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#34563079   2021/08/17 To Up

Predicting University Adjustment from Coping-Styles, Self-Esteem, Self-Efficacy, and Personality: Findings from a Survey in a Sample of Italian Students.

Starting university life requires that students learn to cope with several personal, academic, and social challenges. A wide array of variables affects how students adjust to university life. This study was aimed to investigate which factors among coping styles, self-esteem, self-efficacy, and personality traits (i.e., diligence, relational availability, mental flexibility, activity, and emotional stability) best predicted the levels of university adjustment in a sample of university freshmen ( = 204, 63% women). Data were collected using self-report instruments. Multiple regressions analyses were conducted to identify the most significant predictors of adjustment to college. Our findings reported that self-efficacy, task-, and emotion-oriented coping were the most significant predictors, together with relational availability and mental flexibility. These findings might improve the growing knowledge concerning university adjustment, supporting main previous research. The observed relationships between university adjustment and the measured variables suggest intriguing considerations about the importance for schools and universities of providing interventions for students that aim to develop and strengthen the investigated personality facets, reducing withdrawal, behavioral and/or mental disengagement, and promoting academic achievement and success.
Giusy Danila Valenti, Palmira Faraci

2609 related Products with: Predicting University Adjustment from Coping-Styles, Self-Esteem, Self-Efficacy, and Personality: Findings from a Survey in a Sample of Italian Students.

1-8 Sample Kit16 Arrays/Slide4 Sample Kit1-8 Sample Kit4 Sample Kit

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#34562888   2021/08/27 To Up

An Immunosensor for the Determination of Cathepsin S in Blood Plasma by Array SPRi-A Comparison of Analytical Properties of Silver-Gold and Pure Gold Chips.

The array SPR imaging (SPRi) technique is well suited to the determination of biomarkers in body fluids, called liquid biopsy. No signal enhancement or analyte preconcentration is required. With the aim of achieving signal enhancement and lowering the cost of a single determination, the replacement of gold-covered chips by silver-gold chips was investigated. The aim of this work was to investigate the analytical characteristics of a biosensor formed on a Ag/Au chip and to compare them with those of a biosensor formed on a gold chip. A biosensor for the determination of cathepsin S (Cath S) was chosen as an example. The biosensor consisted of the linker cysteamine and an immobilized rat monoclonal antibody specific for cathepsin S. Both biosensors exhibited a Langmuirian response to Cath S concentration, with linear response ranging from LOQ to 1.5 ng mL. The LOQ is 0.1 ng mL for the biosensor formed on the Ag/Au chip, and 0.22 ng mL for that formed on the gold chip. Recoveries and precision for medium and high Cath S concentrations were acceptable for both biosensors, i.e., precision better than 10% and recoveries within the range 102-105%. However, the results for the lowest Cath S concentration were better for the biosensor formed on the Ag/Au chip (9.4 and 106% for precision and recovery, respectively). Generally, no significant differences in analytical characteristics were observed between the Ag/Au and Au chips. The two biosensors were also compared in the determination of Cath S in real samples. Nine plasma samples from healthy donors and nine from patients with ovarian cancer were analyzed for Cath S concentration with the biosensors formed on Ag/Au and Au chips. The results obtained with the two biosensors were very similar and show no significant differences on the Bland-Altman plot. The Cath S concentration in the blood plasma of ovarian cancer patients was elevated by one order of magnitude as compared with the control (12.6 ± 3.6 vs. 1.6 ± 1.2 ng mL).
Pawel Falkowski, Piotr Mrozek, Zenon Lukaszewski, Lukasz Oldak, Ewa Gorodkiewicz

2135 related Products with: An Immunosensor for the Determination of Cathepsin S in Blood Plasma by Array SPRi-A Comparison of Analytical Properties of Silver-Gold and Pure Gold Chips.

2 Pieces/Box8 Sample Kit

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#34562879   2021/09/09 To Up

Compound Heterozygosity for Truncating Variant and Genomic Rearrangement Cause Autosomal Recessive Sensorineural Hearing Loss in an Italian Family.

Hearing loss (HL) affects 1-3 newborns per 1000 and, in industrialized countries, recognizes a genetic etiology in more than 80% of the congenital cases. Excluding and , is one of the leading genes associated with autosomal recessive non-syndromic HL. Allelic heterogeneity linked to also includes genomic rearrangements facilitated by non-allelic homologous recombination with the neighboring pseudogene. We present a couple of Italian siblings affected by moderate to severe sensorineural hearing loss (SNHL) due to compound heterozygosity at the locus. Multigene panel next-generation sequencing identified the c.2223G>A, p.(Trp741*) variant transmitted from the unaffected mother. Assuming the existence of a second paternal deleterious variant which evaded detection at sequencing, genomic array analysis found a ~150 Kb microdeletion of paternal origin and spanning part of . Both deleterious alleles were identified for the first time. This study demonstrates the utility of an integrated approach to solve complex cases and allow appropriate management to affected individuals and at-risk relatives.
Rocco Pio Ortore, Maria Pia Leone, Orazio Palumbo, Antonio Petracca, Eleonora M C Trecca, Aurelio D'Ecclesia, Ciro Lucio Vigliaroli, Lucia Micale, Francesco Longo, Salvatore Melchionda, Marco Castori

2615 related Products with: Compound Heterozygosity for Truncating Variant and Genomic Rearrangement Cause Autosomal Recessive Sensorineural Hearing Loss in an Italian Family.

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#34562815   2021/09/16 To Up

High-resolution imaging and fast number estimation of suspended particles using dewetted polymer microlenses in a microfluidic channel.

We have fabricated polymer micro-lens array by self-organized dewetting inside the microchannel, which shows remarkable enhancement in the resolution, contrast and more than 10 times add-on magnification to a microscope. These lenses are demonstrated to resolve sub-micrometer features and detect moving micro-particles when suspension is flown in a microchannel. Polystyrene (PS) micro-lenses are fabricated on a polydimethylsiloxane (PDMS) substrate using the controlled dewetting of PS thin film then this PDMS substrate is used to close the microchannel with inverted micro-lenses on it. An aqueous suspension of polystyrene particles is flown through the microchannel and we have observed the particles through an optical microscope. Focusing and magnification through PS micro-lenses is analyzed to get a quantitative estimate of the particle number density in the solution. This method offers a promising low-cost high throughput solution for determining the approximate number density of flowing particles or suitably stained biological cells. Particularly in a pathology lab it can tremendously increase detection limit by enabling visibility of sub-micrometer pathogens using a standard laboratory microscope.
Shubham Mishra, Manish M Kulkarni, Ankur Verma

1887 related Products with: High-resolution imaging and fast number estimation of suspended particles using dewetted polymer microlenses in a microfluidic channel.

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#34562613   2021/09/22 To Up

DNA methylation-based classification of small B-cell lymphomas: a proof-of-principle study.

While most small B-cell lymphomas (SBCLs) can be diagnosed using routine methods, challenges exist. For example, marginal zone lymphomas (MZLs) can be difficult to rule-in, in large part because there is no widely-available, sensitive, and specific biomarker for the marginal zone cell-of-origin. In this study, we hypothesize that DNA methylation array profiling can assist with the classification of SBCLs, including MZLs. Extramedullary SBCLs, including challenging cases, were reviewed internally for pathology consensus and profiled. By combining the resulting array dataset with datasets from other groups, a set of 26 informative probes was selected, and used to train machine learning models to classify four common SBCLs: chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma, and MZL. Applying a prediction probability cutoff to separate classifiable from unclassifiable cases, we found that the trained model was able to classify 95% of independent test cases (264/279). The concordance between model predictions and pathology diagnoses was 99.6% (262/263) among classifiable test cases. One validation reference test case was re-classified based on model prediction. The model was also used to predict the diagnoses of two challenging SBCLs. Although the differential examined and data on difficult cases are limited, our results support accurate methylation-based classification of SBCLs. Further, high specificities of predictions suggest that methylation signatures can be used to rule-in MZLs.
Daniel Xia, Alberto Jose Leon, Jiong Yan, Anjali Silva, Mehran Bakhtiari, Rosemarie Tremblay-LeMay, Shamini Selvarajah, Peter Sabatini, Phedias Diamandis, Trevor Pugh, Robert Kridel, Jan Delabie

1721 related Products with: DNA methylation-based classification of small B-cell lymphomas: a proof-of-principle study.



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#34561946   2021/09/24 To Up

Hierarchical 3D Cuprous Sulfide Nanoporous Cluster Arrays Self-Assembled on Copper Foam as a Binder-Free Cathode for Hybrid Magnesium-Based Batteries.

On account of easy accessibility, high theoretical volumetric capacity and dendrite-free magnesium (Mg) anode, Mg battery has a great promise to be next generation rechargeable batteries, yet still remains a challenging task in acquiring fast Mg kinetics and effective cathode materials. Herein, hierarchical 3D cuprous sulfide porous nanosheet decorated nanowire cluster arrays with robust adhesion on copper foam (Cu S HP/CF), which is employed as a binder-free conversion cathode material for magnesium/lithium hybrid battery, delivering impressively initial and reversible specific capacity of 383 and 311 mAh g at 100 mA g , respectively, which are obviously outperformed corresponding powder cathode in a traditional method by using polymer binder, is reported. Intriguingly, benefiting from the hierarchical nanoporous array architecture and self-assembly feature, Cu S HP/CF cathode shows a remarkable cycling stability with a high capacity of 129 mAh g at 300 mA g over 500 cycles. This work not only highlights a guide for designing hierarchical nanoporous materials derived from metal-organic frameworks, but also provides a novel strategy of in situ formation to fabricate binder-free cathodes.
Guilei Zhu, Guanglin Xia, Xuebin Yu

2154 related Products with: Hierarchical 3D Cuprous Sulfide Nanoporous Cluster Arrays Self-Assembled on Copper Foam as a Binder-Free Cathode for Hybrid Magnesium-Based Batteries.

100tests 100 G96 Tests100g100 assays1,000 tests100Tests100100tests

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#34561918   2021/09/24 To Up

Nanosystems and exosomes as future approaches in treating Multiple sclerosis.

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system which leads to neurological dysfunctions and severe disabilities. MS pathology is characterized by damage of the blood-brain barrier and infiltration of autoreactive T cells that over-activate glial cells, thereby initiating neuroinflammation accompanied by the formation of demyelinating plaques and neurodegeneration. Clinical deficits in this multifactorial disease depend on the progression of myelin loss, the stage of inflammation, the status of axons and the activity of oligodendrocyte precursor cells (OPCs). Despite significant progress in the treatment of MS, current therapies remain limited and new approaches are highly desirable. Nanosystems based on liposomes and nanoparticles are among some of the more noteworthy therapeutic strategies being investigated. Applications of nanosystems alone or as drug carriers in animal models of MS have been found to successfully alleviate the symptoms of the disease and exert anti-inflammatory potential. Exosomes are a specific type of nanosystem based on nanometer-sized extracellular vesicles released by different cells which exhibit important healing features. Exosomes contain an array of anti-inflammatory and neuroprotective agents which may contribute to modulation of the immune system as well as promoting remyelination and tissue repair. In this review, opportunities to use nanosystems against progression of MS will be discussed in context of cell-specific pathologies associated with MS.
Marta Sidoryk-Węgrzynowicz, Beata Dąbrowska-Bouta, Grzegorz Sulkowski, Lidia Strużyńska

1526 related Products with: Nanosystems and exosomes as future approaches in treating Multiple sclerosis.

96 samples100 assays16 Arrays/Slide900 tests100 assays16 Arrays/Slide

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#34561860   2021/09/24 To Up

Molecular genetic evidence supporting diverse histogenic origins of germ cell tumors.

Germ cell tumors (GCTs) originate during the histogenesis of primordial germ cells to mature gametes. Previous studies identified five histogenic mechanisms in ovarian mature teratomas (type I: failure of meiosis I, type II: failure of meiosis II, type III: duplication of the genome of a mature gamete, type IV: no meiosis, and type V: fusion of two different ova), but those of other GCTs remain elusive. In this study, we analyzed 84 GCTs of various pathologic types to identify the histogenesis using single-nucleotide polymorphism array by analyzing copy-neutral loss-of-heterozygosity (CN-LOH) and copy number alterations (CNAs). We detected types I and II in ovarian teratomas, type III in ovarian teratomas and yolk sac tumors (YSTs), and type IV in all GCT types. The GCTs with multiple type histogenesis (I-IV) (ovarian mature/immature teratomas and YST) show meiotic CN-LOHs with scant CNAs. Type IV-only GCTs are either with mitotic CN-LOHs and abundant CNAs (seminoma, dysgerminoma, testicular mixed GCTs) or with scant CNAs and no CN-LOH (pediatric testicular and mediastinal teratomas). The development sequences of CN-LOH and CNA are different between the multiple type (I-IV) GCTs and type IV-only GCTs. We analyzed two different histologic areas in eight GCTs (1 mature teratoma with a mucin-secreting adenoma, 2 immature teratomas, and 5 mixed GCTs). We found that GCTs (mature teratoma, immature teratoma and mixed GCT) showed different genomic alterations between histologic areas, suggesting that genomic differences within a GCT could accompany histologic differentiation. Of note, we found evidence for collision tumors in a mixed GCT. Our data indicate that GCTs may have various histogenesis and intratumoral genomic difference, which might provide important information for the identification of GCTs, especially for those with different histologic areas. This article is protected by copyright. All rights reserved.
Seung-Hyun Jung, Hyeon-Chun Park, Youn Jin Choi, Sang Yong Song, Yeun-Jun Chung, Sug Hyung Lee

1802 related Products with: Molecular genetic evidence supporting diverse histogenic origins of germ cell tumors.

1 kit96 assays5 x 5 ml5 mgEach50 assays

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#34561474   2021/09/24 To Up

Persistence of functional microbiota composition across generations.

Holobionts are defined as a host and its microbiota, however, only a fraction of the bacteria are inherited vertically and thus coevolve with the host. The "it's the song, not the singer" theory proposes that functional traits, instead of taxonomical microbiota composition, could be preserved across generations if interspecies interaction patterns perpetuate themselves. We tested conservation of functional composition across generations using zooplankton, mosquito, and plant datasets. Then, we tested if there is a change of functional microbiota composition over time within a generation in human datasets. Finally, we simulated microbiota communities to investigate if (pairwise) interactions can lead to multiple stable community compositions. Our results suggest that the vertically transmitted microbiota starts a predictable change of functions performed by the microbiota over time, whose robustness depends on the arrival of diverse migrants. This succession culminates in a stable functional composition state. The results suggest that the host-microbiota interaction and higher order interactions in general have an important contribution to the robustness of the final community. If the proposed mechanism proves to be valid for a diverse array of host species, this would support the concept of holobionts being used as units of selection, including animal breeding, suggesting this has a wider applicability.
Christian Ramos, Mario Calus, Dirkjan Schokker

2126 related Products with: Persistence of functional microbiota composition across generations.

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