Search results for: adenocarcinoma
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Aqueous ethanol extract of Libidibia ferrea (Mart. Ex Tul) L.P. Queiroz (juca) exhibits antioxidant and migration-inhibiting activity in human gastric adenocarcinoma (ACP02) cells.Libidibia ferrea (juca) is a plant belonging to the Fabaceae (Leguminosae) family, whose antioxidant activity has been widely described in the literature. We evaluated this parameter of Aqueous ethanol extract (AE), ethyl acetate (ACO), chloroform (CLO) and hexane (HEX) extracts of L. ferrea. We then tested the most active extract for its toxicity and ability to inhibit migratory activity in the ACP02 gastric adenocarcinoma cell line in vitro. The AE and ACO extracts both had antioxidant activity, the AE extract showing greater potential. This may reflect that both extracts contained phenolic compounds. Although AE extract showed no cytotoxic, mutagenic or genotoxic effect, it altered cell morphology and migration activity. Analysis of apoptosis/necrosis indicated that this parameter does not appear to account for the apparent ability of AE to inhibit cancer cell migration. We speculate that the morphological changes in AE-treated cells could be due to cytoskeleton alterations related to the presence of myo-inositol in AE extract. Together, our results demonstrate this extract of L. ferrea can act as an exogenous antioxidant and might prove useful in efforts to fight secondary tumors.
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GANT61 and Curcumin loaded PLGA Nanoparticles for GLI-1 and PI3K/Akt Mediated Inhibition in Breast Adenocarcinoma.Current conventional mono and combination therapeutic strategies often fail to target breast cancer tissue effectively due to tumor heterogeneity comprising of cancer stem cells (CSCs) and bulk tumor cells. This is further associated with drug toxicities and resistivity in the long run. Nanomedicine platform incorporating combination anti-cancer treatment might overcome these challenges and generate synergistic anti-cancer effects and also reduce drug toxicities. GANT61 and curcumin were co-delivered via polymeric nanoparticles for the first time to elicit enhanced anti-tumor activity against heterogeneous breast cancer cell line MCF-7. We adopted the single emulsion solvent evaporation method for the preparation of the therapeutic nanoparticles. The GANT61-curcumin PLGA nanoparticles were characterized for their size, shape, chemical properties, and anti-cancer cell studies were performed for the plausible explanation of our hypothesis. The synthesized GANT61-curcumin PLGA NPs had a spherical, smooth surface morphology, and an average size of 347.4 d. nm. The nanoparticles induced cytotoxic effects to breast cancer cells at a mid-minimal dosage followed by cell death via autophagy and apoptosis, reduction in their target protein expression along with compromising the self-renewal property of CSCs as revealed by their in vitro cell studies. The dual drug NPs thus provides a novel perspective on the aid of existing anti-cancer nano-medicine therapies to target a heterogeneous tumor mass effectively.
2547 related Products with: GANT61 and Curcumin loaded PLGA Nanoparticles for GLI-1 and PI3K/Akt Mediated Inhibition in Breast Adenocarcinoma.Rabbit Anti-Rat Androgen Androgen Receptor , Mouse Androgen Receptor (Phosph Androgen Receptor (Ab 650 GDC-0941 Mechanisms: PI3K PF-04691502 Mechanisms: P Anti Androgen Receptor pr Indole 4 carboxaldehyde ( Androgen Receptor Androgen Receptor Androsta-3,5,16-trien-17- IPI-145 (INK-1197) Mechan
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Comprehensive analysis of prognostic biomarkers in lung adenocarcinoma based on aberrant lncRNA-miRNA-mRNA networks and Cox regression models.Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide. Accumulating evidence has highlighted that lncRNA acts as ceRNA and plays an important role in the occurrence and development of LUAD. Here, we comprehensively analyzed the lncRNAs, miRNAs, and mRNAs associated with LUAD from TCGA database. Then, differentially expressed lncRNAs (DElncRNA), miRNAs (DEmiRNA), and mRNAs (DEmRNA) were used to construct a lncRNA-miRNA-mRNA regulatory network according to interaction information from miRcode, TargetScan, miRTarBase, and miRDB. Finally, the RNAs of the network were analyzed for survival and submitted for Cox regression analysis to construct prognostic indicators. A total of 1,123 DElncRNAs, 95 DEmiRNAs, and 2,296 DEmRNAs were identified (|log2FoldChange| (FC) > 2 and false discovery rate (FDR) < 0.01). The ceRNA network was established based on this and included 102 lncRNAs, 19 miRNAs, and 33 mRNAs. The DEmRNAs in the ceRNA network were found to be enriched in various cancer-related biological processes and pathways. We detected 22 lncRNAs, 12 mRNAs, and 1 miRNA in the ceRNA network that were significantly associated with the overall survival of patients with LUAD (P<0.05). We established three prognostic prediction models and calculated the area under the 1,3,5-year curve values of lncRNA, mRNA and miRNA, respectively. Among them, the prognostic index (PI) of lncRNA showed good predictive ability which was 0.737, 0.702 and 0.671 respectively, and eight lncRNAs can be used as candidate prognostic biomarkers for LUAD. In conclusion, our study provides a new perspective on the prognosis and diagnosis of LUAD on a genome-wide basis.
2088 related Products with: Comprehensive analysis of prognostic biomarkers in lung adenocarcinoma based on aberrant lncRNA-miRNA-mRNA networks and Cox regression models.Lung adenocarcinoma tissu Lung adenocarcinoma and n Lung adenocarcinoma tissu Lung adenocarcinoma tissu Middle advanced stage lun Rectum adenocarcinoma tis Lung cancer tissue array Lung tumor survey tissue Lung adenocarcinoma (grad Stomach adenocarcinoma ti Lung carcinoma tissue arr Lung cancer test tissue a
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[The Value of MRI Texture Analysis in Identifying Intraductal Carcinoma of the Prostate Gland].To explore the value of a radiomics approach based on MRI texture analysis (TA) in identifying intraductal carcinoma of the prostate gland (IDCP).
2983 related Products with: [The Value of MRI Texture Analysis in Identifying Intraductal Carcinoma of the Prostate Gland].FDA Standard Frozen Tissu FDA Standard Frozen Tissu Breast intraductal carcin FDA Standard Frozen Tissu Multiple organ tumor tiss FDA Standard Frozen Tissu Thermal Shaker with cooli Hyperplasia and carcinoma FDA Standard Frozen Tissu MultiGene Gradient therm FDA Standard Frozen Tissu Prostate cancer tissue ar
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Fucosyltransferase 8 plays a crucial role in the invasion and metastasis of pancreatic ductal adenocarcinoma.Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It is an aggressive malignancy associated with poor prognosis because of recurrence, metastasis, and treatment resistance. Aberrant glycosylation of cancer cells triggers their migration and invasion and is considered one of the most important prognostic cancer biomarkers. The current study aimed to identify glycan alterations and their relationship with the malignant potential of PDAC.
2050 related Products with: Fucosyltransferase 8 plays a crucial role in the invasion and metastasis of pancreatic ductal adenocarcinoma.Breast invasive ductal ca Anti beta3 AR Human, Poly Ovary serous papillary ad Pancreatic duct adenocarc Prostate adenocarcinoma t Colon poorly differentiat Breast invasive ductal ca Pancreatic cancer tissue Anti VGLUT 1 Rat, polyclo Breast invasive ductal ca Rectum adenocarcinoma tis Breast invasive ductal ca
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[S3 guidelines on gastric cancer-diagnosis and treatment of adenocarcinoma of the stomach and esophagogastric junction : Version 2.0-August 2019. AWMF register number: 032/009OL].
2519 related Products with: [S3 guidelines on gastric cancer-diagnosis and treatment of adenocarcinoma of the stomach and esophagogastric junction : Version 2.0-August 2019. AWMF register number: 032/009OL].Ofloxacin CAS Number [824 Stomach cancer progressio 19 Hydroxy 4 androstene 3 Epiandrosterone (3 beta H 4 Androstene 3,17 dione C 1,4 Androstadiene 3,17 di Andrographolide CAS Numbe Stomach cancer high densi Stomach adenocarcinoma (g (5α,16β)-N-Acetyl-16-ac Androst-4-ene-3,17-dion-1 5α-Androstan-3β-ol �
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Interobserver Variability in the Diagnosis of High-Grade Prostatic Intraepithelial Neoplasia in a Tertiary Hospital in Northern Jordan.Prostate intraepithelial neoplasia is described as a precursor lesion to prostatic adenocarcinoma. High-grade prostate intraepithelial neoplasia (HGPIN) is classified as both grade 2 and 3 prostate intraepithelial neoplasia due to inconsistency between pathologists' findings. In our study, we assessed the interobserver variability in the diagnosis of HGPIN among genitourinary and nongenitourinary pathologists. All cases with prostate adenocarcinoma diagnosis on needle core biopsy, radical prostatectomy, and transurethral resection of prostate (TURP) between the years 2005 and 2014 were included. In total, 191 prostate cancer cases were included: 109 needle core biopsies, 45 radical prostatectomies, and 37 TURP. All were independently reviewed by 2 urologic pathologists for the presence of HGPIN. High-grade prostate intraepithelial neoplasia was diagnosed in 65 cases (34%), among which the lesion was recognized by the reporting pathologists in 36 (55%) of the cases and was missed in 29 (45%) of the cases with a κ coefficient of 0.53. There was a moderate interobserver agreement in the diagnosis of HGPIN. Consultation with genitourinary pathologist can improve HGPIN diagnosis.
2315 related Products with: Interobserver Variability in the Diagnosis of High-Grade Prostatic Intraepithelial Neoplasia in a Tertiary Hospital in Northern Jordan.Prostate cancer, PIN (pro High density stomach canc High density cervix cance High density larynx and p High density esophageal c High density multiple org High density ovarian canc Multiple organ tumor tiss High density Lung cancer Colon cancer high density High density colon cancer High density liver cancer
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A patient with a pancreatic neuroendocrine tumor and multiple liver metastases achieved a long-term partial response to third-line streptozocin treatment.The Japanese guideline for gastroenteropancreatic neuroendocrine tumor treatment recommends everolimus or sunitinib as first-line treatment for unresectable pancreatic neuroendocrine tumors (PNETs). Streptozocin (STZ) is recommended as an alternative. We encountered a patient with PNET who had multiple liver metastases and who showed a remarkable response to third-line STZ. The patient was a 50-year-old man with a pancreatic head tumor 32 mm in diameter. We planned to perform subtotal stomach-preserving pancreaticoduodenectomy, but abandoned resecting the pancreas during the surgery upon discovering a small liver tumor 3 mm in diameter, examination of frozen sections of which revealed a poorly differentiated adenocarcinoma. However, the final pathological examination revealed that the liver nodule was a PNET; hence, we completed the subtotal stomach-preserving pancreaticoduodenectomy 5 weeks after the first laparotomy. The patient received no adjuvant chemotherapy after surgery. Twenty-one months later, we discovered 20 scattered liver metastases via computed tomography; these were considered unresectable. Therefore, we administered everolimus for 7 months, but the patient developed interstitial pneumonia and experienced metastatic progression. Subsequent sunitinib administration for 6 months was ineffective. Finally, we chose STZ (1000 mg/m, weekly) as a third-line treatment, which produced a partial response for 10 months. The patient remains alive 38 months after the detection of recurrence. As the order in which anti-cancer drugs should be administered to treat PNET has not been determined, additional predictors of their therapeutic efficacy should be investigated.
2765 related Products with: A patient with a pancreatic neuroendocrine tumor and multiple liver metastases achieved a long-term partial response to third-line streptozocin treatment.1,1'-Dioctadecyl-3,3,3',3 Multiple tumor and normal Goat Anti-Human Wilms tum Goat Anti-Human TOM1L2, ( Multiple organ tumor tiss LIVER DISEASES Total Bile Multiple organs tumor and Multiple pancreatic cance Multiple head and neck tu Liver cancer tissue array Multiple pancreatic cance Liver late stage tumor ti
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Rectal cancer with extensive distal intramural spread treated by abdominoperineal resection.Distal intramural spread refers to microscopic tumor implantation in the intestinal wall, distal to the inferior edge of a macroscopic tumor but rarely beyond 2 cm. We report a case of rectal cancer with preoperatively diagnosed distant intramural spread to approximately 6.5 cm. A 75-year-old woman diagnosed with upper rectal cancer was scheduled to undergo low anterior resection 5 weeks after initial presentation. However, preoperative digital rectal examination and anoscopy under general anesthesia revealed a rectal tumor 4 cm proximal to the anal verge; adenocarcinoma was diagnosed based on frozen section analysis of the rectal tumor. Therefore, abdominoperineal resection was performed, and histopathological examination confirmed a moderately differentiated adenocarcinoma with distal intramural spread of 6.5 cm. The patient died 18 months postoperatively owing to lung metastasis. Although distal intramural spread is rare and can be difficult to detect prior to surgery, repeated rectal examination, with prompt histological examination of suspicious lesions, can ensure earlier diagnosis to achieve better local control by radical surgery including sufficient distal margin.
2099 related Products with: Rectal cancer with extensive distal intramural spread treated by abdominoperineal resection.Rectal cancer tissue arra Rectal cancer and normal Rectum disease spectrum ( Rectal cancer tissue arra Rectal cancer and normal Rectal cancer mid density Rectal cancer test tissue Multiple rectal cancer ti GI cancer (gastric, colon Rectal cancer tissue arra Multiple rectal cancer ti Rectal normal adjacent ti
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A case report of paraneoplastic syndrome in β-hCG-secreting duodenal adenocarcinoma.Human chorionic gonadotropin (hCG) is a glycoprotein hormone that is used in clinical practice to detect pregnancy and serves as a sensitive marker for trophoblastic tumors. Other organs besides placental trophoblasts naturally express the hormone at low levels, which can be elevated in nontrophoblastic malignancies. Some studies have suggested that elevated β-hCG levels in nontrophoblastic tumors are a sign of aggressive disease and strongly associated with poor prognosis. We describe a case of a 50-year-old post-menopausal woman with metastatic duodenal adenocarcinoma who presented with a negative pregnancy test that later changed to positive. Biopsy of the primary duodenal mass showed positive immunohistochemical expression of β-hCG. The patient was also found to have multiple brain metastases, which is uncommon in gastrointestinal cancer. This is a rare case of paraneoplastic syndrome in a β-hCG-secreting duodenal adenocarcinoma.
1993 related Products with: A case report of paraneoplastic syndrome in β-hCG-secreting duodenal adenocarcinoma.Colon adenocarcinoma with Frozen colorectal adenoca Rectal adenocarcinoma (gr Colon adenocarcinoma (com Endometrioid adenocarcino Stomach adenocarcinoma ti Colon poorly differentiat Lung adenocarcinoma tissu Prostate adenocarcinoma t Ovary adenocarcinoma tiss Pancreas adenocarcinoma t Colon adenocarcinoma tiss
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