Search results for: cancer
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Effect of ANGPTL7 on Proliferation and Differentiation of MC3T3-E1 Cells.BACKGROUND Angiopoietin-like proteins (ANGPTL) are a family of secretory glycoproteins that are involved in many pathophysiological processes. ANGPTL7 is a newly-discovered member of the ANGPTL family and plays a role in corneal morphogenesis, angiogenesis, glaucoma, and cancer. To date, whether ANGPTL7 is involved in osteoporosis is unknown. Therefore, to discover the effects of ANGPTL7 on osteoporosis, we explored the expression of ANGPTL7 in preosteoblasts and assessed the mechanism underlying its effects on proliferation and differentiation abilities of preosteoblasts. MATERIAL AND METHODS Mouse MC3T3-E1 cells were cultured in osteogenic medium for osteogenic differentiation. The expression levels of ANGPTL7 were detected by RT-qPCR and Western blot assays. Moreover, the overexpressed plasmid of ANGPTL7 pMSCV-ANGPTL7 was transfected into MC3T3-E1 cells. CCK-8 was used to evaluate cell proliferation. ALP activity detection and alizarin red staining were performed to measure the effect of ANGPTL7 on osteogenic differentiation. The expression levels bone morphogenetic proteins (BMPs) and osteogenic markers ALP, runt-related transcription factor 2 (Runx2), osteocalcin (OCN), and collagen I (Col I) were analyzed by Western blot. RESULTS When MC3T3-E1 cells were exposed to osteogenic medium, there was a significant increase in ANGPTL7, and overexpression of ANGPTL7 markedly promoted cell proliferation, ALP activity, and mineralization. Moreover, ANGPTL7 upregulated the levels of BMPs, especially BMP2/7, and the osteogenic markers ALP, Runx2, OCN, and Col I. CONCLUSIONS The results suggest that by regulating the expression of BMPs, ANGPTL7 directly promotes proliferation, differentiation, and mineralization of osteoblasts.
1566 related Products with: Effect of ANGPTL7 on Proliferation and Differentiation of MC3T3-E1 Cells.Epidermal Growth Factor ( Epidermal Growth Factor ( Ofloxacin CAS Number [824 Canine Red Blood Cells 25 c-erbB-3 Oncoprotein; Cl (5α)-Androst-2-en-17-one T-cell proliferation grad Androgen Receptor (Phosph Human Small Intestine Mic Bovine Red Blood Cells, P c-erbB-3 Oncoprotein; Cl 1,4 Androstadiene 3,17 di
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ComBat harmonization for radiomic features in independent phantom and lung cancer patient computed tomography datasets.To evaluate the Combatting Batch effect (ComBat) harmonization algorithm's ability to reduce the variation in radiomic features arising from different imaging protocols and independently verify published results.
2118 related Products with: ComBat harmonization for radiomic features in independent phantom and lung cancer patient computed tomography datasets.Top 4 types of cancer (co Lung cancer tissue array Lung cancer test tissue a Lung cancer and adjacent Lung cancer tissue array Multiple lung carcinoma ( Lung cancer test tissue a Lung cancer survey tissue Lung cancer tissue array, Lung cancer tissue array, Lung cancer tissue array, Lung cancer test tissue a
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A phase II of gemcitabine combined with pazopanib followed by pazopanib maintenance, as second-line treatment in patients with advanced leiomyosarcomas: A unicancer French Sarcoma Group study (LMS03 study).Options in second-line therapy after doxorubicin-based chemotherapy for metastatic/advanced leiomyosarcoma include gemcitabine (G), trabectedin and pazopanib (P) monotherapy. Currently, no combination therapy is better than monotherapy. LMS03 is an open-label multicentre single-group phase II study designed to assess the efficacy and tolerance of G + P in the second-line setting.
1539 related Products with: A phase II of gemcitabine combined with pazopanib followed by pazopanib maintenance, as second-line treatment in patients with advanced leiomyosarcomas: A unicancer French Sarcoma Group study (LMS03 study).MarkerGeneTM Live Dead As Mid advanced stage ovary EMAP-II Inhibitor Z-ASTD- Mid advanced stage bladde Caspase 8 Inhibitor Drug Middle advanced stage lun Mouse Anti-Insulin-Like G Screen Quest™ Fluo 8 Me Anti 3 DG imidazolone Mon Advanced colon cancer tis MMP-13 inhibitor assay ki MMP-1 Inhibitor Screening
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Treatment and outcomes in patients with central nervous system metastases from breast cancer in the real-life ESME MBC cohort.The aims of the present study were to describe treatment patterns and survival outcomes in patients with central nervous system metastases (CNSM) selected among metastatic breast cancer (MBC) patients included in a retrospective study from the Epidemiological Strategy and Medical Economics (ESME) MBC cohort.
2142 related Products with: Treatment and outcomes in patients with central nervous system metastases from breast cancer in the real-life ESME MBC cohort.Human breast invasive duc Breast cancer tissue arra Breast cancer tissue arra Breast cancer tissue arra ER Immunohistochemistry c Breast cancer tissue arra Breast cancer test tissue Middle advanced stage bre High density (188 cases 2 Breast cancer tissue arra Tissue microarray of brea Breast cancer tissue arra
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Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor.Myeloid-derived suppressor cells (MDSCs) expand in tumor-bearing host. They suppress anti-tumor immune response and promote tumor growth. Chemokines play a vital role in recruiting MDSCs into tumor tissue. They can also induce the generation of MDSCs in the bone marrow, maintain their suppressive activity, and promote their proliferation and differentiation. Here, we review CCL2/CCL12-CCR2, CCL3/4/5-CCR5, CCL15-CCR1, CX3CL1/CCL26-CX3CR1, CXCL5/2/1-CXCR2, CXCL8-CXCR1/2, CCL21-CCR7, CXCL13-CXCR5 signaling pathways, their role in MDSCs recruitment to tumor tissue, and their correlation with tumor development, metastasis and prognosis. Targeting chemokines and their receptors may serve as a promising strategy in immunotherapy, especially combined with other strategies such as chemotherapy, cyclin-dependent kinase or immune checkpoints inhibitors.
2341 related Products with: Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor.Multiple organ cancer tis Tissue array of ovarian g Pfu DNA Polymerase protei Multiple organ tumor tiss Rat monoclonal anti mouse Single Strand DNA Ligase, FDA Standard Frozen Tissu Recombinant Human PKC the Normal rat multiple organ BACTERIOLOGY BACTEROIDES CSL Gradient Thermal Cycl Recombinant Thermostable
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Gender of offspring and risk of ovarian cancer: The HOPE study.To examine the association between gender of offspring and epithelial ovarian cancer (EOC).
CA125, Ovarian Cancer An High density ovarian canc Tissue array of ovarian g Ovarian cancer metastasis Ovarian disease spectrum Ovarian cancer and normal Multiple ovarian cancer t Ovarian cancer (multiple Ovarian cancer mid densit Ovarian cancer and normal CA125, Ovarian Cancer An Ofloxacin CAS Number [824
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HPV33+ HNSCC is associated with poor prognosis and has unique genomic and immunologic landscapes.To determine the influence of high-risk HPV genotype on outcomes in HNSCC patients.
2309 related Products with: HPV33+ HNSCC is associated with poor prognosis and has unique genomic and immunologic landscapes.Androgen Receptor , Mouse Androgen Receptor (5α)-2'H-Androst-2-eno[3 Rabbit Anti-Human Androge (3β)-Androsta-5,16-diene Rabbit Anti-Rat Androgen (5α)-Androstane-3,11,17- Androgen Receptor (Ab-650 Androstane 3a,17b diol Gl Bovine Androstenedione,AS (5α,16β)-N-Acetyl-16-ac Androgen Receptor (Phosph
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Prediction of survival of HPV16-negative, p16-negative oral cavity cancer patients using a 13-gene signature: A multicenter study using FFPE samples.To test the performance of an oral cancer prognostic 13-gene signature for the prediction of survival of patients diagnosed with HPV-negative and p16-negative oral cavity cancer.
1775 related Products with: Prediction of survival of HPV16-negative, p16-negative oral cavity cancer patients using a 13-gene signature: A multicenter study using FFPE samples.Oral cavity (tongue and p Oral cavity disease spect Oral cavity disease spect Oral cavity cancer test t PARP in vivo Pharmacodyna Cancer Samples: Rectum A Colon cancer tissue array Tetramethylrhodamine, eth prostaglandin F2 receptor Breast cancer tissue arra Goat Anti-LPS (gram negat Gram Negative Endotoxin a
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Assessing localized conformational stability of antibody-drug conjugate by protein conformation assay.Antibody-drug conjugates (ADCs) are a class of attractive therapeutic agents to fight cancer with conjugation of potent chemical agents on target-selective antibodies. The conceptually elegant approach has encountered mounting practical challenges in combining the mAb and potent drug while maintaining the conformational and physiochemical stability of the bioconjugates. The attachment of hydrophobic drug-linker with antibody could potentially alter the antibody conformational scaffold, locally or globally. Here we propose to use a protein conformation assay (PCA) to measure the higher-order structure of antibodies upon drug-linker conjugation. The PCA analysis provides insights into the formation of partially unfolded ADCs, which may correlate with protein stability and aggregation propensity. To further elucidate the cause of the unfolding events, in-depth peptide mapping combined with the PCA conformational footprints were performed on a commercial ADC trastuzumab emtansine in this study. The locally altered conformational hot-spots observed in PCA matched with conjugation sites with high occupancy rate identified in peptide mapping. In summary, by combining PCA and in-depth peptide mapping, a snapshot of ADC structural conformation and stability profile could be obtained and provide a swift and convenient measurement of the 'fitness' of ADC to facilitate payload selection, conjugation process development and early predictive developability assessment.
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Polycyclic aromatic compounds in urban soils of Stockholm City: Occurrence, sources and human health risk assessment.Polycyclic aromatic compounds (PACs) are ubiquitous pollutants that are found everywhere in our environment, including air, soil and water. The aim of this study was to determine concentrations, distribution, sources and potential health risk of 43 PACs in soils collected from 25 urban parks in Stockholm City, Sweden. These PACs included 21 PAHs, 11 oxygenated PAHs, 7 methylated PAHs, and 4 azaarenes whose concentrations ranged between 190 and 54 500, 30.5-5 300, 14.9-680, and 4.17-590 ng/g soil, respectively. Fluoranthene was found at the highest levels ranging between 17.7 and 9800 ng/g, benzo[a]pyrene between 9.64 and 4600 ng/g, and the highly potent carcinogen dibenzo[a,l]pyrene up to 740 ng/g. The most abundant oxy-PAH was 6H-benzo[cd]pyren-6-one (2.09-2300 ng/g). Primary sources of PAHs were identified by use of diagnostic ratios and Positive Matrix Factorization modelling and found to be pyrogenic including vehicle emissions and combustion of biomass. Estimating the incremental lifetime cancer risks (ILCRS) associated with exposure to PAHs in these soils indicated that the PAH levels in some parks constitute a considerable increased risk level for adults and children (total ILCR > 1 × 10). Compared to worldwide urban parks contamination, we conclude that the PAC soil levels in parks of Stockholm City in general are low, but that some parks are more heavily contaminated and should be considered for clean-up actions to limit human health risks.
2450 related Products with: Polycyclic aromatic compounds in urban soils of Stockholm City: Occurrence, sources and human health risk assessment.Goat Anti-Human NODAL, (i Mouse Anti-Human Insulin Recombinant Human Interfe Goat Anti-Human CHRNB3, ( Cytokine (Human) Antibody Goat Anti-Human EGR2, (in Inhibitory mouse monoclo Goat Anti-Human Frizzled Goat Anti-Human F2R PAR1, Goat Anti-Human IGFBP3, ( Goat Anti-Human MEFV, (in Goat Anti-Human MTHFS, (i
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