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Simultaneous MRI water-fat separation and quantitative susceptibility mapping of carotid artery plaque pre- and post-ultrasmall superparamagnetic iron oxide-uptake.Imaging carotid artery plaques to identify features of vulnerability typically requires a multicontrast MRI protocol. The identification of regions of inflammation with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles requires separate pre- and postcontrast scans. We propose a method of joint water-fat separation and quantitative susceptibility mapping (QSM) to aid classification of atherosclerotic plaques and offer a positive contrast mechanism in USPIO-imaging.
1374 related Products with: Simultaneous MRI water-fat separation and quantitative susceptibility mapping of carotid artery plaque pre- and post-ultrasmall superparamagnetic iron oxide-uptake.Androgen Receptor (Ab 650 Androgen Receptor , Mouse (5α,16β)-N-Acetyl-16-[2 (5α)-Androst-2-en-17-one EnzyChrom™ Free Fatty A 1,4 Androstadiene 3,17 di ELISA 5α-Androstane-3α, ∆1-Androstene-3α,17β- Androgen Receptor (Ab-650 Androgen Receptor (Phosph Anti Androgen Receptor pr Androgen Receptor Antibod
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Selection of Aptamers with Large Hydrophobic 2'-Substituents.Previously, we evolved a DNA polymerase, SFM4-3, for the recognition of substrates modified at their 2' positions with a fluoro, -methyl, or azido substituent. Here we use SFM4-3 to synthesize 2'-azido-modified DNA; we then use the azido group to attach different, large hydrophobic groups via click chemistry. We show that SFM4-3 recognizes the modified templates under standard conditions, producing natural DNA and thereby allowing amplification. To demonstrate the utility of this remarkable property, we use SFM4-3 to select aptamers with large hydrophobic 2' substituents that bind human neutrophil elastase or the blood coagulation protein factor IXa. The results indicate that SFM4-3 should facilitate the discovery of aptamers that adopt novel and perhaps more protein-like folds with hydrophobic cores that in turn allow them to access novel activities.
flashBAC selection box N-GEN Nitrile Gloves, Lar GI cancer (esophageal, ga Diffuse large B-cell lymp pCAMBIA1391Z Vector (gusA Recombinant Measles Virus Large cell carcinoma of l Diffuse large B cell lymp pCAMBIA0380 Vector (No Re to M-Calpain (E.C. 3.4.2 Recombinant Measles Large ChromaLink™ Digoxigenin
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Antiaromaticity gain increases the potential for n-type charge transport in hydrogen-bonded π-conjugated cores.Density functional theory computations suggest that formally non-aromatic organic dyes, like diketopyrrolopyrrole, naphthodipyrrolidone, indigo, and isoindigo, show increased [4n] π-antiaromatic character and decreased LUMO orbital energies upon hydrogen bonding, making them suitable molecular candidates for applications in n-type organic field effect transistors.
1093 related Products with: Antiaromaticity gain increases the potential for n-type charge transport in hydrogen-bonded π-conjugated cores.Multiple types of kidney FDA Standard Frozen Tissu Top 4 types of cancer (co High density (188 cases 2 Multiple types of cancer FDA Standard Frozen Tissu Multiple lung carcinoma ( Breast invasive ductal ca Multiple organ cancer and Multiple cancer (12 type) Multiple organ tumor tiss High density (188 cases 2
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Fluorescein-guided resection of gliomas.Standard of care in the management of high-grade gliomas includes gross total resection (GTR) followed by treatment with radiation and temozolomide. GTR remains one of the few independent prognostic factors for improved survival in this disease. Sodium fluorescein is an organic fluorophore that has been studied as a surgical adjunct to improve the likelihood of achieving GTR in gliomas. Though sodium fluorescein does not selectively accumulate in glioma cells, it allows for real-time identification of regions of blood brain barrier breakdown, corresponding to the contrast-enhancing cores of high-grade gliomas. In addition to its high predictive value for identifying pathologic tissue, use of fluorescein has been shown to improve rates of GTR. In stereotactic needle biopsies, it helps reduce procedure time by rapidly confirming the presence of diagnostic tissue. Furthermore, in non-enhancing, low-grade gliomas, it labels focal regions of vascular dysregulation that have been correlated with high-grade features. Fluorescein has also been shown to be significantly less expensive than other contemporary surgical adjuncts such as intraoperative ultrasound, intraoperative MRI, and the recently FDA approved fluorophore, 5-aminolevulinic acid (5-ALA). Here, we review the current literature on the effectiveness of fluorescein as a surgical tool in the resection of gliomas.
Antibodies, Rabbit: Rabb Anti ATM Protein Kinase p Proteins and Antibodies H CaspGLOW Fluorescein Acti HCV core recombinant anti Active Caspase 3 Stainin 5 FITC [FITC Isomer I; fl Fluorescein mono beta D G Fluorescein, disodium sal Fluorescein diphosphate, Tide Fluor™ 2, succinim Fluorescein mono-β-D-N-A
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Decreased carbon accumulation feedback driven by climate-induced drying of two southern boreal bogs over recent centuries.Northern boreal peatlands are important ecosystems in modulating global biogeochemical cycles, yet their biological communities and related carbon dynamics are highly sensitive to changes in climate. Despite this, the strength and recent direction of these feedbacks are still unclear. The response of boreal peatlands to climate warming has received relatively little attention compared with other northern peatland types, despite forming a large northern hemisphere-wide ecosystem. Here we studied the response of two ombrotrophic boreal peatlands to climate variability over the last c. 200 years for which local meteorological data are available. We used remains from plants and testate amoebae to study historical changes in peatland biological communities. These data were supplemented by peat property (bulk density, carbon and nitrogen content), C, Pb and Cs analyses and were used to infer changes in peatland hydrology and carbon dynamics. In total, six peat cores, three per study site, were studied that represent different microhabitats: low hummock, high lawn and low lawn. The data show a consistent drying trend over recent centuries, represented mainly as a change from wet habitat Sphagnum spp. to dry habitat S. fuscum. Summer temperature and precipitation appeared to be important drivers shaping peatland community and surface moisture conditions. Data from the driest microhabitat studied, low hummock, revealed a clear and strong negative linear correlation (R = 0.5031, p < 0.001) between carbon accumulation rate and peat surface moisture conditions: under dry conditions, less carbon was accumulated. This suggests that at the dry end of the moisture gradient, availability of water regulates carbon accumulation. It can be further linked to the decreased abundance of mixotrophic testate amoebae under drier conditions (R = 0.4207, p < 0.001). Our study implies that if effective precipitation decreases in the future, the carbon uptake capacity of boreal bogs may be threatened.
1194 related Products with: Decreased carbon accumulation feedback driven by climate-induced drying of two southern boreal bogs over recent centuries.Breast cancer and normal 5-Amino-1-tert-butyl-3-(3 Cardiovascular disease ti 1'-Benzyl-1,4'-bipiperidi Esophageal cancer mid den (2S,4S)-4-(Acetylthio)-2- Twort's Counterstain Kit Kidney cancer and normal Bis(O-(N-benzyl-N-(1,1-di Jurkat Cell Extract (Indu Liver cancer mid density 3-[(Benzyloxy)amino]-N-[(
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Ligand structure and charge state-dependent separation of monolayer protected Au clusters using non-aqueous reversed-phase HPLC.The synthesis of atomically precise noble metal clusters using various protocols often results in a mixture of clusters with different cores. Hence, it is important to isolate such clusters in their pure form in terms of composition especially for crystallization. High-performance liquid chromatography (HPLC) is a powerful tool to achieve this. The interaction of ligands with column functionalities determine the extent of separation and their stability under conditions used. We demonstrate a systematic flow rate dependent study of three different aliphatic ligand protected Au25 clusters, with three commercially available alkyl and aryl functionalized reversed-phase HPLC columns, as they represent the variations encountered commonly. Molecular docking simulations were carried out to understand the interactions between the stationary phase and the cluster surface. These investigations enabled the selection of an appropriate column for better separation of structurally different ligand protected clusters. High-resolution separation of anionic and neutral Au25 clusters was acheived with a selectivity (α) of 1.2 by tuning the chromatographic conditions. This study would provide new insights in developing better methods for the efficient separation of monolayer protected clusters.
2145 related Products with: Ligand structure and charge state-dependent separation of monolayer protected Au clusters using non-aqueous reversed-phase HPLC.Mouse Anti-S. aureus Ente AURKC Non small cell lung carci Recombinant Mouse Flt3 Li Cytosol/Particulate Separ Androgen Receptor (Ab-650 Recombinant Human AURKA P Aurora Kinase B Inhibitor Multiple ovarian cancer t Trypan Blue, sodium salt N,N-Dimethylformamide, HP Auranofin C20H34AuO9PS CA
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Prolonged production of C during the ~660 BCE solar proton event from Japanese tree rings.Annual rings record the intensity of cosmic rays (CRs) that had entered into the Earth's atmosphere. Several rapid C increases in the past, such as the 775 CE and 994CE C spikes, have been reported to originate from extreme solar proton events (SPEs). Another rapid C increase, also known as the ca. 660 BCE event in German oak tree rings as well as increases of Be and Cl in ice cores, was presumed similar to the 775 CE event; however, as the C increase of approximately 10‰ in 660 BCE had taken a rather longer rise time of 3-4 years as compared to that of the 775 CE event, the occurrence could not be simply associated to an extreme SPE. In this study, to elucidate the rapid increase in C concentrations in tree rings around 660 BCE, we have precisely measured the C concentrations of earlywoods and latewoods inside the annual rings of Japanese cedar for the period 669-633 BCE. Based on the feature of C production rate calculated from the fine measured profile of the C concentrations, we found that the C rapid increase occurred within 665-663.5 BCE, and that duration of C production describing the event is distributed from one month to 41 months. The possibility of occurrence of consecutive SPEs over up to three years is offered.
1874 related Products with: Prolonged production of C during the ~660 BCE solar proton event from Japanese tree rings.Pfu DNA Polymerase protei 2',7' Bis(2 carboxyethyl) Normal mouse multiple org MultiGene Gradient therm 2-Amino-5-benzoyl-1-methy FDA Standard Frozen Tissu Multiple organ tumor tiss Recombinant Human BCEI TF FDA Standard Frozen Tissu Normal rat multiple organ Thermal Shaker with cooli Custom Polyclonal Antibod
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Comparison of multiple algorithms to reliably detect structural variants in pears.Structural variations (SVs) have been reported to play an important role in genetic diversity and trait regulation. Many computer algorithms detecting SVs have recently been developed, but the use of multiple algorithms to detect high-confidence SVs has not been studied. The most suitable sequencing depth for detecting SVs in pear is also not known.
2219 related Products with: Comparison of multiple algorithms to reliably detect structural variants in pears.MarkerGeneTM Carbohydrate Multiple organ stromal tu Multiple head and neck tu Multiple organ diseased t FDA Standard Frozen Tissu Multiple cancer tissue ar Multiple organ tumor tiss Multiple stomach cancer t Inflammation (Human) Quan Multiple organ cancer and Frozen multiple human org Influenza B (B Tokio 53 9
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Stable Lithium Storage in Nitrogen-Doped Carbon-Coated Ferric Oxide Yolk-Shell Nanospindles with Preserved Hollow Space.Iron oxide (Fe O ) is a promising anode material for next-generation high-energy lithium-ion batteries owing to its high theoretical specific capacity, but it suffers from unstable electrochemistry, as represented by a significant volume variation upon (de)lithiation and unstable solid-electrolyte interface. To target these issues, a double-coating synthetic route has been developed to prepare a yolk-shell-structured γ-Fe O /nitrogen-doped carbon composite, in which spindle-like γ-Fe O cores are encapsulated in the highly conductive carbon shell. Through precisely controlling the void space between the γ-Fe O core and the carbon shell, volume variation in γ-Fe O during (de)lithiation is well accommodated, while the composite maintains an intact and relatively dense structure, which stabilizes the solid-electrolyte interface and is beneficial for improving the practical energy density of the material. With a stabilized (de)lithiation electrochemistry and a synergistic storage effect between the two active components, the composite enables excellent lithium storage performance, in terms of reversible capacity, cycling ability, and rate capability.
2180 related Products with: Stable Lithium Storage in Nitrogen-Doped Carbon-Coated Ferric Oxide Yolk-Shell Nanospindles with Preserved Hollow Space.Syringe pump can be contr Rat inducible nitric oxid Rabbit Anti-Nitric Oxide ELECTROLYTES Lithium Ion Cytokine (Human) Antibody Goat Anti- NOTCH2, (inter Late stage ovarian tumor Rabbit Anti-Integrin alph D,L-7-Aza-3-indolylglycin MAPK8 & RHOA Protein Prot Stomach cancer and normal Recombinant Porcine Inter
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Anion recognition by neutral chalcogen bonding receptors: experimental and theoretical investigation.The utilization of neutral receptors for the molecular recognition of anions based on chalcogen bonding (ChB) is an undeveloped area of host-guest chemistry. In this manuscript, the synthesis of two new families of sulfur, selenium and tellurium-based ChB binding motifs are reported. The stability of the thiophene, selenophene and tellurophene binding motifs has enabled the determination of association constants for ChB halide anion binding in the polar aprotic solvent THF by 1 H-, 77 Se- and 125 Te-NMR experiments. We have used two different aromatic cores and incorporated one or two Ch-binding motifs with the purpose to encapsulate the anion offering up to two concurrent chalcogen bonds. Theoretical calculations and NMR experiments reveal that, for S and Se receptors, hydrogen bonding interactions involving the acidic H-atom adjacent to the chalcogen atom are energetically favored over the ChB interaction. However, for the tellurophene binding motif, the σ-hole interaction is competitive and more favored than the H-bond.
2144 related Products with: Anion recognition by neutral chalcogen bonding receptors: experimental and theoretical investigation.Androgen Receptor (Phosph Androgen Receptor Androgen Receptor , Mouse CD10, CALLA (Neutral End (5α,16β)-N-Acetyl-16-[2 anti CD16 monoclonal anti (5α)-Androst-2-en-17-one anti CD7 All T cells Reco 1,4 Androstadiene 3,17 di anti Cortical thymocytes ELISA 5α-Androstane-3α, Nuclear Membrane Receptor
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