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Bioinspired Artificial Tobacco Mosaic Virus with Combined Oncolytic Properties to Completely Destroy Multidrug-Resistant Cancer.Although biomimetic virus-like strategies have been widely used in antitumor applications, construction of uniquely shaped virus-like agents and optimization of their specific morphological features to achieve diverse antitumor functions are worthwhile pursuits. Here, a novel strategy to construct an artificial tobacco mosaic virus (ATMV) that closely mimics the structure of the rod-like tobacco mosaic virus (TMV) is developed. The supramolecular array is self-assembled from small, repeated subunits of tailor-made capsid-mimicking dendrons onto RGD-modified single-walled carbon nanotube to construct the ATMVs with high structural stability. The ATMVs are tactfully designed with shielding, targeting, and arming approaches, including shielding the viruses against premature elimination, selectively targeting tumor tissue, and arming the viruses with oncolytic abilities. The elongated particles are concealed in blood until they arrived at a tumor site, then they induce robust composite oncolytic processes including cytomembrane penetration, endoplasmic reticulum disruption to cause Ca release, chemotherapeutic delivery, and photothermal therapy. Excitingly, the ATMVs not only lyse primary infected cells, but permeate adjacent cells for secondary infection, spreading cell-to-cell and continuing to induce lysis even deep in solid tumors. This work inspires a uniquely shaped virus-like agent with tactically optimized oncolytic functions that completely defeated large drug-resistant colon tumor (LoVo/Adr, ≈500 mm ).
1170 related Products with: Bioinspired Artificial Tobacco Mosaic Virus with Combined Oncolytic Properties to Completely Destroy Multidrug-Resistant Cancer.Recombinant Tobacco Etch Recombinant Tobacco Etch Recombinant Tobacco Etch Rubella virus E1 mosaic r Soybean mosaic virus (SM FIV Core Ag, recombinant Bean common mosaic virus Recombinant Human Interfe Multiple organ cancer wit Oral cavity (tongue and p Soybean mosaic virus (SM Bean common mosaic virus
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Same Data Set, Different Conclusions: Preschool Delay of Gratification Predicts Later Behavioral Outcomes in a Preregistered Study.One simple marshmallow test in preschool children predicts an array of important life outcomes, according to multiple studies spanning several decades. However, a recent conceptual replication casts doubt on these famous findings. We conducted an independent, preregistered secondary analysis to test whether previously observed longitudinal associations between preschool delay of gratification and adolescent outcomes would be conceptually replicated. Associations were significant for three of the five outcomes we tested using the analytic approach employed in the original studies of the marshmallow test. Relationships between delay of gratification and problem behavior held in bivariate, multivariate, and multilevel models; in contrast, no significant relationships between delay and problem behavior were found in the other recent replication, even though both studies used the same data set. These relationships were better explained by social support than by self-control, suggesting that the marshmallow test is predictive because it reflects aspects of a child's early environment that are important over the long term. This novel interpretation of the classic findings points to new directions for intervention.
2631 related Products with: Same Data Set, Different Conclusions: Preschool Delay of Gratification Predicts Later Behavioral Outcomes in a Preregistered Study.Advanced module Infinicyt High density larynx and p Colon well differentiated Colon poorly differentiat Goat Anti- T-cell differe Stomach poorly differenti Small intestine disease s High density breast invas Colon moderately differen Prostate cancer, PIN (pro Cytokine (Rat) Antibody A Monoclonal anti-human CD5
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Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles.We outline a conceptual blueprint that provides direct and atom economical access to a wide range of complex polyheterocycles. Our method capitalizes on the ambiphilic reactivity of rhodacyclopentanones that arise upon exposure of cyclopropanes to Rh(I) catalysts and CO. Using this approach, a wide array of polycyclizations are achieved, including variants that involve powerful dearomatizations and medium ring formations.
1097 related Products with: Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles.Cultrex In Vitro Angiogen Anti-DAM1(Kinetochore ass QuantiChrom™ Formaldehy MarkerGeneTM Fluorescent MarkerGene™ LysoLive™ Endothelial Tube Formatio Glucose Assay With the La Monoclonal Anti Assembly Anti DAM1(Kinetochore ass QuantiChrom™ Formaldehy Formate Assay Kit Monoclonal Anti-Assembly
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Impact of the MLC leaf-tip model in a commercial TPS: Dose calculation limitations and IROC-H phantom failures.Treatment planning system (TPS) dose calculation is sensitive to multileaf collimator (MLC) modeling, especially when treating with intensity-modulated radiation therapy (IMRT) or VMAT. This study investigates the dosimetric impact of the MLC leaf-tip model in a commercial TPS (RayStation v.6.1). The detectability of modeling errors was assessed through both measurements with an anthropomorphic head-and-neck phantom and patient-specific IMRT QA using a 3D diode array.
2854 related Products with: Impact of the MLC leaf-tip model in a commercial TPS: Dose calculation limitations and IROC-H phantom failures.Tyrosine Kinase Adaptors Goat Anti-Human TCF3 ITF1 Rabbit Anti-APIP Apaf1 In Influenza A H5N1 (Avian) Goat Anti-Human Complemen Goat Anti-Human FMR1, (in Goat Anti-Human FSD1, (in Hyperplasia and carcinoma HNF4A & FOXO1 Protein Pro LPAM-1(Integrin α4, CD49 Goat Anti-Human GABRA4, ( Goat Anti-Human RPS19, (i
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Liposomal simvastatin sensitizes C26 murine colon carcinoma to the antitumor effects of liposomal 5-fluorouracil in vivo.5-fluorouracil-based therapy remains the main approach in colorectal cancer, even though there are still some drawbacks, such as chemoresistance. In this study we combined 5-fluorouracil encapsulated in long-circulating liposomes with simvastatin also encapsulated in long-circulating liposomes that was previously proved to exert antitumor actions on the same tumor model. The production of angiogenic/inflammatory proteins was assessed by protein array and the production of markers for tumor aggressiveness (Bcl-2, Bax, and NF-kB) were determined via western blot. Intratumor oxidative stress was evaluated through measurement of malondialdehyde level via HPLC, and through spectrophotometric analysis of catalytic activity of catalase and of total antioxidant capacity. Immunohistochemical analysis of tumors for CD 31 expression was assessed. Intratumor activity of matrix metalloprotease-2 by gelatin zymography was also performed. Our results revealed that combined therapies based on liposomal formulations exerted enhanced antitumor activities compared with combined administration of free drugs, sequential administration of liposomal simvastatin and liposomal 5-fluorouracil showing the strongest antitumor activity in C26 colon carcinoma in vivo mainly, via inhibition of tumor angiogenesis. Important markers for cancer progression (Bcl-2, Bax, NF-kB, and intratumor antioxidants) demonstrated that liposomal simvastatin might sensitize C26 cells to liposomal 5-fluorouracil administration in both regimens tested. The outcome of simultaneous administration of liposomal formulations was superior to sequential administrations of both liposomal types as invasive capacity of C26 tumors was strongly increased after the latest treatment. The antitumor efficacy of combined therapy in C26 colon carcinoma might be linked to the restorative effects on proteins balance involved in tumor angiogenesis.
1209 related Products with: Liposomal simvastatin sensitizes C26 murine colon carcinoma to the antitumor effects of liposomal 5-fluorouracil in vivo.Colon carcinoma antibody FDA Standard Frozen Tissu Colon carcinoma tissue ar FDA Standard Frozen Tissu Colon carcinoma tissue ar FDA Standard Frozen Tissu FDA Standard Frozen Tissu Colon carcinoma tissue ar Breast invasive ductal ca Colon disease spectrum ti Metastatic colon carcinom Colon cancer and normal t
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Activating Semantic Knowledge During Spoken Words and Environmental Sounds: Evidence From the Visual World Paradigm.Two visual world experiments investigated the activation of semantically related concepts during the processing of environmental sounds and spoken words. Participants heard environmental sounds such as barking or spoken words such as "puppy" while viewing visual arrays with objects such as a bone (semantically related competitor) and candle (unrelated distractor). In Experiment 1, a puppy (target) was also included in the visual array; in Experiment 2, it was not. During both types of auditory stimuli, competitors were fixated significantly more than distractors, supporting the coactivation of semantically related concepts in both cases; comparisons of the two types of auditory stimuli also revealed significantly larger effects with environmental sounds than spoken words. We discuss implications of these results for theories of semantic knowledge.
2660 related Products with: Activating Semantic Knowledge During Spoken Words and Environmental Sounds: Evidence From the Visual World Paradigm.Normal rat multiple organ BAFF (B cell activating f MyGenie 96 Gradient Therm (5α,16β)-N-Acetyl-16-ac MultiGene OptiMax Thermal Androst-4-ene-3,17-dion-1 Mouse Anti-Human Fas CD95 Thermostable TDG Enzyme & Androstadienone C19H26O C AZD-3514 Mechanisms: Andr Recombinant Human PKC the Androstane-3a, 17b-diol 5
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Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex.Having reported associations between catechol-O-methyltransferase (COMT) genotypes at SNPs rs4818 and rs4680 with levels of soluble COMT (S-COMT) in human dorsolateral prefrontal cortex (DLPFC), we postulated that changes in the levels of cortical S-COMT could impact on behavioural abilities associated with COMT genotype through S-COMT-mediated changes in gene expression. To test this hypothesis, we have examined the relationships between COMT genotypes and gene expression measured using the Affymetrix™ Human Exon 1.0 ST Array in the DLPFC from 141 individuals, some of whom had had a psychiatric disorder. There were significant differences in levels of expression of 15 genes between individuals with a homozygous genotype at rs4818 (GG vs CC), compared to differences in levels of expression of 6 genes between homozygotes at rs4680 (GG vs AA); levels of expression of CEP128, EFCAB13, and FAM133A differed between homozygotes at both SNPs. Fourteen of the genes differentially expressed in the DLPFC according to COMT genotypes have oestrogen receptor elements and their expression could, therefore, be regulated by catecholestrogens, which are substrates for COMT that occupy and activate oestrogen receptors. In addition, the changes in gene expression between the homozygotes at rs4818 or rs4680 would be expected to impact on neuronal function, synaptic plasticity, cognition, and attention. These data would support a hypothesis that the mechanism underlying the association between COMT genotype and cognition involves differential changes in cortical gene expression.
2499 related Products with: Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex.DNA (cytosine 5) methyltr Rabbit Anti-Human Androge Goat Anti-Human Androgen CAR,CAR,Constitutive acti Goat Anti-Human PNPLA2 AT Recombinant Human Androge Atherosclerosis (Human) A Goat Anti-Human COMT (int Rabbit Anti-Human Androge Rabbit Anti-Human Androge Goat Anti-Human ATP13A1, Human Epstein-Barr Virus
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Genomic dynamics of species and mobile genetic elements in a prolonged blaIMP-4-associated carbapenemase outbreak in an Australian hospital.Hospital outbreaks of carbapenemase-producing organisms, such as blaIMP-4-containing organisms, are an increasing threat to patient safety.
2722 related Products with: Genomic dynamics of species and mobile genetic elements in a prolonged blaIMP-4-associated carbapenemase outbreak in an Australian hospital.Proteasome inhibitor PI31 Interferon-a Receptor Typ Integrin â3 (Ab 785) Ant Protease Inhibitor 15 ant Integrin alpha6 antibody Integrin â3 (Ab 773) Ant INPP1 antibody Source Rab α-Internexin Antibody So Interferon alpha-8 antibo Human interleukin 2(IL-2) ING5 antibody Source Rabb Interferon alpha-2 antibo
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Commensal Escherichia coli are a reservoir for the transfer of XDR plasmids into epidemic fluoroquinolone-resistant Shigella sonnei.Despite the sporadic detection of fluoroquinolone-resistant Shigella in Asia in the early 2000s and the subsequent global spread of ciprofloxacin-resistant (cipR) Shigella sonnei from 2010, fluoroquinolones remain the recommended therapy for shigellosis. The potential for cipR S. sonnei to develop resistance to alternative second-line drugs may further limit future treatment options. Here, we aim to understand the evolution of novel antimicrobial resistant (AMR) S. sonnei variants after introduction into Vietnam. We found that cipR S. sonnei displaced the resident ciprofloxacin-susceptible (cipS) lineage while rapidly acquiring additional resistance to multiple alternative antimicrobial classes. We identified several independent acquisitions of extensively drug-resistant/multidrug-resistant-inducing plasmids, probably facilitated by horizontal transfer from commensals in the human gut. By characterizing commensal Escherichia coli from Shigella-infected and healthy children, we identified an extensive array of AMR genes and plasmids, including an identical multidrug-resistant plasmid isolated from both S. sonnei and E. coli in the gut of a single child. We additionally found that antimicrobial usage may impact plasmid transfer between commensal E. coli and S. sonnei. These results suggest that, in a setting with high antimicrobial use and a high prevalence of AMR commensals, cipR S. sonnei may be propelled towards pan-resistance by adherence to outdated international treatment guidelines.
2475 related Products with: Commensal Escherichia coli are a reservoir for the transfer of XDR plasmids into epidemic fluoroquinolone-resistant Shigella sonnei.Mouse Anti-Escherichia co Mouse Anti-Escherichia co Mouse Anti-Escherichia co Mouse Anti-Escherichia co Mouse Anti-Escherichia co Goat Anti-Escherichia col Mouse Anti-Escherichia co Mouse Anti-Escherichia co Mouse Anti-Escherichia co Growth Differentiation Fa Mouse Anti-Escherichia co Mouse Anti-Escherichia co
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