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#32668511   2020/07/02 To Up

Gaps between supply and demand of acute myocardial infarction treatment in Mexico.

To analyze acute myocardial infarction (AMI) admissions and in-hospital mortality rates and evaluate the competence of the Ministry of Health (MOH) hospitals to provide AMI treatment.
Ricardo Pérez-Cuevas, Saúl Eduardo Contreras-Sánchez, Svetlana V Doubova, Sebastián García-Saisó, Odet Sarabia-González, Paulina Pacheco-Estrello, Alexandra Arias-Mendoza

1464 related Products with: Gaps between supply and demand of acute myocardial infarction treatment in Mexico.

100 μg1 Set100 μg5ugcase100 μg500 1 mg100 μg500 tests

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#32668510   2020/07/02 To Up

[Mortality associated with fine and coarse suspended particles, in inhabitants of Monterrey Metropolitan Area].

To estimate the mortality risk of fine (PM2.5) and coarse (PM2.5-10) particles in the Metropolitan Area of Monterrey (MAM).
Alfonso Martínez-Muñoz, Magali Hurtado-Díaz, Julio César Cruz, Horacio Riojas-Rodríguez

1873 related Products with: [Mortality associated with fine and coarse suspended particles, in inhabitants of Monterrey Metropolitan Area].

50ug50ug100 μg1 Set100 μg2ug 500 G

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#32668508   2020/07/15 To Up

A GT-seq panel for walleye (Sander vitreus) provides important insights for efficient development and implementation of amplicon panels in non-model organisms.

Targeted amplicon sequencing methods, such as genotyping-in-thousands by sequencing (GT-seq), facilitate rapid, accurate, and cost-effective analysis of hundreds of genetic loci in thousands of individuals. Development of GT-seq panels is non-trivial, but studies describing trade-offs associated with different steps of GT-seq panel development are rare. Here, we construct a dual-purpose GT-seq panel for walleye (Sander vitreus), discuss trade-offs associated with different development and genotyping approaches, and provide suggestions for researchers constructing their own GT-seq panels. Our GT-seq panel was developed using an ascertainment set consisting of restriction site-associated DNA data from 954 individuals sampled from 23 populations in Minnesota and Wisconsin. We then conducted simulations to test the utility of all loci for parentage analysis and genetic stock identification and designed 600 primer pairs to maximize joint accuracy for these analyses. We conducted three rounds of primer optimization to remove loci that overamplified and our final panel consisted of 436 loci. We also explored different approaches for DNA extraction, multiplexed polymerase chain reaction (PCR) amplification, and cleanup steps during the GT-seq process and discovered the following: (1) inexpensive Chelex extractions performed well for genotyping, (2) the exonuclease I and shrimp alkaline phosphatase (ExoSAP) procedure included in some current protocols did not improve results substantially and was likely unnecessary, and (3) it was possible to PCR amplify panels separately and combine them prior to adapter ligation. Well-optimized GT-seq panels are valuable resources for conservation genetics and our findings and suggestions should aid in their construction in myriad taxa.
Matthew L Bootsma, Kristen M Gruenthal, Garrett J McKinney, Levi Simmons, Loren Miller, Greg G Sass, Wesley A Larson

1508 related Products with: A GT-seq panel for walleye (Sander vitreus) provides important insights for efficient development and implementation of amplicon panels in non-model organisms.

100 mg1 g500 1.0 mg0.1 mg 1 G20 ug 500 G

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#32668506   2020/07/15 To Up

Theoretical and Experimental Analysis of Protoporphyrin IX Photodegradation Using Multi-Wavelength Light Sources.

Photodynamic procedures have been used in many applications, ranging from cancer treatment to microorganism inactivation. Photodynamic reactions start with the activation of a photosensitizing molecule with light, leading to the production of cytotoxic molecules that promote cell death. However, establishing the correct light and photosensitizer dosimetry for a broadband light source remains challenging. In this study, we proposed a theoretical mathematical model for the photodegradation of protoporphyrin-IX (PpIX), when irradiated by multi-wavelength light sources. The theoretical model predicts the experimental photobleaching (temporal change in PpIX concentration) of PpIX for different light sources. We showed that photobleaching occurs independently of the light source wavelengths but instead depends only on the number of absorbed photons. The model presented here can be used as an important mathematical approach to better understand current photodynamic therapy protocols and help achieve optimization of the doses delivered.
Víctor Sánchez, Marlon Rodrigues Garcia, Michelle Barreto Requena, Renan Arnon Romano, Leonardo de Boni, Francisco E G Guimarães, Sebastião Pratavieira

2755 related Products with: Theoretical and Experimental Analysis of Protoporphyrin IX Photodegradation Using Multi-Wavelength Light Sources.

25 mg1 module5mg1 module 6 ml Ready-to-use 200 10 mg1 mg100ug

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#32668505   2020/07/15 To Up

Neutropenic sepsis rates in patients receiving BEP chemotherapy using olanzapine and reduced doses of dexamethasone compared to a standard antiemetic regimen.

Bleomycin, Etoposide and Cisplatin (BEP) chemotherapy is the conventional treatment regimen for patients with germ cell tumours. The regimen is highly emetogenic and immunosuppressive. High dose steroids are often prescribed with this regimen as antiemetic prophylaxis but may have adverse effects in the context of immunosuppression.
Ernese Gjafa, Kenrick Ng, Tami Grunewald, Myria Galazi, Erik Skyllberg, Peter Wilson, Constantine Alifrangis, Jonathan Shamash

1442 related Products with: Neutropenic sepsis rates in patients receiving BEP chemotherapy using olanzapine and reduced doses of dexamethasone compared to a standard antiemetic regimen.

100 100 μg1 kit1 mg25 100

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#32668504   2020/07/15 To Up

Brain-targeted co-delivery of β-amyloid converting enzyme 1 shRNA and epigallocatechin-3-gallate by multifunctional nanocarriers for Alzheimer's disease treatment.

Progressive memory loss and cognitive dysfunction are hallmark clinical features of Alzheimer's disease (AD). As a possible treatment for AD, we developed an epigallocatechin-3-gallate (EGCG) and β-site amyloid precursor protein (APP) cleaving enzyme 1 antisense (BACE1-AS) shRNA-encoded plasmid. The plasmid was loaded on to RVG29 peptide-targeted multifunctional nanoparticles (NPs) (REGS-PN). The polymeric NPs were characterized by flow cytometry, biocompatibility assay, pharmacokinetic analysis, Western blot analysis, and the Morris water maze (MWM) test. The differences in plasma and brain NP accumulation following intravenous administration showed a significantly longer circulation time for EGS-PN and REGS-PN in the blood stream. In contrast, free EGCG was rapidly eliminated from the circulation. REGS-PM successfully travelled through the blood-brain barrier and was present at a higher concentration in the brain compared with both non-targeted NPs and free EGCG. REGS-PN administration to APPswe/PS1dE9 double transgenic mice (APP/PS1 mice) resulted in downregulation of the key enzyme in amyloid-β formation (BACE1) and amyloid beta, indicating synergistic therapeutic activity. The MWM test revealed that simultaneous delivery of a therapeutic gene and EGCG (REGS-PN) remarkably improved the spatial learning and memory capabilities of APP/PS1 mice as well as wild type mice compared with the free EGCG-treated group. With these results, we propose that co-delivery of a therapeutic gene (shRNA) and EGCG in a multifunctional nanocarrier could achieve higher therapeutic concentrations in the brain and could be an excellent strategy for AD treatment.
Lijie Lv, Fan Yang, He Li, Jiuli Yuan

2163 related Products with: Brain-targeted co-delivery of β-amyloid converting enzyme 1 shRNA and epigallocatechin-3-gallate by multifunctional nanocarriers for Alzheimer's disease treatment.

96 tests96 tests96 tests96 tests100μg100μg100μg100μg 100ul100ug100μg100ug

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#32668502   2020/07/15 To Up

Design of an inhibitor of Helicobacter pylori cholesteryl-α-glucoside transferase critical for bacterial colonization.

Fifty percent of the world's population surves as a host for Helicobacter pylori, gastric cancer causing bacteria, that colonizes the gastric region of digestive tract. It has a remarkable capacity to infect the host stomach for the entire lifetime despite an activated host immune response.
Soumiya Pal, Nishat Sarker, Majjid Qaria, Kshitij Tandon, Yusuf Akhter, Niyaz Ahmed

2180 related Products with: Design of an inhibitor of Helicobacter pylori cholesteryl-α-glucoside transferase critical for bacterial colonization.

1 mg96T0.2 mg1 mg 5 G0.2 mg100μg100 µg100ug Lyophilized500 100ug100ul

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#32668501   2020/07/15 To Up

Childhood wheeze trajectory-specific risk factors: a systematic review and meta-analysis.

There is growing interest in the use of latent trajectory methodology to identify wheeze patterns inheterogenous populations of children. This study systematically reviewed and meta-analyzed childhood wheeze trajectory studies to identify childhood wheeze trajectory group-specific risk factors among children from birth through to adolescence.
Arthur H Owora, Yijia Zhang

1281 related Products with: Childhood wheeze trajectory-specific risk factors: a systematic review and meta-analysis.

1 module4 Arrays/Slide2 modules2 Pieces/Box1 kit(96 Wells) 6 ml Ready-to-use 100ug Lyophilized100ug4 Membranes/Box1 module100 mg2 Pieces/Box

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#32668489   2020/07/15 To Up

Fatty liver is associated with advanced fibrosis but does not predict adverse outcomes in patients with chronic hepatitis B.

Hepatic steatosis is increasingly common and has been implicated in progression of liver fibrosis in chronic hepatitis B (CHB) patients. We aimed to investigate the impact of hepatic steatosis on liver fibrosis and clinical outcomes in CHB patients. Consecutive CHB patients who underwent transient elastography between 2013 and 2017 at a tertiary hospital were included in this longitudinal cohort study. Presence of hepatic steatosis was defined as controlled attenuation parameter, CAP ≥248 dB/m, while advanced liver fibrosis was defined as liver stiffness measurement, LSM ≥9.4 kPa. Cardiovascular events, liver-related complications, malignancy and mortality and a composite of these outcomes were evaluated with Kaplan-Meier analysis and Cox proportional hazards regression. Our study cohort included 614 patients with median follow-up of 45 (32 - 63) months. Hepatic steatosis was present in 294 patients (47.9%) and advanced liver fibrosis was present in 127 patients (21.0%). Presence of hepatic steatosis (OR:1.956, 95% CI: 1.250 - 3.060) and diabetes mellitus (OR: 3.507, 95% CI: 2.069 - 5.944) were independently associated with advanced fibrosis. Advanced fibrosis was independently associated with composite outcome (HR: 2.496, 95% CI: 1.352 - 4.606), liver-related complications (HR: 3.765, 95% CI: 1.380 - 10.271), and mortality (HR: 3.632, 95% CI: 1.342 - 9.826), but not cardiovascular events and malignancy. Hepatic steatosis was not associated with any adverse outcomes. We conclude that Hepatic steatosis is common and associated with advanced fibrosis in CHB patients. Unlike advanced fibrosis, hepatic steatosis does not predict adverse outcomes in CHB patients.
Sui-Weng Wong, Wah-Kheong Chan, Rosmawati Mohamed

1203 related Products with: Fatty liver is associated with advanced fibrosis but does not predict adverse outcomes in patients with chronic hepatitis B.

50 UG100ug Lyophilized100ug Lyophilized100ug Lyophilized 25 G100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#32668487   2020/07/15 To Up

Acupuncture for pain, mandibular function and oral health-related quality of life in patients with masticatory myofascial pain: A randomized controlled trial.

Masticatory myofascial pain is the most prevalent muscular temporomandibular disorder (TMD). It primarily affects masseter and temporal muscles. Several treatments, including acupuncture, have been recommended. However, systematic reviews have highlighted gaps in studies and absence of conclusive results.
Franklin Teixeira de Salles-Neto, Janice Simpson de Paula, João Gabriel de Azevedo José Romero, Camila Megale Almeida-Leite

2112 related Products with: Acupuncture for pain, mandibular function and oral health-related quality of life in patients with masticatory myofascial pain: A randomized controlled trial.

2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box

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