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Search results for: Androstane-3a,17b-diol Glucuronide(5a) Antibody

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#34525434   2021/09/04 To Up

Seroepidemiological study of severe fever with thrombocytopenia syndrome in animals and humans in Okinawa, Japan.

In Okinawa prefecture, Japan, the first case of severe fever with thrombocytopenia syndrome (SFTS) was confirmed in August 2016, and this case remains to be the only reported case of SFTS in Okinawa. The epidemiological investigation indicated that the patient had been infected on the main island of Okinawa, but source and route of infection were unknown. Therefore, to understand the possible source and route of SFTS virus (SFTSV) infection in Okinawa, we performed a seroepidemiological study of SFTSV among animals and dwellers in Okinawa and conducted a questionnaire survey to investigate risk factors for tick bites in Okinawa. Among the 1,035 serum samples from four different animal species, anti-SFTSV antibodies were detected in only 4.2% wild mongoose (Herpestes auropunctatus) serum samples. To our knowledge, this is the first study to report the detection of anti-SFTSV antibodies in wild mongooses. Meanwhile, all 1,104 human inhabitants tested negative for anti-SFTSV antibodies, suggesting that the frequency of SFTSV exposure is low in Okinawa. Logistic regression analysis of the questionnaire results showed that outdoor activity was associated with an increased risk of tick bite among Okinawa residents. Despite the current low frequency of SFTSV infection in animals and humans, endemic circulation of the virus in Okinawa should be carefully monitored in the area for preventing future infections.
Yumani Kuba, Hisako Kyan, Yasuhito Azama, Yoshimune Fukuchi, Eun-Sil Park, Tetsuya Kakita, Minori Oyama, Noriyuki Maeshiro, Masato Miyahira, Minoru Nidaira, Ken Maeda, Shigeru Morikawa, Kiyosu Taniguchi

1878 related Products with: Seroepidemiological study of severe fever with thrombocytopenia syndrome in animals and humans in Okinawa, Japan.

100 μg900 tests100 μg5 mg100 μg100ug Lyophilized100 μg 5 G

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#34525328   2021/08/24 To Up

Effects of COVID-19 on preclinical and clinical research in neurology: Examples from research on neurodegeneration and Alzheimer's disease.

The COVID-19 pandemic has had a profound impact on neuroscientists, including those involved in translational research. In this NeuroView, we discuss the positive and negative effects of the pandemic on preclinical research and clinical studies in humans.
B Joy Snider, David M Holtzman

2295 related Products with: Effects of COVID-19 on preclinical and clinical research in neurology: Examples from research on neurodegeneration and Alzheimer's disease.

96 tests96 tests100 96 tests1 mg

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#34525286   // To Up

Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine.

Although Zika virus (ZIKV) infection is typically self-limiting, other associated complications such as congenital birth defects and the Guillain-Barré syndrome are well described. There are no approved vaccines against ZIKV infection.
Pablo Tebas, Christine C Roberts, Kar Muthumani, Emma L Reuschel, Sagar B Kudchodkar, Faraz I Zaidi, Scott White, Amir S Khan, Trina Racine, Hyeree Choi, Jean Boyer, Young K Park, Sylvie Trottier, Celine Remigio, Diane Krieger, Susan E Spruill, Mark Bagarazzi, Gary P Kobinger, David B Weiner, Joel N Maslow

2254 related Products with: Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine.

100ug Lyophilized1 mg0.2 mg100ug Lyophilized100ug0.1 mg100 100 μg96T1 mL100ug Lyophilized1 mL

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#34525212   2021/09/15 To Up

Seroprevalence of Anti-Brucella spp. Antibodies in Wild Boars (Sus scrofa), Hunting Dogs, and Hunters of Brazil.

All 86 wild boars (Sus scrofa), 170 hunting dogs, and 49 hunters sampled from three Brazilian regions were seronegative to Brucella spp. by the standard tube agglutination and 2-mercaptoethanol tests, suggesting a low circulation of Brucella spp. in wild boars, hunting dogs, and hunters in such areas.
Louise Bach Kmetiuk, Lília M S Paulin, Eliana Monteforte Cassaro Villalobos, Maria do Carmo Custódio de Souza, Hunold Lara, Ivan Roque de Barros Filho, Monicque Silva Pereira, Renato van Wilpe Bach, Leandro Cavalcante Lipinski, Giovani Marino Fávero, Andrea Pires Dos Santos, Alexander Welker Biondo

1192 related Products with: Seroprevalence of Anti-Brucella spp. Antibodies in Wild Boars (Sus scrofa), Hunting Dogs, and Hunters of Brazil.

100 μg100 100 μg1 mg100 μg100 μg100 μg100 μg100 μg100 μg100 μg100 μg

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#34525131   2021/09/15 To Up

Trypanosoma brucei triggers a broad immune response in the adipose tissue.

Adipose tissue is one of the major reservoirs of Trypanosoma brucei parasites, the causative agent of sleeping sickness, a fatal disease in humans. In mice, the gonadal adipose tissue (AT) typically harbors 2-5 million parasites, while most solid organs show 10 to 100-fold fewer parasites. In this study, we tested whether the AT environment responds immunologically to the presence of the parasite. Transcriptome analysis of T. brucei infected adipose tissue revealed that most upregulated host genes are involved in inflammation and immune cell functions. Histochemistry and flow cytometry confirmed an increasingly higher number of infiltrated macrophages, neutrophils and CD4+ and CD8+ T lymphocytes upon infection. A large proportion of these lymphocytes effectively produce the type 1 effector cytokines, IFN-γ and TNF-α. Additionally, the adipose tissue showed accumulation of antigen-specific IgM and IgG antibodies as infection progressed. Mice lacking T and/or B cells (Rag2-/-, Jht-/-), or the signature cytokine (Ifng-/-) displayed a higher parasite load both in circulation and in the AT, demonstrating the key role of the adaptive immune system in both compartments. Interestingly, infections of C3-/- mice showed that while complement system is dispensable to control parasite load in the blood, it is necessary in the AT and other solid tissues. We conclude that T. brucei infection triggers a broad and robust immune response in the AT, which requires the complement system to locally reduce parasite burden.
Henrique Machado, Tiago Bizarra-Rebelo, Mariana Costa-Sequeira, Sandra Trindade, Tânia Carvalho, Filipa Rijo-Ferreira, Barbara Rentroia-Pacheco, Karine Serre, Luisa M Figueiredo

2175 related Products with: Trypanosoma brucei triggers a broad immune response in the adipose tissue.



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#34525121   2021/09/15 To Up

Selenium inhibits growth of trastuzumab-resistant human breast cancer cells via downregulation of Akt and beclin-1.

The response rate to treatment with trastuzumab (Tz), a recombinant humanized anti-HER2 monoclonal antibody, is only 12-34% despite demonstrated effectiveness on improving the survival of patients with HER2-positive breast cancers. Selenium has an antitumor effect against cancer cells and can play a cytoprotective role on normal cells. This study investigated the effect of selenium on HER2-positive breast cancer cells and the mechanism in relation to the response of the cells to Tz. HER2-positive breast cancer cell lines, SK-BR-3 as trastuzumab-sensitive cells, and JIMT-1 as Tz-resistant cells were treated with Tz and sodium selenite (selenite). Cell survival rates and expression of Her2, Akt, and autophagy-related proteins, including LC3B and beclin 1, in both cell lines 72 h after treatment were evaluated. Significant cell death was induced at different concentrations of selenite in both cell lines. A combined effect of selenite and Tz at 72 h was similar to or significantly greater than each drug alone. The expression of phosphorylated Akt (p-Akt) was decreased in JIMT-1 after combination treatment compared to that after only Tz treatment, while p-Akt expression was increased in SK-BR-3. The expression of beclin1 increased particularly in JIMT-1 after only Tz treatment and was downregulated by combination treatment. These results showed that combination of Tz and selenite had an antitumor effect in Tz-resistant breast cancer cells through downregulation of phosphorylated Akt and beclin1-related autophagy. Selenite might be a potent drug to treat Tz-resistant breast cancer by several mechanisms.
Joohyun Woo, Jong Bin Kim, Taeeun Cho, Eun Hye Yoo, Byung-In Moon, Hyungju Kwon, Woosung Lim

2924 related Products with: Selenium inhibits growth of trastuzumab-resistant human breast cancer cells via downregulation of Akt and beclin-1.

100 ug/vial5 x 50 ug100 ug/vial1 kit(96 Wells) 100ul50 ug500 ìg5 x 10A5 cells/vial5 x 50 ug

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#34525096   2021/09/15 To Up

Seroprevalence of SARS-CoV-2 antibodies among homeless people living rough, in shelters and squats: A large population-based study in France.

Overcrowded housing, as well as inadequate sanitary conditions, contribute to making homeless people particularly vulnerable to the SARS-CoV-2 infection. We aimed to assess the seroprevalence of the SARS-CoV-2 infection among people experiencing homelessness on a large city-wide scale in Marseille, France, taking into account different types of accommodation.
Sandrine Loubiere, Elisabetta Monfardini, Camille Allaria, Marine Mosnier, Agathe Allibert, Laetitia Ninove, Thomas Bosetti, Cyril Farnarier, Ilyes Hamouda, Pascal Auquier, Emilie Mosnier, Aurélie Tinland

1776 related Products with: Seroprevalence of SARS-CoV-2 antibodies among homeless people living rough, in shelters and squats: A large population-based study in France.

100 μg25mg100 μg100 μg4 Membranes/Box100 μg100ug Lyophilized100 μg100 μg100 μg100 μg2 Pieces/Box

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#34524976   2021/09/01 To Up

Genome-wide analysis of thyroid function in Australian adolescents highlights SERPINA7 and NCOA3.

Objective Genetic factors underpin the narrow intraindividual variability of thyroid function, although precise contributions of environmental versus genetic factors remain uncertain. We sought to clarify the heritability of thyroid function traits and thyroid peroxidase antibody (TPOAb) positivity and identify single nucleotide polymorphisms (SNPs) contributing to the trait variance. Methods Heritability of thyroid stimulating hormone (TSH), free T4 (fT4), free T3 (fT3) and TPOAb in a cohort of 2854 euthyroid, dizygous and monozygous twins (age range 11.9-16.9 years) from the Brisbane Longitudinal Twin Study (BLTS) was assessed using structural equation modelling. A genome-wide analysis was conducted on 2832 of these individuals across 7,522,526 single nucleotide polymorphisms as well as gene-based association analyses. Replication analysis of the association results was performed in the Raine Study (n= 1115) followed by meta-analysis to maximise power for discovery. Results Heritability of thyroid function parameters in the BLTS was 70.8% (95% CI: 66.7-74.9%) for TSH, 67.5% (59.8-75.3%) for fT4, 59.7% (54.4-65.0%) for fT3 and 48.8% (40.6-56.9%) for TPOAb. The genome-wide association study (GWAS) in the discovery cohort identified a novel association between rs2026401 upstream of NCOA3 and TPOAb. GWAS meta-analysis found associations between TPOAb and rs445219, also near NCOA3, and fT3 and rs12687280 near SERPINA7. Gene-based association analysis highlighted SERPINA7 for fT3 and NPAS3 for fT4. Conclusion Our findings resolve former contention regarding heritability estimates of thyroid function traits and TPOAb positivity. GWAS and gene-based association analysis identified variants accounting for a component of this heritability.
James Nolan, Purdey J Campbell, Suzanne J Brown, Gu Zhu, Scott Gordon, Ee Mun Lim, John Joseph, Simone Cross, Vijay Panicker, Sarah E Medland, Phillip Melton, Lawrence J Beilin, Trevor A Mori, Benjamin Mullin, Craig Pennell, Carol Wang, Frank Dudbridge, John P Walsh, Nicholas G Martin, Scott G Wilson

2341 related Products with: Genome-wide analysis of thyroid function in Australian adolescents highlights SERPINA7 and NCOA3.

1roll (50 m)1roll100 μg

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