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#32791428   2020/07/24 To Up

Improving the physicochemical stability and functionality of nanoliposome using green polymer for the delivery of pelargonidin-3-O-glucoside.

This study aimed to improve the physicochemical stability of nanoliposome (NL) with enhanced functionality for the delivery of Pelargonidin-3-O-glucoside (P3G) using biopolymers, i.e. chitosan (CH) and pectin (P). In this study, we successfully developed stabilized liposomal carriers, i.e. CH-conjugated NL (CH-NL) and P-conjugated CH-NL (P-CH-NL) using an optimum concentration of CH (0.6 wt%) and P (0.5 wt%). Results revealed that P-CH-NL had better physical stability to salt and pH with maximum P3G retention (>97%) under oxidative, thermal, and UV conditions. Nanoliposomes were more stable under refrigerated-storage and ensured high P3G retention (>96%). In vitro mucoadhesion study revealed that CH-NL had better mucin adsorption efficiency (59.72%) followed by P-CH-NL and NL. Furthermore, CH-NL and P-CH-NL alternatively had better stability to serum than NL. Taken together, the stabilization of nanoliposome using chitosan and pectin can be a promising approach for the delivery of hydrophilic compounds in association with enhanced stability and functionality.
Mohammad Rezaul Islam Shishir, Naymul Karim, Yang Xu, Jiahong Xie, Wei Chen

2593 related Products with: Improving the physicochemical stability and functionality of nanoliposome using green polymer for the delivery of pelargonidin-3-O-glucoside.

100 U500 Units 100 G 100ul1100.00 ulmin 2 cartons200 units100

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#32791389   2020/08/01 To Up

Novel rhodamine probe for colorimetric and fluorescent detection of Fe ions in aqueous media with cellular imaging.

A novel rhodamine-pyridine conjugated spectroscopic probe RhP was synthesized and its X-ray single crystalline properties were revealed with tabulation. The RhP displayed a distinct pale-pink colorimetric and "turn-on" fluorescent response to Fe in aqueous media [HO:DMSO (95:5, v/v)] than that of other interfering ions. During the Fe recognition, the absorption (UV-Vis) and photoluminescence (PL) spectral studies revealed new peaks at 561 and 592 nm, respectively. The 1:1 stoichiometry and binding sites were verified by Job's plot, ESI-mass, and H NMR titrations. Subsequently, LOD and binding constant for RhP + Fe complex were estimated as 102.3 nM and 6.265 × 10 M from linear fitting and Benesi-Hildebrand plots, correspondingly. Sensor reversibility of RhP + Fe by EDTA was demonstrated by UV/PL and TRPL investigations. Moreover, the photoinduced energy transfer mechanism and band gap changes were established from the DFT interrogations. Lastly, cellular imaging studies were carried out to authenticate the real applicability of RhP in Fe detection.
Muthaiah Shellaiah, Natesan Thirumalaivasan, Basheer Aazaad, Kamlesh Awasthi, Kien Wen Sun, Shu-Pao Wu, Ming-Chang Lin, Nobuhiro Ohta

2575 related Products with: Novel rhodamine probe for colorimetric and fluorescent detection of Fe ions in aqueous media with cellular imaging.

500 ml10reactions 50 ml100tests96 wells100 ml

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#32791124   2020/08/10 To Up

Vaginal Estrogen Therapy Is Associated with Increased Lactobacillus in the Urine of Post-Menopausal Women with Overactive Bladder Symptoms.

Previous work has shown that the vaginal microbiome decreases in Lactobacillus predominance and becomes more diverse following menopause. It has also been shown that estrogen therapy restores Lactobacillus-dominance in the vagina, and that topical estrogen is associated with OAB symptom improvement. We now know that the bladder contains a unique microbiome, and increased bladder microbiome diversity is associated with OAB. However, there is no understanding of how quickly each pelvic floor microbiome responds to estrogen or if those changes are associated with symptom improvement.
Krystal Thomas-White, Susanne Taege, Roberto Limeira, Cynthia Brincat, Cara Joyce, Evann E Hilt, Laura Mac-Daniel, Katherine A Radek, Linda Brubaker, Elizabeth R Mueller, Alan J Wolfe

2819 related Products with: Vaginal Estrogen Therapy Is Associated with Increased Lactobacillus in the Urine of Post-Menopausal Women with Overactive Bladder Symptoms.

100ug Lyophilized100 ul100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100 samples100ug Lyophilized100ug Lyophilized

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#32790391   2020/08/06 To Up

Effects of Nitridation and Vinylation of Imidazolium Rings on Hydrogen Bonding Interactions, π-π Stacking Structures, and Dynamical Heterogeneities in Imidazolium and Triazolium Ionic Liquids.

Extensive atomistic simulations have been performed to investigate how nitridation and vinylation of cations affect hydrogen bonding structures and dynamics, $\pi$-$\pi$ stacking interactions between cation ring planes, and translational and rotational dynamics of ion species in ionic liquids (ILs) consisting of bis(trifluoromethylsulfonyl)imide anions coupled with either imidazolium or triazolium cations. Both nitridation and vinylation of cations have remarkable effects on molecular electrostatic potential contours of cations and polarities of cation ring hydrogen atoms, leading to distinct structures and dynamics in their hydrogen bonding associations with representative atoms in anions and in triazolium cations. Both imidazolium and triazolium ring planes exhibit varied $\pi$-$\pi$ stacking structures depending on nitridation positions on imidazolium rings. The vinyl-substituted cations have prominent $\pi$-$\pi$ stacking interactions than their methyl-based counterparts due to the formation of $\pi$-conjugated ring-vinyl moieties. Polar and apolar groups in ion species exhibit remarkable translational and rotational dynamics, and distinct diffusion distributions in IL matrices at different timescales. The nitridation and vinylation of cations lead to enhanced deviation of translational mobilities of ion species from Gaussian behavior, and cations have a higher degree of dynamical heterogeneity than their coupled anions.
Yong-Lei Wang

1237 related Products with: Effects of Nitridation and Vinylation of Imidazolium Rings on Hydrogen Bonding Interactions, π-π Stacking Structures, and Dynamical Heterogeneities in Imidazolium and Triazolium Ionic Liquids.

1000 tests100ug10 mg25 mg10 mg100.00 ul100ug500 mg 5 G 5 G100ul1000

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#32790323   2020/08/12 To Up

Multiplexed Graphene Quantum Dots with Excitation-Wavelength-Independent Photoluminescence, as Two-Photon Probes, and in Ultraviolet-Near Infrared Bioimaging.

In this study, sorted nitrogen-doped graphene quantum dots were prepared and subsequently conjugated with polymers. The synthesized materials exhibited excitation-wavelength-independent photoluminescence emissions ranging from ultraviolet to near-infrared and were 0.9-8.4 nm in size. The materials also exhibited high photoluminescence quantum yields and excellent two-photon properties. Therefore, in two-photon bioimaging, the materials with different emission spectra can be effective two-photon contrast agents. Specific antibodies were used to label organelles in cancer cells and identify nuclear antigens, thereby enabling the simultaneous detection of four targets in cells at a single two-photon excitation wavelength. The sorted nitrogen-doped graphene quantum dot materials were determined to be considerably more advantageous than organic dyes in identifying multiplexed targets, and they can be effective probes in cellular imaging.
Wen-Shuo Kuo, Xing-Can Shen, Chia-Yuan Chang, Hui-Fang Kao, Sheng-Han Lin, Jiu-Yao Wang, Ping-Ching Wu

1771 related Products with: Multiplexed Graphene Quantum Dots with Excitation-Wavelength-Independent Photoluminescence, as Two-Photon Probes, and in Ultraviolet-Near Infrared Bioimaging.

1 kit1 kit1 kit20 ul (10 mM)96 assays 1 kit100 assays48 assays100 assays24 tests

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#32790004   2020/08/12 To Up

Mesoporous Polymeric Cyanamide-Triazole-Heptazine Photocatalysts for Highly-Efficient Water Splitting.

Conjugated polymers are promising light harvesters for water reduction/oxidation due to their simple synthesis and adjustable bandgap. Herein, both cyanamide and triazole functional groups are first incorporated into a heptazine-based carbon nitride (CN) polymer, resulting in a mesoporous conjugated cyanamide-triazole-heptazine polymer (CTHP) with different compositions by increasing the quantity of cyanamide/triazole units in the CN backbone. Varying the compositions of CTHP modulates its electronic structures, mesoporous morphologies, and redox energies, resulting in a significantly improved photocatalytic performance for both H and O evolution under visible light irradiation. A remarkable H evolution rate of 12723 µmol h g is observed, resulting in a high apparent quantum yield of 11.97% at 400 nm. In parallel, the optimized photocatalyst also exhibits an O evolution rate of 221 µmol h  g , 9.6 times higher than the CN counterpart, with the value being the highest among the reported CN-based bifunctional photocatalysts. This work provides an efficient molecular engineering approach for the rational design of functional polymeric photocatalysts.
Chongbei Wu, Guanhang Yu, Yue Yin, Yuze Wang, Li Chen, Qing Han, Junwang Tang, Bo Wang

2185 related Products with: Mesoporous Polymeric Cyanamide-Triazole-Heptazine Photocatalysts for Highly-Efficient Water Splitting.

4 Arrays/Slide96 Tests2 Pieces/Box100μg4 Membranes/Box100 mg2 Pieces/Box 500 ml 20 L

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#32789933   2020/08/13 To Up

Gas-Phase Ion Fluorescence Spectroscopy of Tailor-made Rhodamine Homo- and Heterodyads: Quenching of Electronic Communication by π-Conjugated Linkers.

While many key photophysical features are understood for electronic communication between chromophores in neutral compounds, there is limited information on the effect of charges in practically relevant ionic chromo/fluorophores. Here we have chosen positively charged rhodamines and prepared a selection of homo- and heterodimers with alkyl or π-conjugated, acetylenic bridges. Protonated molecules were transferred as isolated ions to gas phase where there is no solvent screening of charges, and fluorescence spectra were measured with a custom-made ion-trap setup. Our work reveals strong polarization of the π-spacer (induced dipole/quadrupole) when it experiences the electric field from one / two dyes. Hence, π-spacers provide efficient shielding of charges by reducing the Coulomb interaction, whereas two dye cations polarize each other when connected by an alkyl. The screening influences the Förster Resonance Energy Transfer efficiency that relies on the dipole-dipole interaction.
Steen Brondsted Nielsen, Anne Ugleholdt Petersen, Christina Kjaer, Cecilie Jensen, Mogens Brøndsted Nielsen

1267 related Products with: Gas-Phase Ion Fluorescence Spectroscopy of Tailor-made Rhodamine Homo- and Heterodyads: Quenching of Electronic Communication by π-Conjugated Linkers.

5 G100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug1 kit100ug Lyophilized 5 G

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#32789394   2020/08/13 To Up

A photoproduct of DXCF cyanobacteriochromes without reversible Cys ligation is destabilized by rotating ring twist of the chromophore.

Cyanobacteriochrome photoreceptors (CBCRs) ligate linear tetrapyrrole chromophores via their first (canonical) Cys residue and show reversible photoconversion triggered by light-dependent Z/E isomerization of the chromophore. Among the huge repertoire of CBCRs, DXCF CBCRs contain a second Cys residue within the highly conserved Asp-Xaa-Cys-Phe (DXCF) motif. In the typical receptors, the second Cys covalently attaches to the 15Z-chromophore in the dark state and detaches from the 15E-chromophore in the photoproduct state, whereas atypical ones that lack reversible ligation activity show red-shifted absorption in the dark state due to a more extended π-conjugated system. Moreover, some DXCF CBCRs show blue-shifted absorption in the photoproduct state due to the twisted geometry of the rotating ring. During the process of rational color tuning of a certain DXCF CBCR, we unexpectedly found that twisted photoproducts of some variant molecules showed dark reversion to the dark state, which prompted us to hypothesize that the photoproduct is destabilized by the twisted geometry of the rotating ring. In this study, we comprehensively examined the photoproduct stability of the twisted and relaxed molecules derived from the same CBCR scaffolds under dark conditions. In the DXCF CBCRs lacking reversible ligation activity, the twisted photoproducts showed faster dark reversion than the relaxed ones, supporting our hypothesis. By contrast, in the DXCF CBCRs exhibiting reversible ligation activity, the twisted photoproducts showed no detectable photoconversion. Reversible Cys adduct formation thus results in drastic rearrangement of the protein-chromophore interaction in the photoproduct state, which would contribute to the previously unknown photoproduct stability.
Keiji Fushimi, Takumi Matsunaga, Rei Narikawa

1022 related Products with: A photoproduct of DXCF cyanobacteriochromes without reversible Cys ligation is destabilized by rotating ring twist of the chromophore.

5 mg100ug Lyophilized100ug Lyophilized0.1ml (1mg/ml)100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100 ul100ug Lyophilized

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#32789370   2020/08/13 To Up

Exploring the properties and potential biomedical applications of NSAID-capped peptide hydrogels.

The development of strategies to minimise the adverse side-effects of non-steroidal anti-inflammatory drugs (NSAIDs) remains a challenge for medicinal chemists. One such strategy is the development of NSAID-peptide prodrug conjugates and this conjugation to a peptide often confers the additional property of hydrogelation. This review summarises the work published by our research group, alongside other research groups, on supramolecular hydrogels consisting of short peptides conjugated to NSAIDs. Generally, supramolecular low molecular weight hydrogels (LMWHs) are composed of amphiteric molecules, usually consisting of short peptides attached to an aromatic capping group. When the aromatic capping group is switched for an NSAID to afford hybrid gelators, some conjugates exhibit retained or improved anti-inflammatory properties of the parent drug, and sometimes new and unexpected biological activities are observed. Conjugation to peptides often provides selective COX-2 inhibition over COX-1 inhibtion, which is key to retaining the anti-inflammatory benefits of NSAIDs whilst minimising gastric side-effects. Naproxen is the most commonly employed NSAID capping group, partly due to its similarity in structure to commonly employed naphthalene capping groups. Biomimetic approaches, where canonical amino acids are switched for non-natural amino acids such as d-amino acids or dehydroamino acids, are often employed, to tune the stability. The future direction for this area of research is discussed.
Peter J Jervis, Carolina Amorim, Teresa Pereira, José A Martins, Paula M T Ferreira

1604 related Products with: Exploring the properties and potential biomedical applications of NSAID-capped peptide hydrogels.

0.1mg50 ug50 ug50 ug50 ug50 ug200ul1mg50 ug96 tests50 ug50 ug

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