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#32791572   2020/08/13 To Up

Practical recommendations for systemic treatment in psoriasis in case of coexisting inflammatory, neurologic, infectious or malignant disorders (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis; part 2).

Psoriasis patients carry an increased risk for associated comorbidities. Dermatologists have to be aware of the effects of systemic treatments not only on psoriasis but also on co-occurring diseases. In case of other coexisting inflammatory diseases, the right psoriasis treatment may improve both disorders. For infectious and malignant disorders, some treatments have to be avoided as they may be harmful.
J L W Lambert, S Segaert, P D Ghislain, T Hillary, A Nikkels, F Willaert, J Lambert, R Speeckaert

2401 related Products with: Practical recommendations for systemic treatment in psoriasis in case of coexisting inflammatory, neurologic, infectious or malignant disorders (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis; part 2).



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#32791516   2020/08/13 To Up

JBPOS0101 regulates amyloid beta, tau, and glial cells in an Alzheimer's disease model.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease characterized by cognitive dysfunction and memory loss as the main symptoms. The deposition of amyloid beta (Aβ) and tau hyperphosphorylation are hallmarks of AD and are major therapeutic targets. However, the exact etiology has not yet been fully elucidated; thus, no drug that cures the disease has been approved. JBPOS0101 is a phenyl carbamate compound that has been tested as a drug for epileptic diseases. In our previous study, we showed that JBPOS0101 attenuated the accumulation of Aβ as well as the deficits in learning and memory in the 5xFAD mouse model. Here, we tested the dose effect (70 or 35 mg/kg) of JBPOS0101 on the memory defect and pathological markers and further investigated the underlying mechanisms in 5xFAD mice. In the behavior tests, JBPOS0101 treatment ameliorated deficits in learning and memory. Moreover, JBPOS0101 attenuated Aβ accumulation and tau phosphorylation. The elevated phosphorylation levels of the active GSK3β form (GSK3β-y216) in 5xFAD, which are responsible for tau phosphorylation, decreased in the JBPOS0101-treated groups. Furthermore, the elevation of reactive astrocytes and microglia in 5xFAD mice was attenuated in JBPOS0101-treated groups. These data suggest that JBPOS0101 may be a new drug candidate to lessen amyloid- and tau-related pathology by regulating glial cells.
Jihoon Jeong, Hyung Joon Park, Bo-Ram Mun, Ju Kyong Jang, Yong Moon Choi, Won-Seok Choi

2458 related Products with: JBPOS0101 regulates amyloid beta, tau, and glial cells in an Alzheimer's disease model.

96 tests96 tests96 tests96 tests 100ul500 tests 100ul2 Pieces/Box500 tests100μg

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#32791515   2020/08/13 To Up

Impact of and risk factors for pediatric acute kidney injury defined by the pROCK criteria in a Chinese PICU population.

The definition of pediatric AKI continues to evolve. We aimed to find a better AKI definition to predict outcomes and identify risk factors for AKI in a Chinese PICU.
Cui Wei, Gao Hongxia, Fang Hui, Qin Xianhui, Jin Danqun, Liu Haipeng

2945 related Products with: Impact of and risk factors for pediatric acute kidney injury defined by the pROCK criteria in a Chinese PICU population.

96T

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#32791506   2020/08/13 To Up

The Effect of Bronchoconstriction by Methacholine Inhalation in a Murine Model of Asthma.

Bronchoconstriction was recently shown to cause airway remodeling and induce allergic airway inflammation in asthma. However, the mechanisms how mechanical stress via bronchoconstriction could induce airway inflammation and remodeling remain unclear.
Yoshito Miyata, Shin Ohta, Akihiko Tanaka, Ayaka Kashima, Hiromitsu Suganuma, Tomoki Uno, Haruna Sato, Hitomi Ida, Tomoyuki Kimura, Megumi Jinno, Kuniaki Hirai, Tetsuya Homma, Mayumi Yamamoto, Yoshio Watanabe, Shintaro Suzuki, Hironori Sagara

1752 related Products with: The Effect of Bronchoconstriction by Methacholine Inhalation in a Murine Model of Asthma.

18 kgs1100 μg

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#32791453   2020/07/23 To Up

Inhibition of Circulating miR-194-5p Reverses Osteoporosis through Wnt5a/β-Catenin-Dependent Induction of Osteogenic Differentiation.

Mesenchymal stem cells (MSCs) critically contribute to bone formation, and proper induction of osteogenic differentiation can lead to an increase in bone mass. In the present study, we reported that an increased miR-194-5p level in plasma is inversely related to the degree of bone formation in osteoporosis patients. We also noted that increased miR-194-5p in the MSCs of ovariectomized (OVX) mice and agomiR-194-5p manipulation of miR-194-5p significantly suppressed bone formation, both in aged and OVX mice. Furthermore, our in vitro study showed that overexpression of miR-194-5p suppresses osteogenic differentiation, as evidenced by the decreased bone formation marker genes and matrix mineralization. The luciferase assay indicated that Wnt family member 5a (Wnt5a) is a target gene of miR-194-5p that positively regulates osteogenic differentiation. Collectively, these data indicated that miR-194-5p inhibition may be a potential strategy for osteoporosis prevention.
Bobin Mi, Chenchen Yan, Hang Xue, Lang Chen, Adriana C Panayi, Liangcong Hu, Yiqiang Hu, Faqi Cao, Yun Sun, Wu Zhou, Yuan Xiong, Guohui Liu

2190 related Products with: Inhibition of Circulating miR-194-5p Reverses Osteoporosis through Wnt5a/β-Catenin-Dependent Induction of Osteogenic Differentiation.

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#32791412   2020/07/27 To Up

Use of silver nanoparticles to counter fungicide-resistance in Monilinia fructicola.

The potential of Ag-NPs to suppress Monilia fructicola isolates and to broaden the effectiveness of fungicides to overcome resistance was tested in vitro and in vivo. Twenty-three M. fructicola isolates were subjected to fungitoxicity screening with a number of fungicides in vitro, which resulted in the detection of 18 isolates resistant to benzimidazoles (BEN-R) thiophanare methyl (TM) and carbendazim (CARB). DNA sequencing revealed the E198A resistance mutation in the β-tubulin gene, target site of the benzimidazole fungicides in all resistant isolates. Ag-NPs effectively suppressed mycelial growth in both sensitive (BENS) and resistant isolates. The combination of Ag-NPs with TM led to a significantly enhanced fungitoxic effect compared to the individual treatments regardless resistant phenotype (BEN-R/S) both in vitro and when applied on apple fruit. The above observed additive/synergistic action is probably associated with an enhanced Ag-NPs activity/availability as indicated by the positive correlation between Ag-NPs and TM + Ag-NPs treatments. No correlation was found between AgNO and Ag-NPs suggesting that difference(s) exist in the fungitoxic mechanism of action between nanoparticles and their ionic counterparts. Synergy observed between Ag-NPs and the oxidative phosphorylation-uncoupler fluazinam (FM) against both resistance phenotypes indicates a possible role of energy (ATP) metabolism in the mode of action of Ag-NPs. Additionally, the role of released silver ions on the fungitoxic action of Ag-NPs against M. fructicola was found to be limited because the combination with NaCl revealed a synergistic rather than the antagonistic effect that would be expected from silver ion binding with chlorine ions. The results of this study suggested that Ag-NPs can be effectively used against M. fructicola and when used in combination with conventional fungicides they could provide the means for countering benzimidazole resistance and at the same time reduce the environmental impact of synthetic fungicides by reducing doses needed for the control of the pathogen.
Anastasios A Malandrakis, Nektarios Kavroulakis, Constantinos V Chrysikopoulos

1119 related Products with: Use of silver nanoparticles to counter fungicide-resistance in Monilinia fructicola.

100 500 gm.96 wells (1 kit)100 25 1 mg1 mg1mg

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#32791354   2020/07/31 To Up

Low magnitude high frequency vibration promotes chondrogenic differentiation of bone marrow stem cells with involvement of β-catenin signaling pathway.

Mesenchymal stem cells (MSCs) are well known to have the capability to form bone and cartilage, and chondrogenesis derived from MSCs is reported to be affected by mechanical stimuli. This research aimed to study the effects of low magnitude high frequency (LMHF) vibration on the chondrogenic differentiation of bone marrow-derived MSCs (BMSCs) which were cultured with chondrogenic medium, and to investigate the role of β-catenin cascade in this process.
Weiwei Hou, Denghui Zhang, Xiaoxia Feng, Yi Zhou

1789 related Products with: Low magnitude high frequency vibration promotes chondrogenic differentiation of bone marrow stem cells with involvement of β-catenin signaling pathway.

2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box1.5x10(6) cells2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box1.5 x 10^6 cells

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#32791341   2020/08/10 To Up

Can interaction with informal urban green space reduce depression levels? An analysis of potted street gardens in Tangier, Morocco.

The purpose of this study was to investigate the association between ownership of a potted street garden (PSG) and depression levels in a densely populated, disadvantaged Moroccan neighbourhood.
A Afrad, Y Kawazoe

2211 related Products with: Can interaction with informal urban green space reduce depression levels? An analysis of potted street gardens in Tangier, Morocco.

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#32791334   2020/08/10 To Up

Moderate treadmill exercise improves spatial learning and memory deficits possibly via changing PDE-5, IL-1 β and pCREB expression.

Alzheimer's is a progressive disorder of the nervous system. Prior studies suggested that physical activity contributes to the improvement of cognitive impairment and slows down pathogenesis of AD; however, the exact mechanisms for this have not been fully understood. Therefore, in this study, we examined the effect of aerobic training before and after induction of Alzheimer's on spatial learning and memory, expression of interleukin-1 beta (IL-1β), cAMP-responsive element-binding protein (pCREB), and Phosphodiesterase-5 (PDE-5) in the hippocampus of male rats Wistar. Aβ was microinjected into the CA1 area of the hippocampus animals. The moderate treadmill exercise protocols for pre and post induction of Alzheimer's were the same (5 days/week, for 4 weeks with a customized regime). The Morris Water Maze (MWM) method has been to assess spatial learning and memory. The real time-PCR method was used to measure gene expression. Our results showed that intra-hippocampal injection of Aβ1-42 impaired spatial learning and memory which was accompanied by reduced pCREB activity and elevated IL-1β and PDE-5 in the hippocampus of rats. In contrast, moderate treadmill exercise ameliorated the Aβ1-42-induced spatial learning and memory deficit, which was accompanied by restored pCREB activity and decreasing IL-1β and PDE-5 levels. In conclusion, our finding suggests that exercise before and after Alzheimer's induction leads to an increase in pCREB and an alleviation of inflammation which likely involved in ameliorating spatial learning and memory deficits in an animal model of AD.
Mostafa Sabouri, Mohammadreza Kordi, Fatemeh Shabkhiz, Pejman Taghibeikzadehbadr, Zeinabosadat Geramian

1636 related Products with: Moderate treadmill exercise improves spatial learning and memory deficits possibly via changing PDE-5, IL-1 β and pCREB expression.

1000 tests1000 TESTS/0.65ml100ug100ul1000 tests100ug100ug10 mg100ul100 mg100ug100ug

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#32791303   2020/08/10 To Up

H. pylori slyD, a novel virulence factor, is associated with Wnt pathway protein expression during gastric disease progression.

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Aining Chu, Xiuwen Yu, Qianqian Guo, Qiuping Li, Mingjun Sun, Yuan Yuan, Yuehua Gong

1442 related Products with: H. pylori slyD, a novel virulence factor, is associated with Wnt pathway protein expression during gastric disease progression.

100ul100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized0.1 mg Protein A100ug Lyophilized100ug Lyophilized100ug Lyophilized

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