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#31962374   // Save this To Up

Autopsy of a multiple lobar hemorrhage case with amyloid-β-related angiitis.

A 92-year-old man died of multiple lobar hemorrhage with amyloid-β protein (Aβ)-related angiitis (ABRA) with an unusual pathological appearance. Although he had shown relatively rapid progressive dementia, starting 1 year before death, there was no detailed clinical investigation, and no immunosuppressive or anticoagulant therapy, because of his advanced age. The autopsy showed two lobar hemorrhagic lesions in the right parietal lobe and temporal lobes. Microscopically, almost all the brain's blood vessels showed cerebral amyloid angiopathy with many foci of transmural vasculitis. Infiltrating cells were predominantly CD8-positive T-lymphocytes, but we observed no granulomatous inflammation with appearance of multinucleated giant cells. We found fibrinoid necrosis in some blood vessels and disruption of these blood vessels in the arachnoid space-cerebral cortex junction in the hemorrhagic lesion at the temporal lobe. We also observed an unusual, neutrophil-predominant, abscess-like vasculitis in the subarachnoid space; almost all such unusual vasculitides were located at a short distance from the two lobar hemorrhagic lesions. Serum anti-neutrophil cytoplasmic myeloperoxidase and proteinase-3 antibodies were negative, and the genotype of the apolipoprotein E (ApoE) gene (ApoE) was ε2/ε3. Although we did not observe some of ABRA's typical histopathological findings, transmural and vascular destructive inflammation with Aβ deposition was consistent with ABRA. Vulnerability of blood vessels to fibrinoid necrosis might be associated with disruption of the relevant blood vessels, leading to lobar hemorrhage. ABRA exhibits various clinical and histopathological findings, depending on the patient's age, immune function status, treatment, and ApoE genotype. This is the first case and the oldest (92 years old) autopsy of ABRA associated with ApoE-ε2/ε3 genotype.

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#31962308   // Save this To Up

Membranous Nephropathy Due to Anti-GBM Antibodies of Mice and Men.


1586 related Products with: Membranous Nephropathy Due to Anti-GBM Antibodies of Mice and Men.

Goat Anti- TOX3, (N Termi Rabbit Anti-Human TOSO (C Rabbit Anti-Human Toll-Li Mouse Anti-Diphtheria Tox Goat Anti-Clostridium tet Mouse Anti-C. difficile T Mouse Anti-E. coli Labile Rabbit Anti-Toxic Shock S Mouse Anti-Clostridium di Rabbit Anti-Staphylococca Goat Anti-Diphtheria Toxi Mouse Anti-Cholera Toxin

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#31962194   // Save this To Up

Toxoplasma gondii infection in meat-producing small ruminants: Meat juice serology and genotyping.

The consumption of ovine and caprine meat is considered one of the major transmission routes for Toxoplasma gondii infection in humans. The present study aimed at obtaining epidemiological and molecular data on T. gondii infection in small ruminants slaughtered or commercialized in Italy. Meat juices from 227 sheep and 51 goats were analyzed with a commercial ELISA and antibodies were detected in 28.6% sheep and 27.5% goats. A significant difference was highlighted between adult sheep and the other considered categories (young sheep, young and adult goats) concerning the detection of antibodies (94.1%; p-value = .008). Muscles of positives samples were submitted to molecular analysis, and T. gondii DNA was detected in 15 sheep and three goats; sequencing of B1 gene showed that all belonged to Type II. The present study confirmed small ruminants' meat as a possible source of T. gondii infection for consumers eating raw or undercooked meat, particularly in those countries where the consumption of sheep and goats' meat products is a traditional gastronomic habit.

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Toxoplasma gondii GRA8, r Small intestine disease s Toxoplasma gondii MIC 3 r Recombinant Toxoplasma go Small cell lung carcinoma Multiple lung carcinoma ( Small intestine adenocarc Recombinant Toxoplasma go Lung small cell carcinoma Alkaline Phospatase (ALP) Infection diseases: Heli NATtrol TOXOPLASMA GONDII

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#31962162   // Save this To Up

Efficacy of baricitinib on periodontal inflammation in patients with rheumatoid arthritis.

Despite a widely recognized bidirectional pathobiologic relationship between rheumatoid arthritis (RA) and periodontal disease, the impact of innovative anti-rheumatic drugs in modulating not only inflammatory and immune articular damage, but also periodontal microenvironment remains debatable. We aimed to evaluate the periodontal status in RA with and without baricitinib, a Janus kinase (JAK) inhibitor, and to better describe association between these entities.

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The contribution of sex and auto-antibodies to microangiopathy assessed by nailfold videocapillaroscopy in systemic sclerosis: a systematic review of the literature.

Microangiopathy and dysregulation of the immune system play important roles in the pathogenesis of Systemic Sclerosis (SSc). Factors that trigger vascular injury in SSc have not been elucidated so far. To evaluate whether sex or expression of specific antinuclear auto-antibodies might associate with the degree of microangiopathy we performed a systematic review summarizing what is known about these associations.

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FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu Multiple organ tumor tiss FDA Standard Frozen Tissu Mouse Anti-Bacteroides th Sheep Anti-Theophylline 3 Goat Anti-Human TOM1L1 SR Rat Anti-CCT theta Antibo Thermal Shaker with cooli Rabbit Anti-Theophylline Rabbit Anti-Human Toll In

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Hepatitis E as a cause of adult hospitalization in Bangladesh: Results from an acute jaundice surveillance study in six tertiary hospitals, 2014-2017.

In the absence of reliable data on the burden of hepatitis E virus (HEV) in high endemic countries, we established a hospital-based acute jaundice surveillance program in six tertiary hospitals in Bangladesh to estimate the burden of HEV infection among hospitalized acute jaundice patients aged ≥14 years, identify seasonal and geographic patterns in the prevalence of hepatitis E, and examine factors associated with death. We collected blood specimens from enrolled acute jaundice patients, defined as new onset of either yellow eyes or skin during the past three months of hospital admission, and tested for immunoglobulin M (IgM) antibodies against HEV, HBV and HAV. The enrolled patients were followed up three months after hospital discharge to assess their survival status; pregnant women were followed up three months after their delivery to assess pregnancy outcomes. From December'2014 to September'2017, 1925 patients with acute jaundice were enrolled; 661 (34%) had acute hepatitis E, 48 (8%) had hepatitis A, and 293 (15%) had acute hepatitis B infection. Case fatality among hepatitis E patients was 5% (28/589). Most of the hepatitis E cases were males (74%; 486/661), but case fatality was higher among females-12% (8/68) among pregnant and 8% (7/91) among non-pregnant women. Half of the patients who died with acute hepatitis E had co-infection with HAV or HBV. Of the 62 HEV infected mothers who were alive until the delivery, 9 (15%) had miscarriage/stillbirth, and of those children who were born alive, 19% (10/53) died, all within one week of birth. This study confirms that hepatitis E is the leading cause of acute jaundice, leads to hospitalizations in all regions in Bangladesh, occurs throughout the year, and is associated with considerable morbidity and mortality. Effective control measures should be taken to reduce the risk of HEV infections including improvements in water quality, sanitation and hygiene practices and the introduction of HEV vaccine to high-risk groups.

2746 related Products with: Hepatitis E as a cause of adult hospitalization in Bangladesh: Results from an acute jaundice surveillance study in six tertiary hospitals, 2014-2017.

Alkaline Phospatase (ALP) Cultrex In Vitro Angiogen EMAP II Inhibitor Z ASTD  EpiQuik MBD2 Binding Ac SMURF1 & ECSIT Protein Pr Anti C1 Esterase Inhibito E2F2 & E2F1 Protein Prote TGFA & ERBB2 Protein Prot Goat Anti-Human EGLN3, (i Directed In Vivo Angiogen EGFR & ERBB2 Protein Prot MAPK14 & EGFR Protein Pro

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Association of antinuclear antibodies with the risk of intracranial arterial stenosis.

The prevalence of intracranial arterial stenosis (IAS) as well as antinuclear antibody (ANA) positivity was found to be higher in Asians than that in the Western population. To investigate the relation of ANAs with IAS in patients with acute ischemic cerebrovascular disease, we enrolled 2492 patients with acute ischemic stroke or transient ischemic attack into the study. All the patients were categorized into 3 groups according to the IAS burden. Multinomial logistic regression analyses were used in statistical analysis. The positive rate of ANAs in the IAS ≥ 2 group was higher than that in the single IAS group and the no IAS group (p<0.001). The adjusted odds ratio (OR) for IAS ≥ 2 in ANAs-positive patients was 3.737 (95%CI=2.676-5.220, p<0.001) compared with the ANAs-negative patients. ANAs were associated with multiple IAS rather than single IAS in both male and female subgroups. Besides, ANAs were significantly associated with single and multiple IAS in individuals ≤ 60 years. However, ANAs were only associated with two or more IAS in two age groups (between 61 to 75 years and >75 years old). In summary, ANAs are associated with IAS in patients with acute ischemic cerebrovascular disease.

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Multiple organ tumor tiss Sheep Anti-Theophylline 3 Rat Anti-CCT theta Antibo Ofloxacin CAS Number [824 Multiple organ cancer tis Rabbit Anti-Theophylline Mouse Anti-Bacteroides th Goat Anti- CGR19 CGRRF1, Rat monoclonal anti mouse E. coli antibody, Monoclo Rabbit Anti-Human Androge Goat Anti-Human MEL18 PCG

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Elevated anti-citrullinated protein antibodies prior to rheumatoid arthritis diagnosis and risks for chronic obstructive pulmonary disease or asthma.

To investigate elevation of anti-citrullinated protein antibodies (ACPA) before RA diagnosis and risks for chronic obstructive pulmonary disease (COPD) or asthma.

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Rabbit Anti-Rat Androgen Rabbit Anti-Human Toll In Proteins and Antibodies H Rabbit Anti-SARS Virus Sp Mouse Anti-Cholera Toxin Proteins and Antibodies H Mouse Anti-HPV-16 E7 Prot Sheep Anti-Uromucoid (Tam Proteins and Antibodies H Goat Anti-Human ORP1, (C Proteins and Antibodies H Proteins and Antibodies H

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Early adalimumab and anti-adalimumab antibody levels for prediction of primary nonresponse in ankylosing spondylitis patients.

This study aimed at exploring the concentration-effect relationship of adalimumab and early adalimumab and anti-adalimumab antibodies (AAA) levels in predicting primary nonresponse in a real-world pilot cohort of patients with ankylosing spondylitis (AS). Thirty-one patients were included. The Ankylosing Spondylitis Disease Activity Score improved with increasing adalimumab trough level at week 12 and reached a major improvement with levels between 8 and 12 μg/mL. Moreover, week 4 and 2 adalimumab levels below 4.28 and 3.37 μg/mL were predictive of primary nonresponse (AUC=0.89, 0.88, P=0.0003, P=0.034, respectively). Week 4 AAA signal-to-noise levels were significantly higher among primary nonresponders, and the cutoff for primary nonresponse prediction was above 5.31 (AUC=0.81, P=0.004). Adalimumab trough levels in a range of 8-12 μg/mL are optimum to reach major improvement, and lower adalimumab with higher AAA levels at the early stage (week 4) predict primary nonresponse, by supporting proactive monitoring to optimize adalimumab therapy.

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Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease.

Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research. We used 120 paired-plasma samples collected at enrollment and >7 days after the onset of illness from HFMD patients infected with enterovirus A71 (EV-A71), coxsackievirus A (CVA) 6, CVA10, and CVA16 to study cross neutralization. For homotypic viruses, seropositivity increased from <60% at enrollment to 97%-100% at follow-up, corresponding to seroconversion rates of 57%-93%. Seroconversion for heterotypic viruses was recorded in only 3%-23% of patients. All plasma samples from patients infected with EV-A71 subgenogroup B5 could neutralize the emerging EV-A71 subgenogroup C4. Collectively, our results support previous reports about the potential benefit of EV-A71 vaccine but highlight the necessity of multivalent vaccines to control HFMD.

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Mouse Anti-Foot and Mouth Mouse Anti-Foot-and-Mouth Goat Anti- SOX1, (interna Cell cycle antibody array Goat Anti-Human THRB, (in Rat monoclonal anti mouse Goat Anti- Dopamine recep Goat Anti-Human NPFFR1, ( Mouse Anti-Human CD103 (I Cytokine (Mouse) Antibody Goat Anti- NAT2 (aa182-19 Goat Anti-Human FBP17 FNB

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