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#33249794   // To Up

Highlights in Autoimmunity: 2020.

Innate and adaptive immune response dysregulations are equally involved in the induction of autoimmunity. Toll-like receptors play a leading role in the activation of innate immune cells, thus priming auto-reactive T cells. Th17 cells and related cytokines are widely involved in many immune-mediated diseases such as rheumatoid arthritis. Thus, the recent introduction of anti-IL-17 therapies should be further evaluated. Janus kinase inhibitors and Fc receptor-targeting drugs are some of the new therapeutic strategies that are being implemented when old classical therapies lack sufficient beneficial outcomes.
Elias Toubi, Zehava Vadasz

1472 related Products with: Highlights in Autoimmunity: 2020.

1 Set100 1 Set50 1 Set100ug Lyophilized1 Set20 1 mg1 kit(96 Wells)100 μg

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#33249789   // To Up

Re-Appraisal of Echocardiographic Assessment in Patients with Pulmonary Embolism: Prospective Blinded Long-Term Follow-Up.

Acute pulmonary embolism (PE) is considered to be one of the most common cardiovascular diseases with considerable mortality. Conflicting data imply possible role for echocardiography in assessing this disease.
Hezzy Shmueli, Arie Steinvil, Galit Aviram, Sileman Moaad, Adam Sharon, Achiude Bendet, Simon Biner, Yacov Shacham, Jack Sherez, Ricki Megidish, Yifat Hasin, Ester Elazar, Sevan Letourneau-Shesaf, Gad Keren, Shlomo Berliner, Yan Topilsky

2979 related Products with: Re-Appraisal of Echocardiographic Assessment in Patients with Pulmonary Embolism: Prospective Blinded Long-Term Follow-Up.

100 μg100 μg 0.1 mg 100 μg100 μg100 μg100 μg100 μg100 μg50 100 μg

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#33249785   // To Up

The Impact of the COVID-19 Pandemic on General Surgery Acute Admissions and Urgent Operations: A Comparative Prospective Study.

As part of the effort to control the coronavirus disease-19 (COVID-19) outbreak, strict emergency measures, including prolonged national curfews, have been imposed. Even in countries where healthcare systems still functioned, patients avoided visiting emergency departments (EDs) because of fears of exposure to COVID-19.
Eyal Aviran, Shachar Laks, Haggai Benvenisti, Saed Khalilieh, Dan Assaf, Nimrod Aviran, David Hazzan, Yoram Klein, Amir Cohen, Mordechai Gutman, Aviram Nissan, Lior Segev

2037 related Products with: The Impact of the COVID-19 Pandemic on General Surgery Acute Admissions and Urgent Operations: A Comparative Prospective Study.

100ul100.00 ul100 100.00 ul1 ml

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#33249783   2020/11/29 To Up

Plasma phosphorylated tau181 and neurodegeneration in Alzheimer's disease.

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Oskar Hansson, Nicholas Cullen, Henrik Zetterberg, , Kaj Blennow, Niklas Mattsson-Carlgren

1665 related Products with: Plasma phosphorylated tau181 and neurodegeneration in Alzheimer's disease.

96 tests96 tests96 tests96 tests96T1ml

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#33249780   2020/11/29 To Up

Triacetyluridine treats epileptic encephalopathy from CAD mutations: a case report and review.

Refractory epilepsy and encephalopathy are frequently encountered in patients with inborn errors of metabolism. We report a case of an 8-year-old girl with history of developmental delay, autism and intractable epilepsy that was found to have a pathogenic variant in CAD. We briefly review the biochemical pathway of CAD and the preclinical and clinical studies that suggest uridine supplementation can rescue the CAD deficiency phenotypes. Our case demonstrates a relatively late-onset case of refractory epilepsy with a rapid response to treatment using the uridine pro-drug triacetyluridine (TAU), the FDA-approved treatment for hereditary orotic aciduria.
Aliya Frederick, Kimberly Sherer, Linda Nguyen, Shawn Ali, Anupam Garg, Richard Haas, Michelle Sahagian, Jonathan Bui

2494 related Products with: Triacetyluridine treats epileptic encephalopathy from CAD mutations: a case report and review.

96T100.00 ug

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#33249778   2020/11/29 To Up

Reduced Leukocyte Telomere Lengths and Sirtuin 1 gene expression in long-term survivors of Type 1 Diabetes - A Dialong sub-study.

The shortening of leukocyte telomere length with age has been associated with coronary disease, whereas the association with type 1 diabetes is unclear. We aimed to explore telomere lengths in diabetes subjects with regard to coronary artery disease, compared to healthy controls. The longevity factors sirtuin 1 and growth-differentiating factor 11 were investigated accordingly.
Trine Baur Opstad, Tore Julsrud Berg, Kristine Bech Holte, Harald Arnesen, Svein Solheim, Ingebjørg Seljeflot

2503 related Products with: Reduced Leukocyte Telomere Lengths and Sirtuin 1 gene expression in long-term survivors of Type 1 Diabetes - A Dialong sub-study.

100μg100μg100ug100ug100ug Lyophilized100ug Lyophilized100.00 ug100ug 100ul100ug100ug100ug

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#33249770   2020/11/29 To Up

Histologic effects of MicroPulse™ transscleral cyclophotocoagulation in normal equine eyes.

Determine the immediate post-operative effects of MicroPulse transscleral cyclophotocoagulation (MP-TSCPC) in healthy equine eyes.
Braidee C Foote, Jodi D Smith, Rachel A Allbaugh, Lionel Sebbag

1156 related Products with: Histologic effects of MicroPulse™ transscleral cyclophotocoagulation in normal equine eyes.



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#33249766   2020/11/29 To Up

First expert elicitation of knowledge on drivers of emergence of influenza D in Europe.

The influenza D virus (IDV) was first identified and characterized in 2011. Considering the virus' zoonotic potential, its genome nature (segmented RNA virus), its worldwide circulation in livestock, and its role in bovine respiratory disease, an increased interest is given to IDV. However, few data are available on drivers of emergence of IDV. We first listed fifty possible drivers of emergence of IDV in ruminants and swine. As recently carried out for COVID19 in pets (Saegerman e,t al, 2020b), a scoring system was developed per driver and scientific experts (N = 28) were elicited to: (i) allocate a score to each driver, (ii) weight the drivers scores within each domain and (iii) weight the different domains among themselves. An overall weighted score was calculated per driver; and drivers were ranked in decreasing order. Drivers with comparable likelihoods to play a role in the emergence of IDV in ruminants and swine in Europe were grouped using a regression tree analysis. Finally, the robustness of the expert elicitation was verified. Eight drivers were ranked with the highest probability to play a key role in the emergence of IDV: current species specificity of the causing agent of the disease; influence of (il)legal movements of live animals (ruminants, swine) from neighbouring/European Union member states and from Third countries for the disease to (re-)emerge in a given country; detection of emergence; current knowledge of the pathogen; vaccine availability; animal density; and transport vehicles of live animals. As there is still limited scientific knowledge on the topic, expert elicitation of knowledge and multi-criteria decision analysis, in addition to clustering and sensitivity analyses, are very important to prioritize future studies, starting from the top eight drivers. The present methodology could be applied to other emerging animal diseases.
Claude Saegerman, Juana Bianchini, Chantal J Snoeck, Ana Moreno, Chiara Chiapponi, Siamak Zohari, Mariette F Ducatez

2139 related Products with: First expert elicitation of knowledge on drivers of emergence of influenza D in Europe.

5 G0.1mg500 tests1 ml20 ul250 mg1mg100 μg100 μg

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#33249761   2020/11/29 To Up

Trifluridine/tipiracil plus bevacizumab as a first-line treatment for elderly patients with metastatic colorectal cancer (KSCC1602): A multicenter phase II trial.

A previous Phase I/II study demonstrated that TAS-102 (trifluridine/tipiracil [FTD/TPI]) plus bevacizumab (Bev) has encouraging efficacy and controllable safety for patients with previously treated metastatic colorectal cancer. Therefore, we designed for assessing the efficacy and safety of FTD/TPI plus Bev in elderly patients with previously untreated metastatic colorectal cancer.
Eiji Oki, Akitaka Makiyama, Yuji Miyamoto, Masahiko Kotaka, Hirofumi Kawanaka, Keisuke Miwa, Akira Kabashima, Tomohiro Noguchi, Kotaro Yuge, Tomomi Kashiwada, Koji Ando, Mototsugu Shimokawa, Hiroshi Saeki, Yoshito Akagi, Hideo Baba, Yoshihiko Maehara, Masaki Mori

2768 related Products with: Trifluridine/tipiracil plus bevacizumab as a first-line treatment for elderly patients with metastatic colorectal cancer (KSCC1602): A multicenter phase II trial.

100 plates1 ST100 tests1,000 tests

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#33249760   2020/11/28 To Up

Machine learning models predict coagulopathy in spontaneous intracerebral hemorrhage patients in ER.

Coagulation abnormality is one of the primary concerns for patients with spontaneous intracerebral hemorrhage admitted to ER. Conventional laboratory indicators require hours for coagulopathy diagnosis, which brings difficulties for appropriate intervention within the optimal window. This study evaluates the possibility of building efficient coagulopathy prediction models using data mining and machine learning algorithms.
Fengping Zhu, Zhiguang Pan, Ying Tang, Pengfei Fu, Sijie Cheng, Wenzhong Hou, Qi Zhang, Hong Huang, Yirui Sun

1824 related Products with: Machine learning models predict coagulopathy in spontaneous intracerebral hemorrhage patients in ER.

1 Set1 Set0.1ml1 Set96T100 μg1 Set1mg100 μg

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