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#30905782   2019/03/21 To Up

Apelin-36 exerts the cytoprotective effect against MPP-induced cytotoxicity in SH-SY5Y cells through PI3K/Akt/mTOR autophagy pathway.

Parkinson's disease (PD) is a common neurodegenerative disease typically associated with the accumulation of α-synuclein. Autophagy impairment is thought to be involved in the dopaminergic neurodegeneration in PD. We investigate the effect of Apelin-36 on the activated phosphatidylinositol 3-kinase (PI3K)/protein kinase B(Akt)/the mammalian target of rapamycin (mTOR) autophagy pathway in 1-methyl-4-phenylpyridinium (MPP)-treated SH-SY5Y cells, which is involved in the cytoprotective effect of Apelin-36.
Junge Zhu, Shanshan Dou, Yunlu Jiang, Bo Bai, Jing Chen, Chunmei Wang, Baohua Cheng

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10mg5mg5mg5mg50mg2 Pieces/Box5mg1.00 flask2 Pieces/Box1.5x10(6) cells400 ug

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