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#33249348   2020/11/18 To Up

Fish oil supplementation enhances colon recovery after experimental colitis.

Fish oil (FO) has an anti-inflammatory and pro-resolution activity and it has been used to restore physiological disturbances on inflammatory conditions. Here, we investigate whether FO supplementation could, acutely, prevent or restore inflammatory damages on experimental colitis.
Igor Pedroso Soares, Bruna A C Oliveira, Suelen C S Baal, Lucelia Donatti, Max Ingberman, Breno C B Beirão, Marcia H Appel, Luiz C Fernandes

1585 related Products with: Fish oil supplementation enhances colon recovery after experimental colitis.

Box of 250 Tubes/Unit x2050 ug200 uL 2.5L

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#33249238   2020/11/26 To Up

Acute intestinal inflammation depletes/recruits histamine-expressing myeloid cells from the bone marrow leading to exhaustion of MB-HSCs.

Histidine decarboxylase (HDC), the histamine-synthesizing enzyme, is expressed in a subset of myeloid cells but also marks quiescent myeloid-biased hematopoietic stem cells (MB-HSCs) that are activated upon myeloid demand injury. However, the role of MB-HSCs in dextran sulfate sodium (DSS) - induced acute colitis has not been addressed.
Na Fu, Feijing Wu, Zhengyu Jiang, Woosook Kim, Tuo Ruan, Ermanno Malagola, Yosuke Ochiai, Osmel Companioni Nápoles, Giovanni Valenti, Ruth A White, Bryana R Belin, Leah B Zamechek, Jonathan S LaBella, Timothy C Wang

2983 related Products with: Acute intestinal inflammation depletes/recruits histamine-expressing myeloid cells from the bone marrow leading to exhaustion of MB-HSCs.

1.00 flask1.00 flask100.00 ug1.00 flask1.00 flask1.00 flask1.00 flask

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#33249181   2020/11/26 To Up

An efficient approach for wholemount preparation of the myenteric plexus of rat colon.

The nerve plexus of the enteric nervous system (ENS) plays a crucial part in regulating gastrointestinal functions, such as muscle contractile activity and nutrient absorption. Studying the nerve plexus can provide vital information for research on ENS disorders. Whole-mount preparation is an important technique for investigating the nerve plexus. However, currently available methods are time consuming and highly technical.
Zitong Huang, Lu Liao, Zhesheng Wang, Yulin Lu, Weiming Yan, Hongying Cao, Bo Tan

1186 related Products with: An efficient approach for wholemount preparation of the myenteric plexus of rat colon.

100μg 100ul500ml500 100μg100μl0.1 mg0.1ml (1mg/ml)

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#33249141   2020/11/26 To Up

Factors Influencing Supportive Care Needs of Colorectal Cancer Survivors.

There is an increasing number of colorectal cancer survivors in South Korea. However, no research has identified supportive care needs of survivors of colorectal cancer in South Korea. Thus, the purpose of this study was to determine the level of supportive care needs and effects of emotional state and quality of life (QoL) on supportive care needs of colorectal cancer survivors.
Hyekyung Kim, Yang-Sook Yoo

2538 related Products with: Factors Influencing Supportive Care Needs of Colorectal Cancer Survivors.

Each96

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#33249075   2020/11/26 To Up

Promising targets of chrysin and daidzein in colorectal cancer: amphiregulin, CXCL1, and MMP-9.

Colorectal cancer is one of the primary causes of cancer-related mortality worldwide. The tumor microenvironment contains growth factors; inflammatory chemokines, matrix metalloproteinases, and pro-oxidants leading to cancer development and progression. Phytochemicals have been used as the main source of anti-cancer agents. Accordingly, the effect of two natural flavonoids (Chrysin and Daidzein) was investigated on the level of amphiregulin (AREG), chemokine ligand (CXCL1), and matrix metalloproteinase-9 (MMP-9) in 1, 2-dimethylhydrazine dihydrochloride (DMH) induced colorectal cancer. Rats were injected by DMH (40 mg/kg/week S.C.) for 16 weeks concomitantly with 2% dextran sodium sulfate (DSS) in drinking water for three cycles. Rats were orally treated with chrysin (125 and 250 mg/kg) and daidzein (5 and10 mg/kg) three times/week for the last 8 weeks. DMH+DSS group showed a significant (P < 0.05) increase in the levels of AREG (2386±18 vs 1377±10 pg/ml), CXCL1 (18±0.9 vs 6±0.83 g/ml), MMP-9 (1355±88 vs 452±7 pg/ml) compared to normal rats. These findings were associated with a potent antioxidant activity against cytochrome P450 2E1; (CYP2E1). Histopathological findings of the DMH+DSS group showed focal hyperplasia of the mucosa lining overlying crypts with moderate inflammation, dysplastic epithelial cells, and loss of goblet cells. Chrysin and daidzein treatment significantly (P < 0.05) restored the biochemical alterations and reverted histopathological findings near to the normal status. Moreover, chrysin and daidzein exerted anticancer activity against SW620 cells that were associated with decreased the protein expression of p-ERK/ERK and p-AKT/AKT. In conclusion, this study highlighted the potential anticancer role of chrysin and daidzein in the treatment of colon cancer.
Abeer A A Salama, Rasha M Allam

2357 related Products with: Promising targets of chrysin and daidzein in colorectal cancer: amphiregulin, CXCL1, and MMP-9.

100 mg

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#33249002   2020/11/26 To Up

Proprotein convertases blockage up-regulates specifically metallothioneins coding genes in human colon cancer stem cells.

Despite continuous exertion made, colon cancer still represents a major health problem and its incidence continues being high worldwide. There is growing evidence in support of the cancer stem cells (CSCs) being central in the initiation of this cancer, and CSCs have been the focus of various studies for the identification of new ways of treatment. Lately, the proprotein convertases (PCs) were reported to regulate the maturation and expression of various molecules involved in the malignant phenotype of colon cancer cells, however, the identity of the molecules regulated by these serine proteases in CSCs is unknown. In this study, we used the general PCs inhibitor, the Decanoyl-RVKR-chloromethylketone (Decanoyl-RVKR-CMK) that inhibits all the PCs found in the secretory pathway, and analyzed its effect on CSCs using RNA-seq analysis. Remarkably, from the only 9 up-regulated genes in the human SW620-derived sphere-forming cells, we identified 7 of the 11 human metallothioneins, all of them localized on chromosome 16, and zinc related proteins as downstream effectors of the PCs. The importance of these molecules in the regulation of cell proliferation, differentiation and chemoresistance, and their reported potential tumor suppressor role and loss in colon cancer patients associated with worse prognosis, suggests that targeting PCs in the control of the malignant phenotype of CSCs is a new potential therapeutic strategy in colon cancer.
Daniela Gerovska, Patricia García-Gallastegi, Jean Descarpentrie, Olatz Crende, María Casado-Andrés, Ander Martín, Jokin Eguia, Abdel-Majid Khatib, Marcos J Araúzo-Bravo, Iker Badiola

1095 related Products with: Proprotein convertases blockage up-regulates specifically metallothioneins coding genes in human colon cancer stem cells.

1 mg10 ug11.00 flask

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#33248914   2020/11/25 To Up

Corrigendum to "Correlation of clinicopathological features and LGR5 expression in colon adenocarcinoma" Ann. Diagn. Pathol. 2020 Oct;48:151587. doi: 10.1016/j.anndiagpath.2020.151587. Epub 2020 Aug 14.


Koichi Sato, Takeshi Uehara, Mai Iwaya, Tomoyuki Nakajima, Yusuke Miyagawa, Hiroyoshi Ota, Eiji Tanaka

2955 related Products with: Corrigendum to "Correlation of clinicopathological features and LGR5 expression in colon adenocarcinoma" Ann. Diagn. Pathol. 2020 Oct;48:151587. doi: 10.1016/j.anndiagpath.2020.151587. Epub 2020 Aug 14.

100 mg100

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#33248853   2020/11/16 To Up

Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors.

A series of pyrido [2, 3-d]pyrimidin-7(8H)-ones were designed and synthesized as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors. One of the representative compounds, 5o, exhibited strong binding affinity with a K value of 0.15 nM, but was significantly less potent against a panel of 402 wild-type kinases at 100 nM. The compound also potently inhibited the kinase activity of TTK with an IC value of 23 nM, induced chromosome missegregation and aneuploidy, and suppressed proliferation of a panel of human cancer cell lines with low μM IC values. Compound 5o demonstrated good oral pharmacokinetic properties with a bioavailability value of 45.3% when administered at a dose of 25 mg/kg in rats. Moreover, a combination therapy of 5o with paclitaxel displayed promising in vivo efficacy against the HCT-116 human colon cancer xenograft model in nude mice with a Tumor Growth Inhibition (TGI) value of 78%. Inhibitor 5o may provide a new research tool for further validating therapeutic potential of TTK inhibition.
Minhao Huang, Yongjun Huang, Jing Guo, Lei Yu, Yu Chang, Xiaolu Wang, Jinfeng Luo, Yanhui Huang, Zhengchao Tu, Xiaoyun Lu, Yong Xu, Zhimin Zhang, Zhang Zhang, Ke Ding

1065 related Products with: Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors.

400Tests8 inhibitors5 inhibitors400 Assays96T100400 Assays5 Inhibitors 100ul96T1x96 well plate40 assays

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#33248713   2020/10/22 To Up

Novel urea linked ciprofloxacin-chalcone hybrids having antiproliferative topoisomerases I/II inhibitory activities and caspases-mediated apoptosis.

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Hamada H H Mohammed, Samar H Abbas, Alaa M Hayallah, Gamal El-Din A Abuo-Rahma, Yaser A Mostafa

2542 related Products with: Novel urea linked ciprofloxacin-chalcone hybrids having antiproliferative topoisomerases I/II inhibitory activities and caspases-mediated apoptosis.

100 assays200 100 ug5ug200 100 assays100ug Lyophilized100 mg1 kit100ug3 x 25 units

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#33248671   2020/11/25 To Up

The Effect of Preoperative Anemia and Perioperative Transfusion on Surgical Outcomes After Gastrectomy for Gastric Cancer.

The aim of this study is to examine the interaction between preoperative anemia and perioperative transfusions with postoperative morbidity and mortality among patients undergoing gastrectomy for cancer.
Araz Kouyoumdjian, Maude Trepanier, Ruqaiya Al Shehhi, Jonathan Cools-Lartigue, Lorenzo E Ferri, Lawrence Lee, Carmen L Mueller

2483 related Products with: The Effect of Preoperative Anemia and Perioperative Transfusion on Surgical Outcomes After Gastrectomy for Gastric Cancer.

Each 6 ml Ready-to-use

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