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#35045493   // To Up

[Two Cases of Chemotherapy after Self-Expandable Metallic Stent Placement for Obstructive Sigmoid Cancer with Unresectable Liver Metastasis].

Immediate decompression and induction of chemotherapy are exceedingly critical for obstructive colorectal cancer patients with unresectable liver metastasis. Systematic chemotherapy was administered after self-expandable metallic stent(SEMS) placement in 2 patients with obstructive sigmoid cancer with unresectable liver metastasis. Chemotherapy-induced tumor shrinkage led to SEMS migration, enabling the use of an anti-VEGF drug. Eventually, both patients underwent successful management without restenosis.
Yoshinori Ueda, Shuji Saito, Ayako Miyajima, Kazunori Sasaki, Akira Ema, Ryouichi Hirayama, Ryo Otsuka, Tetsuya Oochi

2686 related Products with: [Two Cases of Chemotherapy after Self-Expandable Metallic Stent Placement for Obstructive Sigmoid Cancer with Unresectable Liver Metastasis].



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#35045376   2022/01/13 To Up

Identification of anti-lipoarabinomannan antibodies against mannan core and their effects on phagocytosis of mycobacteria by human neutrophils.

Mycobacterium tuberculosis (MTB) and M. avium-intracellulare complex (MAC) enter host phagocytes, such as neutrophils through lipoarabinomannan (LAM) binding to pattern-recognition receptors, inducing innate immune responses including phagocytosis. Phagocytosis of mycobacteria by human neutrophils depends on the binding of α(1 → 2)-monomannose branching α(1 → 6)-mannan core of LAM/lipomannan (LM), a common component among mycobacterial species, to lactosylceramide (LacCer)-enriched lipid microdomains. We investigated the binding specificities of several anti-LAM antibodies (Abs) to LAMs/LM and found anti-LAM monoclonal IgMs TMDU3 and LA066 were directed against mannan core. Each IgM showed different binding specificity to mannan core. Confocal and stimulated emission depletion microscopy revealed TMDU3 and LA066 strongly bind to MTB and MAC, respectively. Flow cytometric analysis revealed human neutrophils do not express Dectin-2, DC-SIGN or mannose receptor. Furthermore, neutrophil phagocytosis of mycobacteria was markedly inhibited by TMDU3 and LA066, respectively. Similarly, treatment of each mAb with neutrophils reduced the numbers of intracellular MAC. Together, our results suggest that the interaction of LacCer-enriched lipid microdomains with mannan core and its blocking are therapeutic or diagnostic targets for both TB and non-tuberculous mycobacteria infection.
Hitoshi Nakayama, Eriko Oshima, Tomomi Hotta, Kei Hanafusa, Kota Nakamura, Noriko Yokoyama, Hideoki Ogawa, Kenji Takamori, Kazuhisa Iwabuchi

1894 related Products with: Identification of anti-lipoarabinomannan antibodies against mannan core and their effects on phagocytosis of mycobacteria by human neutrophils.

5000.1 mg1 ml200 TESTS50 100.00 ug1mg100 μg100 μg

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#35045368   2022/01/13 To Up

Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway.

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Hong-Xu Xie, Yan-Hong Wang, Jin-He Zhang, Juan Zhang, Ying-Nan Zhong, Yong-Xi Ge, Zhi-Qiang Cheng, Cheng-Shi Jiang, Ning Meng

1509 related Products with: Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway.

100 0.5 ml100ug Lyophilized200 100ug Lyophilized0.2 mL100ug Lyophilized20 100ul100ug Lyophilized50 ul0.5 ml

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#35045357   2022/01/16 To Up

Anagliptin prevents lipopolysaccharide (LPS)- induced inflammation and activation of macrophages.

Sepsis is a multiple organ dysfunction syndrome (MODS) induced by infection, which significantly threatens public health. The overactivation of inflammatory reactions and oxidative stress participate in the pathogenesis of sepsis. Anagliptin, a novel anti-diabetic agent widely applied for the treatment of type II diabetes, has been recently claimed to possess anti-inflammatory properties. Here, the protective effects of anagliptin on lipopolysaccharide (LPS)- stimulated macrophages will be checked to explore the possible pharmacological property of anagliptin on sepsis. The state of oxidative stress was dramatically activated by LPS, accompanied by the upregulation of toll-like receptor 4 (TLR4) and high mobility group box-1 (HMGB-1), as well as the elevated expression of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO). After treatment with anagliptin, the state of oxidative stress in macrophages was alleviated, with the downregulation of TLR4, HMGB-1, iNOS, and the declined release of NO. The excessive secretion of inflammatory factors, activation of the NF-κB pathway, and promoted expression level of receptor-interacting protein 1 (RIP1) were observed in LPS- stimulated macrophages, all of which were greatly reversed by the introduction of anagliptin. Lastly, the protective properties of anagliptin on LPS- treated macrophages, including the inhibitory effects on inflammation and the NF-κB pathway, were dramatically abolished by the overexpression of RIP1 in macrophages. Collectively, anagliptin prevented LPS-induced inflammation and activation of P338D1 macrophages by repressing the expression level of RIP1.
Fangfang Yu, Wenxia Tian, Jie Dong

1097 related Products with: Anagliptin prevents lipopolysaccharide (LPS)- induced inflammation and activation of macrophages.

100ug100ug50 ul200ul1 ml1mg10 mg16-22 Sample Kit16 Arrays/Slide100 mg100μg

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#35045351   2022/01/16 To Up

The effect of trehalose administration on vascular inflammation in patients with coronary artery disease.

In recent years, several trials investigated the role of anti-inflammatory agents in reducing cardiovascular events. Trehalose is a natural disaccharide able to reduce inflammation by enhancing macrophage autophagic activity. This action has been demonstrated to attenuate atherosclerotic plaque development in various pro-atherogenic animal models. However, at present, no data about the efficacy of this compound in human subjects have been published.
Tannaz Jamialahmadi, Farshad Emami, Ramin Khameneh Bagheri, Hedieh Alimi, Fabio Bioletto, Simona Bo, Behzad Aminzadeh, Mohammad Ali Ansari, Faezeh Ehsani, Omid Rajabi, Shiva Ganjali, Maciej Banach, Amirhossein Sahebkar

2831 related Products with: The effect of trehalose administration on vascular inflammation in patients with coronary artery disease.

4 Membranes/Box128 Sample Kit100ug32-50 Sample Kit96 tests

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#35045342   2022/01/16 To Up

Hepatorenal protective effect of nano-curcumin against nano‑copper oxide-mediated toxicity in rats: Behavioral performance, antioxidant, anti-inflammatory, apoptosis, and histopathology.

Metal oxide nanoparticles (NPs) induce oxidative stress that can cause cellular toxicity. A natural antioxidant that can be used to protect tissues from oxidative stress is curcumin.
Hossam G Tohamy, Osama S El Okle, Amira A Goma, Mohamed M Abdel-Daim, Mustafa Shukry

1260 related Products with: Hepatorenal protective effect of nano-curcumin against nano‑copper oxide-mediated toxicity in rats: Behavioral performance, antioxidant, anti-inflammatory, apoptosis, and histopathology.

100ul100 100ul100 100μg100 μg100 100ug Lyophilized100 μg100ug1 ml100ug

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#35045330   2022/01/16 To Up

The ubiquitination-dependent and -independent functions of cereblon in cancer and neurological diseases.

Cereblon (CRBN) mediates the teratogenic effect of thalidomide in zebrafish, chicken, and humans. It additionally modulates the anti-myeloma effect of the immunomodulatory drugs (IMiDs) thalidomide, lenalidomide, and pomalidomide. IMiDs bind to CRBN and recruit neo-substrates for their ubiquitination and proteasome-mediated degradation, which significantly expands the application of proteolysis-targeting chimeras (PROTACs) for targeted drug discovery. However, the underlying molecular mechanisms by which CRBN mediates the teratogenicity and anti-myeloma effect of IMiDs are not fully elucidated. Furthermore, the normal physiological functions of endogenous CRBN have not been extensively studied, which precludes the thorough assessment of side effects of the CRBN ligand-based PROTACs in the treatment of cancer and neurological diseases. To advance our understanding of the diverse functions of CRBN, in this review, we will survey the ubiquitination-dependent and -independent functions of CRBN, summarize recent advances in the discovery of constitutive and neo-substrates of CRBN, and explore the molecular functions of CRBN in cancer treatment and in the development of neurological diseases. We will also discuss the potential future directions towards the identification of CRBN substrates and interacting proteins, and CRBN-ligand-based drug discovery in the treatment of cancer and neurological diseases.
Liang Zhou, Guoqiang Xu

2545 related Products with: The ubiquitination-dependent and -independent functions of cereblon in cancer and neurological diseases.

1000 tests

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#35045328   2022/01/16 To Up

Co-administration of rotavirus nanospheres VP6 and NSP4 proteins enhanced the anti-NSP4 humoral responses in immunized mice.

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Atefeh Afchangi, Somayeh Jalilvand, Arash Arashkia, Tayebeh Latifi, Mohammad Farahmand, Maryam Mashhadi Abolghasem Shirazi, Seyed Dawood Mousavi Nasab, Sayed Mahdi Marashi, Farzin Roohvand, Zabihollah Shoja

1581 related Products with: Co-administration of rotavirus nanospheres VP6 and NSP4 proteins enhanced the anti-NSP4 humoral responses in immunized mice.

25mg100ug100 μg1mg1 mg100 μg100ug Lyophilized

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