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#35973807   2022/08/16 To Up

Computed Tomography Embolus Texture Analysis as a Prognostic Marker of Acute Pulmonary Embolism.

Texture analysis is a quantitative imaging analysis that provides novel biomarkers beyond conventional image reading. Our aim was to use texture analysis of pulmonary emboli derived from thoracic computed tomography for prediction of mortality and prognosis of acute pulmonary embolism (PE). Overall, 216 patients (116 female, 53.7%) were included in the analysis. Texture analysis was calculated on axial slices of the contrast enhanced pulmonary angiography of the proximal embolus. Clinical scores, serological parameters, need for intubation, intensive care unit (ICU) admission and mortality was assessed and correlated with the texture features. In the correlation analysis, there were several associations with mortality in days, the highest for the parameter S(0,5)SumVarnc ( = -0.43, < 0.001). Another parameter, S(3,-3)AngScMom correlated with sepsis-related organ failure assessment score (SOFA)-score ( = 0.31, < 0.001). Several texture features correlated with venous lactate and glucose levels. In discrimination analysis, there were significant differences in regard to texture features between survivors and non-survivors and between patients with and without the need for ICU admission ( = 0.02, respectively). These results highlight the potential clinical benefit of texture features in patients with acute PE as novel imaging biomarkers. Further studies are needed to validate these results.
Jakob Leonhardi, Nikolaos Bailis, Marianne Lerche, Timm Denecke, Alexey Surov, Hans-Jonas Meyer

1781 related Products with: Computed Tomography Embolus Texture Analysis as a Prognostic Marker of Acute Pulmonary Embolism.



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#35973765   2022/07/14 To Up

Profile of commercialized aphicides on the survivorship and feeding behavior of the cotton aphid, Aphis gossypii.

The cotton aphid, Aphis gossypii Glover (Hemiptera: Aphididae), is one of the most destructive agricultural pests due to photosynthate removal and horizontal transmission of plant viruses. Horizontal transmission of plant viruses by aphids occurs during distinct feeding behavioral events, such as probing for non-persistent viruses or phloem feeding for persistent viruses. We employed toxicity bioassays and electrical penetration graph (EPG) methodology to compare toxicity and quantify changes to feeding behavior and toxicity of A. gossypii after exposure to commercialized aphicides. Commercialized aphicides containing flupyradifurone, sulfoxaflor, thiamethoxam, thiamethoxam + lambda cyhalothrin, and bifenthrin induced >90% aphid mortality within 4 h of exposure. Flupyradifurone was the most acutely toxic aphicide studied with an LT of 8.9 min after exposure, which was approximately 3-fold lower than bifenthrin and thiamethoxam + lambda cyhalothrin. This was supported by our EPG results that showed a significant reduction in the proportion of aphids that continued to probe on cotton 4 h after exposure to flonicamid, thiamethoxam, flupyradifurone, bifenthrin, and thiamethoxam + lambda cyhalothrin. The commercialized aphicides containing spirotetramat, flonicamid, thiamethoxam, flupyradifurone, bifenthrin, sulfoxaflor, and pymetrozine significantly (P < 0.05) decreased the time to first probe when compared to the untreated control. Lastly, E1 (phloem salivation) and E2 (phloem ingestion) waveforms were significantly (P < 0.05) reduced for flupyradifurone, flonicamid, thiamethoxam, sulfoxaflor, and thiamethoxam. These data provide a comparative study for the development of new aphicides aiming to induce acute lethality and reduce aphid transmission of plant viruses.
Flinn M O'Hara, Jeffrey A Davis, Daniel R Swale

2359 related Products with: Profile of commercialized aphicides on the survivorship and feeding behavior of the cotton aphid, Aphis gossypii.

12 5 G50 IU100.00 ul1500 Units 100ul

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#35973750   2022/08/16 To Up

[Acute respiratory tract infections and antibiotic prescriptions: What are patients' expectations?]

 The use of antibiotics in human medicine is partly responsible for the global increase in antibiotic resistance. Significant reductions in antibiotic prescribing were realised through educational campaigns, communication training and prescribing feedback. Based on data from the cluster-randomised CHANGE-3 trial, the present analysis focuses on the question of patient expectations for an antibiotic in acute respiratory infections.
Anja Wollny, Attila Altiner, Katharina Garbe, Anja Klingenberg, Petra Kaufmann-Kolle, Martina Köppen, Martina Kamradt, Regina Poß-Doering, Michel Wensing, Mirko Leyh, Arwed Voss, Gregor Feldmeier

2916 related Products with: [Acute respiratory tract infections and antibiotic prescriptions: What are patients' expectations?]