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Search results for: antibody

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#34118734   2021/05/27 To Up

Epidemiological feature, viral shedding, and antibody seroconversion among asymptomatic SARS-CoV-2 carriers and symptomatic/presymptomatic COVID-19 patients.

Novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is pandemic. However, data concerning the epidemiological features, viral shedding, and antibody dynamics between asymptomatic SARS-CoV-2 carriers and COVID-19 patients remain controversial.
Yi Chen, Ping Li, Yibo Ding, Miao Liu, Leijie Liu, Bo Yi, Ting Wu, Hongjun Dong, Xuying Lao, Keqing Ding, Haibo Wang, Dongliang Zhang, Xiaojie Tan, Zhongfa Wang, Guozhang Xu, Guangwen Cao

2965 related Products with: Epidemiological feature, viral shedding, and antibody seroconversion among asymptomatic SARS-CoV-2 carriers and symptomatic/presymptomatic COVID-19 patients.

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#34118732   2021/04/24 To Up

Nationwide Seroprevalence of SARS-CoV-2 in Saudi Arabia.

Estimated seroprevalence of Coronavirus Infectious Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is a critical evidence for a better evaluation of the virus spread and monitoring the progress of COVID-19 pandemic in a population. In the Kingdom of Saudi Arabia (KSA), SARS-CoV-2 seroprevalence has been reported in specific regions, but an extensive nationwide study has not been reported. Here, we report a nationwide study to determine the prevalence of SARS-CoV-2 in the population of KSA during the pandemic, using serum samples from healthy blood donors, non-COVID patients and healthcare workers (HCWs) in six different regions of the kingdom, with addition samples from COVID-19 patients.
Naif Khalaf Alharbi, Suliman Alghnam, Abdullah Algaissi, Hind Albalawi, Mohammed W Alenazi, Areeb M Albargawi, Abdullah G Alharbi, Abdulaziz Alhazmi, Ali Al Qarni, Ali Alfarhan, Hosam M Zowawi, Hind Alhatmi, Jahad Alghamdi, Fayhan Alroqi, Khalid Batarfi, Yaseen M Arabi, Anwar M Hashem, Mohammed Bosaeed, Omar Aldibasi

1531 related Products with: Nationwide Seroprevalence of SARS-CoV-2 in Saudi Arabia.

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#34118585   2021/05/28 To Up

The occurrence of myelin oligodendrocyte glycoprotein antibodies in aquaporin-4-antibody seronegative Neuromyelitis Optica Spectrum Disorder: A systematic review and meta-analysis.

Despite inclusion in neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated diseases are increasingly recognized as an independent disease entity. In this study, we conducted a systematic review and meta-analysis to comprehensively update the rate of occurrence of MOG-Ab in Aquaporin4 (AQP4)-antibody seronegative NMOSD.
Xindi Li, Chengyi Zhang, Dongmei Jia, Moli Fan, Ting Li, De-Cai Tian, Yaou Liu, Fu-Dong Shi

2744 related Products with: The occurrence of myelin oligodendrocyte glycoprotein antibodies in aquaporin-4-antibody seronegative Neuromyelitis Optica Spectrum Disorder: A systematic review and meta-analysis.

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#34118539   2021/06/05 To Up

Generation of recombinant antibodies by mammalian expression system for detecting S-metolachlor in environmental waters.

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Xiaoting Yu, Xu Zhang, Jingjing Xu, Pengyan Guo, Xiangmei Li, Hong Wang, Zhenlin Xu, Hongtao Lei, Xing Shen

2843 related Products with: Generation of recombinant antibodies by mammalian expression system for detecting S-metolachlor in environmental waters.

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#34118456   2021/06/09 To Up

Letter to the editor: Serum anti-Aβ antibodies in cerebral amyloid angiopathy.


Yannick Chantran, Jean Capron, Diana Doukhi, Johanna Felix, Mélanie Féroul, Florian Kruse, Thomas Chaigneau, Guillaume Dorothée, Thibault Allou, Xavier Ayrignac, Zina Barrou, Thomas de Broucker, Corina Cret, Guillaume Turc, Roxane Peres, Anne Wacongne, Marie Sarazin, Dimitri Renard, Charlotte Cordonnier, Sonia Alamowitch, Pierre Aucouturier

1903 related Products with: Letter to the editor: Serum anti-Aβ antibodies in cerebral amyloid angiopathy.

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#34118428   2021/06/09 To Up

Level of Maternal Respiratory Syncytial Virus (RSV) F Antibodies in Hospitalized Children and Correlates of Protection.

RSV is a major cause of lower respiratory infections among children, where no vaccine is available. The stabilized form of the fusion (F) protein, pre-F, is a leading vaccine candidate targeting different populations, including pregnant women. This study aimed to determine the magnitude and nature of RSV-directed maternal antibodies (matAbs) in hospitalized children with RSV infection.
Sara A Taleb, Khalid Al-Ansari, Gheyath K Nasrallah, Mohamed A Elrayess, Asmaa A Al-Thani, Alexandrine Derrien-Colemyn, Tracy J Ruckwardt, Barney S Graham, Hadi M Yassine

1473 related Products with: Level of Maternal Respiratory Syncytial Virus (RSV) F Antibodies in Hospitalized Children and Correlates of Protection.

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#34118402   2021/06/09 To Up

Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults.

Endemic human coronaviruses (hCoVs) are common causative agents of respiratory tract infections, affecting especially children. However, in the ongoing SARS-CoV-2 pandemic, children are the least affected age-group. The objective of this study was to investigate the magnitude of endemic hCoVs antibodies in Finnish children and adults, and pre-pandemic antibody cross-reactivity with SARS-CoV-2. Antibody levels against endemic hCoVs start to rise at a very early age, reaching to overall 100% seroprevalence. No difference in the antibody levels was detected for OC43 but the magnitude of 229E-specific antibodies was significantly higher in the sera of children. OC43 and 229E hCoV antibody levels of children correlated significantly with each other and with the level of cross-reactive SARS-CoV-2 antibodies, whereas these correlations completely lacked in adults. Although none of the sera showed SARS-CoV-2 neutralization, the higher overall hCoV cross-reactivity observed in children might, at least partially, contribute in controlling SARS-CoV-2 infection in this population.
Kirsi Tamminen, Marjo Salminen, Vesna Blazevic

1477 related Products with: Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults.

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#34118379   2021/06/09 To Up

B cells acquire a unique and differential transcriptomic profile during pregnancy.

Pregnancy alters B cell development and function. B cell activation is initiated by antigens binding to the BCR leading to B cell survival, proliferation, antigen presentation and antibody production. We performed a genome-wide transcriptome profiling of splenic B cells from pregnant (P) and non-pregnant (NP) mice and identified 1136 genes exhibiting differential expression in B cells from P mice (625 up- and 511 down-regulated) compared to NP animals. In silico analysis showed that B cell activation through BCR seems to be lowered during pregnancy. RT-qPCR analysis confirmed these data. Additionally, B cells from pregnant women stimulated in vitro through BCR produced lower levels of inflammatory cytokines compared to non-pregnant women. Our results suggest that B cells acquire a state of hypo-responsiveness during gestation, probably as part of the maternal immune strategy for fetal tolerance but also open new avenues to understand why pregnant women are at highest risk for infections.
Natalin Valeff, Damian Oscar Muzzio, Franziska Matzner, Marcos Dibo, Janine Golchert, Georg Homuth, Martin C Abba, Marek Zygmunt, Federico Jensen

1983 related Products with: B cells acquire a unique and differential transcriptomic profile during pregnancy.

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#34118347   2021/06/09 To Up

Recent Advances in Potential Drug Therapies Combating COVID-19 and Related Coronaviruses-A Perspective.

Coronaviruses (CoVs) are a large family of viruses responsible for the severe pathophysiological effects on human health. The most severe outbreak includes Severe Acute Respiratory Syndrome (SARS-CoV), Middle East Respiratory Syndrome (MERS-CoV) and Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). The COVID-19 poses major challenges to clinical management because no specific FDA-approved therapy yet to be available. Thus, the existing therapies are being used for the treatment of COVID-19, which are under clinical trials and compassionate use, based on in vitro and in silico studies. In this review, we summarize the potential therapies utilizing small molecules, bioactive compounds, nucleoside and nucleotide analogs, peptides, antibodies, natural products, and synthetic compounds targeting the complex molecular signaling network involved in COVID-19. In this review>230 natural and chemically synthesized drug therapies are described with their recent advances in research and development being done in terms of their chemical, structural and functional properties. This review focuses on possible targets for viral cells, viral proteins, viral replication, and different molecular pathways for the discovery of novel viral- and host-based therapeutic targets against SARS-CoV-2.
Shivraj Hariram Nile, Arti Nile, Shivkumar Jalde, Guoyin Kai

2175 related Products with: Recent Advances in Potential Drug Therapies Combating COVID-19 and Related Coronaviruses-A Perspective.

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#34118338   2021/06/09 To Up

Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood-brain barrier permeability for drug delivery to the brain in a non-human primate.

Claudin-5 (CLDN-5) is an essential component of the tight junction seal in the blood-brain barrier. Previously, we showed that CLDN-5 modulation in vitro via an anti-CLDN-5 monoclonal antibody (mAb) may be useful for increasing the permeability of the blood-brain barrier for drug delivery to the brain. Based on these findings, here we examined the safety and efficacy of the anti-CLDN-5 mAb in a non-human primate. Cynomolgus monkeys were intravenously administered the anti-CLDN-5 mAb followed by fluorescein dye (376 Da), and the concentrations of the dye in the cerebrospinal fluid was examined. When the mAb was administered at 3.0 mg/kg, the concentration of dye in the cerebrospinal fluid was increased, and no behavioral changes or changes in plasma biomarkers for inflammation or liver, kidney, or heart injury were observed. However, a monkey that received the mAb at 6 mg/kg experienced convulsions, and subsequent histopathological examination of this animal revealed vasodilation in the liver, lung, and kidney; hemorrhage in the lung; and edema in the brain. Together, our data indicate that CLDN-5 might be a potential target for enhancing drug delivery to the brain, but also that the therapeutic window of the anti-CLDN-5 mAb may be narrow for separating efficacy and toxicity.
Keisuke Tachibana, Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Ryuichi Hirayama, Yumi Iwashita, Itsuki Nishino, Yukio Ago, Hiroyuki Takeda, Hiroki Kuniyasu, Masuo Kondoh

2240 related Products with: Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood-brain barrier permeability for drug delivery to the brain in a non-human primate.

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