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#32650356   2020/07/03 To Up

Covid-19: A systemic disease treated with a wide-ranging approach: A case report.

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Rosanna Massabeti, Maria Stella Cipriani, Ivana Valenti

2486 related Products with: Covid-19: A systemic disease treated with a wide-ranging approach: A case report.



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#32650355   2020/06/27 To Up

Antirheumatic drugs for COVID-19 treatment based on the phases of the disease: Current concept.

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Marco Valentini, Hassan Zmerly

2844 related Products with: Antirheumatic drugs for COVID-19 treatment based on the phases of the disease: Current concept.

1100.1 mg100 IU1 ml500 Units11

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#32650354   2020/06/29 To Up

Obesity and Higher Risk for Severe Complications of Covid-19: What to do when the two pandemics meet.

The coronavirus disease 2019 (COVID-19) pandemic has spread around the globe, infecting more than ten million individuals, with more than 500,000 dead; about one half of the infected people have recovered. Despite this fact, a subgroup of individuals affected by COVID-19 is at greater risk of developing worse outcomes and experience a high rate of mortality. Data on the association between obesity and COVID-19 are growing; the available studies, have reported a high prevalence of overweight and obesity in patients experiencing a severe COVID-19 course, with serious complications requiring hospitalization and admission to intensive care units. This paper attempts to highlight potential mechanisms behind the greater vulnerability to COVID-19 of individuals with obesity. The presence of uncontrolled chronic obesity-related comorbidities, particularly pulmonary diseases, can present a primary fertile soil for respiratory tract infection. Combined with immune system impairments, such as alteration in the T-cell proliferation and macrophage differentiation, and the high pro-inflammatory cytokine production by the adipose organ, this may worsen the general condition toward a systemic diffusion of infection. Prevention remains the first line of intervention in these patients that can be achieved by adhering to social distancing and adopting hygiene precautions, combined with a healthy lifestyle. Patients with obesity require preferential access dedicated to primary care services to ensure they are regularly taking their medications for the treatment of any concurrent chronic diseases. Finally, their physicians must promptly manage any medical signs or symptoms in the case of suspected severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) infection to prevent the risk of severe outcomes.
Alessandra Valerio, Enzo Nisoli, Andrea P Rossi, Massimo Pellegrini, Tiziana Todesco, Marwan El Ghoch

2526 related Products with: Obesity and Higher Risk for Severe Complications of Covid-19: What to do when the two pandemics meet.

100μg 1 G100μg100μg100gm 25 MG

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#32650344   2020/07/10 To Up

Current Insights into Exercise-based Cardiac Rehabilitation in Patients with Coronary Heart Disease and Chronic Heart Failure.

Cardiac rehabilitation is a package of lifestyle secondary prevention strategies designed for patients with coronary heart disease and chronic heart failure. A community-based cardiac rehabilitation programme provides patients with a structured exercise training intervention alongside educational support and psychological counselling. This review provides an update regarding the clinical benefits of community-based cardiac rehabilitation from a psycho-physiological perspective, and also focuses on the latest epidemiological evidence regarding potential survival benefits. Behaviour change is key to long-term adoption of a healthy and active lifestyle following a cardiac event. In order for lifestyle interventions such as structured exercise interventions to be adopted by patients, practitioners need to ensure that behaviour change programmes are mapped against patient's priorities and values, and adapted to their level of readiness and intention to engage with the target behaviour. We review the evidence regarding behaviour change strategies for cardiac patients and provide practitioners with the latest guidance. The 'dose' of exercise training delivered to patients attending exercise-based cardiac rehabilitation is an important consideration because an improvement in peak oxygen uptake requires an adequate physiological stimulus to invoke positive physiological adaptation. We conclude by critically reviewing the latest evidence regarding exercise dose for cardiac patients including the role of traditional and more contemporary training interventions including high intensity interval training.
Simon Nichols, Gordon McGregor, Jeff Breckon, Lee Ingle

2467 related Products with: Current Insights into Exercise-based Cardiac Rehabilitation in Patients with Coronary Heart Disease and Chronic Heart Failure.

100 UG 50 UG30 reactions1.0 mg500 tests50 µg

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#32650341   2020/07/10 To Up

Defining EUS Features of Chronic Pancreatitis in Asians - A Multicentre Validation Study.

INTRODUCTION Although EUS features and criteria have been described in chronic pancreatitis, challenges remain with inter-operator variability and ease of adoption. AIMS The aim of the study was to define and validate EUS features of chronic pancreatitis in a multi-center prospective study in Asia. METHOD The study was conducted in 2 phases. In phase I, expert endosonographers across Asia reviewed standardized EUS videos of the pancreas for features diagnostic for chronic pancreatitis. Features that had good overall interobserver agreement were selected to derive EUS features for the diagnosis of chronic pancreatitis in Asians in a multi-centre case-control phase II study. Prospectively-enrolled cases had standard internationally validated radiologic or histologic features of chronic pancreatitis, and controls were patients without chronic pancreatitis who underwent EUS examination. RESULTS The top 6 EUS features that had good interobserver agreement (mean kappa = 0.73; range 0.60-0.90) were selected to be further evaluated in phase II study. These included: hyper-echoic foci with shadowing, lobularity with honeycombing, cysts, dilated ducts, dilated side branches, and calculi in main pancreatic duct. 284 subjects (132 cases, 152 controls) were enrolled from 12 centres in Asia. All 6 features had high accuracy ranging from 63.3% to 89.1%. 2 or more of these 6 EUS features accurately defined chronic pancreatitis (sensitivity 94.7% specificity 98.0%), with an AUROC of 0.986. CONCLUSION This is a multicentre Asian study that characterizes and defines the EUS features of chronic pancreatitis. This provides a useful tool in clinical practice and further research in pancreatic cancer surveillance.
Calvin Koh, Sundeep Lakhtakia, Mitsuhiro Kida, Cosmas Rinaldi Lesmana, Tiing Ang, Charles K F Vu, Than Aye Than, Sun Hwa Park, Majid Almadi, Charing Chong, Raymond Tang, Xi Wu, Hilmi Ida, Vinay Dhir, Nonthalee Pausawasdi, Basha Jahangeer, Zhendong Jin, Ai-Ming Yang, Anthony Teoh, Dong Wan Seo, Hsiu-Po Wang, Khek-Yu Ho

1183 related Products with: Defining EUS Features of Chronic Pancreatitis in Asians - A Multicentre Validation Study.

50 UG1 Set1 Set

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#32650339   2020/07/10 To Up

Variability in patient sociodemographics, clinical characteristics, and healthcare service utilization among 107,302 treatment seeking smokers in Ontario: A cross-sectional comparison.

Since 2005, the Smoking Treatment for Ontario Patients (STOP) program has provided smoking cessation treatment of varying form and intensity to smokers through 11 distinct treatment models, either in-person at partnering healthcare organizations or remotely via web or telephone. We aimed to characterize the patient populations reached by different treatment models.
Dolly Baliunas, Laurie Zawertailo, Sabrina Voci, Evgenia Gatov, Susan J Bondy, Longdi Fu, Peter L Selby

1245 related Products with: Variability in patient sociodemographics, clinical characteristics, and healthcare service utilization among 107,302 treatment seeking smokers in Ontario: A cross-sectional comparison.



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#32650338   2020/07/10 To Up

Structural basis for RIFIN-mediated activation of LILRB1 in malaria.

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Thomas E Harrison, Alexander M Mørch, James H Felce, Akihito Sakoguchi, Adam J Reid, Hisashi Arase, Michael L Dustin, Matthew K Higgins

1718 related Products with: Structural basis for RIFIN-mediated activation of LILRB1 in malaria.

2 mg500 MG100μg 100 G100ug25 Bags/Unit250 mg 1 G100ug500 tests500 tests 1 G

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#32650324   2020/07/10 To Up

Biofabrication of endothelial cell, dermal fibroblast, and multilayered keratinocyte layers for skin tissue engineering.

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Natan Barros, Hanjun Kim, Marcus J Goudie, KangJu Lee, Praveen Bandaru, Ethan A Banton, Einollah Sarikhani, Wujin Sun, Shiming Zhang, Hyun-Jong Cho, Martin C Hartel, Serge Ostrovidov, Samad Ahadian, Saber Hussain, Nureddin Ashammakhi, Mehmet R Dokmeci, Rondinelli Donizetti Herculano, Junmin Lee, Ali Khademhosseini

1807 related Products with: Biofabrication of endothelial cell, dermal fibroblast, and multilayered keratinocyte layers for skin tissue engineering.

50 assays

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#32650312   2020/07/10 To Up

International electives in neurological surgery training: a survey of program directors from Accreditation Council for Graduate Medical Education-approved neurological surgery programs.

The burden of neurosurgical disease in low- and middle-income countries (LMICs) has emerged as a significant factor in global health. Additionally, calls have been growing for first-world neurosurgeons to find ways to help address the international need. Allowing residents to pursue international elective opportunities in LMICs can help alleviate the burden while also providing unique educational opportunities. However, pursuing international work while in residency requires overcoming significant logistical and regulatory barriers. To better understand the general perspectives, perceived barriers, and current availability of international rotations, a survey was sent out to program directors at Accreditation Council for Graduate Medical Education (ACGME)-approved residencies.
Christopher Miller, Paige Lundy, Sarah Woodrow

2371 related Products with: International electives in neurological surgery training: a survey of program directors from Accreditation Council for Graduate Medical Education-approved neurological surgery programs.



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#32650308   2020/07/10 To Up

Quality-of-life trajectories after stereotactic radiosurgery for brain metastases.

Quality of life (QOL) is an important endpoint measure of cancer treatment. The authors' goal was to evaluate QOL trajectories and prognostic value in cancer patients treated with stereotactic radiosurgery (SRS) for brain metastases.
Adomas Bunevicius, Karen Lavezzo, Leah Shabo, Jesse McClure, Jason P Sheehan

1758 related Products with: Quality-of-life trajectories after stereotactic radiosurgery for brain metastases.

1000 ml 1 G2ug100 ml100μg100ug500 100ug50ug

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