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#35045530   2022/01/17 To Up

Psychometric validation of the Persian version of the Mental Health Knowledge Schedule.

Determining the reliability and validity of the Mental Health Knowledge Schedule (MAKS-P) in Iran was the purpose of this study. We translated the MAKS into Persian and back into English. The validation process included linguistic validation, face validity, internal consistency, test-retest reliability, and construct validity. We perform multiple linear regressions to test the association between mental health knowledge and independent variables. A total of 384 people completed the Persian version of the questionnaire. In total, 64.6% of the respondents were women. The majority of respondents (51.6%) were married and did not have a full-time job (67.7%). The linguistic validation was confirmed. All the items of the questionnaire had acceptable face validity, except question number one, which was deleted due to incompatibility with the Iranian culture. Good internal consistency and reliability were shown by an overall Cronbach's alpha coefficient of 0.77. The test-retest approach was performed and the Cronbach's alpha was 0.845. Eigenvalues and the scree plot supported a 2-factorial nature of the translated survey form. The first and the second factors explained 33.14 and 14.92% of the variance, respectively. Age, education, and working status can be considered possible predictors of the MAKS-P score. The MAKS-P is a trustworthy questionnaire to assess stigma-related mental health knowledge in Persian-speaking societies.
Bahareh Hakimi, Fateme Farhoudi, Ehsan Abedini

1970 related Products with: Psychometric validation of the Persian version of the Mental Health Knowledge Schedule.

100 U100.00 ul

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#35045525   2022/01/17 To Up

Lidocaine hampers colorectal cancer process via circITFG2/miR-1204/SOCS2 axis.

Colorectal cancer (CRC) is a deadly disease with a poor prognosis. Lidocaine is preferred by surgical procedures due to the excellent anesthesia. Circular RNA integrin alpha FG-GAP repeat containing 2 (circITFG2) has been recognized as a momentous participator in CRC progression. The specific role of circITFG2 was further studied in this research.
Huashe Wang, Xuexia Zhang, Yi Li, Yanan Li, Ting Pang

2243 related Products with: Lidocaine hampers colorectal cancer process via circITFG2/miR-1204/SOCS2 axis.

Each1 kit(96 Wells)

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#35045400   2022/01/19 To Up

Advanced three-dimensional hierarchical porous α-MnO2 nanowires network toward enhanced supercapacitive performance.

Hierarchical α-MnO2 nanowires with oxygen vacancies grown on carbon fiber have been synthesized by a simple hydrothermal method with the assistance of Ti4+ ions. Ti4+ ions play an important role in controlling the morphology and crystalline structure of MnO2. The morphology and structure of the as-synthesized MnO2 could be tuned from δ-MnO2 nanosheets to hierarchical α-MnO2 nanowires with the help of Ti4+ ions. Based on its fascinating properties, such as many oxygen vacancies, high specific surface area and the interconnected porous structure, the α-MnO2 electrode delivers a high specific capacitance of 472 F g-1 at a current density of 1 A g-1 and the rate capability of 57.6% (from 1 to 16A g-1). The assembled symmetric supercapacitor based on α-MnO2 electrode exhibits remarkable performance with a high energy density of 44.5 Wh kg-1 at a power density of 2.0 kW kg-1 and good cyclic stability (92.6% after 10000 cycles). This work will provide a reference for exploring and designing high-performance MnO2 materials.
Xiaohui Su, Zicong Liang, Qingqing He, Yanxin Guo, Gaodan Luo, Shengbo Han, Lin Yu

2167 related Products with: Advanced three-dimensional hierarchical porous α-MnO2 nanowires network toward enhanced supercapacitive performance.

125 ml 10 UG96 Tests/kit 50 UG

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#35045399   2022/01/19 To Up

Determination of the Tricritical point, H-T phase diagram and Exchange Interactions in the Antiferromagnet MnTaO.

Using the analysis of the temperature and field dependence of the magnetization measurements, the H-T phase diagram, tricritical point and exchange constants of the antiferromagnetic (AFM) MnTaOare determined in this work. Temperature dependence of magnetic susceptibility χ(T) yields the Néel temperature T= 5.97 K determined from the peak in the ∂(χT)/∂T vs. T plot, in agreement with the T= 6K determined from the peak in the Cvs. T data. The experimental data of Cvs. T near Tis fitted to C= A|T-T|yielding the critical exponent α = 0.09 (0.13) for T > T(T < T). The χ-T data for T > 25 K fits well with the modified Curie-Weiss law: χ = χ+ C/(T-θ) with χ= -2.12 × 10emu.molOeyielding θ = -24 K, and C = 4.44 emu.K.molOe, the later giving μ= 5.96 μper Mn. This yields the effective spin S = 5/2 and g = 2.015 for Mn, in agreement with g = 2.0165 measured using ESR spectroscopy. Using the magnitudes of θ and Tand molecular field theory, the AFM exchange constants J/k= -1.5 ± 0.2 K and J/kB = -0.85 ± 0.05 K for Mnions along the chain c-axis and perpendicular to the c-axis respectively are determined. The χ-T data when compared to the prediction of a Heisenberg linear chain model provides semiquantitative agreement with the observed variation. The H-T phase diagram is mapped using the M-H isotherms and M-T data at different H yielding the tricritical point T(H, T) = (17.0 kOe, 5.69 K) separating the paramagnetic, AFM, and spin-flop phases. At 1.5 K, the experimental magnitudes of the exchange field H= 206.4 kOe and spin-flop field H= 23.5 kOe yield the anisotropy field H= 1.34 kOe.
Maruthi R, Mohindar Seehra, Sayandeep Ghosh, Rohit Medwal, Rajdeep Singh Rawat, Bruno Weise, Eun Sang Choi, Subhash Thota

1780 related Products with: Determination of the Tricritical point, H-T phase diagram and Exchange Interactions in the Antiferromagnet MnTaO.

1500IU400Tests

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#35045386   2022/01/13 To Up

Preparation of high solid content oxidized starch by acid pretreatment-HO oxidation and its performance as the ligand in zirconium tanning.

Highly-oxidized starch (HOS) is an excellent ligand for zirconium tanning in leather making. However, oxidation reaction can only be undertaken in diluted solution due to the high viscosity of starch, which leads to high oxidant consumption and low solid content of HOS, and therefore greatly limits its industrial application. Starch was predegraded by using HCl followed by HO oxidation for preparing a practical oxidized starch (OST) ligand with high solid content. HCl (5%) remarkably reduced the viscosity of starch and simplified the subsequent oxidation, resulting in a decrease in HO dosage from 60% to 40% and an increase in solid content from 10% to 38%. HCl broke the α-(1-4) glycosidic bond between glucose units, and HO oxidation led to the generation of abundant carboxyl groups in OST. The OST with moderate molecular weight (Mw 5609 g/mol) and carboxyl content (6.48 mmol/g) made the tanning performance of OST-Zr comparable to those of HOS-Zr and chrome tanning agents. Therefore, this work gives new insights into the crop-polysaccharides based ligands application and exhibits huge potential for promoting industrial applications of zirconium tanning.
Jiaying Wang, Yue Yu, Wang Yue, Yuhe Feng, Ya-Nan Wang, Bi Shi

2408 related Products with: Preparation of high solid content oxidized starch by acid pretreatment-HO oxidation and its performance as the ligand in zirconium tanning.

0.1ml (1mg/ml)96 assays400Tests4 Membranes/Box 5 G1004 Arrays/Slide50 ug 100 UG

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#35045376   2022/01/13 To Up

Identification of anti-lipoarabinomannan antibodies against mannan core and their effects on phagocytosis of mycobacteria by human neutrophils.

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Hitoshi Nakayama, Eriko Oshima, Tomomi Hotta, Kei Hanafusa, Kota Nakamura, Noriko Yokoyama, Hideoki Ogawa, Kenji Takamori, Kazuhisa Iwabuchi

1395 related Products with: Identification of anti-lipoarabinomannan antibodies against mannan core and their effects on phagocytosis of mycobacteria by human neutrophils.

5000.1 mg1 ml200 TESTS50 100.00 ug1mg100 μg100 μg

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#35045360   2022/01/16 To Up

Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit.

Ubiquitin-specific proteases (USPs) act as proto-oncogenes or tumor suppressors in a wide variety of cancers. In this study, we intended to explore the role of USP1 in hepatocellular carcinoma (HCC).
Zhangbin Chen, Yifei Ma, Zhitang Guo, Dingyuan Song, Zili Chen, Min Sun

2356 related Products with: Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit.

100ul100ug100ug Lyophilized100ug Lyophilized100μg100ug Lyophilized100ug100ug100ug Lyophilized100ug100ug

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#35045345   2022/01/16 To Up

In-silico identification of lysine residue for α-Amylase immobilization on dialdehyde cellulose.

Enzymes are the precious gift of nature to humans. The wise utilization of enzymes may reduce energy needs of humans and the Immobilization technique can help a lot in this regard. This aspect overcomes limitations of the enzymes, therefore providing an opportunity to explore enzymatic chemistry further. In the present context, it is quite cumbersome & costly to identify the amino acid of enzymes involved in the covalent mode of Immobilization. In the present study, molecular modeling techniques were used to do this difficult task. The present work used molecular modeling methods to extract information about the immobilization of α-Amylase (E.C.3.2.1.1) on Dialdehyde Cellulose. The Lysine residue is the most probable residue to interact with Dialdehyde Cellulose. In the present work, a total of 23 lysine residues were used to study covalent binding behavior with α-Amylase. It was found that if Lys is involved in binding with Dialdehyde Cellulose then binding affinity (-6.1 & -5.9 kcal mol), as well as the involvement of amino acids of both free α-Amylase and Lys immobilized α-Amylase with the starch substrate, were found to be similar. The technique reported here is used for the identification of amino acid residue for the Immobilization of enzymes.
Nitin Kumar Verma, Neera Raghav

1486 related Products with: In-silico identification of lysine residue for α-Amylase immobilization on dialdehyde cellulose.

5 g 100 G100 mg100 assays 0.1 ml 500ul 6 ml Ready-to-use 0.1ml (1mg/ml)10 ml100 500 ml 100.00 ug

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#35045269   2022/01/19 To Up

The "LLQY" motif on SARS-CoV-2 spike protein affects S incorporation into virus particles.

S
Shouwen Du, Wang Xu, Yuhang Wang, Letian Li, Pengfei Hao, Mingyao Tian, Maopeng Wang, Tiyuan Li, Shipin Wu, Quan Liu, Jieying Bai, Xiaoyun Qu, Ningyi Jin, Boping Zhou, Ming Liao, Chang Li

1794 related Products with: The "LLQY" motif on SARS-CoV-2 spike protein affects S incorporation into virus particles.

20 ug Product tipe: Antib100 100 100 100 100 1000100500100 1000100

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#35045268   2022/01/19 To Up

Noncognate Signals Drive Enhanced Effector CD8 T Cell Responses through an IFNAR1-Dependent Pathway after Infection with the Prototypic Vaccine, 0ΔNLS, against Herpes Simplex Virus 1.

Previous studies by our group identified a highly efficacious vaccine 0ΔNLS (deficient in the nuclear localization signal of infected cell protein 0) against HSV-1 in an experimental ocular mouse model. However, details regarding fundamental differences in the initial innate and adaptive host immune response were not explored. Here, we present a side-by-side analysis of the primary infection characterizing differences of the host immune response in mice infected with 0ΔNLS versus the parental, GFP105. The results show that local viral infection and replication are controlled more efficiently in mice exposed to 0ΔNLS versus GFP105 but clearance of infectious virus is equivalent comparing the two groups. Moreover, the 0ΔNLS-infected mice displayed enhanced effector CD8 but not CD4 T cell responses from the draining lymph nodes at day 7 post infection measured by IFN-γ and TNF-α production along with changes in cell metabolism. The increased effector function of CD8 T cells from 0ΔNLS-infected mice was not driven by changes in antigen presentation but lost in the absence of a functional type I IFN pathway. These results are further supported by enhanced local expression of type I IFN and IFN-inducible genes along with increased IL-12 production by CD8αDCs in the draining lymph nodes of 0ΔNLS-infected mice compared to the GFP105-infected animals. It was also noted the recall to HSV-1 antigen by CD8 T cells was elevated in mice infected with HSV-1 0ΔNLS compared to GFP105. Collectively, the results underscore the favorable qualities of HSV-1 0ΔNLS as a candidate vaccine against HSV-1 infection. Cytotoxic T lymphocytes (CTLs) play a critical role in the clearance for many viral pathogens including herpes simplex virus 1 (HSV-1). Here, we compared the cellular innate and adaptive immune response in mice infected with an attenuated HSV-1 (0ΔNLS) found to be a highly successful experimental prophylactic vaccine to parental HSV-1 virus. We found that CD8 T cell effector function is elevated in 0ΔNLS-infected mice through noncognate signals including IL-12 and type I interferon (IFN) pathways along with changes in CD8 T cell metabolism whereas other factors including cell proliferation, co-stimulatory molecule expression and antigen presentation were dispensable. Thus, an increase in CTL activity established by exposure to HSV-1 0ΔNLS in comparison to parental HSV-1 likely contributes to the efficacy of the vaccine and underscores the nature of the attenuated virus as a vaccine candidate for HSV-1 infection.
Grzegorz B Gmyrek, Paul Predki, Edward Gershburg, Daniel J J Carr

1047 related Products with: Noncognate Signals Drive Enhanced Effector CD8 T Cell Responses through an IFNAR1-Dependent Pathway after Infection with the Prototypic Vaccine, 0ΔNLS, against Herpes Simplex Virus 1.

1 mL1 mL1 mL1 mL1 mL200ug0.25 mg25 TESTS20 1 ml100

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