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#34130304   2021/06/15 To Up

Abdominal Panniculectomy Can Simplify Kidney Transplantation in Obese Patients.

Obesity is frequently present in patients suffering from end-stage renal disease (ESRD). However, overweight kidney transplant candidates are a challenge for the transplant surgeon. Obese patients tend to develop a large abdominal panniculus after weight loss creating an area predisposed to wound-healing disorders. Due to concerns about graft survival and postoperative complications after kidney transplantation, obese patients are often refused in this selective patient cohort. The study aimed to analyze the effect of panniculectomies on postoperative complications and transplant candidacy in an interdisciplinary setting.
Dominik Promny, Theresa Hauck, Aijia Cai, Andreas Arkudas, Katharina Heller, Bernd Wullich, Hendrik Apel, Raymund E Horch, Ingo Ludolph

1684 related Products with: Abdominal Panniculectomy Can Simplify Kidney Transplantation in Obese Patients.



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#34130289   2021/06/15 To Up

Cariogenic Potential of Human and Bovine Milk on Enamel Demineralization.

The higher cariogenicity of human milk when compared with bovine milk is still a debatable subject. Therefore, we evaluated the effect of human or bovine milk exposure on biofilm composition and enamel demineralization using a validated cariogenic biofilm model. Streptococcus mutans UA159 biofilms (n = 8) were grown on human saliva-coated bovine enamel slabs of known surface hardness. The biofilms were exposed 8×/day to 0.9% NaCl (negative control), human milk, bovine milk, 7.0% lactose (active human milk control), 4.5% lactose (active bovine milk control), or 10% sucrose (positive control). The culture medium was changed twice daily, and the pH was analyzed as an indicator of biofilm acidogenicity. After 120 h of growth, biofilms were harvested to evaluate viable cells, and soluble and insoluble extracellular polysaccharides (EPS). Enamel demineralization was assessed by the percentage of surface hardness loss (%SHL). Data were analyzed by one-way ANOVA/Tukey's test (α = 5%). In terms of %SHL, negative control (7.7 ± 3.1), human milk control (13.3 ± 7.5), bovine milk control (15.3 ± 8.2), human milk (7.5 ± 5.0), and bovine milk (8.7 ± 6.3) did not differ among them (p > 0.05) but differed (p < 0.05) from sucrose (55.1 ± 5.4). The findings of enamel demineralization (%SHL) were statistically supported by the data of biofilm acidogenicity, bacterial counts and EPS biofilm composition. This experimental study suggests that human and bovine milk have low cariogenic potential to provoke caries lesions in enamel.
Antonio P Ricomini Filho, Ana Camila M de Assis, Bárbara E Costa Oliveira, Jaime A Cury

2084 related Products with: Cariogenic Potential of Human and Bovine Milk on Enamel Demineralization.

100ug Lyophilized100ug Lyophilized1 kit(96 Wells)100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized 100 UG100ug Lyophilized100ug Lyophilized1 mg

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#34130269   2021/06/15 To Up

Hierarchical CoFe LDH/MOF nanorods array with strong coupling effect grown on carbon cloth enables efficient oxidation of water and urea.

The construction of bifunctional non-noble electrocatalyst for oxygen evolution reaction (OER) and urea oxidation reaction (UOR) is urgent for overall water and urea splitting. Herein, a facile one-step chemical etching- reconstruction strategy is presented for fabricating one-dimensional hierarchical nanorods array composed of CoFe layered double hydroxide (LDH)/MOF supported on carbon cloth as OER and UOR catalysts. By precisely controlling the etching rate, the ligands from Co-MOFs are partially removed, and corresponding metal centers coordinates with hydroxyl ions to generate ultrathin amorphous CoFe LDH nanosheets. The CoFe LDH nanosheets possesses large active surface area, enhanced conductivity and extended electron/mass transfer channels, which are beneficial for catalytic reactions. Additionally, the formed heterojunctions between CoFe LDH and MOFs modulates the local electronic structure of the catalytic active site, leading to enhanced adsorption of oxygen-containing intermediates to facilitate fast electrocatalytic reaction. Therefore, the optimized catalyst of CoFe LDH/MOF-0.06 exhibited superior OER activity with a low overpotential of 276 mV at a current density of 10 mA cm-2 and satisfactory long-term durability. Additionally, it merely required a voltage of 1.45 V to realize 10 mA cm-2 in 1 M KOH electrolyte with 0.33 urea, which 56 mV lower than the voltage under pure KOH. This work here may provide a perspective for the rational design of multi-functional electrocatalysts for water splitting, CO2 reduction, nitrogen reduction reactions and so on.
Shoushuang Huang, Ye Wu, Jie Fu, Peijun Xin, Qian Zhang, Zhiqiang Jin, Jie Zhang, Zhangjun Hu, Zhiwen Chen

2626 related Products with: Hierarchical CoFe LDH/MOF nanorods array with strong coupling effect grown on carbon cloth enables efficient oxidation of water and urea.

500 MG16 Arrays/Slide 1KG

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#34130235   2021/06/12 To Up

Advances in the study of GPCRs by F NMR.

Crystallography and cryo-electron microscopy have advanced atomic resolution perspectives of inactive and active states of G protein-coupled receptors (GPCRs), alone and in complex with G proteins or arrestin. F NMR can play a role in ascertaining activation mechanisms and understanding the complete energy landscape associated with signal transduction. Fluorinated reporters are introduced biosynthetically via fluorinated amino acid analogs or chemically, via thiol-specific fluorinated reporters. The chemical shift sensitivity of these reporters makes it possible to discern details of conformational ensembles. In addition to spectroscopic details, paramagnetic species can be incorporated through orthogonal techniques to obtain distance information on fluorinated reporters, while T-and T-based relaxation experiments provide details on exchange kinetics in addition to fluctuations within a given state.
Louis-Philippe Picard, Robert Scott Prosser

1780 related Products with: Advances in the study of GPCRs by F NMR.

0.1 mg0.2 mg500 ml1 Set100ug Lyophilized1 Set

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#34130234   2021/06/08 To Up

Utility of multi-parametric quantitative magnetic resonance imaging of the lacrimal gland for diagnosing and staging Graves' ophthalmopathy.

To explore radiological changes of the lacrimal gland (LG) in Graves' ophthalmopathy (GO) based on multi-parametric quantitative MRI and its clinical utility in LG diagnosis and activity in GO.
Dide Wu, Hongzhang Zhu, Shubin Hong, Bin Li, Mengsha Zou, Xiaoyi Ma, Xiaojuan Zhao, Pengxia Wan, Zhiyun Yang, Yanbing Li, Haipeng Xiao

1827 related Products with: Utility of multi-parametric quantitative magnetic resonance imaging of the lacrimal gland for diagnosing and staging Graves' ophthalmopathy.

5 G100Tests100tests100ul96 Tests n10 mg16 Arrays/Slide 1000 ml 1 kit(s) 25 μg

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#34130222   2021/05/28 To Up

Lipolytic enzymes and free fatty acids at the endothelial interface.

Lipids released from circulating lipoproteins by intravascular action of lipoprotein lipase (LpL) reach parenchymal cells in tissues with a non-fenestrated endothelium by transfer through or around endothelial cells. The actions of LpL are controlled at multiple sites, its synthesis and release by myocytes and adipocytes, its transit and association with the endothelial cell luminal surface, and finally its activation and inhibition by a number of proteins and by its product non-esterified fatty acids. Multiple pathways mediate endothelial transit of lipids into muscle and adipose tissues. These include movement of fatty acids via the endothelial cell fatty acid transporter CD36 and movement of whole or partially LpL-hydrolyzed lipoproteins via other apical endothelial cell receptors such as SR-B1and Alk1. Lipids also likely change the barrier function of the endothelium and operation of the paracellular pathway around endothelial cells. This review summarizes in vitro and in vivo support for the key role of endothelial cells in delivery of lipids and highlights incompletely understood processes that are the focus of active investigation.
Ira J Goldberg, Ainara G Cabodevilla, Dmitri Samovski, Vincenza Cifarelli, Debapriya Basu, Nada A Abumrad

2335 related Products with: Lipolytic enzymes and free fatty acids at the endothelial interface.

1,000 tests500gm1kg100100gm500g50gm100g

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#34130217   2021/06/07 To Up

"Clicking" fragment leads to novel dual-binding cholinesterase inhibitors.

Cholinesterase inhibitors are potent therapeutics in the treatment of Alzheimer's disease. Among them, dual binding ligands have recently gained a lot of attention. We discovered novel dual-binding cholinesterase inhibitors, using "clickable" fragments, which bind to either catalytic active site (CAS) or peripheral anionic site (PAS) of the enzyme. Copper(I)-catalyzed azide-alkyne cycloaddition allowed to effectively synthesize a series of final heterodimers, and modeling and kinetic studies confirmed their ability to bind to both CAS and PAS. A potent acetylcholinesterase inhibitor with IC = 18 nM (compound 23g) was discovered. A target-guided approach to link fragments by the enzyme itself was tested using butyrylcholinesterase.
Zuzanna Molęda, Anna Zawadzka, Zbigniew Czarnocki, Leticia Monjas, Anna K H Hirsch, Armand Budzianowski, Jan K Maurin

1502 related Products with: "Clicking" fragment leads to novel dual-binding cholinesterase inhibitors.

1 ml100 µg5 g1 kit(96 Wells)1000 100 ml0.1 mg 2 ml Ready-to-use 0.2 mg1x96 well plate1 module50ug

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#34130216   2021/06/06 To Up

Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.

We report the discovery of a fluorescent small molecule probe. This probe exhibits an emission increase in the presence of the oncoprotein MYC that can be attenuated by a competing inhibitor. Hydrogen-deuterium exchange mass spectrometry analysis, rationalized by induced-fit docking, suggests it binds to the "coiled-coil" region of the leucine zipper domain. Point mutations of this site produced functional MYC constructs resistant to inhibition in an oncogenic transformation assay by compounds that displace the probe. Utilizing this probe, we have developed a high-throughput assay to identify MYC inhibitor scaffolds. Screening of a diversity library (N = 1408, 384-well) and a library of pharmacologically active compounds (N = 1280, 1536-well) yielded molecules with greater drug-like properties than the probe. One lead is a potent inhibitor of oncogenic transformation and is specific for MYC relative to resistant mutants and transformation-inducing oncogenes. This method is simple, inexpensive, and does not require protein modification, DNA binding, or the dimer partner MAX. This assay presents an opportunity for MYC inhibition researchers to discover unique scaffolds.
Ryan J Shirey, Jonathan R Hart, BanuPriya Sridharan, Scott J Novick, Lewis D Turner, Bin Zhou, Alexander L Nielsen, Lisa M Eubanks, Lynn Ueno, Mark S Hixon, Luke L Lairson, Timothy P Spicer, Louis D Scampavia, Patrick R Griffin, Peter K Vogt, Kim D Janda

1714 related Products with: Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.

400Tests100 assays4 Sample Kit1 kit

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#34130214   2021/06/08 To Up

Lectins: Biological significance to biotechnological application.

Lectins are a set of non-enzymatic carbohydrate binding proteins appearing in all domains of life. They function to recognize, interact and bring about reversible binding of a specific sugar moiety present in a molecule. Since glycans are ubiquitous in nature and are an essential part of various biological process, the lectins are been investigated to understand the profile of these versatile but complex glycan molecule. The knowledge gained can be used to explore and streamline the various mechanisms involving glycans and their conjugates. Thus, lectins have gained importance in carbohydrate-protein interactions contributing to the development in the field of glycobiology. This has led to a deeper understanding of the importance of saccharide recognition in life. Since their discovery, the lectins have become a great choice of research in the field of glycobiology and their biological significances have recently received considerable attention in the biocontrol field as well as medical sectors.
Dixita Chettri, Manswama Boro, Lija Sarkar, Anil Kumar Verma

2483 related Products with: Lectins: Biological significance to biotechnological application.

0.1ml (1.3mg/ml) 100ul 100ul50ul25 mg0.5mg50ul 100ul 100ul 100ul 100ul 100ul

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#34130210   2021/06/12 To Up

Computational models of the "active self" and its disturbances in schizophrenia.

The notion that self-disorders are at the root of the emergence of schizophrenia rather than a symptom of the disease, is getting more traction in the cognitive sciences. This is in line with philosophical approaches that consider an enactive self, constituted through action and interaction with the environment. We thereby analyze different definitions of the self and evaluate various computational theories lending to these ideas. Bayesian and predictive processing are promising approaches for computational modeling of the "active self". We evaluate their implementation and challenges in computational psychiatry and cognitive developmental robotics. We describe how and why embodied robotic systems provide a valuable tool in psychiatry to assess, validate, and simulate mechanisms of self-disorders. Specifically, mechanisms involving sensorimotor learning, prediction, and self-other distinction, can be assessed with artificial agents. This link can provide essential insights to the formation of the self and new avenues in the treatment of psychiatric disorders.
Tim Julian Möller, Yasmin Kim Georgie, Guido Schillaci, Martin Voss, Verena Vanessa Hafner, Laura Kaltwasser

2861 related Products with: Computational models of the "active self" and its disturbances in schizophrenia.

300 units1

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