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#39297298 
2024/09/19
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"Straw in the Clay Soil" Strategy: Anticarbon Corrosive Fluorine-Decorated Graphene Nanoribbons@CNT Composite for Long-Term PEMFC.
Carbon corrosion poses a significant challenge in polymer exchange membrane fuel cells (PEMFCs), leading to reduced cell performance due to catalyst layer degradation and catalyst detachment from electrodes. A promising approach to address this issue involves incorporating an anticorrosive carbon material into the oxygen reduction reaction (ORR) electrode, even in small quantities (≈3 wt% in electrode). Herein, the successful synthesis of fluorine-doped graphene nanoribbons (F-GNR) incorporated with graphitic carbon nanotubes (F-GNR@CNT), demonstrating robust resistance to carbon corrosion is reported. By controlling the synthesis conditions using an exfoliation method, the properties of the composite are tailored. Electronic structural studies, employing density functional theory (DFT) calculations, to elucidate the roles of fluorine dopants and graphitic carbon nanotubes (CNTs) in mitigating carbon corrosion are conducted. Physicochemical and electrochemical characterization of F-GNR@CNT reveal its effectiveness as a cathode additive at the single-cell scale. The addition of F-GNR@CNT to the Pt/C cathode improves durability by enhancing carbon corrosion resistance and water management, thus mitigating the flooding effect through tailored surface properties. Furthermore, advanced impedance analysis using a transmission line model is performed to gain insights into the internal resistance and capacitive properties of electrode structure.Song Jin, JunHwa Kwon, Jong Min Lee, Ye-Rim Kim, Justin Georg Albers, Young-Woo Choi, Sung Mook Choi, KwangSup Eom, Min Ho Seo
2286 related Products with: "Straw in the Clay Soil" Strategy: Anticarbon Corrosive Fluorine-Decorated Graphene Nanoribbons@CNT Composite for Long-Term PEMFC.
100 μg100 μg100ug100 μg 0.1 mg 100 100μg100 ug25 μg
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#39297294 2024/09/19
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Developing non-radioactive, radical methods to screen for radiolytic stability.
Radiolytically generated radicals cause degradation of nutrients in food, materials in satellites and solar cells, and human health. Radiation effects are studied using gamma radiolysis, a low-throughput, high-cost, and low-accessibility method. We developed a higher-throughput, low-cost, non-radioactive, radical assay that produces radicals similar to those generated in gamma radiolysis and examined monoamide degradation. Our radical assay results correspond to those from gamma irradiation in both monoamide stability and decomposition products, establishing this radical assay as a proof-of-concept screening tool for radiolytic stability.Brandon G Wackerle, Madison R Vicente, Fatema Tuz Zohara, Dean R Peterman, Modi Wetzler, Julia L Brumaghim
2308 related Products with: Developing non-radioactive, radical methods to screen for radiolytic stability.
96 Tests n100 ug5 g1 kit(96 Wells)100 Plates100 50 50 ml100 assays1 module50 mL
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#39297287 2024/09/19
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Chronic sleep deprivation induces erectile dysfunction through increased oxidative stress, apoptosis, endothelial dysfunction, and corporal fibrosis in a rat model.
Sleep is foundational for nocturnal erections, facilitating nutrient exchange and waste removal, which has brought widespread attention to the relationship between sleep and erectile dysfunction (ED). However, there is currently a lack of basic research confirming whether chronic sleep deprivation (CSD) leads to erectile impairment and its underlying pathological mechanisms.Yuyang Zhang, Mingqin Su, Guodong Liu, Xu Wu, Xingliang Feng, Dongdong Tang, Hui Jiang, Xiansheng Zhang
2734 related Products with: Chronic sleep deprivation induces erectile dysfunction through increased oxidative stress, apoptosis, endothelial dysfunction, and corporal fibrosis in a rat model.
100 UG1.00 flask100 μg2 Pieces/Box100 ug96 tests2 Pieces/Box100 50 UG100 ug100ul
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#39297283 2024/09/19
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Trifold origin of the reptilian ear ossicle and its relation to the evolutionary modification of the temporal skull region.
Whereas mammals are characterized by the presence of three middle ear ossicles, reptiles have only one, the columella (stapes). Nevertheless, there is a great diversity of columellar anatomy among sauropsids, especially in the unique and cartilaginous "extracolumella"-portion. Molecular studies revealed the "columella" of chicken and quails to be formed within the second pharyngeal arch, although conflicting evidence exists for the columellar footplate and distal parts of the columella in these birds. We studied columellar development in four turtles, one lizard, and one caiman species and argue, using early blastematous stages, that, distally, the so-called "extracolumella" in turtles is mainly of quadrate, that is, first pharyngeal arch origin. Differently, the dorsal aspect of the "extracolumella" of the lizard and a part of the "dorsal columella process" of the caiman are likely quadrate-derived. This indicates only a partial homology of the distal columellar compartments among reptiles. Moreover, we observed in most species that, at early stages, the footplate differentiates from the otic capsule, which confirms widespread experimental findings of mesodermal cells contributing to the proximal part of the columella. We provide a hypothetical framework for the changes in the columella and quadrate morphology in reptilian evolution. Originally, as evidenced by the fossil record, the columella served as a stabilizing brace between the quadrate and braincase. Associated with changes in the feeding mode of late Permian taxa, the quadrate was integrated along the stress flows from biting, and in early development part of the quadrate differentiated to differently contribute to the distal part of the "columella-complex," which now contacts the tympanic membrane. In addition, part of the original otic capsule contributes to the footplate of the mobile columella, providing a connection with the inner ear.Ingmar Werneburg, Mario Bronzati
2268 related Products with: Trifold origin of the reptilian ear ossicle and its relation to the evolutionary modification of the temporal skull region.
500 Units11mg1100.00 ul2000 IU500 Units
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#39297227 2024/09/19
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Emerging severe acute respiratory syndrome coronavirus 2 variants and their impact on immune evasion and vaccine-induced immunity.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants harboring mutations in the structural protein, especially in the receptor binding domain (RBD) of spike protein, have raised concern about potential immune escape. The spike protein of SARS-CoV-2 plays a vital role in infection and is an important target for neutralizing antibodies. The mutations that occur in the structural proteins, especially in the spike protein, lead to changes in the virus attributes of transmissibility, an increase in disease severity, a notable reduction in neutralizing antibodies generated and thus a decreased response to vaccines and therapy. The observed multiple mutations in the RBD of the spike protein showed immune escape because it increases the affinity of spike protein binding with the ACE-2 receptor of host cells and increases resistance to neutralizing antibodies. Cytotoxic T-cell responses are crucial in controlling SARS-CoV-2 infections from the infected tissues and clearing them from circulation. Cytotoxic T cells efficiently recognized the infected cells and killed them by releasing soluble mediator's perforin and granzymes. However, the overwhelming response of T cells and, subsequently, the overproduction of inflammatory mediators during severe infections with SARS-CoV-2 may lead to poor outcomes. This review article summarizes the impact of mutations in the spike protein of SARS-CoV-2, especially mutations of RBD, on immunogenicity, immune escape and vaccine-induced immunity, which could contribute to future studies focusing on vaccine design and immunotherapy.Ramendra Pati Pandey, Sachin Kumar, D N Rao, Dablu Lal Gupta
1383 related Products with: Emerging severe acute respiratory syndrome coronavirus 2 variants and their impact on immune evasion and vaccine-induced immunity.
200ul10 mg200ul200ug200ug10 mg1000 100ug1000 tests500 mg100ug25 mg
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#39297207 2024/09/19
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Treatment of oral cancer cells using natural drug fisetin: an effective phytotherapy.
Vinothini Gunasekaran, Sathishkumar Palanivel
1533 related Products with: Treatment of oral cancer cells using natural drug fisetin: an effective phytotherapy.
1 mg25 96T0.1 mg200 100ul 6 ml Ready-to-use 100 µg
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#39297205 2024/09/19
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Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease.
Arteriovenous fistulae (AVFs) are the preferred vascular access for hemodialysis in patients with end-stage kidney disease. Chronic kidney disease (CKD) is associated with endothelial injury, impaired AVF maturation, and reduced patency, as well as utilization. Because CKD is characterized by multiple pathophysiological processes that induce endothelial-to-mesenchymal transition (EndMT), we hypothesized that CKD promotes EndMT during venous remodeling and that disruption of endothelial TGF (transforming growth factor)-β signaling inhibits EndMT to prevent AVF failure even in the end-stage kidney disease environment.Weichang Zhang, Luis Gonzalez, Xin Li, Hualong Bai, Zhuo Li, Ryosuke Taniguchi, John Langford, Yuichi Ohashi, Carly Thaxton, Aoyagi Yukihiko, Bogdan Yatsula, Kathleen Martin, Julie Goodwin, George Tellides, Xiaochun Long, Chang Shu, Alan Dardik