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Search results for: APOL1

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#33942030   2021/04/28 To Up

Molecular Analysis of the Kidney From a Patient With COVID-19-Associated Collapsing Glomerulopathy.

Recent Case reports suggest COVID-19 is associated with collapsing glomerulopathy in African Americans with risk alleles, however, it is unclear if disease pathogenesis is similar to HIVAN. Here RNA sequencing analysis of a kidney biopsy specimen from a patient with COVID-19-associated collapsing glomerulopathy and risk alleles (G1/G1) revealed similar levels of and mRNA transcripts as compared to 12 control kidney samples downloaded from the GTEx Portal. Whole genome sequencing of the COVID-19-associated collapsing glomerulopathy kidney sample identified four indel gene variants, three of which are of unknown significance with respect to chronic kidney disease and/or FSGS. Molecular profiling of the kidney demonstrated activation of COVID-19-associated cell injury pathways such as inflammation and coagulation. Evidence for direct SARS-CoV-2 infection of kidney cells was lacking, which is consistent with the findings of several recent studies. Interestingly, immunostaining of kidney biopsy sections revealed increased expression of phospho-STAT3 in both COVID-19-associated collapsing glomerulopathy and HIVAN as compared to control kidney tissue. Importantly, IL-6-induced activation of STAT3 may be a targetable mechanism driving COVID-19-associated acute kidney injury.
Kristin Meliambro, Xuezhu Li, Fadi Salem, Zhengzi Yi, Zeguo Sun, Lili Chan, Miriam Chung, Jorge Chancay, Ha My T Vy, Girish Nadkarni, Jenny S Wong, Jia Fu, Kyung Lee, Weijia Zhang, John C He, Kirk N Campbell

2606 related Products with: Molecular Analysis of the Kidney From a Patient With COVID-19-Associated Collapsing Glomerulopathy.

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#33925460   2021/04/27 To Up

Identification of an 11-Autophagy-Related-Gene Signature as Promising Prognostic Biomarker for Bladder Cancer Patients.

Survival rates for highly invasive bladder cancer (BC) patients have been very low, with a 5-year survival rate of 6%. Accurate prediction of tumor progression and survival is important for diagnosis and therapeutic decisions for BC patients. Our study aims to develop an autophagy-related-gene (ARG) signature that helps to predict the survival of BC patients.
Chaoting Zhou, Alex Heng Li, Shan Liu, Hong Sun

1143 related Products with: Identification of an 11-Autophagy-Related-Gene Signature as Promising Prognostic Biomarker for Bladder Cancer Patients.

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#33875279   2021/04/17 To Up

APOL1 and Preeclampsia: Intriguing Links, Uncertain Causality, Troubling Implications.


John R Sedor, Leslie A Bruggeman, John F O'Toole

1651 related Products with: APOL1 and Preeclampsia: Intriguing Links, Uncertain Causality, Troubling Implications.

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#33853887   2021/04/14 To Up

Diagnosis, Education, and Care of Patients with -Associated Nephropathy: A Delphi Consensus and Systematic Review.

variants contribute to the markedly higher incidence of ESKD in Blacks compared with Whites. Genetic testing for these variants in patients with African ancestry who have nephropathy is uncommon, and no specific treatment or management protocol for -associated nephropathy currently exists.
Barry I Freedman, Wylie Burke, Jasmin Divers, Lucy Eberhard, Crystal A Gadegbeku, Rasheed Gbadegesin, Michael E Hall, Tiffany Jones-Smith, Richard Knight, Jeffrey B Kopp, Csaba P Kovesdy, Keith C Norris, Opeyemi A Olabisi, Glenda V Roberts, John R Sedor, Erika Blacksher

2739 related Products with: Diagnosis, Education, and Care of Patients with -Associated Nephropathy: A Delphi Consensus and Systematic Review.

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#33815781   2021/03/26 To Up

Proteinuria in COVID-19.

Upper respiratory and pulmonary diseases are the primary manifestations of coronavirus disease 2019 (COVID-19). However, kidney involvement has also been recognized and extensively described. A large percentage of affected patients present with acute kidney injury (AKI). However, specific phenotypic aspects of AKI or other renal manifestations of COVID-19 remain sparsely characterized. Many reports indicate that proteinuria can be detected in AKI associated with COVID-19 (CoV-AKI) despite CoV-AKI being largely described as a form of acute tubular injury. On the other hand, individuals of African ancestry with the high-risk genotype are uniquely at risk of developing collapsing glomerulopathy when they are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the entity now known as COVID-19-associated nephropathy (COVAN). Patients with COVAN typically present with nephrotic-range proteinuria. The exact incidence of proteinuria in COVID-19 is unclear due to heterogeneity in the frequency with which proteinuria has been assessed in cases of COVID-19, as well as methodological differences in the way proteinuria is measured and/or reported. In this review we discuss the current evidence of proteinuria as a manifestation of COVID-19 and elaborate on potential pathophysiological mechanisms associated with it.
Muner M B Mohamed, Juan Carlos Q Velez

2504 related Products with: Proteinuria in COVID-19.

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#33811605   // To Up

Correction to: COVID-19-related collapsing glomerulopathy revealing a rare risk variant of APOL1: lessons for the clinical nephrologist.


Timothée Laboux, Jean-Baptiste Gibier, Nicolas Pottier, François Glowacki, Aghilès Hamroun

1002 related Products with: Correction to: COVID-19-related collapsing glomerulopathy revealing a rare risk variant of APOL1: lessons for the clinical nephrologist.

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