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Search results for: Monoclonal Anti-Bcl-xL< SUBXY[[\H[X

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#35764219   2022/06/25 To Up

Computational Fluid Dynamic Simulations of Temperature, Cryoconcentration, and Stress Time during Large-Scale Freezing and Thawing of Monoclonal Antibody Solutions.

Large-scale freezing and thawing experiments of monoclonal antibody (mAb) solutions are time and material consuming. Computational Fluid Dynamic (CFD) modeling of temperature, solute composition as well as the stress time, defined as the time between start of freezing and reaching T' at any point in the container, could be a promising approach to ease and speed up process development.
Oliver Bluemel, Andraž Pavlišič, Blaž Likozar, Miguel A Rodrigues, Vitor Geraldes, Karoline Bechtold-Peters, Wolfgang Friess

2627 related Products with: Computational Fluid Dynamic Simulations of Temperature, Cryoconcentration, and Stress Time during Large-Scale Freezing and Thawing of Monoclonal Antibody Solutions.

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#35763952   2022/06/13 To Up

A monoclonal antibody for identifying capsaicin congeners in illegal cooking oil and its applications.

In this work, we studied the preparation of a high-affinity antibody and its immunochromatographic applications to simultaneously identify capsaicin(LJJ), dihydrocapsaicin(HLJ), nordihydrocapsaicin, homodihydrocapsaicin, and other congeners in illegal cooking oil. We used dihydrocapsaicin hapten-conjugated carrier protein BSA as the immunogen according to the formaldehyde method, and conjugated capsaicin and OVA as the coated detection antigen according to the formaldehyde method. We subsequently screened and cloned a hybridoma cell line 2B3 with the highest affinity, which could stably secrete monoclonal antibodies against compounds in the capsaicin family. We then established a capsaicin indirect ELISA standard curve, which was fitted using the linear regression equation R = 0.9987, curve y = -2.3x + 0.2, and IC = 0.2 ng/mL. The cross-reaction rate for capsaicin was 100%, 116% for dihydrocapsaicin, 88% for homodihydrocapsaicin, and 94% for nordihydrocapsaicin. In the second application, we established a simple and accurate sample pretreatment method and a quantum dot-labeled test strip to quickly and quantitatively detect capsaicin family compounds in illegal cooking oil in 8 min. The average recovery rates for each spiked concentration were between 75% and 107.8%, and the coefficient of variation values for each spiked concentration were less than 15%. The high-affinity antibody we identified could simultaneously identify capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homodihydrocapsaicin, and other congeners in illegal cooking oil, and the antibody could be quickly and accurately applied for the qualitative and quantitative detection of capsaicin family residues in illegal cooking oil.
Yuxiang Wu, Jie Liu, Jinzhi Yu, Jinqiu Zhuang, Fengyun Ma, Jing Tan, Zhiqiang Shen

2452 related Products with: A monoclonal antibody for identifying capsaicin congeners in illegal cooking oil and its applications.

25 µg0.25 mg1 ml0.2 mg25 µg100 TESTS100ug100ug100ug Lyophilized100 ul100ug

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#35763113   2022/06/28 To Up

Conversion from chronic to episodic migraine in patients treated with galcanezumab in real life in Italy: the 12-month observational, longitudinal, cohort multicenter GARLIT experience.

To investigate in real-life the conversion from chronic migraine (CM) to episodic migraine (EM), specifically to EM with High-Frequency (HFEM: 8-14 monthly migraine days, MMDs), Medium-Frequency (MFEM, 4-7 MMDs), and Low-Frequency EM (LFEM, 0-3 MMDs), and its persistence during 1 year of treatment with galcanezumab.
Claudia Altamura, Nicoletta Brunelli, Marilena Marcosano, Cinzia Aurilia, Gabriella Egeo, Carlo Lovati, Valentina Favoni, Armando Perrotta, Ilaria Maestrini, Francesca Schiano Di Cola, Florindo d'Onofrio, Cinzia Finocchi, Davide Bertuzzo, Francesco Bono, Angelo Ranieri, Maria Albanese, Roberta Messina, Alberto Doretti, Vittorio Di Piero, Sabina Cevoli, Piero Barbanti, Fabrizio Vernieri,

2245 related Products with: Conversion from chronic to episodic migraine in patients treated with galcanezumab in real life in Italy: the 12-month observational, longitudinal, cohort multicenter GARLIT experience.

1 mg2511 kit

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#35762593   2022/06/28 To Up

The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia.

Persistent SARS-CoV-2 replication and systemic dissemination are linked to increased COVID-19 disease severity and mortality. However, the precise immune profiles that track with enhanced viral clearance, particularly from systemic RNAemia, remain incompletely defined. To define whether antibody characteristics, specificities, or functions that emerge during natural infection are linked to accelerated containment of viral replication, we examined the relationship of SARS-CoV-2-specific humoral immune evolution in the setting of SARS-CoV-2 plasma RNAemia, which is tightly associated with disease severity and death. On presentation to the emergency department, S-specific IgG3, IgA1, and Fc-γ-receptor (Fcγ R) binding antibodies were all inversely associated with higher baseline plasma RNAemia. Importantly, the rapid development of spike (S) and its subunit (S1/S2/receptor binding domain)-specific IgG, especially FcγR binding activity, were associated with clearance of RNAemia. These results point to a potentially critical and direct role for SARS-CoV-2-specific humoral immune clearance on viral dissemination, persistence, and disease outcome, providing novel insights for the development of more effective therapeutics to resolve COVID-19. We showed that persistent SARS-CoV-2 RNAemia is an independent predictor of severe COVID-19. We observed that SARS-CoV-2-targeted antibody maturation, specifically Fc-effector functions rather than neutralization, was strongly linked with the ability to rapidly clear viremia. This highlights the critical role of key humoral features in preventing viral dissemination or accelerating viremia clearance and provides insights for the design of next-generation monoclonal therapeutics. The main key points will be that (i) persistent SARS-CoV-2 plasma RNAemia independently predicts severe COVID-19 and (ii) specific humoral immune functions play a critical role in halting viral dissemination and controlling COVID-19 disease progression.
Chuangqi Wang, Yijia Li, Paulina Kaplonek, Matteo Gentili, Stephanie Fischinger, Kathryn A Bowman, Moshe Sade-Feldman, Kyle R Kays, James Regan, James P Flynn, Marcia B Goldberg, Nir Hacohen, Michael R Filbin, Douglas A Lauffenburger, Galit Alter, Jonathan Z Li

2525 related Products with: The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia.

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#35762373   // To Up

The future of long-acting agents for preexposure prophylaxis.

The main reason for the failure of oral preexposure prophylaxis (PrEP) regimens for HIV is poor adherence. Intramuscular cabotegravir was recently approved for PrEP, and a number of other long-acting antiretroviral formulations and products are currently in clinical development. This includes subcutaneous and intravenous injections, implants, and microarray (microneedle) patches, as well as extended duration oral drugs. The success and future uptake of these products will depend on a variety of factors.
Charles Flexner

1100 related Products with: The future of long-acting agents for preexposure prophylaxis.

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#35762356   2022/06/28 To Up

Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis.

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies used to activate the immune system against tumor cells. Despite therapeutic benefits, ICIs have the potential to cause immune-related adverse events such as myocarditis, a rare but serious side effect with up to 50% mortality in affected patients. Histologically, patients with ICI myocarditis have lymphocytic infiltrates in the heart, implicating T cell-mediated mechanisms. However, the precise pathological immune subsets and molecular changes in ICI myocarditis are unknown.
Han Zhu, Francisco X Galdos, Daniel Lee, Sarah Waliany, Yuhsin Vivian Huang, Julia Ryan, Katherine Dang, Joel W Neal, Heather A Wakelee, Sunil A Reddy, Sandy Srinivas, Lih-Ling Lin, Ronald M Witteles, Holden T Maecker, Mark M Davis, Patricia K Nguyen, Sean M Wu

2509 related Products with: Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis.

400 ug5 mg1 mg1 mg1 mg0.1ml (1mg/ml)400 ug96 assays20 ul (10 mM)1 mg

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#35762152   2022/06/28 To Up

Patient characteristics and treatment utilization among patients with migraine initiating self-injectable calcitonin gene-related peptide monoclonal antibody and novel acute medication.

This study described patient characteristics and utilization of recently approved novel acute medication and calcitonin gene-related peptide (CGRP) monoclonal antibodies.
Oralee J Varnado, Maggie Hoyt, Wenyu Ye, Robert Nicholson

2492 related Products with: Patient characteristics and treatment utilization among patients with migraine initiating self-injectable calcitonin gene-related peptide monoclonal antibody and novel acute medication.

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#35762136   2022/06/28 To Up

Anti-SARS-CoV-2 monoclonal antibodies for the treatment of active COVID-19 in multiple sclerosis: An observational study.


Federica Magnè, Maria Cellerino, Elisa Balletto, Kenda Aluan, Matilde Inglese, Malgorzata Mikulska, Matteo Bassetti

1851 related Products with: Anti-SARS-CoV-2 monoclonal antibodies for the treatment of active COVID-19 in multiple sclerosis: An observational study.

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#35761503   2022/06/27 To Up

FGF23 Actions in CKD-MBD and in Other Organs during CKD.

Fibroblast growth factor 23 (FGF23) is a new endocrine product discovered in the past decade. In addition to being related to bone diseases, it has also been found to be related to kidney metabolism and parathyroid metabolism, especially as a biomarker and a key factor to be used in the kidney field. FGF23 is upregulated as early as the second and third stages of chronic kidney disease (CKD) in response to relative phosphorus overload. The early rise of FGF23 is a protective effect for the body and is essential for maintaining phosphate balance. However, with the decline of renal function, eGFR (estimated glomerular filtration rate) declines, the phosphorus excretion effect caused by FGF23 is weakened. It eventually leads to a variety of complications, such as bone disease (Chronic Kidney Disease-Mineral and Bone Metabolism Disorder), vascular calcification (VC), and more. Monoclonal antibodies against FGF23 are currently used to treat genetic diseases with increased FGF23. CKD is also a state of increased FGF23. This article reviews the current role of FGF23 in CKD and discusses the crosstalk between various organs under CKD conditions and FGF23. And we proposed that to study the effect of hyperphosphatemia on different organs of CKD is important. We also expounded the prospect of FGF23 for therapy.
Ting Sun, Xijie Yu

2811 related Products with: FGF23 Actions in CKD-MBD and in Other Organs during CKD.

48 assays1 Set100 μg100 μg

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#35760627   2022/06/24 To Up

Incidental Finding of Multiple Synchronous Neoplasms in Explanted Liver After Transplantation: A Case Report.

Liver transplantation is the only potentially curative treatment for patients with end-stage liver disease. After the procedure, histopathologic analysis of the liver explant may reveal neoplasms that were not previously diagnosed in preoperative imaging examinations. This incidental finding of primary liver neoplasms in the explant is not an uncommon situation in liver transplant, and hepatocarcinomas and cholangiocarcinomas are the types of tumors most frequently encountered in this scenario. These are the most common primary neoplasms of the liver, and liver transplantation is often a curative treatment for these types of tumors when they are in their earlier stages. In contrast, liver plasmacytoma is a rare type of plasma cell neoplasm, consisting of a single mass of monoclonal plasma cells, which is treated primarily by radiotherapy and is seldom encountered in the setting of liver transplant. We report the case of a patient who underwent liver transplantation for the treatment of cryptogenic cirrhosis, with no preoperative diagnosis of liver tumors. Analysis of the liver explant revealed the presence of three synchronous neoplasms with different histologic origins: a 27-mm hepatocellular carcinoma, a 17-mm intrahepatic cholangiocarcinoma, and a 25-mm solitary hepatic plasmacytoma. The patient received no further adjuvant treatment and remained well and with no signs of disease recurrence over an observation period of 44 months. We found no previous report in the literature of the synchronous presence of these three types of liver neoplasms.
Maria Clara Borges Murta, Gustavo de Sousa Arantes Ferreira, André Luis Conde Watanabe, Natalia Carvalho Trevizoli, Ana Virgínia Ferreira Figueira, Gabriel Oliveira Nunes Caja, Clara Antunes Ferreira, Carolina de Fatima Couto

2555 related Products with: Incidental Finding of Multiple Synchronous Neoplasms in Explanted Liver After Transplantation: A Case Report.



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