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#32640488   2020/07/08 To Up

p67 -derived self-assembled peptides prevent Nox2 NADPH oxidase activation by an auto-inhibitory mechanism.

Activation of the Nox2-dependent NADPH oxidase is the result of a conformational change in Nox2 induced by interaction with the cytosolic component p67 . In preliminary work we identified a cluster of overlapping 15-mer synthetic peptides, corresponding to p67 residues 259-279, which inhibited oxidase activity in an in vitro, cell-free assay, but the results did not point to a competitive mechanism. We recently identified an auto-inhibitory intramolecular bond in p67 , one extremity of which was located within the 259-279 sequence, and we hypothesized that inhibition by exogenous peptides might mimic intrinsic auto-inhibition. In this study, we found that: (i) progressive N- and C-terminal truncation of inhibitory p67 peptides, corresponding to residues 259-273 and 265-279, revealed that inhibitory ability correlated with the presence of residues NIVFVL , exposed at either the N- or C-termini of the peptides; (ii) inhibition of oxidase activity was associated exclusively with self-assembled peptides, which pelleted upon centrifugation at 12,000 ×g; (iii) self-assembled p67 peptides inhibited oxidase activity by specific binding of p67 and the ensuing depletion of this component, essential for interaction with Nox2; and (iv) peptides subjected to scrambling or reversing the order of residues in NIVFVL retained the propensity for self-assembly, oxidase inhibitory ability, and specific binding of p67 , indicating that the dominant parameter was the hydrophobic character of five of the six residues. This appears to be the first description of inhibition of oxidase activity by self-assembled peptides derived from an oxidase component, acting by an auto-inhibitory mechanism.
Edna Bechor, Anat Zahavi, Yevgeny Berdichevsky, Edgar Pick

2192 related Products with: p67 -derived self-assembled peptides prevent Nox2 NADPH oxidase activation by an auto-inhibitory mechanism.

1mg100 μl250 TESTS 100ul100ug1100 μg100ug100 μg0.1 mg100.00 ug1mg

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#32640487   2020/07/08 To Up

BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy.

Bruton's tyrosine kinase (BTK) signaling is involved in innate immune responses and regulates the production of proinflammatory cytokines that can contribute to COVID-19 immunopathology. Clinical trials with BTK inhibitors in COVID-19 treatment have been proposed, and previous studies have attempted to investigate the therapeutic effects of ibrutinib and underlying mechanisms in treating viral pneumonia. These attempts, however, did not consider potential off target effect of BTK inhibitors on T cell differentiation, function, and survival, which may be beneficial in treatment for COVID-19. Here, we summarize the current knowledge of BTK/IL-2-inducible T-cell kinase (ITK) signaling in immunopathology and lymphopenia and discuss the potential of BTK/ITK dual inhibitors such as ibrutinib in modulating immunopathology and lymphopenia, for COVID-19 therapy.
Michael C McGee, Avery August, Weishan Huang

2621 related Products with: BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy.

1 G1 g100 mg25 mg100ug1000 TESTS/0.65ml500 ml 1 G2x96 well plate1 g200ul

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#32640485   2020/07/08 To Up

CoVID-19 insights from transfusion medicine.

The emergence of CoVID-19 infection in the first months of 2020 resulted in a massive surge in admissions to hospitals and intensive care units due to the nature of the respiratory pathophysiology. In some countries, health care systems were rapidly overwhelmed, while in others their hospitals coped with the first wave and all patients received the level of care needed, depending upon both the containment measured and the level of development of the heath care systems.
Willy A Flegel

2735 related Products with: CoVID-19 insights from transfusion medicine.

10 mg 1KG25 g1 g 5 G 25 G1 mg 5 G 5 G100 mg5 mg100 mg

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#32640484   2020/07/08 To Up

Blood Component Use in Critical Care in Patients with COVID-19 Infection: A Single Centre Experience.

There has been a significant surge in admissions to critical care during the COVID-19 pandemic. At present, the demands on blood components have not been described. We reviewed their use during the first 6 weeks of the outbreak from 3 March 2020 in a tertiary-level critical care department providing veno-venous extracorporeal membrane oxygenation (vv-ECMO). 265 patients were reviewed - 235 not requiring ECMO and 30 requiring vv-ECMO. In total, 50 patients required blood components during their critical care admission. Red cell concentrates were the most frequently transfused component in COVID-19 infected patients with higher rates of use during vv-ECMO. The use of fresh frozen plasma, cryoprecipitate and platelet transfusions was low in a period prior to the use of convalescent plasma.
Andrew J Doyle, Anicee Danaee, Charlene I Furtado, Scott Miller, Tim Maggs, Susan E Robinson, Andrew Retter

2785 related Products with: Blood Component Use in Critical Care in Patients with COVID-19 Infection: A Single Centre Experience.

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#32640479   2020/06/21 To Up

Venous thromboembolism in COVID-19: systematic review of reported risks and current guidelines.

Many centres have noticed a high number of venous thromboembolism (VTE) events among critically ill inpatients with COVID-19 pneumonia. The aims of this study were (1) to summarise the reported risk of VTE associated with COVID-19 infections and (2) to summarise guidance documents on thromboprophylaxis in COVID-19 patients, in a systematic review.
Pierre Fontana, Alessandro Casini, Helia Robert-Ebadi, Frederic Glauser, Marc Righini, Marc Blondon

2931 related Products with: Venous thromboembolism in COVID-19: systematic review of reported risks and current guidelines.

96 wells96 tests100 assays100 μg10 96T100 μg100ug100ug Lyophilized100 100ug Lyophilized

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#32640478   // To Up

Focus on Systems to Improve Morbidity and Mortality Conference Relevance.

Morbidity and mortality conference (MMC) is educationally important. However, resident physicians rate it less positively than faculty, citing focus on assigning blame rather than targeting change. Additionally, many MMC presentations are selected for clinical novelty instead of avoidable outcome. Despite significant time and resources routinely committed to MMC, its educational and clinical impact is generally limited. This warrants shifting focus toward quality improvement and systems-based care.
Christina W Chiang, Jenna B Greenberg, Caroline R Richardson

2583 related Products with: Focus on Systems to Improve Morbidity and Mortality Conference Relevance.

5 mg100ug25 mg1 module1000 tests200 1 module200ug100 1 mg1 kit(96 Wells)

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#32640477   // To Up

Moving Toward a Standardized National Family Medicine Subinternship Curriculum: Results From a CERA Clerkship Directors Survey.

Although the subinternship (sub-I) is considered integral in many medical schools' curricula, family medicine does not have standardized course recommendations. Given the variable nature of this clinical experience, this study investigated the potential role of a standardized sub-I curriculum in family medicine.
Tomoko Sairenji, Sarah E Stumbar, Nana Aisha Garba, Prasad Bhoite, Maria Syl de la Cruz, Chivon Stubbs, John Emerson, Dolapo Babalola, David Kelley, Kelly M Everard

2084 related Products with: Moving Toward a Standardized National Family Medicine Subinternship Curriculum: Results From a CERA Clerkship Directors Survey.

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#32640473   // To Up

Point-of-Care Ultrasound in Family Medicine Residencies 5-Year Update: A CERA Study.

In 2014, family medicine residency programs began to integrate point-of-care ultrasound (POCUS) into training, although very few had an established POCUS curriculum. This study aimed to evaluate the resources, barriers, and scope of POCUS training in family medicine residencies 5 years after its inception.
Jeffrey W W Hall, Harland Holman, Tyler W Barreto, Paul Bornemann, Andrew Vaughan, Kevin J Bennett, Jeffrey Chamberlain, Taft Micks, Douglas M Maurer, George R Bergus

1782 related Products with: Point-of-Care Ultrasound in Family Medicine Residencies 5-Year Update: A CERA Study.

20 100 2 Pieces/Box100 μg 100ul100ug Lyophilized100 μg100 assays100 μg100 μg100ug Lyophilized12 x 25 ul

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#32640463   2020/07/08 To Up

OpenSAFELY: factors associated with COVID-19 death in 17 million patients.

COVID-19 has rapidly affected mortality worldwide. There is unprecedented urgency to understand who is most at risk of severe outcomes, requiring new approaches for timely analysis of large datasets. Working on behalf of NHS England, here we created OpenSAFELY: a secure health analytics platform covering 40% of all patients in England, holding patient data within the existing data centre of a major primary care electronic health records vendor. Primary care records of 17,278,392 adults were pseudonymously linked to 10,926 COVID-19-related deaths. COVID-19-related death was associated with: being male (hazard ratio (HR) 1.59, 95% confidence interval (CI) 1.53-1.65); older age and deprivation (both with a strong gradient); diabetes; severe asthma; and various other medical conditions. Compared with people with white ethnicity, Black and South Asian people were at higher risk even after adjustment for other factors (HR 1.48, 1.30-1.69 and 1.44, 1.32-1.58, respectively). We have quantified a range of clinical risk factors for COVID-19-related death in the largest cohort study conducted by any country to date. OpenSAFELY is rapidly adding further patients' records; we will update and extend results regularly.
Elizabeth J Williamson, Alex J Walker, Krishnan Bhaskaran, Seb Bacon, Chris Bates, Caroline E Morton, Helen J Curtis, Amir Mehrkar, David Evans, Peter Inglesby, Jonathan Cockburn, Helen I McDonald, Brian MacKenna, Laurie Tomlinson, Ian J Douglas, Christopher T Rentsch, Rohini Mathur, Angel Y S Wong, Richard Grieve, David Harrison, Harriet Forbes, Anna Schultze, Richard Croker, John Parry, Frank Hester, Sam Harper, Rafael Perera, Stephen J W Evans, Liam Smeeth, Ben Goldacre

2221 related Products with: OpenSAFELY: factors associated with COVID-19 death in 17 million patients.

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#32640462   2020/07/08 To Up

Frailty Prevalence in Younger End-Stage Kidney Disease Patients Undergoing Dialysis and Transplantation.

Frailty, originally characterized in community-dwelling older adults, is increasingly being studied and implemented for adult patients with end-stage kidney disease (ESKD) of all ages (>18 years). Frailty prevalence and manifestation are unclear in younger adults (18-64 years) with ESKD; differences likely exist based on whether the patients are treated with hemodialysis (HD) or kidney transplantation (KT).
Nadia M Chu, Xiaomeng Chen, Silas P Norman, Jessica Fitzpatrick, Stephen M Sozio, Bernard G Jaar, Alena Frey, Michelle M Estrella, Qian-Li Xue, Rulan S Parekh, Dorry L Segev, Mara A McAdams-DeMarco

2209 related Products with: Frailty Prevalence in Younger End-Stage Kidney Disease Patients Undergoing Dialysis and Transplantation.



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