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#34130358   2021/06/15 To Up

Sexual harassment and assault predict sleep disturbances and is partly mediated by nightmares: Findings from a national survey of all university students in Norway.

Sexual harassment and assault is common in most domains of society, and has been linked to several adverse outcomes, including reduced sleep quality. However, less is known about the possible impact of sexual harassment and assault on various sleep problems among university students. In a sample of 49,051 students in Norway (69.2% women), we examined i) the associations of varying extents of sexual harassment (unwanted sexual comments, looks or gestures, photographs, indecent exposure, and physical harassment) and sexual assault (attempted or completed rape), with meeting Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) diagnostic criteria of insomnia and with sleep duration, ii) the association of cumulative exposure to sexual harassment/assault with insomnia and sleep duration, and iii) to what extent nightmares could explain the association between sexual harassment and insomnia and sleep duration. For both genders, all forms of harassments with the exception of "indecent exposure" and "unwanted sexual photographs" for men were negatively associated with sleep duration, with the strongest associations being found for "rape" and "attempted rape". For both genders, the odds of insomnia increased as a function of cumulative harassment exposure. Similarly, a graded, negative association was found between cumulative harassment and sleep duration for both genders. Mediation analyses showed that 28% of the observed association between cumulative harassment and insomnia, and 15% of the association between cumulative harassment and sleep duration, was mediated by frequency of nightmares.
Iris M Steine, Jens Christoffer Skogen, Mari Hysing, Lidia Puigvert, Viktor Schønning, Børge Sivertsen

1975 related Products with: Sexual harassment and assault predict sleep disturbances and is partly mediated by nightmares: Findings from a national survey of all university students in Norway.

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#34130349   2021/06/15 To Up

Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin.

 Sunitinib is a multitarget tyrosine kinase inhibitor (TKI) used for cancer treatment. In platelets, sunitinib affects collagen-induced activation under noncoagulating conditions. We investigated (1) the effects of sunitinib on thrombus formation induced by other TK-dependent receptors, and (2) the effects under coagulating conditions. Cardiovascular disease is a comorbidity in cancer patients, resulting in possible aspirin treatment. Sunitinib and aspirin are associated with increased bleeding risk, and therefore we also investigated (3) the synergistic effects of these compounds on thrombus and fibrin formation.
Bibian M E Tullemans, Delia I Fernández, Alicia Veninga, Constance C F M J Baaten, Linsey J F Peters, Maureen J B Aarts, Johannes A Eble, Elena Campello, Luca Spiezia, Paolo Simioni, Emiel P C van der Vorst, Paola E J van der Meijden, Johan W M Heemskerk, Marijke J E Kuijpers

1372 related Products with: Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin.

8 inhibitors5 inhibitors0.1ml96T7 inhibitors5 mg5 mg96T5 mg100ul5 mg

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#34130335   2021/06/15 To Up

Interleukin-17 in Liver Disease Pathogenesis.

Interleukin 17A (IL-17A)-producing T helper 17 (Th17) cells were identified as a subset of T helper cells that play a critical role in host defense against bacterial and fungal pathogens. Th17 cells differentiate from Th0 naïve T-cells in response to transforming growth factor β1 (TGF-β1) and IL-6, the cytokines which also drive development of liver fibrosis, require activation of transcription factor retinoic acid receptor-related orphan nuclear receptor gamma (RORγ). IL-17A signals through the ubiquitously expressed receptor IL-17RA. Expression of IL-17RA is upregulated in patients with hepatitis B virus/hepatitis C virus (HBV/HCV) infections, nonalcoholic steatohepatitis (NASH), alcohol-associated liver disease (AALD), hepatocellular carcinoma (HCC), and experimental models of chronic toxic liver injury. The role of IL-17 signaling in the pathogenesis of NASH- and AALD-induced metabolic liver injury and HCC will be the focus of this review. The role of IL-17A-IL-17RA axis in mediation of the cross-talk between metabolically injured hepatic macrophages, hepatocytes, and fibrogenic myofibroblasts will be discussed.
Na Li, Gen Yamamoto, Hiroaki Fuji, Tatiana Kisseleva

2429 related Products with: Interleukin-17 in Liver Disease Pathogenesis.

5ug96 wells (1 kit)5ug5ug2ug5ug96 tests96 wells (1 kit)

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#34130292   2021/06/15 To Up

Long-Term Outcomes of Kidney Transplants from Older/Marginal Donors: A Cohort Study.

To safely expand the donor pool, we introduced a strategy of biopsy-guided selection and allocation to single or dual transplantation of kidneys from donors >60 years old or with hypertension, diabetes, and/or proteinuria (older/marginal donors). Here, we evaluated the long-term performance of this approach in everyday clinical practice.
Boris Bikbov, Piero Ruggenenti, Annalisa Perna, Norberto Perico, Eliana Gotti, AnnaRita Plati, Flavio Gaspari, Fabiola Carrara, Vincenzo Gambara, Tobia Peracchi, Giuseppe Rossini, Giovanni Rota, Francesco Lacanna, Annalisa Amaduzzi, Michele Colledan, Giuseppe Remuzzi

2892 related Products with: Long-Term Outcomes of Kidney Transplants from Older/Marginal Donors: A Cohort Study.

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#34130268   2021/06/15 To Up

Detection of fixation points using a small visual landmark for brain-computer interfaces.

Abstract- Objective: The speed of visual brain-computer interfaces (v-BCIs) has been greatly improved in recent years. However, the traditional v-BCI paradigms require users to directly gaze at the intensive flickering items, which would cause severe problems such as visual fatigue and excessive visual resource consumption in practical applications. Therefore, it is imperative to develop a user-friendly v-BCI.
Xiaoyu Zhou, Minpeng Xu, Xiaolin Xiao, Yijun Wang, Tzyy-Ping Jung, Dong Ming

1426 related Products with: Detection of fixation points using a small visual landmark for brain-computer interfaces.

100 mg500 tests50 assays1mg 100ul

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#34130254   2021/06/12 To Up

Corticomotor excitability of gluteus maximus and hip extensor strength: The influence of sex.

To compare hip extensor strength and corticomotor excitability (CME) of gluteus maximus (GM) between males and females. A secondary purpose was to determine if CME of GM is predictive of hip extensor strength.
Yo Shih, Beth E Fisher, Jason J Kutch, Christopher M Powers

2480 related Products with: Corticomotor excitability of gluteus maximus and hip extensor strength: The influence of sex.

5 G250ul200ul100.00 ul100ug Lyophilized25 mg500 Units100ug Lyophilized10 ug1000 tests100ug

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#34130248   2021/05/13 To Up

Differential auditory brain response abnormalities in two intellectual disability conditions: SYNGAP1 mutations and Down syndrome.

Altered sensory processing is common in intellectual disability (ID). Here, we study electroencephalographic responses to auditory stimulation in human subjects presenting a rare condition (mutations in SYNGAP1) which causes ID, epilepsy and autism.
Valérie Côté, Inga S Knoth, Kristian Agbogba, Phetsamone Vannasing, Lucie Côté, Philippe Major, Jacques L Michaud, Fanny Barlaam, Sarah Lippé

2735 related Products with: Differential auditory brain response abnormalities in two intellectual disability conditions: SYNGAP1 mutations and Down syndrome.

96 tests 100 UG 50 UG96T

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#34130243   2021/04/21 To Up

D-cycloserine normalizes long-term motor plasticity after transcranial magnetic intermittent theta-burst stimulation in major depressive disorder.

Major Depressive Disorder (MDD) is associated with glutamatergic alterations, including the N-methyl-D-aspartate receptor (NMDA-R). The NMDA-R plays an important role in synaptic plasticity, and individuals with MDD have been shown to have impairments in repetitive Transcranial Magnetic Stimulation (rTMS) motor plasticity. Here, we test whether D-cycloserine, a NMDA-R partial agonist, can rescue TMS motor plasticity in MDD.
Jaeden Cole, Ben Selby, Zahinoor Ismail, Alexander McGirr

2938 related Products with: D-cycloserine normalizes long-term motor plasticity after transcranial magnetic intermittent theta-burst stimulation in major depressive disorder.

100 μg100 μg100 μg100 μg100 μg100 μg 0.1 mg 100 μg100 μg100 μg100 μg100 μg

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#34130241   2021/06/12 To Up

The Relationship Between Visceral Obesity and Post-operative Complications: A Meta-analysis.

Body composition can have important influence on surgical outcome. There is substantial literature examining sarcopenia, however much less in known about the impact of fat. Visceral fat area (VFA) is a reliable measures of fat distribution that can be quantified with CT scan. The aim of this study is to determine the impact of VFA to predict complications and mortality after emergent or elective surgery.
Bianka Saravana-Bawan, Michael Goplen, Mahmoud Alghamdi, Rachel G Khadaroo

2740 related Products with: The Relationship Between Visceral Obesity and Post-operative Complications: A Meta-analysis.

15 ml 1 module1 module10 mg1 module 5 G16 Arrays/Slide100.00 ul1 module2.5 mg

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#34130235   2021/06/12 To Up

Advances in the study of GPCRs by F NMR.

Crystallography and cryo-electron microscopy have advanced atomic resolution perspectives of inactive and active states of G protein-coupled receptors (GPCRs), alone and in complex with G proteins or arrestin. F NMR can play a role in ascertaining activation mechanisms and understanding the complete energy landscape associated with signal transduction. Fluorinated reporters are introduced biosynthetically via fluorinated amino acid analogs or chemically, via thiol-specific fluorinated reporters. The chemical shift sensitivity of these reporters makes it possible to discern details of conformational ensembles. In addition to spectroscopic details, paramagnetic species can be incorporated through orthogonal techniques to obtain distance information on fluorinated reporters, while T-and T-based relaxation experiments provide details on exchange kinetics in addition to fluctuations within a given state.
Louis-Philippe Picard, Robert Scott Prosser

2599 related Products with: Advances in the study of GPCRs by F NMR.

0.1 mg0.2 mg500 ml1 Set100ug Lyophilized1 Set

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