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#39502458   2024/10/18 To Up

Rapidly progressive central retinal pigmented epithelium atrophy after Ivospemin (SBP-101) treatment for pancreatic adenocarcinoma.

We report a case of retinal toxicity induced by SBP-101, a polyamine inhibitor for the treatment of metastatic pancreatic adenocarcinoma, presenting as rapidly progressive bilateral central retinal pigmented epithelium (RPE) atrophy in a patient with a silent ocular history.
Matteo Mario Carlà, Carlos Mateo

1288 related Products with: Rapidly progressive central retinal pigmented epithelium atrophy after Ivospemin (SBP-101) treatment for pancreatic adenocarcinoma.

25 μg50 assays100μg50ul10 mg1.00 flask 1000 ml 50 UG

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#39498180   2024/09/01 To Up

A case of mixed neuroendocrine carcinoma-acinar adenocarcinoma: Utilization of triplet therapy for prostate cancer.

Neuroendocrine prostate cancer is an aggressive histological subtype of prostate cancer with a poor prognosis. Neuroendocrine prostate cancer is traditionally treated with cisplatin-based chemotherapy, similar to that used in treating small-cell lung cancer. However, the therapeutic effectiveness of chemotherapy for neuroendocrine prostate cancer has been limited. This case report describes a response to triplet therapy using darolutamide, androgen deprivation therapy, and docetaxel, which was administered in a patient with mixed neuroendocrine prostate cancer.
Junichi Ikeda, Hisanori Taniguchi, Hiroki Takayama, Yuki Masuo, Takahiro Nakamoto, Katsunori Uchida, Hidefumi Kinoshita

2795 related Products with: A case of mixed neuroendocrine carcinoma-acinar adenocarcinoma: Utilization of triplet therapy for prostate cancer.



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#39495073   2024/11/04 To Up

A microarray-based IgE-molecular mimicry index (IgE-MMI): A biomarker for disease severity, clinical phenotypes, and therapeutic response in atopic dermatitis?

The role of autoimmune IgE responses in atopic dermatitis (AD) is highly debated. While IgE targeting self-proteins has been extensively studied, IgE responses induced by human-homologous exogenous molecular allergens (HEMAs) remains less understood.
Enrico Scala, Stefania Madonna, Damiano Abeni, Lorenzo Cecchi, Barbara Cocuroccia, Anna Dattolo, Gaia Moretta, Alessia Provini, Filomena Russo, Donatella Sordi, Sabatino Pallotta, Marco Galluzzo, Marina Talamonti, Valeria Villella, Mauro Giani, Elisabetta Caprini, Cristina Albanesi, Danilo Villalta, Riccardo Asero, Paolo Maria Matricardi

1967 related Products with: A microarray-based IgE-molecular mimicry index (IgE-MMI): A biomarker for disease severity, clinical phenotypes, and therapeutic response in atopic dermatitis?

1ml

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#39488928   2024/10/21 To Up

The important role of the Wnt/β-catenin signaling pathway in small molecules mediated gingival mesenchymal stem cells transdifferentiate into neuron-like cells.

Given their neural crest origin, gingival mesenchymal stem cells (GMSCs) possess high neurogenic potential, which makes them suitable for cell replacement therapy against neurodegenerative diseases. This study investigated whether GMSCs can be transdifferentiated into neurons in vitro using a protocol involving small molecules VCRFY (VPA, CHIR99021, Repsox, Forskolin, and Y-27632). The regulatory mechanisms of key signaling pathways were also investigated.
Qiuying Liang, Chuhan Zhang, Peiyi Lv, Yongmao Huang, Hang Zhao, Shan Jiang, Wenan Xu

1227 related Products with: The important role of the Wnt/β-catenin signaling pathway in small molecules mediated gingival mesenchymal stem cells transdifferentiate into neuron-like cells.

150 ug1.5x10(6) cells5 x 10A5 cells/vial1.00 flask1 mg10 ug1.5 x 10^6 cells5 x 50 ug1x10e7 cells1

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#39483155   2024/10/19 To Up

ENO1 as a Biomarker of Breast Cancer Progression and Metastasis: A Bioinformatic Approach Using Available Databases.

Metabolic reprogramming is one of the hallmarks of cancer, and in breast cancer (BC), several metabolic enzymes are overexpressed and overactivated. One of these, Enolase 1 (ENO1), catalyses glycolysis and is involved in the regulation of multiple signalling pathways.
Athina Giannoudis, Alistair Heath, Vijay Sharma

2271 related Products with: ENO1 as a Biomarker of Breast Cancer Progression and Metastasis: A Bioinformatic Approach Using Available Databases.



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#39486769   2024/10/30 To Up

HS protects rat cerebral ischemia-reperfusion injury by inhibiting expression and activation of hippocampal ROCK at the Thr436 and Ser575 sites.

HS is an endogenous gas signal molecule, which protects cerebral ischemia/reperfusion (I/R) injury by phosphorylating rho-associated coiled coil-containing protein kinase 2 (ROCK) at Tyr722, and inhibiting ROCK protein expression and activities. We previously reported that HS protected rat neurons from hypoxia/reoxygenation injury in vitro through inhibiting phosphorylation of ROCK at Thr436 and Ser575, but it is unclear whether these two sites are involved in protection of HS against cerebral I/R injury.
Fang Fang, Yi-Ning Guan, Mei-Jing Zhong, Ji-Yue Wen, Zhi-Wu Chen

1682 related Products with: HS protects rat cerebral ischemia-reperfusion injury by inhibiting expression and activation of hippocampal ROCK at the Thr436 and Ser575 sites.

200 5 G100ul10 mg100ul10 mg501 mg

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#39486280   2024/10/24 To Up

Proteomic analysis of wild boar meat: Effect of storage method and time on muscle protein stability.

Oxidation processes affect proteins from various molecular pathways and are crucial for wild boar meat quality, shelf life and human health. This study investigated the effects of different storage methods on the formation and composition of oxygen-induced protein aggregates in the muscles of European wild boar (Sus scrofa scrofa). Vacuum packaging (VAC), modified atmosphere packaging (MAP) and dry-ageing (DA) were compared over a 21-day storage period. The results showed significant differences in protein aggregation depending on the method and storage time. The most intense protein aggregation occurred in the MAP (80 % O), while air DA (20.9 % O) resulted in intermediate levels of protein aggregation. Crucial myofibrillar proteins involved in aggregate formation were titin, myosin isoforms (MYH1, MYH2 and MYH7) and nebulin, which were cross-linked with small sarcoplasmic enzymes, such as muscle creatine kinase, isocitrate dehydrogenase and ATPase 1. High‑oxygen storage conditions also promoted the oxidation of ATP synthase, beta-enolase 3, ADP/ATP translocase and myoglobin.
Natalia Kasałka-Czarna, Anna Stachniuk, Emilia Fornal, Magdalena Montowska

2659 related Products with: Proteomic analysis of wild boar meat: Effect of storage method and time on muscle protein stability.

96 wells100ul1000 TESTS/0.65ml 5 G200ul96 wells50.1 mg1mg100 µg

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#39482176   2024/10/30 To Up

Effect of Intravenous Lidocaine on Postoperative Cognitive Dysfunction in Patients Undergoing General Anesthesia Surgery: A Systematic Review of a Randomized Controlled Trial.

Postoperative cognitive dysfunction (POCD) is a common neurologic complication that occurs after surgery, which prolongs the hospital stay of patients to a certain extent, increases the occurrence of complications, and even leads to the patient's death. Intravenous lidocaine can reduce perioperative inflammatory response in patients undergoing surgery, but its effect on postoperative cognitive function has not been systematically evaluated. Notably, prior findings regarding the impact of intravenous lidocaine on postoperative cognitive function have been variable. Therefore, on this basis, this study explored the effects of intravenous lidocaine on postoperative cognitive function of patients undergoing general anesthesia through a systematic review and meta-analysis.
Xian-Xue Wang, Jing Dai, Hui-Wei Deng, Qi Wang, Yun Liu, Hua-Jing Guo

1167 related Products with: Effect of Intravenous Lidocaine on Postoperative Cognitive Dysfunction in Patients Undergoing General Anesthesia Surgery: A Systematic Review of a Randomized Controlled Trial.

100ug100ug1 Set100 μg1 Set100 μg100 μg100 μg

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