Search results for: ABCD3
#33937400 2021/04/14 To Up
A Novel Clinical Nomogram to Predict Transient Symptomatic Associated with Infarction: The ABCD3-SLOPE Score.It is hard to differentiate transient symptoms associated with infarction (TSI) from transient ischemic stroke (TIA) without MRI in the early onset. However, they have distinct clinical outcomes and respond differently to therapeutics. Therefore, we aimed to develop a risk prediction model based on the clinical features to identify TSI.
YanQin Lu, QianQian Bi, Wang Fu, LiLi Liu, Yin Zhang, XiaoYu Zhou, Jue Wang
2959 related Products with: A Novel Clinical Nomogram to Predict Transient Symptomatic Associated with Infarction: The ABCD3-SLOPE Score.1 module96 tests
#33708373 2021/02/25 To Up
ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk.We aimed to evaluate the ABCD3-I score and compare it with the ABCD2 score in short- (1 week) and long-term (3 months; 1 year) stroke risk prediction in our post-TIA stroke risk study, MIDNOR TIA.
Fredrik Ildstad, Hanne Ellekjær, Torgeir Wethal, Stian Lydersen, Hild Fjærtoft, Bent Indredavik100 μg100 μg1-8 Sample Kit100 μg1 mL100 μg100 μg100ug Lyophilized100 μg
#33565298 // To Up
Predictive value of ABCD3 score combined with vascular stenosis in the progression of TIA to cerebral infarction.
L Wang, H L Dai, X Tang, Y J Yang, K Y Sun, L Yu
1947 related Products with: Predictive value of ABCD3 score combined with vascular stenosis in the progression of TIA to cerebral infarction.1096 wells (1 kit)100
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#33389129 2021/01/02 To Up
A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes.Peroxisomes, single-membrane intracellular organelles, play an important role in various metabolic pathways. The translocation of proteins from the cytosol to peroxisomes depends on peroxisome import receptor proteins and defects in peroxisome transport result in a wide spectrum of peroxisomal disorders. Here, we report a large consanguineous family with autosomal recessive congenital cataracts and developmental defects. Genome-wide linkage analysis localized the critical interval to chromosome 12p with a maximum two-point LOD score of 4.2 (θ = 0). Next-generation exome sequencing identified a novel homozygous missense variant (c.653 T > C; p.F218S) in peroxisomal biogenesis factor 5 (PEX5), a peroxisome import receptor protein. This missense mutation was confirmed by bidirectional Sanger sequencing. It segregated with the disease phenotype in the family and was absent in ethnically matched control chromosomes. The lens-specific knockout mice of Pex5 recapitulated the cataractous phenotype. In vitro import assays revealed a normal capacity of the mutant PEX5 to enter the peroxisomal Docking/Translocation Module (DTM) in the presence of peroxisome targeting signal 1 (PTS1) cargo protein, be monoubiquitinated and exported back into the cytosol. Importantly, the mutant PEX5 protein was unable to form a stable trimeric complex with peroxisomal biogenesis factor 7 (PEX7) and a peroxisome targeting signal 2 (PTS2) cargo protein and, therefore, failed to promote the import of PTS2 cargo proteins into peroxisomes. In conclusion, we report a novel missense mutation in PEX5 responsible for the defective import of PTS2 cargo proteins into peroxisomes resulting in congenital cataracts and developmental defects.
Muhammad Ali, Shahid Y Khan, Tony A Rodrigues, Tânia Francisco, Xiaodong Jiao, Hang Qi, Firoz Kabir, Bushra Irum, Bushra Rauf, Asma A Khan, Azra Mehmood, Muhammad Asif Naeem, Muhammad Zaman Assir, Muhammad Hassaan Ali, Mohsin Shahzad, Khaled K Abu-Amero, Shehla Javed Akram, Javed Akram, Sheikh Riazuddin, Saima Riazuddin, Michael L Robinson, Myriam Baes, Jorge E Azevedo, J Fielding Hejtmancik, S Amer Riazuddin
2866 related Products with: A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes.0.25 mg1 g1 ml250 ml200 0.1 ml25 µg1 LITRE0.1 mg0.1ml (1mg/ml)100 TESTS100 ml
#33362869 2020/12/11 To Up
Multi-Omics Analysis of Diabetic Nephropathy Reveals Potential New Mechanisms and Drug Targets.Diabetic nephropathy (DN) is one of the most common diabetic complications, which is the major course of end-stage renal disease (ESRD). However, the systematical molecular characterizations during DN pathogenesis and progression has not been not well understood. To identify the fundamental mediators of the pathogenesis and progression of DN. we performed a combination RNASeq, proteomics, and metabolomics analyses of both patients' derived kidney biopsy samples and kidneys from DN model. As a result, molecular changes of DN contain extracellular matrix accumulation, abnormal activated inflamed microenvironment, and metabolism disorders, bringing about glomerular sclerosis and tubular interstitial fibrosis. Specificity, Further integration analyses have identified that the linoleic acid metabolism and fatty-acids β-oxidation are significantly inhibited during DN pathogenesis and progression, the transporter protein ABCD3, the fatty acyl-CoA activated enzymes ACOX1, ACOX2, and ACOX3, and some corresponding metabolites such as 13'-HODE, stearidonic acid, docosahexaenoic acid, (±)10(11)-EpDPA were also significantly reduced. Our study thus provides potential molecular mechanisms for DN progression and suggests that targeting the key enzymes or supplying some lipids may be a promising avenue in the treatment of DN, especially advanced-stage DN.
Qian Sha, Jinxiu Lyu, Meng Zhao, Haijuan Li, Mengzhe Guo, Qiang Sun
1212 related Products with: Multi-Omics Analysis of Diabetic Nephropathy Reveals Potential New Mechanisms and Drug Targets.5mg5mg 25 MG 15 ml 100ul5mg1 module10mg100 ml20mg
#33128234 2020/12/03 To Up
Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin.ABC transporters (ATP-binding cassette transporter) traffic drugs and their metabolites across membranes, making ABC transporter expression levels a key factor regulating local drug concentrations in different tissues and individuals. Yet, quantification of ABC transporters remains challenging because they are large and low-abundance transmembrane proteins. Here, we analysed 200 samples of crude and membrane-enriched fractions from human liver, kidney, intestine, brain microvessels and skin, by label-free quantitative mass spectrometry. We identified 32 (out of 48) ABC transporters: ABCD3 was the most abundant in liver, whereas ABCA8, ABCB2/TAP1 and ABCE1 were detected in all tissues. Interestingly, this atlas unveiled that ABCB2/TAP1 may have TAP2-independent functions in the brain and that biliary atresia (BA) and control livers have quite different ABC transporter profiles. We propose that meaningful biological information can be derived from a direct comparison of these data sets.
Zubida M Al-Majdoub, Brahim Achour, Narciso Couto, Martyn Howard, Yasmine Elmorsi, Daniel Scotcher, Sarah Alrubia, Eman El-Khateeb, Areti-Maria Vasilogianni, Noura Alohali, Sibylle Neuhoff, Lutz Schmitt, Amin Rostami-Hodjegan, Jill Barber
1429 related Products with: Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin.96 tests100 μg100 μg96 tests96 tests100 μg100 μg100 μg96 tests96T
#32961782 2020/09/19 To Up
Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1.Exercise in humans and animals increases plasma bilirubin levels, but the mechanism by which this occurs is unknown. In the present study, we utilized rats genetically selected for high capacity running (HCR) and low capacity running (LCR) to determine pathways in the liver that aerobic exercise modifies to control plasma bilirubin. The HCR rats, compared to the LCR, exhibited significantly higher levels of plasma bilirubin and the hepatic enzyme that produces it, biliverdin reductase-A (BVRA). The HCR also had reduced expression of the glucuronyl hepatic enzyme UGT1A1, which lowers plasma bilirubin. Recently, bilirubin has been shown to activate the peroxisome proliferator-activated receptor-α (PPARα), a ligand-induced transcription factor, and the higher bilirubin HCR rats had significantly increased PPARα-target genes , , and . These are known to promote liver function and glycogen storage, which we found by Periodic acid-Schiff (PAS) staining that hepatic glycogen content was higher in the HCR versus the LCR. Our results demonstrate that exercise stimulates pathways that raise plasma bilirubin through alterations in hepatic enzymes involved in bilirubin synthesis and metabolism, improving liver function, and glycogen content. These mechanisms may explain the beneficial effects of exercise on plasma bilirubin levels and health in humans.
Terry D Hinds, Justin F Creeden, Darren M Gordon, Adam C Spegele, Steven L Britton, Lauren G Koch, David E Stec
2501 related Products with: Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1.96T 100ul2 Pieces/Box50 mg100 tests100ug100 assays 1 G
#32727840 2020/07/29 To Up
Prospective observational cohort study of early recurrent TIA: Features, frequency, and outcome.To evaluate the frequency, clinical and etiologic features, and short- and long-term outcomes of early recurrent TIA.
Matteo Foschi, Lucia Pavolucci, Francesca Rondelli, Luca Spinardi, Elisabetta Favaretto, Massimo Filippini, Daniela Degli Esposti, Enrico Strocchi, Gianluca Faggioli, Pietro Cortelli, Maria Guarino,
2356 related Products with: Prospective observational cohort study of early recurrent TIA: Features, frequency, and outcome.100ug96T100 mg100 1000 tests100ug500 MG1000 25 mg110 mg100 μg
#32473308 2020/05/28 To Up
Safety of Triple Neuroprotection with Targeted Hypothermia, Controlled Induced Hypertension, and Barbiturate Infusion during Emergency Carotid Endarterectomy for Acute Stroke after Missing the 24 Hours Window Opportunity.The aim of this study is to establish the initial safety of triple neuroprotection (TNP) in an acute stroke setting in patients presenting outside the window for systemic tissue plasminogen activator (tPA).
Sherif Sultan, Makinderjit Dulai, John Laffey, Kevin Clarkson, Abdelaly M A Abedi, Nora Barrett, Mohamed Elsherif, Wael Tawfick, Niamh Hynes
2609 related Products with: Safety of Triple Neuroprotection with Targeted Hypothermia, Controlled Induced Hypertension, and Barbiturate Infusion during Emergency Carotid Endarterectomy for Acute Stroke after Missing the 24 Hours Window Opportunity.100ug1,000 tests50 ul1mgmin 2 cartons10 mg 1000 ml 501 mg100.00 ul
#32269631 2020/03/16 To Up
Abnormal expression of ABCD3 is an independent prognostic factor for colorectal cancer.ATP binding cassette subfamily D member 3 (ABCD3) is a member of the superfamily of ATP-binding cassette (ABC) transporters, which serve crucial roles in the process of tumor cell resistance to chemotherapy. The present study investigated the diagnostic and prognostic capabilities of ABCD3 in colorectal cancer (CRC) by bioinformatics analysis. Gene expression data and corresponding clinical information of patients with CRC were collected from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The results demonstrated that ABCD3 mRNA level was decreased in CRC tissues compared with normal tissues following Wilcoxon test analysis. Furthermore, ABCD3 protein expression was significantly higher in normal colon tissues compared with colon adenocarcinoma tissues according to the Human Protein Atlas. In addition, the area under the Receiver Operating Characteristic curve based on comparison between the tumor and normal groups derived from TCGA and GEO databases demonstrated that the use of ABCD3 mRNA level may be used for the diagnosis of CRC. ABCD3 expression was significantly associated with clinical stage, T stage, and lymph node status following Kruskal-Wallis test or Wilcoxon rank sum test, logistic regression and χ test. Furthermore, the results from Kaplan-Meier survival analysis indicated that low ABCD3 mRNA expression had a poorer prognosis value compared with ABCD3 high expression in patients with CRC. In addition, results from univariate Cox regression analysis indicated that ABCD3 mRNA expression was associated with overall survival (OS), and results from multivariate Cox analysis indicated that ABCD3 mRNA expression may be considered an independent prognostic factor from other clinical factors, such as clinical stage, sex and age. The results from Gene Set Enrichment Analysis demonstrated that the ABCD3 high-expression phenotype was differentially enriched in five biological processes, including apoptosis, cell cycle, renal cell carcinoma, thyroid cancer and colorectal cancer. The findings from this study demonstrated that ABCD3 mRNA expression may be considered as a potential diagnostic and prognostic biomarker in patients with CRC. ABCD3 expression levels may participate in the regulation of cell apoptosis and cell cycle. In addition, GSEA analysis identified Kyoto Encyclopaedia of Genes and Genomes pathways for renal cell carcinoma, thyroid cancer and CRC involving ABCD3.
Yujiao Zhang, Yaqi Zhang, Jiping Wang, Jiyuan Yang, Guodong Yang
1992 related Products with: Abnormal expression of ABCD3 is an independent prognostic factor for colorectal cancer.100 ug25 µg 100ul100ug Lyophilized1 ml100ug100ug Lyophilized0.1ml (1mg/ml)100 TESTS0.25 mg100ug Lyophilized100 ul
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