein (AP)-1B. We investigated the role of AP-1B-mediated protein sorting in the maintenance of gastrointestinal immune homeostasis.
Daisuke Takahashi, Koji Hase, Shunsuke Kimura, Fubito Nakatsu, Masumi Ohmae, Yasushi Mandai, Toru Sato, Yasuhiro Date, Masashi Ebisawa, Tamotsu Kato, Yuuki Obata, Shinji Fukuda, Yuki I Kawamura, Taeko Dohi, Tatsuro Katsuno, Osamu Yokosuka, Satoshi Waguri, Hiroshi Ohno

1512 related Products with: The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice.

4 Membranes/Box4 Membranes/Box4 Membranes/Box4 Membranes/Box4 Membranes/Box4 Membranes/Box2 Pieces/Box4 Membranes/Box4 Membranes/Box4 Membranes/Box4 Membranes/Box4 Membranes/Box

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