Search results for: carrier
#33091907 2020/10/22 To Up
Lacune and Large Perivascular Space: Two Kinds of Cavities Are of Different Risk Factors and Stroke Risk.To compare the risk factors and risk of stroke between lacune and large perivascular spaces (PVSs) in a community-based sample.
Jiangtao Zhang, Fei Han, Xinyu Liang, Mingli Li, Dingding Zhang, Feifei Zhai, Lixin Zhou, Jun Ni, Ming Yao, Shuyang Zhang, Liying Cui, Zhengyu Jin, Yi-Cheng Zhu
2296 related Products with: Lacune and Large Perivascular Space: Two Kinds of Cavities Are of Different Risk Factors and Stroke Risk.100.00 ul200 200ug1000 TESTS/0.65ml10 mg100ug200ul25 mg1000 tests10 mg100ul
#33091529 2020/10/19 To Up
Development of A2G80 peptide-gene complex for targeted delivery to muscle cells.Therapeutic strategies based on antisense oligonucleotides and therapeutic genes are being extensively investigated for the treatment of hereditary muscle diseases and hold great promise. However, the cellular uptake of these polyanions to the muscle cells is inefficient. Therefore, it is necessary to develop more effective methods of gene delivery into the muscle tissue. The A2G80 peptide (VQLRNGFPYFSY) from the laminin α2 chain has high affinity for α-dystroglycan (α-DG) which is expressed on the membrane of muscle cells. In this study, we designed a peptide-modified A2G80 with oligoarginine and oligohistidine (A2G80-R9-H8), and prepared peptide/plasmid DNA (pDNA) complex, to develop an efficient gene delivery system for the muscle tissue. The peptide/pDNA complex showed α-DG-dependent cellular uptake of the A2G80 sequence and significantly improved gene transfection efficiency mediated by the oligohistidine sequence in C2C12 myoblast cells. Further, the peptide/pDNA complex promoted efficient and sustained gene expression in the Duchenne muscular dystrophy mouse models. The A2G80-R9-H8 peptide has the potential for use as a specific carrier for targeting muscle in gene therapy in muscular dystrophy.
Kei Nirasawa, Keisuke Hamada, Yukiko Naraki, Yamato Kikkawa, Eri Sasaki, Yoko Endo-Takahashi, Nobuhito Hamano, Fumihiko Katagiri, Motoyoshi Nomizu, Yoichi Negishi
1261 related Products with: Development of A2G80 peptide-gene complex for targeted delivery to muscle cells.50 ug50 ug50 ug50 ug50 ug50 ug50 ug50 300 units50 ug50 ug50 ug
#33091526 2020/10/19 To Up
Serum protein-based nanoparticles for cancer diagnosis and treatment.Serum protein as naturally essential biomacromolecules has recently emerged as a versatile carrier for diagnostic and therapeutic drug delivery for cancer nanomedicine with superior biocompatibility, improved pharmacokinetics and enhanced targeting capacity. A variety of serum proteins have been utilized for drug delivery, mainly including albumin, ferritin/apoferritin, transferrin, low-density lipoprotein, high-density lipoprotein and hemoglobin. As evidenced by the success of paclitaxel-bound albumin nanoparticles (Abraxane), serum protein-based nanoparticles have gained attractive attentions for precise biological design and potential clinical application. In this review, we summarize the general design strategies, targeting mechanisms and recent development of serum protein-based nanoparticles in the field of cancer nanomedicine. Moreover, we also concisely specify the current challenges to be addressed for a bright future of serum protein-based nanomedicines.
Haroon Iqbal, Tao Yang, Ting Li, Miya Zhang, Hengte Ke, Dawei Ding, Yibin Deng, Huabing Chen96TEachEach1x96 well plate20096T10 mgEach0.025 mgEach100ul96T
#33091477 2020/10/19 To Up
Preparation, characterization and in vitro antitumor activity evaluation of hyaluronic acid-alendronate-methotrexate nanoparticles.As an anti-metabolic drug, methotrexate (MTX) plays an important role in the treatment of various malignant tumors. However, several side effects such as low selectivity and high toxic of MTX limited its further applications. With aims to increase its accumulation in the tumor sites and reduce the toxicity of normal tissue nonspecific uptake, a self-assembled hyaluronic acid-alendronate-methotrexate nanoparticle (HA-ALN-MTX NPs) with a dual-tumor-targeted drug loaded system was designed and synthesized with an average particle size of 265.6 ± 13.3 nm. The advantage of this nanosystem is that the anticancer drug MTX can be used as a tumor-targeted ligand for folate acid receptors (FA), and hyaluronic acid (HA) can be used as another tumor targeted ligand for CD44 receptors. In vitro experiments confirmed that HA-ALN-MTX NPs has lower toxic effect on normal tissue cells HUVECs and has relatively high proliferation inhibition effect on tumor cells A549. Moreover, the inhibition effect could be adjusted by altering the dose of given drugs. All these results revealed that the prepared HA-ALN-MTX NPs could be selectively taken up by tumor cells by FA and CD44 receptor-mediated endocytosis. Therefore, self-assembled HA-ALN-MTX NPs targeted by these FA/CD44 receptors for anticancer drugs could act as effective antitumor drugs.
Chunxia Gao, Mengmeng Wang, Peizhi Zhu, Caifeng Yan
1185 related Products with: Preparation, characterization and in vitro antitumor activity evaluation of hyaluronic acid-alendronate-methotrexate nanoparticles.5 G1mg96tests 1 G48 assays 100ug Lyophilized96T0.1ml (1mg/ml)96 assays 100ug Lyophilized
#33091302 2020/10/22 To Up
Formation of Large Crystalline Domains in a Semiconducting Polymer with Semi-fluorinated Alkyl Side Chains and Application to High-Performance Thin-Film Transistors.The semi-fluorinated alkyl (SFA) side chain introduced thienylenevinylene (TV)-based p-type polymer, PC12TVC5F7T, was synthesized for use in organic thin-film transistors (OTFTs). Herein, we investigated the influence of SFA side chains on the morphology, molecular orientation, and crystalline structure using a combination of atomic force microscopy (AFM), scanning electron microscopy (SEM), two-dimensional (2D) grazing-incidence wide-angle X-ray scattering (GIWAXS), and density functional theory (DFT) calculations. Interestingly, the incorporation of SFA side chains led to the evolution of plate-like large-sized domains and also strongly intermolecular stacked high crystalline structures. Furthermore, due to the strong interactions between SFA side chains, several (00h) peaks could be observed for PC12TVC5F7T, in spite of their fairly large dihedral angle. As a result, due to the well-developed microstructure of PC12TVC5F7T, the OTFT devices based on it exhibited a high hole mobility of 1.91 cm V s, which is an outstanding value among the poly(thiophene) derivative polymers. These observations indicate that large-sized domains and strongly intermolecular stacked high crystalline structures, which are beneficial for charge carrier transport, could be attained by the introduction of SFA side chains, further enhancing the performance of the OTFTs.
Youn-Jung Heo, Hyung-Gu Jeong, Jihong Kim, Bogyu Lim, Juhwan Kim, Yunseul Kim, Boseok Kang, Jin-Mun Yun, Kilwon Cho, Dong-Yu Kim
1024 related Products with: Formation of Large Crystalline Domains in a Semiconducting Polymer with Semi-fluorinated Alkyl Side Chains and Application to High-Performance Thin-Film Transistors.100ug Lyophilized400Tests50 ul50ul50ul 100ul0.1ml 100ul 100ul 100ul
#33091215 2020/10/22 To Up
Can domestic pigeon be a potential carrier of zoonotic Salmonella?S
Edyta Kaczorek-Łukowska, Patrycja Sowińska, Antoni Franaszek, Daria Dziewulska, Joanna Małaczewska, Tomasz Stenzel100.00 ug100 µg100 100ul1 mg
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#33090173 // To Up
Synthesis of luminescent core/shell α-ZnP/ZnS quantum dots.Metal chalcogenide nanoparticles offer vast control over their optoelectronic properties via size, shape, composition, and morphology which has led to their use across fields including optoelectronics, energy storage, and catalysis. While cadmium and lead-based nanocrystals are prevalent in applications, concerns over their toxicity have motivated researchers to explore alternate classes of nanomaterials based on environmentally benign metals such as zinc and tin. The goal of this research is to identify material systems that offer comparable performance to existing metal chalcogenide systems from abundant, recyclable, and environmentally benign materials. With band gaps that span the visible through the infrared, II-V direct band gap semiconductors such as tetragonal zinc phosphide (α-Zn3P2) are promising candidates for optoelectronics. To date, syntheses of α-Zn3P2 nanoparticles have been hindered because of the toxicity of zinc and phosphorus precursors, surface oxidation, and defect states leading to carrier trapping and low photoluminescence quantum yield. This work reports a colloidal synthesis of quantum confined α-Zn3P2 nanoparticles from common phosphorus precursor tris(trimethylsilyl)phosphine and environmentally benign zinc carboxylates. Shelling of the nanoparticles with zinc sulfide is shown as a method of preventing oxidation and improving the optical properties of the nanoparticles. These results show a route to stabilizing α-Zn3P2 nanoparticles for optoelectronic device applications.
Ingrid J Paredes, Clara Beck, Scott Lee, Shuzhen Chen, Mersal Khwaja, Michael R Scimeca, Shuang Li, Sooyeon Hwang, Zhen Lian, Kevin M McPeak, Su-Fei Shi, Ayaskanta Sahu 0.1 mg 1 mg100ug Lyophilized100 µg100ulEA 100ul1 mg100 25 ml Ready-to-use 100 100ug Lyophilized
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