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#34525421   2021/08/10 To Up

Endocrine regulation of fetal metabolism towards term.

Hormones have an important role in regulating fetal metabolism in relation to the prevailing nutritional conditions both in late gestation and during the prepartum period as the fetus prepares for birth. In particular, the pancreatic, thyroid and adrenal hormones all affect fetal uptake and utilization of nutrients for oxidative metabolism, tissue accretion and fuel storage. These hormones also influence the fetal metabolic preparations for the nutritional transition from intra- to extra-uterine life. This review discusses the role of insulin, glucagon, thyroxine, tri-iodothyronine, cortisol and the catecholamines in these processes during normal intrauterine conditions and in response to maternal undernutrition with particular emphasis on the sheep fetus. It also considers the metabolic interactions between these hormones and their role in the maturation of key tissues, such as the liver, skeletal muscle and adipose tissue, in readiness for their new metabolic functions after birth. Endocrine regulation of fetal metabolism is shown to be multifactorial and dynamic with a central role in optimizing metabolic fitness for survival both in utero and at birth.
Abigail L Fowden, Alison J Forhead

2621 related Products with: Endocrine regulation of fetal metabolism towards term.

0.1 mg0.1 ml50 0.1 ml0.1 mg500 ml 0.1 mg 0.1 mg100 ul0.1 mg50

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#34525353   // To Up

Metabolic endotoxemia is dictated by the type of lipopolysaccharide.

Lipopolysaccharides (LPSs) can promote metabolic endotoxemia, which is considered inflammatory and metabolically detrimental based on Toll-like receptor (TLR)4 agonists, such as Escherichia coli-derived LPS. LPSs from certain bacteria antagonize TLR4 yet contribute to endotoxemia measured by endotoxin units (EUs). We found that E. coli LPS impairs gut barrier function and worsens glycemic control in mice, but equal doses of LPSs from other bacteria do not. Matching the LPS dose from R. sphaeroides and E. coli by EUs reveals that only E. coli LPS promotes dysglycemia and adipose inflammation, delays intestinal glucose absorption, and augments insulin and glucagon-like peptide (GLP)-1 secretion. Metabolically beneficial endotoxemia promoted by R. sphaeroides LPS counteracts dysglycemia caused by an equal dose of E. coli LPS and improves glucose control in obese mice. The concept of metabolic endotoxemia should be expanded beyond LPS load to include LPS characteristics, such as lipid A acylation, which dictates the effect of metabolic endotoxemia.
Fernando F Anhê, Nicole G Barra, Joseph F Cavallari, Brandyn D Henriksbo, Jonathan D Schertzer

2011 related Products with: Metabolic endotoxemia is dictated by the type of lipopolysaccharide.

25 µg0.1 mg100 ug0.25 mg25 µg100 ug250 ml100 TESTS96T1 LITRE0.1 mg16 Arrays/Slide

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#34525197   2021/09/15 To Up

Adiponectin, leptin and resistin and the risk of dementia.

Adipokines are hormones secreted by adipose tissue with roles in energy homeostasis and regulation of metabolism. Their dysregulation is suggested to contribute to the increased risk of dementia seen with midlife obesity, but longitudinal studies investigating this are scarce. We determined the association between plasma levels of adiponectin, leptin and resistin with the risk of dementia.
Sanne S Mooldijk, M Kamran Ikram, M Arfan Ikram

1141 related Products with: Adiponectin, leptin and resistin and the risk of dementia.

200ug10 mg100ul50 ug 200ul25 mg1000 tests100ug5mg10 mg100 mg

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#34525175   2021/09/15 To Up

Plasminogen activator inhibitor-1and Adiponectin are associated with metabolic syndrome components.

We aimed to study the associations of adipocytokines, endothelial damage markers, and hs-CRP with metabolic syndrome (MetS) components.
Andrea Vecchiola, Killén García, Luis M González-Gómez, Alejandra Tapia-Castillo, Rocío Artigas, René Baudrand, Alexis M Kalergis, Cristian A Carvajal, Carlos E Fardella

1574 related Products with: Plasminogen activator inhibitor-1and Adiponectin are associated with metabolic syndrome components.

200 100.00 ug100.00 ug1mg200 100.00 ug0.1mg200 96 Tests/kit250ul2 mg5mg

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#34525131   2021/09/15 To Up

Trypanosoma brucei triggers a broad immune response in the adipose tissue.

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Henrique Machado, Tiago Bizarra-Rebelo, Mariana Costa-Sequeira, Sandra Trindade, Tânia Carvalho, Filipa Rijo-Ferreira, Barbara Rentroia-Pacheco, Karine Serre, Luisa M Figueiredo

1847 related Products with: Trypanosoma brucei triggers a broad immune response in the adipose tissue.



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#34524919   // To Up

Liver Fat, Adipose Tissue, and Body Composition Changes After Switching from a Protease Inhibitor or Efavirenz to Raltegravir.

Integrase inhibitors appear to increase body weight, but paradoxically some data indicate that raltegravir (RAL) may decrease liver fat. Our objective was to study the effects of switching from a protease inhibitor (PI) or efavirenz (EFV) to RAL on liver fat, body composition, and metabolic parameters among people living with HIV (PLWH) with high risk for nonalcoholic fatty liver disease (NAFLD). We randomized overweight PLWH with signs of metabolic syndrome to switch a PI or EFV to RAL ( = 19) or to continue unchanged antiretroviral therapy (control,  = 24) for 24 weeks. Liver fat was measured by magnetic resonance spectroscopy (MRS), body composition by magnetic resonance imaging, and bioimpedance analysis; subcutaneous fat biopsies were obtained. Median (interquartile range) liver fat content was normal in RAL 2.3% (1.1-6.0) and control 3.1% (1.6-7.3) group at baseline. Liver fat and visceral adipose tissue remained unchanged during the study. Body weight [from 85.9 kg (76.1-97.7) to 89.3 (78.7-98.7),  = 0.019], body fat mass [from 20.3 kg (14.6-29.7) to 22.7 (17.0-29.7),  = 0.015], and subcutaneous adipose tissue (SAT) volume [from 3979 mL (2068-6468) to 4043 (2206-6433),  = 0.048] increased, yet, adipocyte size [from 564 pL (437-733) to 478 (423-587),  = 0.019] decreased in RAL but remained unchanged in control group. Circulating lipids and inflammatory markers improved in RAL compared to control group. The median liver fat measured by MRS was unexpectedly within normal range in this relatively small study population with presumably high risk for NAFLD contradicting high prevalence of NAFLD reported with other methods. Despite weight gain, increase in SAT together with decreased adipocyte size and reduced inflammation may reflect improved adipose tissue function. Clinical Trial Registration number: NCT03374358.
Anna Hanttu, Sauli Vuoti, Pia Kivelä, Perttu Arkkila, Nina Lundbom, Antti Hakkarainen, Jesper Lundbom, Tiina Lehtimäki, Hanna Viskari, Ville Lehtinen, Kirsi H Pietiläinen, Jussi Sutinen

1247 related Products with: Liver Fat, Adipose Tissue, and Body Composition Changes After Switching from a Protease Inhibitor or Efavirenz to Raltegravir.

96tests

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#34524564   2021/09/15 To Up

Automatic segmentation of whole-body adipose tissue from magnetic resonance fat fraction images based on machine learning.

To propose a fully automated algorithm, which is implemented to segment subcutaneous adipose tissue (SAT) and internal adipose tissue (IAT) from the total adipose tissue for whole-body fat distribution analysis using proton density fat fraction (PDFF) magnetic resonance images.
Zhiming Wang, Chuanli Cheng, Hao Peng, Yulong Qi, Qian Wan, Hongyu Zhou, Shaocheng Qu, Dong Liang, Xin Liu, Hairong Zheng, Chao Zou

1644 related Products with: Automatic segmentation of whole-body adipose tissue from magnetic resonance fat fraction images based on machine learning.

96 tests100preparations100 assays96 wells

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#34523589   // To Up

Epicardial fat: More than an adipose tissue.


Göksel Çinier, Sanem Nalbantgil

1334 related Products with: Epicardial fat: More than an adipose tissue.



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#34523258   2021/09/14 To Up

Secular and longitudinal trends in body composition: The Tromsø Study, 2001 to 2016.

Overweight, defined as excessive fat mass, is a long-standing worldwide public health challenge. Traditional anthropometric measures used to identify overweight and obesity do not assess body composition. The aim of this study was to examine population trends in general and abdominal fat mass during the past two decades.
Marie Wasmuth Lundblad, Jonas Johansson, Bjarne K Jacobsen, Sameline Grimsgaard, Lene Frost Andersen, Tom Wilsgaard, Laila A Hopstock

1430 related Products with: Secular and longitudinal trends in body composition: The Tromsø Study, 2001 to 2016.

101 kit100 100 96 wells

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