%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
2013-10-23T20:46:15+03:00
2013-10-23T20:46:15+03:00
2013-10-23T20:46:15+03:00
application/pdf
bs-0681R-PE-Cy7
uuid:4c33617b-71a2-45b0-8170-59a4ade5e2b3
uuid:78c5c139-5105-488f-bfcc-e46cc84f2521
Acrobat Web Capture 9.0
endstream
endobj
5 0 obj
<>
endobj
6 0 obj
<>
endobj
3 0 obj
<>
endobj
7 0 obj
<>
endobj
11 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/XObject<>>>/Type/Page>>
endobj
12 0 obj
[31 0 R]
endobj
13 0 obj
<>stream
/CS0 cs 1 scn
10 815.396 574.5 -729.984 re
f
BT
0.2 scn
/TT0 1 Tf
6.5883 0 0 6.5883 21.2001 767.3016 Tm
(www.biossusa.com)Tj
0 -1.5 TD
(support@biossusa.com)Tj
-0.012 Tw T*
[(800.501.7654)-34( )1([DOMESTIC])]TJ
0 -1.5 TD
[(+1.781.569.5821)-57( )1([INTERNATIONAL])]TJ
ET
q
/GS0 gs
140.3308563 0 0 -79.0596313 444.1691589 810.1255951 cm
/Im0 Do
Q
BT
0 scn
/TT1 1 Tf
0 Tw 9.2236 0 0 9.2236 21.2001 715.9128 Tm
[(bs)-67(-)-69(0681R)-12(-)-69(PE)-14(-)-69(Cy7)]TJ
/TT0 1 Tf
-0.04 Tw 7.2471 0 0 7.2471 28.4472 669.7947 Tm
[(Conjugated)-58( Primary)-1( Antibodies)]TJ
/TT1 1 Tf
0 Tw 0 -2.091 TD
(Background:)Tj
/TT0 1 Tf
-0.04 Tw 0 -1.455 TD
[(The)-59( insulin)-11( receptor)-64( is)-52( a)-20( heterotetrameric)-22( membrane)-90( glycoprotein)-68( with)-46( tyrosine)-51(-)-1(protein)-79( kinase)-36( activity,)-44( consisting)]TJ
0 -1.455 TD
[(of)-48( disulfide)-86(-)-1(linked)-43( subunits)-45( in)-31( a)-20( beta)-62(-)-1(alpha)-65(-)-1(alpha)-65(-)-1(beta)-62( configuration.)-19( The)-59( beta)-62( subunit)-37( possesses)-76( a)-20( single)]TJ
0 -1.455 TD
[(transmembrane)-49( domain,)-85( whereas)-44( the)-36( alpha)-64( subunit)-37( is)-52( completely)-79( extracellular.)-67( The)-59( alpha)-64( chains)-41( contribute)-89( to)]TJ
0 -1.455 TD
[(the)-37( formation)-23( of)-48( the)-37( ligand)-80(-)-1(binding)-40( domain,)-85( while)-80( the)-36( beta)-62( chains)-41( carry)-69( the)-37( kinase)-36( domain.)-85( Binding)-4( of)-48( insulin)-11( to)]TJ
0 -1.455 TD
[(the)-37( insulin)-11( receptor)-64( stimulates)-78( its)-82( association)-70( with)-46( downstream)-27( mediators)-8( including)-72( IRS1)-85( and phosphatidylinositol)]TJ
T*
[(3')-61(-)-1(kinase)-36( \(PI3K\))-85( which)-88( leads)-85( to)-32( glucose)-48( uptake.)-67( Two)-40( transcript)-22( variants)-70( encoding)-19( different)-5( isoforms)-2( have)-75( been)]TJ
0 -1.455 TD
[(found)-15( for)-52( this)-69( gene)-19( produced)-75( by)-40( alternative)-83( splicing.)]TJ
0 -2.909 TD
[(Protein)-81( kinases)-45( are)-43( enzymes)-71( that)-67( transfer)-27( a)-20( phosphate)-40( group)-69( from)-30( a)-20( phosphate)-40( donor,)-49( generally)-87( the)-37( g)]TJ
0 -1.455 TD
[(phosphate)-40( of)-48( ATP,)-53( onto)-22( an)-8( acceptor)-55( amino)-32( acid)-50( in)-31( a)-20( substrate)-9( protein.)-48( By)-4( this)-69( basic)-59( mechanism,)-78( protein)-79( kinases)]TJ
0 -1.455 TD
[(mediate)-12( most)-19( of)-48( the)-37( signal)-5( transduction)-86( in)-31( eukaryotic)-13( cells,)-79( regulating)-29( cellular)-65( metabolism,)-86( transcription,)-25( cell)-10( cycle)]TJ
0 -1.455 TD
[(progression,)-35( cytoskeletal)-33( rearrangement)-85( and cell)-9( movement,)-32( apoptosis,)-70( and differentiation.)-12( With)-68( more)-4( than)-25( 500)]TJ
0 -1.455 TD
[(gene)-19( products,)-71( the)-36( protein)-79( kinase)-36( family)-88( is)-52( one)-9( of)-48( the)-36( largest)-27( families)-22( of)-48( proteins)-87( in)-31( eukaryotes.)-65( The)-59( family)-88( has)]TJ
0 -1.455 TD
[(been)-19( classified)-38( in)-31( 8)-90( major)-86( groups)-78( based)-33( on)-81( sequence)-28( comparison)-33( of)-48( their)-84( tyrosine)-51( \(PTK\))-56( or)-6( serine/threonine)]TJ
0 -1.455 TD
[(\(STK\))-50( kinase)-36( catalytic)-40( domains.)-3( The)-59( tyrosine)-51( kinase)-36( \(TK\))-62( group)-69( is)-52( mainly)-30( involved)-2( in)-31( the)-36( regulation)-40( of)-48( cell)-9(-)-1(cell)]TJ
0 -1.455 TD
[(interactions)-79( such)-68( as)-29( differentiation,)-11( adhesion,)-32( motility)-37( and death.)-19( There)-82( are)-44( currently)-25( about)-32( 90)-90( TK)-10( genes)]TJ
0 -1.455 TD
[(sequenced,)-81( 58)-90( are)-43( of)-48( receptor)-64( protein)-79( TK)-10( \(e.g.)-23( EGFR,)-54( EPH,)-1( FGFR,)-3( PDGFR,)-23( TRK,)-86( and VEGFR)-33( families\),)-63( and 32)-90( of)]TJ
0 -1.455 TD
[(cytosolic)-74( TK)-10( \(e.g.)-23( ABL,)-10( FAK,)-79( JAK,)-1( and SRC)-39( families\).)]TJ
/TT1 1 Tf
0 Tw 0 -1.909 TD
(Purification:)Tj
/TT0 1 Tf
-0.04 Tw 6.727 -0.091 Td
[(Was)-36( purified)-38( by)-40( Protein)-81( A)-36( and peptide)-90( affinity)-82( chromatography.)]TJ
/TT1 1 Tf
0 Tw -6.727 -2 Td
(Storage:)Tj
/TT0 1 Tf
-0.04 Tw 0 -1.455 TD
[(Aqueous)-34( buffered)-15( solution)-14( containing)-88( 100ug/ml)-73( BSA,)-42( 50%)-22( glycerol)-55( and less)-80( than)-25( 0.09%)-82( sodium)-13( azide.)-56( Store)-44( at)-50( -)]TJ
T*
[(20\260C)-18( for)-52( 12)-90( months.)-54( Protect)-73( from)-30( light.)-67( [Product)-75( without)-66( BSA)-72( and/or)-79( sodium)-13( azide)-87( is)-52( available)-70( for)-52( special)-31( order.])]TJ
/TT1 1 Tf
0 Tw 0 -1.909 TD
(Reconstitution:)Tj
/TT0 1 Tf
-0.04 Tw 0 -1.455 TD
[(If)-36( the)-36( antibody)-25( is)-52( in)-31( liquid)-13( form,)-91( no)-81( reconstitution)-78( needed.)]TJ
0 -2.909 TD
[(Reconstitution)-90( is)-52( only)-81( required)-62( for)-52( the)-37( lyophilized)-45( antibody.)-86( Please)-15( refer)-92( to)-32( the)-37( reconstitution)-78( instruction)-26( card)-10( in)]TJ
0 -1.455 TD
[(the)-37( package.)]TJ
/TT1 1 Tf
0 Tw 54.182 45.818 Td
(Size:)Tj
/TT0 1 Tf
3 -0.091 Td
(100ul)Tj
/TT1 1 Tf
-3 -2.818 Td
(Concentration:)Tj
/TT0 1 Tf
8.091 -0.091 Td
(1ug/uL)Tj
/TT1 1 Tf
-8.091 -2.818 Td
(Host:)Tj
/TT0 1 Tf
3.273 -0.091 Td
(Rabbit)Tj
/TT1 1 Tf
-3.273 -1.909 Td
(Reactivities:)Tj
0.2 scn
/TT0 1 Tf
6.5883 0 0 6.5883 421.1101 624.3354 Tm
(Human,Mouse,Rat,Chicken,Dog,Bovine,Rabbit,Sheep,)Tj
0 scn
/TT1 1 Tf
7.2471 0 0 7.2471 421.1101 610.5 Tm
(Application:)Tj
ET
q
10 36 575 780 re
W n
q 1 0 0 1 430.9926 593.041 cm
0 0 m
0 1.318 -1.977 1.318 -1.977 0 c
-1.977 -1.318 0 -1.318 0 0 c
f
Q
Q
BT
/TT0 1 Tf
7.2471 0 0 7.2471 437.5808 591.3939 Tm
[(IF\(1:100)-3(-)-1(500\))]TJ
ET
q
10 36 575 780 re
W n
q 1 0 0 1 430.9926 582.4998 cm
0 0 m
0 1.318 -1.977 1.318 -1.977 0 c
-1.977 -1.318 0 -1.318 0 0 c
f
Q
Q
BT
/TT0 1 Tf
-0.04 Tw 7.2471 0 0 7.2471 437.5808 580.8527 Tm
[(Not)-1( yet)-6( tested)-8( in)-31( other)-43( applications.)]TJ
0 -1.455 TD
[(Optimal)-36( working)-62( dilutions)-48( must)-4( be)]TJ
0 -1.455 TD
[(determined)-86( by)-40( the)-36( end)-90( user.)]TJ
/TT1 1 Tf
-0.02 Tw -2.273 -3.818 Td
[(Antibody)-48( Type:)]TJ
/TT0 1 Tf
0 Tw 8.182 -0.091 Td
(Polyclonal)Tj
/TT1 1 Tf
-8.182 -1.909 Td
(Isotype:)Tj
0.2 scn
/TT0 1 Tf
6.5883 0 0 6.5883 463.9341 517.6049 Tm
(IgG)Tj
0 scn
/TT1 1 Tf
-0.02 Tw 7.2471 0 0 7.2471 421.1101 503.7695 Tm
[(Molecular)-1( Weight:)]TJ
0.2 scn
/TT0 1 Tf
0 Tw 6.5883 0 0 6.5883 499.5109 503.7695 Tm
(165kDa)Tj
0 scn
/TT1 1 Tf
7.2471 0 0 7.2471 421.1101 489.9341 Tm
(Note:)Tj
/TT0 1 Tf
0.021 Tw 5.9295 0 0 5.9295 421.1101 462.922 Tm
[(For)-20( )1(research)-16( )1(use)-25( )1(only.)-91( )1(CAUTION:)-13( )1(Not)-12( )1(for)-1( )1(human)-72( )1(or)]TJ
0 -1.333 TD
[(animal)-94( )1(therapeutic)-36( )1(or)-97( )1(diagnostic)-13( )1(use.)]TJ
ET
q
/GS0 gs
560.005722 0 0 -0.6588287 19.8824615 707.3480682 cm
/Im1 Do
Q
BT
/TT0 1 Tf
0 Tw 10.5413 0 0 10.5413 21.2001 87.3888 Tm
( )Tj
ET
q
10 36 575 780 re
W n
/CS3 cs 0.302 0.306 0.333 scn
q 1 0 0 1 19.2236 692.1949 cm
0 0 m
0 1.757 -2.635 1.757 -2.635 0 c
-2.635 -1.757 0 -1.757 0 0 c
f
Q
Q
BT
/CS3 cs 0.302 0.306 0.333 scn
/TT1 1 Tf
-0.007 Tw 9.2236 0 0 9.2236 28.4472 689.5596 Tm
[(Rabbit)-50( Anti)-28(-)-69(Insulin)-49( Receptor)-34( Polyclonal)-4( Antibody,)-47( PE)-14(-)-69(Cy7)-48( conjugated)]TJ
ET
q
/GS0 gs
98.8245392 0 0 -74.4478149 25.1530914 342.3560944 cm
/Im2 Do
Q
BT
/CS0 cs 0 scn
/TT0 1 Tf
0 Tw 10.5413 0 0 10.5413 25.1531 258.6846 Tm
( )Tj
12.062 0 Td
( )Tj
12.125 0 Td
( )Tj
-24.187 -2.25 Td
( )Tj
12.062 0 Td
( )Tj
12.125 0 Td
( )Tj
-24.187 -2.25 Td
( )Tj
12.062 0 Td
( )Tj
12.125 0 Td
( )Tj
-0.04 Tw 7.2471 0 0 7.2471 26.4708 179.625 Tm
[(For)-31( full)-30( size)-82( images)-63( and description)-26( please)-13( click)-31( )]TJ
/CS3 cs 0 0.6 0.8 scn
0 Tw 6.5883 0 0 6.5883 179.3194 179.625 Tm
(HERE)Tj
/CS0 cs 0 scn
7.2471 0 0 7.2471 195.7901 179.625 Tm
(.)Tj
ET
q
/GS0 gs
0.6588287 0 0 -592.9472351 407.2746582 706.6892242 cm
/Im3 Do
Q
q
/GS0 gs
5.9294739 0 0 -40.1886444 578.5705414 125.6009216 cm
/Im4 Do
Q
endstream
endobj
14 0 obj
<>
endobj
15 0 obj
(gW@'Ӂ{MA)
endobj
26 0 obj
<>stream
Hy\E323#3
P̴,HLEK"+E+2VTD%EH# }wfwfvvc_3?{feޝ@HHHHHH*豘V]
zן)@-9.q2BÇEڂ8g "2vn>u2]/Yz \S@ 7.M&p?o9v 0'rKś-;(Au.J%% %&˶0>6`TxOzzo(VDY*AZp ËgAs^.㮌+2Ȱ$E['FC:OMCIVVDD3}`u߈buߨɴ4қԭV^V0XF ϓ@i|Y|.?i'3}Ŵ+ޘaa:
3g},F"kNɳՕx57,H)X7*v/Mո+(fWr=WӃJcߓtG16sPt:t"9G
if
3do\ˢ|c:1&<ЭWnPdq0IRgu~惘n9BWV2T6~}rs4h-D.sgV/n3;q@hThI*jTJqJK2c!QT7;60
5NoJݻ'rBP%ȍ4
P(/CJC1
9eڴ}5S{"wty@P5e*Zg~?S(Sɗ,ʽv 2[̋t_Z\d&}/2YϹO&y#
?P>,0P-
asds[U꼩\=T~)S>B,gk$7+j0?60<&uźg
A]_@en%Mȝ~5PSu$^2s0RSPw L9٦n9$vڣ=f#g 7,Oa
:ܾ.4+H!=MvF(G|YU
ITR)>@✧*[j5KoB{Kp,`姙$JO궒jvż@r3`w\A%jSx+>m;5ا@._1:T#q]wrTC8r:lU4P}~Y]XwJ~b:YQϗLP-X_ֻа2$ݥC=~P]VҘLhu?S'\C:7"4dD*%9 Ogfe\OLoTy5Qkj.84,: t:_YON3˃:O/r犁3t!Psbty{aETu7nMѶ f+^Y6zHic?R%+C,γL =ZJ1H+,x^
I!u2{5x_@LI6[w5LN5:xXoEgf9tu=yùw=aґza*҃K`驪eP/y*sσn3N{ME\8g: *fz#W??L