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#33248825   2020/11/19 To Up

Tailoring molecular permeability of vertically-ordered mesoporous silica-nanochannel films on graphene for selectively enhanced determination of dihydroxybenzene isomers in environmental water samples.

Herein we demonstrate a simple and rapid electrochemical method for selectively enhanced determination of catechol (CC) or hydroquinone (HQ) isomers in environmental water samples by tailoring the molecular permeability of vertically-ordered mesoporous silica-nanochannel films on electrochemically reduced graphene oxide (VMSF/ErGO). Such VMSF/ErGO composite film was fabricated on the gold electrode (AuE) surface using electrochemically assisted self-assembly approach. The as-prepared electrodes with surfactant micelles (SM) template inside silica nanochannels, designed as SM/VMSF/ErGO/AuE, possess hydrophobic hydrocarbon cores and show preferential response to CC via hydrophobic effect. After removing SM from silica nanochannels, the obtained VMSF/ErGO/AuE displays more sensitive response to HQ, which is due to the hydrogen bond effect between the silanol groups of silica walls and HQ. Given the potential-resolved and high electrocatalytic ability of ErGO, and molecular permeability and anti-fouling ability of VMSF, these two present sensors could detect CC and HQ in lake water with a low limit of detection (18 nM for CC and 16 nM for HQ), and a high sensitivity (0.33 μA/μM for CC and 0.37 μA/μM for HQ), without complicated sample pretreatment. Moreover, the proposed sensors provide a convenient, rapid and economic way for direct analysis of environmental water samples, exhibiting excellent long-term stability.
Fei Yan, Tao Luo, Qifan Jin, Huaxu Zhou, Ajabkhan Sailjoi, Guotao Dong, Jiyang Liu, Weizhong Tang

1955 related Products with: Tailoring molecular permeability of vertically-ordered mesoporous silica-nanochannel films on graphene for selectively enhanced determination of dihydroxybenzene isomers in environmental water samples.

100 G250 mg100Tests16 Arrays/Slide 1 G50μl400Tests96 samples100ug

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#33245988   2020/11/24 To Up

Expression of Lymphoid Enhancer Binding Factor 1 (LEF-1) in Breast Fibroepithelial Lesions.

Phyllodes tumors (PT) are rare epithelial-mesenchymal tumors of the breast with malignant potential. Here, we evaluate the nuclear expression of Lymphoid Enhancer Binding Factor 1 (LEF-1), a transcription factor downstream of Wnt/β-catenin signaling, in fibroepithelial lesions of the breast.
Po-Han Chen, Veerle Bossuyt, Emily Reisenbichler

2447 related Products with: Expression of Lymphoid Enhancer Binding Factor 1 (LEF-1) in Breast Fibroepithelial Lesions.

10ug100.00 ug100.00 ug10ug100.00 ug100ul 100ul10ug100.00 ug100ul100.00 ug100ug Lyophilized

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#33245987   2020/11/24 To Up

Breast cancer tumor heterogeneity has only little impact on the estimation of Oncotype DX® recurrence score using Magee equations and Magee Decision Algorithm.

Oncotype DX® assay is used to guide therapeutic decisions in early-stage invasive breast carcinoma but remains expensive. Magee equations (MEs) and Magee Decision Algorithm (MDA) predict Oncotype DX® Recurrence Score (RS) on the basis of histopathological parameters. The influence of intra-tumor heterogeneity on MEs and MDA remains uncertain. We compared Ki-67, estrogen and progesteron receptors and HER2 status on Tissue Micro Array cores with the corresponding findings on the whole slides to calculate MEs scores and to decide if Oncotype DX® testing was required according to MDA in two sets of 175 and 59 tumors, without and with Oncotype DX® results respectively. Agreements in the interpretation of Ki-67, estrogen and progesteron receptors and HER2 status were very good between limited areas and whole slides analyses. This resulted also in very good agreements about the results of MEs and MDA. For 7/175 (4%) and 3/59 (5.1%) cases, MEs and MDA results in different tumor areas would have changed the indication to perform or not perform Oncotype DX® assays. Oncotype DX® RS were significantly correlated with MEs and MDA results but, among cases initially predicted to have a RS ≤25 using MDA, 3/34 (8.8%) had in fact an RS >25. Tumor heterogeneity appears to have little impact on the estimation of Oncotype DX® RS using MEs and MDA and would have permitted to avoid half of Oncotype DX® assays in our series. Caution is nevertheless required in discarding Oncotype DX® assay in cases with MEs scores >18 associated with low mitotic activity.
Annabelle Remoué, Virginie Conan-Charlet, Laura Deiana, Alexandra Tyulyandina, Pascale Marcorelles, Ulrike Schick, Arnaud Uguen

1232 related Products with: Breast cancer tumor heterogeneity has only little impact on the estimation of Oncotype DX® recurrence score using Magee equations and Magee Decision Algorithm.



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#33242122   2020/11/26 To Up

Sediment Records of Polybrominated Diphenyl Ethers (PBDEs) from the Anhui Province Section of Yangtze River, China.

This study investigated the temporal changes of PBDEs in the sediment cores from the Anhui Province section of Yangtze River (YR), China. The dramatic increase of ∑Br-Br-BDEs and BDE-209 concentrations in cores in the period of ca. 1990-2008 was consistent with the booming of regional and national production and consumption of household appliances and electronics. Following declines in BDE-209 and ∑Br-Br-BDEs concentrations can be associated with the deceasing use of legacy commercial PBDE mixtures in recent years. Compared with the different regions around the world, sediments in the YR were moderately polluted by PBDEs. The levels and the detection rates of BDE-209 were highest among the detected PBDEs single congener. The composition analysis indicated that Deca-BDE, Octa-BDE, and Penta-BDE were the dominant forms in the YR. The increasing trends of both BDE-209 and ∑Br-Br-BDEs in the YR during 1990s and 2000s largely reflected the time periods for transferring PBDE sources from the developed countries to China. TOC and finer particles were strongly correlated with distributions of PBDEs in sediments.
Chunnian Da, Ruwei Wang, Qing Huang, Jinyu Mao, Lijin Xie, Chao Xue, Long Zhang

1901 related Products with: Sediment Records of Polybrominated Diphenyl Ethers (PBDEs) from the Anhui Province Section of Yangtze River, China.

5 Gmin 2 cartons0.1 ml 100 G5 mg100.00 ul 25 G5 Pieces/Box100 mg

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#33239969   // To Up

A Trend Toward Aggressive Prostate Cancer.

To compare prostate biopsy (Pbx) characteristics before and after the 2012 United States Preventive Services Task Force (USPSTF) prostate cancer (PCa) screening guidelines, we completed a retrospective comparative analysis of 1703 sequential patients that had a Pbx in 2010 to 2012 (3 years) with 383 patients biopsied in 2018 and 310 patients biopsied in 2019. Data was collected on patient age, race, serum prostate specific antigen (PSA) level, digital rectal examination (DRE) results, total number of biopsies performed, and Gleason sum score (GSS). Data were analyzed to determine whether the 2012 USPSTF screening recommendations against PCa screening may have affected PCa characteristics. Three study groups were defined as Group A, Group B, and Group C. Group A represents Pbx prior to the 2012 USPSTF screening guidelines (2010-2012), Group B represents Pbx in 2018, and Group C represents Pbx in 2019. The patient population consisted of 73% Black men, 16% White men, and 11% men of other races. The number of patients that had a biopsy in Groups A through C, respectively, were 567 patients/year, 383 patients/year, and 310 patients/year. The annual positive Pbx rate for Group A through C was 134/year, 175/year, and 201/year, respectively. High-grade PCa (GSS 7-10) in Groups A through C was 51.5%, 60.5%, and 60.0%. The proportion of patients with a serum PSA level 10 ng/mL or greater in Groups A through C was 25.4%, 29.3%, and 33%. For patients age 70 to 80 years, there was an increasing trend for serum PSA levels 10 ng/mL and higher: 31%, 38%, and 39%, respectively. In this age group, high-grade tumors (GSS 7-10) occurred in 61%, 65%, and 68%, respectively. In 2019, Grade Group 3, 4, and 5 was present in 37.7% of 70- to 80-year-old men and 34.6% of Black men. More than 50% positive biopsy cores were present in 46.3% of 70- to 80-year old men and 36.6% of Black men. Our data through 2019 continued to show that after the 2012 USPSTF recommendations against PCa screening, PCa screening has decreased. We found decreased Pbx, increased PCa diagnosis, and increased high-grade PCa (GSS 7-10). As our patient population consisted of 73% Black patients and 33% of men age 70 to 80 years, our results support aggressive PCa screening for high-risk patients, which include Black men, men with a family history of PCa, and healthy men age 70 to 80 years.
Navin Shah, Vladimir Ioffe

2316 related Products with: A Trend Toward Aggressive Prostate Cancer.



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#33235906   2020/09/05 To Up

SOX2 is a promising predictor of relapse and death in advanced stage high-grade serous ovarian cancer patients with residual disease after debulking surgery.

The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells. We investigated the role of SOX2 protein expression in women with high-grade serous ovarian cancer (HGSOC) to determine its potential prognostic and treatment predictive value. We constructed a tissue microarray of 130 advanced stage HGSOC tumors with an average of 6 cores each, stained for SOX2 protein expression and evaluated survival outcomes. We also treated two HGSOC cell lines with carboplatin and paclitaxel and measured SOX2 expression by RT-PCR and immunoblotting at different doses and time-points. Among patients with non-radical debulking surgery overall and progression-free survival were shorter for patients with SOX2 positive tumors (mean 26 . 39 months, log-rank test: = .0076, and mean 14 . 19 months, = .055, respectively). Knockdown of in cell lines did not affect growth inhibition following chemotherapy treatment. Our results show that SOX2 has a strong prognostic potential among HGSOC patients with residual tumor tissue after debulking surgery and suggest that SOX2 expressing cells remaining after non-radical debulking surgery may constitute a subpopulation of cancer stem cells with greater tumor-initiating potential.
Maria Bååth, Sofia Westbom-Fremer, Laura Martin de la Fuente, Anna Ebbesson, Juliette Davis, Susanne Malander, Anna Måsbäck, Päivi Kannisto, Ingrid Hedenfalk

1992 related Products with: SOX2 is a promising predictor of relapse and death in advanced stage high-grade serous ovarian cancer patients with residual disease after debulking surgery.



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#33235186   2020/11/24 To Up

Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture.

Enhancer RNAs (eRNA) are unstable non-coding RNAs, transcribed bidirectionally from active regulatory sequences, whose expression levels correlate with enhancer activity. We use capped-nascent-RNA sequencing to efficiently capture bidirectional transcription initiation across several human lymphoblastoid cell lines (Yoruba population) and detect ~75,000 eRNA transcription sites with high sensitivity and specificity. The use of nascent-RNA sequencing sidesteps the confounding effect of eRNA instability. We identify quantitative trait loci (QTLs) associated with the level and directionality of eRNA expression. High-resolution analyses of these two types of QTLs reveal distinct positions of enrichment at the central transcription factor (TF) binding regions and at the flanking eRNA initiation regions, both of which are associated with mRNA expression QTLs. These two regions-the central TF-binding footprint and the eRNA initiation cores-define a bipartite architecture of enhancers, inform enhancer function, and can be used as an indicator of the significance of non-coding regulatory variants.
Katla Kristjánsdóttir, Alexis Dziubek, Hyun Min Kang, Hojoong Kwak

1143 related Products with: Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture.

200ug 30 ml 1 kit(96 Wells)Kit1 kit1 kit(96 Wells)96 wells (1 kit) 100ul1 kit(96 Wells)200ug1

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#33233822   2020/11/20 To Up

Joule Heating-Induced Carbon Fibers for Flexible Fiber Supercapacitor Electrodes.

Microscale fiber-based supercapacitors have become increasingly important for the needs of flexible, wearable, and lightweight portable electronics. Fiber electrodes without pre-existing cores enable a wider selection of materials and geometries than is possible through core-containing electrodes. The carbonization of fibrous precursors using an electrically driven route, different from a conventional high-temperature process, is particularly promising for achieving this structure. Here, we present a facile and low-cost process for producing high-performance microfiber supercapacitor electrodes based on carbonaceous materials without cores. Fibrous carbon nanotubes-agarose composite hydrogels, formed by an extrusion process, are converted to a composite fiber consisting of carbon nanotubes (CNTs) surrounded by an amorphous carbon (aC) matrix via Joule heating. When assembled into symmetrical two-electrode cells, the composite fiber (aC-CNTs) supercapacitor electrodes deliver a volumetric capacitance of 5.1 F cm even at a high current density of 118 mA cm. Based on electrochemical impedance spectroscopy analysis, it is revealed that high electrochemical properties are attributed to fast response kinetics with a characteristic time constant of 2.5 s. The aC-CNTs fiber electrodes exhibit a 94% capacitance retention at 14 mA cm for at least 10,000 charge-discharge cycles even when deformed (90° bend), which is essentially the same as that (96%) when not deformed. The aC-CNTs fiber electrodes also demonstrate excellent storage performance under mechanical deformation-for example, 1000 bending-straightening cycles.
Jin Gu Kang, Gang Wang, Sung-Kon Kim

2632 related Products with: Joule Heating-Induced Carbon Fibers for Flexible Fiber Supercapacitor Electrodes.

110 mg10 mg5 g50 ul25 mg 1 G1 g 100ul

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#33232850   2020/11/21 To Up

Recent pollution records in Sidi Moussa coastal lagoon (western Morocco) inferred from sediment radiometric dating.

The Sidi Moussa lagoon, located in western coastal Morocco and ranked as a wetland of biological and ecological importance (Ramsar site), is contaminated due to its proximity to the industrial phosphate plants and other anthropogenic activities around it. This study was carried out to assess the current environmental state of the lagoon as well as historical inputs of pollutants over several decades. Three sediment cores were collected and analyzed for the determination radionuclide activities (Pb, Ra, U and Cs) by gamma spectrometry and element concentrations by Inductively Coupled Plasma - Mass Spectrometry. Age-depth relationships were established in two cores using Pb and Cs as chronometer and time-marker, respectively, and Constant Rate of Supply as radiometric dating model. Pb and U were present in sediment in activities much higher than those reported for non-contaminated coastal systems. Sediment accumulation rates showed a slight increase over time with a depth-averaged value of 0.16 g cm y. Enrichment Factors and practically derived sediment quality guidelines were used to assess sediment contamination/pollution and toxicological effects linked with the measured concentrations of sediment-bound elements. The profiles of Cr, Co, Cu, As and Ni displayed maximums at depths matching the start of the phosphate industrial plants, and decreasing concentrations in the sections above the maximums, revealing the positive effects of the environmental management system adopted by the phosphate company since early 2000s.
A Benmhammed, A Laissaoui, N Mejjad, N Ziad, E Chakir, A Benkdad, H Ait Bouh, A El Yahyaoui

2670 related Products with: Recent pollution records in Sidi Moussa coastal lagoon (western Morocco) inferred from sediment radiometric dating.

100ug Lyophilized100 μg100ug100 μg100ug400 ug100 μg100ug Lyophilized10

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