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#32746485 2020/08/03 To Up
Is There Really an Association of High Circulating Adiponectin Concentration and Mortality or Morbidity Risk in Stable Coronary Artery Disease?Adiponectin has several beneficial properties, namely, on the level of glucose metabolism, but paradoxically, its high concentrations were associated with increased mortality. We aimed to clarify the impact of high serum adiponectin on mortality and morbidity in patients with stable coronary artery heart disease (CAD). A total of 973 patients after myocardial infarction and/or coronary revascularization were followed in a prospective cohort study. All-cause and cardiovascular (CV) death, non-fatal cardiovascular events, and hospitalizations for heart failure (HF) were registered as outcomes. High serum adiponectin levels (≥8.58 ng/ml, i. e., above median) were independently associated with increased risk of 5-year all-cause, CV mortality or HF [with HRR 1.57 (95% CI: 1.07-2.30), 1.74 (95% CI: 1.08-2.81) or 1.94 (95% CI: 1.20-3.12), respectively] when adjusted just for conventional risk factors. However, its significance disappeared if brain natriuretic peptide (BNP) was included in a regression model. In line with this, we observed strong collinearity of adiponectin and BNP. Additionally, major adverse cardiovascular event (i. e., CV death, non-fatal myocardial infarction or stroke, coronary revascularization) incidence risk was not associated with high adiponectin. In conclusion, the observed inverse association between adiponectin concentrations and mortality risk seems to be attributable to concomitantly increased BNP, rather than high adiponectin being a causal factor.
Otto Mayer, Jitka Seidlerová, Jan Bruthans, Julius Gelžinský, Martina Rychecká, Markéta Mateřánková, Petra Karnosová, Peter Wohlfahrt, Renata Cífková, Jan Filipovský
2377 related Products with: Is There Really an Association of High Circulating Adiponectin Concentration and Mortality or Morbidity Risk in Stable Coronary Artery Disease?100ug Lyophilized100ug Lyophilized0.1ml4 Arrays/Slide100ug Lyophilized50ul (1mg/ml)2 Pieces/Box4 Membranes/Box100ug Lyophilized100ug Lyophilized2 Pieces/Box
#32746439 2020/08/03 To Up
Resveratrol isomeric switching during bioreduction of gold nanoparticles: a gateway for-resveratrol.R
Archita Gupta, Padmini Padmanabhan, Sneha Singh
1267 related Products with: Resveratrol isomeric switching during bioreduction of gold nanoparticles: a gateway for-resveratrol.2.5 mg100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug100ug100ug Lyophilized100ug100ug Lyophilized100ug Lyophilized100ug
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#32746358 2020/07/14 To Up
An Electrochemical Biochip for Measuring Low Concentrations of Analytes with Adjustable Temporal Resolutions.Electrochemical micro-sensors made of nanographitic (NG) carbon materials could offer high sensitivity and support voltammetry measurements at vastly different temporal resolutions. Here, we implement a configurable CMOS biochip for measuring low concentrations of bio-analytes by leveraging these advantageous features of NG micro-sensors. In particular, the core of the biochip is a discrete-time ∆∑ modulator, which can be configured for optimal power consumption according to the temporal resolution requirements of the sensing experiments while providing a required precision of ≈ 13 effective number of bits. We achieve this new functionality by developing a design methodology using the physical models of transistors, which allows the operating region of the modulator to be switched ondemand between weak and strong inversion. We show the application of this configurable biochip through in-vitro measurements of dopamine with concentrations as low as 50 nM and 200 nM at temporal resolutions of 100 ms and 10 s, respectively.
Kae-Dyi You, Edoardo Cuniberto, Shao-Cheng Hsu, Bohan Wu, Zhujun Huang, Xiaochang Pei, Davood Shahrjerdi
2206 related Products with: An Electrochemical Biochip for Measuring Low Concentrations of Analytes with Adjustable Temporal Resolutions.25 µg 100ul100μg25 µg100 TESTS1 ml0.2 mg0.25 mg0.1 ml96 Tests100μg500
#32746156 2020/08/03 To Up
Tomographic Field Free Line Magnetic Particle Imaging with an Open-Sided Scanner Configuration.Superparamagnetic iron oxide nanoparticles (SPIONs) have a high potential for use in clinical diagnostic and therapeutic applications. In vivo distribution of SPIONs can be imaged with the Magnetic Particle Imaging (MPI) method, which uses an inhomogeneous magnetic field with a field free region (FFR). The spatial distribution of the SPIONs are obtained by scanning the FFR inside the field of view (FOV) and sensing SPION related magnetic field disturbance. MPI magnets can be configured to generate a field free point (FFP), or a field free line (FFL) to scan the FOV. FFL scanners provide more sensitivity, and are also more suitable for scanning large regions compared to FFP scanners. Interventional procedures will benefit greatly from FFL based open magnet configurations. Here, we present the first open-sided MPI system that can electronically scan the FOV with an FFL to generate tomographic MPI images. Magnetic field measurements show that FFL can be rotated electronically in the horizontal plane and translated in three dimensions to generate 3D MPI images. Using the developed scanner, we obtained 2D images of dot and cylinder phantoms with varying iron concentrations between 11 μg/ml and 770 μg/ml. We used a measurement based system matrix image reconstruction method that minimizes ℓ1-norm and total variation in the images. Furthermore, we present 2D imaging results of two 4 mm-diameter vessel phantoms with 0% and 75% stenosis. The experiments show high quality imaging results with a resolution down to 2.5 mm for a relatively low gradient field of 0.6 T/m.
Can Baris Top, Alper Gungor
1496 related Products with: Tomographic Field Free Line Magnetic Particle Imaging with an Open-Sided Scanner Configuration.1 mg1.00 ml 70 Slides 1 mg1 g1 mg0.25 mg1 mg5 g100 1 mg 25 G
#32746004 2020/05/18 To Up
A Bayesian approach for coincidence resolution in microfluidic impedance cytometry.Cell counting and characterization is fundamental for medicine, science and technology. Coulter-type microfluidic devices are effective and automated systems for cell/particle analysis, based on the electrical sensing zone principle. However, their throughput and accuracy are limited by coincidences (i.e., two or more particles passing through the sensing zone nearly simultaneously), which reduce the observed number of particles and may lead to errors in the measured particle properties. In this work, a novel approach for coincidence resolution in microfluidic impedance cytometry is proposed.
Federica Caselli, Adele De Ninno, Riccardo Reale, Luca Businaro, Paolo Bisegna
1328 related Products with: A Bayesian approach for coincidence resolution in microfluidic impedance cytometry.1 kit100ug Lyophilized100 μg1 Set100 μg1 Set100 μg4 Membranes/Box100 μg
#32745991 2020/07/16 To Up
Decreased levels of urinary di-2-ethylhexyl phthalate (DEHP) metabolites and biomarkers of oxidative stress in children exposed to DEHP-tainted foods in Taiwan in 2011: A 44-month follow-up.A major health scandal involving DEHP-tainted (di-2-ethylhexyl phthalate) foodstuffs occurred in Taiwan in 2011. We investigated temporal relationships between urinary DEHP metabolites and biomarkers of oxidative stress in two cohorts of potentially affected children during that food scandal. One cohort was collected from Kaohsiung Medical University Hospital in southern Taiwan between May and June of 2011 (the KMUH cohort). This cohort was followed up at 2, 6, and 44 months. The other cohort was collected from a nationwide health survey conducted by Taiwan's National Health Research Institutes (the NHRI cohort) for potentially affected people between August 2012 and January 2013. Both cohorts only included children 10 years old and younger who had provided enough urine for analysis of urinary DEHP oxidative metabolites and two markers of oxidative stress: 8-oxo-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA). The KMUH cohort had a simultaneous and significant decrease in urinary DEHP metabolites, 8-OHdG, and MDA, with the lowest concentrations found at the 6-month follow up and maintained until the 44-month follow up, consistent with those from NHRI cohort at ∼15-18 months post-scandal (p > 0.05). There were decreases in both DEHP metabolites and oxidative stress markers across the populations, but no association was observed between DEHP metabolites and oxidative stress markers in individuals in the two cohorts. Continued follow-up is needed to determine long-term health consequences in these children.
Chia-Fang Wu, Chao A Hsiung, Hui-Ju Tsai, Ching-Mei Cheng, Bai-Hsiun Chen, Chiung-Wen Hu, Yeou-Lih Huang, Ming-Tsang Wu
2790 related Products with: Decreased levels of urinary di-2-ethylhexyl phthalate (DEHP) metabolites and biomarkers of oxidative stress in children exposed to DEHP-tainted foods in Taiwan in 2011: A 44-month follow-up.100 UG1 kit100 μg1 kit100 1 mg25
#32745979 2020/07/22 To Up
Serum copper and zinc levels in breast cancer: A meta-analysis.More and more studies have investigated the relationship between serum copper (Cu) and/or zinc (Zn) levels and breast cancer (BC). However, the results are inconsistent. It is unclear whether the serum Cu to Zn ratio (Cu/Zn) is associated with BC risk. Therefore, we evaluated serum Cu and Zn concentrations, and Cu/Zn in BC through meta-analysis.
Yue Feng, Jia-Wei Zeng, Qin Ma, Shuang Zhang, Jie Tang, Jia-Fu Feng
#32745969 2020/06/25 To Up
Determination of morphine and oxymorphone in exhaled breath condensate samples: Application of microwave enhanced three-component deep eutectic solvent-based air-assisted liquid-liquid microextraction and derivatization prior to gas chromatography-mass spectrometry.In this work, a microwave-enhanced air-assisted liquid-liquid microextraction method combined with gas chromatography-mass spectrometry has been developed for morphine and oxymorphone assessment in EBC samples. For this purpose, choline chloride-menthol-phenylacetic acid deep eutectic solvent (as an extraction solvent), butyl chloroformate (as a derivatization agent), and picoline (as a catalyst) are used. After performing predetermined extraction cycles in the microextraction method, the obtained cloudy solution is exposed to microwave irradiations to enhance extraction and derivatization efficiencies. The method provided low limits of detection (morphine 2.1 and oxymorphone 1.5 ng mL) and quantification (morphine 7.2 and oxymorphone 5.2 ng mL) in the EBC samples. The method had proper repeatability, accuracy, and stability expressed as relative standard deviations less than 5.1, 9, and 9%, respectively. The developed method was successfully used to determine morphine and oxymorphone concentrations in the EBC samples of addict patients.
Fatemeh Norouzi, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Jafar Soleymani, Abolghasem Jouyban, Mir Ali Farajzadeh, Mohammad Reza Afshar Mogaddam
2355 related Products with: Determination of morphine and oxymorphone in exhaled breath condensate samples: Application of microwave enhanced three-component deep eutectic solvent-based air-assisted liquid-liquid microextraction and derivatization prior to gas chromatography-mass spectrometry.100 100 100 20 20 20 20 20 100 100 20
#32745935 2020/07/20 To Up
Tungsten disulfide nanosheets-based colorimetric assay for glucose sensing.We have developed a glucose oxidase (GOx)-mediated strategy for glucose detection, which is based on the intrinsic peroxidase-like activity of WS as a catalyst for the 3,3',5,5'-tetramethylbenzidine‑hydrogen peroxide (TMB-HO) reaction. The colorimetric assay involves two parts: generation of HO from the oxidation of glucose catalyzed by GOx, and WS nanosheets that catalyze the reaction between TMB and HO. In this colorimetric assay, the enhancement of colorimetric signals depends directly on the increased HO concentration, which, in turn, relies on the glucose concentration. The results show that the concentrations of the glucose were directly proportional to absorbance of the TMB solutions over a range of 1 nM-500 μM with a limit of detection of 0.1445 nM. In addition, this new colorimetric assay has been utilized for glucose detection in human serum with a satisfactory result.
Yunfei Jiao, Justin Li, Junyi Xiang, Zhengbo Chen
2445 related Products with: Tungsten disulfide nanosheets-based colorimetric assay for glucose sensing.1,000 tests100tests1 kit100 assays48 assays 100tests100 assays100 assays9 x 25 assays
#32745924 2020/07/30 To Up
Motility based assays using cultured fourth stage larvae fail to provide consistent discrimination between known avermectin-resistant and -susceptible isolates of Cooperia spp.The fecal egg count reduction test (FECRT) is the only method commonly used for diagnosing anthelmintic resistance in gastrointestinal nematodes of cattle, but this method has several drawbacks that have limited its widescale implementation. Consequently, there exists a need to develop better methods for diagnosing resistance. Assays based on larval motility are used commonly for screening potential drug candidates, and for detecting drug resistance, but previous work in our lab demonstrated that the L3 stage failed to discriminate between avermectin-resistant and susceptible isolates of Cooperia spp. We hypothesized that the L4 may be a better stage for this purpose because it is a parasitic and actively feeding life stage without a double cuticle. L3 larvae of Cooperia spp. were exsheathed and cultured to L4 by maintaining them in media at 37 °C and 20 % CO, with media changes and observation every 48 h for nine days. Three avermectin-resistant and two avermectin-susceptible GIN isolates (diagnosed by FECRT) containing >88 % Cooperia spp., were used. Three biological replicates were performed for each parasite isolate using both eprinomectin and ivermectin. Eleven drug concentrations from 0.01um to 40um and negative controls were evaluated. Motility readings were taken using the Worminator system before addition of the drug and at 24- and 48 -hs post drug exposure. Resistance ratios for ivermectin and eprinomectin ranged from 0.35 to 2.75 and 0.54-1.03, respectively. Though significant differences (p < 0.05) in percent inhibition were found at some drug concentrations in some assays, there were no consistent significant differences in the dose-response between susceptible and resistant isolates. Inhibition was greater in about half of the assays for the susceptible isolates, and in half the assays for the resistant isolates. The lack of consistency in these data indicate that motility of L4 is not a reliable diagnostic phenotype for measuring resistance to avermectin drugs in Cooperia spp.
Kelsey L Paras, Ray M Kaplan
2183 related Products with: Motility based assays using cultured fourth stage larvae fail to provide consistent discrimination between known avermectin-resistant and -susceptible isolates of Cooperia spp.100 assays100 assays100 extractions100 assays100 assays100 assays
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