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#32781360   2020/08/04 To Up

Intrauterine administration of autologous hCG- activated peripheral blood mononuclear cells improves pregnancy outcomes in patients with recurrent implantation failure; A double-blind, randomized control trial study.

We aimed to investigate the effect of intrauterine administration of autologous hCG-activated PBMCs in RIF women with low Th-17/Treg cell ratio. 248 women with a history of implantation failure volunteered to receive PBMC-therapy. After immunologic consultation and doing flow cytometry analysis, 100 women with at least three IVF/ET failure who had low Th-17/Treg ratio in comparison with healthy control were enrolled in this study. These 100 patients were randomly divided into two groups as PBMC receiving (n = 50) and controls (n = 50). Then PBMCs were obtained from patients and treated with hCG for 48 h. Afterward, PBMCs were administered into the uterine cavity of the patient in the study group, two days before ET. The concentration of inflammatory cytokines was examined in the supernatant of cultured PBMCs after 2, 24, and 48 h of incubation using the ELISA method. The frequency of Th-17, Treg, and the Th-17/Treg ratio was significantly lower in RIF women than the healthy controls (P < 0.0001). The secretion of inflammatory cytokines was significantly higher after 48 h compared to 2 and 24 h (P < 0.0001). The pregnancy and live birth rate were significantly increased in women undergoing the PBMC-therapy compared to control (PBS-injecting) group (P = 0.032 and P = 0.047, respectively). The miscarriage rate was considerably lower in PBMC-therapy group (P = 0.029). Our findings suggest that intrauterine administration of autologous in vitro hCG-activated PBMCs improves pregnancy outcomes in patients with at least three IVF/ET failures.
Zahra Pourmoghadam, Mohammad Sadegh Soltani-Zangbar, Golshan Sheikhansari, Ramyar Azizi, Shadi Eghbal-Fard, Hamed Mohammadi, Homayoon Siahmansouri, Leili Aghebati-Maleki, Shahla Danaii, Amir Mehdizadeh, Mohammad Hojjat-Farsangi, Roza Motavalli, Mehdi Yousefi

2447 related Products with: Intrauterine administration of autologous hCG- activated peripheral blood mononuclear cells improves pregnancy outcomes in patients with recurrent implantation failure; A double-blind, randomized control trial study.

96 tests2 Pieces/Box

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#32781284   2020/08/08 To Up

Hydrogen sulfide: an endogenous regulator of the immune system.

Hydrogen sulfide (HS) is now recognized as an endogenous signaling gasotransmitter in mammals. It is produced by mammalian cells and tissues by various enzymes - predominantly cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST) - but part of the HS is produced by the intestinal microbiota (colonic HS-producing bacteria). Here we summarize the available information on the production and functional role of HS in the various cell types typically associated with innate immunity (neutrophils, macrophages, dendritic cells, natural killer cells, mast cells, basophils, eosinophils) and adaptive immunity (T and B lymphocytes) under normal conditions and as it relates to the development of various inflammatory and immune diseases. Special attention is paid to the physiological and the pathophysiological aspects of the oral cavity and the colon, where the immune cells and the parenchymal cells are exposed to a special "HS environment" due to bacterial HS production. HS has many cellular and molecular targets. Immune cells are "surrounded" by a "cloud" of HS, as a result of endogenous HS production and exogenous production from the surrounding parenchymal cells, which, in turn, importantly regulates their viability and function. Downregulation of endogenous HS producing enzymes in various diseases, or genetic defects in HS biosynthetic enzyme systems either lead to the development of spontaneous autoimmune disease or accelerate the onset and worsen the severity of various immune-mediated diseases (e.g. autoimmune rheumatoid arthritis or asthma). Low, regulated amounts of HS, when therapeutically delivered by small molecule donors, improve the function of various immune cells, and protect them against dysfunction induced by various noxious stimuli (e.g. reactive oxygen species or oxidized LDL). These effects of HS contribute to the maintenance of immune functions, can stimulate antimicrobial defenses and can exert anti-inflammatory therapeutic effects in various diseases.
Nahzli Dilek, Andreas Papapetropoulos, Tracy Toliver-Kinsky, Csaba Szabo

2555 related Products with: Hydrogen sulfide: an endogenous regulator of the immune system.

1 mg0.1 mg 70 Slides 500 Slides 0.1 mg100ug Lyophilized 1 kit(s) 1 ml 70 Slides 10 mg 500 Slides

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#32781102   2020/08/08 To Up

Two new species of Myxobolus (Cnidaria: Myxosporea) infecting freshwater fishes of Ranjit Sagar Wetland, Punjab, India.

Two novel myxosporeans have been identified during the present study namely, Myxobolus upmae sp. nov. infecting gills of Hypophthalmichthys nobilis and Myxobolus hardevi sp. nov. infecting gills of Labeo bata inhabiting Ranjit Sagar Wetland, Punjab (India). The identification was done on the basis of morphological and molecular attributes of the myxospores. Myxospores of both the species possessed distinct morphological and morphometric characteristics, hence, validated as new species. Prevalence of infection was found to be 31.25% and 24% in M. upmae and M. hardevi, respectively. The intensity of infection or the mean abundance was determined by the gill plasmodial index (GPI) and was found to be 3 in M. upmae (heavy infection) and 1 in M. hardevi (light infection). Histopathological analysis of both the myxosporeans showed necrosis, hypertrophy, lamellar fusion and the cavity of each plasmodium was filled with numerous fully mature myxospores. The phylogenetic analysis of M. upmae sp. nov. showed maximum homogeneity with M. catlae (KM029967) infecting gills of Catla catla from India followed by M. dujardini (DQ439804) infecting gills of Leuciscus cephalus from Hungary and M. alvarezae (FJ716096) infecting gills of Aspius aspius from Hungary. The phylogenetic tree obtained by Maximum-Likelihood showed the paraphyletic nature of M. upmae sp. nov. with other myxosporean species.
Aditya Gupta, Harpreet Kaur

2115 related Products with: Two new species of Myxobolus (Cnidaria: Myxosporea) infecting freshwater fishes of Ranjit Sagar Wetland, Punjab, India.

5 G 100ul 100ul 100ul50 ug 96T50 ug 50 ug 50 ug 50ul 100ul 100ul

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#32781015   2020/08/08 To Up

Exosomes in head and neck cancer: Roles, mechanisms and applications.

Exosomes are extracellular vesicles with a diameter of 30-100 nm that exist stably in various body fluids, including the blood, cerebrospinal fluid, urine, saliva, and serous cavity effusion. Compared with other vesicles, exosomes have a unique double-layer saclike structure and an endosomal origin. Depending on the physiological state of donor cells, there is heterogeneity in the bioactive substances present in exosomes, including proteins, RNA, DNA, lipids, and metabolites, providing a rich source of potential biomarkers for disease diagnosis. In head and neck cancer (HNC), exosomes have applications in disease diagnosis and prognosis based on liquid biopsy. Nonetheless, the functions and mechanisms of exosomes in HNC still remain unclear. Recent studies have elucidated the substances and signals transmitted between cancer cells using exosomes and have discussed tumor occurrence, development, metastasis, immune regulation, and drug resistance regulated by exosomes in HNC. In this review, we discuss these recent findings and highlight the significant role of exosomes in HNC, with a focus on the mechanism of tumor progression and the potential clinical value of exosomes as biomarkers and therapeutic targets.
Jun Cao, Mengdi Zhang, Feng Xie, Jianlin Lou, Xiaoxue Zhou, Long Zhang, Meiyu Fang, Fangfang Zhou

2992 related Products with: Exosomes in head and neck cancer: Roles, mechanisms and applications.

5mgEach

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#32780914   2020/08/11 To Up

Stimuli-Responsive Resorcin[4]arene Cavitands: Toward Visible-Light-Activated Molecular Grippers.

Resorcin[4]arene cavitands, equipped with diverse quinone (Q) and [Ru(bpy) dppz] (bpy=2,2'-bipyridine, dppz=dipyrido[3,2-a:2',3'-c]phenazine) photosensitizing walls in different configurations, were synthesized. Upon visible-light irradiation at 420 nm, electron transfer from the [Ru(bpy) dppz] to the Q generates the semiquinone (SQ) radical anion, triggering a large conformational switching from a flat kite to a vase with a cavity for the encapsulation of small guests, such as cyclohexane and heteroalicyclic derivatives, in CD CN. Depending on the molecular design, the SQ radical anion can live for several minutes (≈10 min) and the vase can be generated in a secondary process without need for addition of a sacrificial electron donor to accumulate the SQ state. Switching can also be triggered by other stimuli, such as changes in solvent, host-guest complexation, and chemical and electrochemical processes. This comprehensive investigation benefits the development of stimuli-responsive nanodevices, such as light-activated molecular grippers.
Víctor García-López, Michal Zalibera, Nils Trapp, Martin Kuss-Petermann, Oliver S Wenger, François Diederich

1057 related Products with: Stimuli-Responsive Resorcin[4]arene Cavitands: Toward Visible-Light-Activated Molecular Grippers.

1.5 mg5 ml100ug/vial 6 ml Ready-to-use 0.5 mg50 ml 1000 ml 0.1mg10 mg1 g100 ug

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#32780724   2020/08/11 To Up

Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis.

Tumor-associated macrophages (TAMs) affect cancer progression and therapy. Ovarian carcinoma often metastasizes to the peritoneal cavity. Here, we found two peritoneal macrophage subsets in mice bearing ID8 ovarian cancer based on the Tim-4 (T-cell immunoglobulin and mucin domain containing 4) expression. Tim-4+ TAMs were embryonically originated and locally sustained while Tim-4- TAMs were replenished from circulating monocytes. Tim-4+ TAMs, but not Tim-4- TAMs, promoted tumor growth in vivo. Relative to Tim-4- TAMs, Tim-4+ TAMs manifested high oxidative phosphorylation and adapted mitophagy to alleviate oxidative stress. High levels of arginase-1 in Tim-4+ TAMs contributed to potent mitophagy activities via weakened mTORC1 activation due to low arginine resultant from arginase-1-mediated metabolism. Furthermore, genetic deficiency of autophagy element FIP200 resulted in Tim-4+ TAM loss via ROS-mediated apoptosis, and elevated T cell-immunity and ID8 tumor inhibition in vivo. Moreover, human ovarian cancer-associated CRIg (complement receptor of the Immunoglobulin superfamily) positive macrophages were transcriptionally, metabolically, and functionally similar to murine Tim-4+ TAMs. Thus, targeting CRIg+ (Tim-4+) TAMs may potentially treat ovarian cancer patients with peritoneal metastasis.
Houjun Xia, Shasha Li, Xiong Li, Weichao Wang, Yingjie Bian, Shuang Wei, Sara Grove, Weimin Wang, Linda Vatan, J Rebecca Liu, Karen McLean, Ramandeep Rattan, Adnan R Munkarah, Jun-Lin Guan, Ilona Kryczek, Weiping Zou

2703 related Products with: Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis.

6 ml Ready-to-use Each

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#32780662   // To Up

Computed tomography and magnetic resonance imaging findings of nasal chondromesenchymal hamartoma in a young child: a case report.

Nasal chondromesenchymal hamartoma (NCMH) is a rare destructive benign neoplasm that predominantly develops in infants and young children. The lesion is usually located in the nasal cavity, often in the adjacent paranasal sinuses and orbital region and especially in the ethmoid sinus. Because the imaging characteristics of NCMH often mimic the features of malignant tumors, it is clinically important to study the radiographic appearance of this disease. Therefore, we herein present the computed tomography and magnetic resonance imaging findings of NCMH occurring in a 7-year-old girl. The mass was resected via an endoscopic surgical approach and definitively diagnosed as NCMH based on histologic and immunohistochemical analysis. However, signs of tumor recurrence manifested 45 months after surgery. NCMH can be locally aggressive with an expansive and destructive radiographic appearance, which highly implies a malignant neoplasm. Hence, an accurate diagnosis is essential to avoid potentially harmful therapies, and detailed computed tomography or magnetic resonance imaging should be performed prior to surgery. Selective arterial embolization is also an important part of preoperative management because the degree of enhancement may not be adequate to determine the blood supply of the tumor. Moreover, complete radical excision cannot guarantee that the lesion will not recur.
Ya-Qiong Cui, Li-Li Wang, Gang Huang, Lian-Ping Zhao

1391 related Products with: Computed tomography and magnetic resonance imaging findings of nasal chondromesenchymal hamartoma in a young child: a case report.



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#32780500   2020/08/11 To Up

Re-defining the virtual reality dental simulator: Demonstrating concurrent validity of clinically relevant assessment and feedback.

Virtual reality (VR) dental simulators are gaining momentum as a useful tool to educate dental students. To date, no VR dental simulator exercise has been designed which is capable of reliably providing validated, meaningful clinical feedback to dental students. This study aims to measure the concurrent validity of the assessment, and the provision of qualitative feedback, pertaining to cavity preparations by VR dental simulators.
Jonathan Dixon, Ashley Towers, Nicolas Martin, James Field

1222 related Products with: Re-defining the virtual reality dental simulator: Demonstrating concurrent validity of clinically relevant assessment and feedback.

25 mg200 units2.5 mg1000 tests100 100 G100ug1100.00 ul 5 G500IU50 ug

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#32780273   2020/08/11 To Up

Pharmacokinetic Basis of the Hydroxychloroquine Response in COVID-19: Implications for Therapy and Prevention.

Chloroquine/hydroxychloroquine has recently been the subject of intense debate regarding its potential antiviral activity against SARS-Cov-2, the etiologic agent of COVID-19. Some report possible curative effects; others do not. Therefore, the objective of this study was to simulate possible scenarios of response to hydroxychloroquine in COVID-19 patients using mathematical modeling.
Mohammad Tarek, Andrea Savarino

2950 related Products with: Pharmacokinetic Basis of the Hydroxychloroquine Response in COVID-19: Implications for Therapy and Prevention.

96T 100 UG 1 G 5 G

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