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#34130351   2021/06/15 To Up

Effects of Ultrashort Wave Therapy on Inflammation and Macrophage Polarization after Acute Lung Injury in Rats.

Acute lung injury (ALI) features dysregulated pulmonary inflammation. Ultrashort waves (USWs) exert anti-inflammatory effects but no studies have evaluated their activity in ALI. Herein, we used an in vivo lipopolysaccharide (LPS)-induced ALI model to investigate whether the anti-inflammatory activity of USWs is mediated by altering the polarization of M1 to M2 macrophages. Twenty-four male Sprague-Dawley rats were randomly divided into control, untreated ALI, and ALI treated with USW groups (n = 8 in each group). ALI was induced by intratracheal LPS instillation. Rats in the USW group were treated for 15 min at 0, 4, and 8 h after a single LPS intratracheal instillation. Histopathologic examination, wet/dry lung weight ratio, enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, and western blot analyses were performed to evaluate the degree of lung injury and to determine macrophage phenotypes. Histopathologic examination disclosed attenuation of ALI, with reduced alveolar hemorrhage and neutrophilic infiltration in the USW group. Serum levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were significantly decreased after USW therapy. Moreover, the messenger RNA (mRNA) expressions of TNF-α and IL-1β were significantly decreased in the USW group, whereas the mRNA expression of Arginase 1 (Arg1) and the protein expression of mannose receptor significantly increased in comparison with the untreated ALI group. We conclude that USW therapy may attenuate inflammation in LPS-induced ALI through the modulation of macrophage polarization. © 2021 Bioelectromagnetics Society.
Lan Li, Mengjian Qu, Lu Yang, Jing Liu, Qian Wang, Peirui Zhong, Yahua Zeng, Ting Wang, Hao Xiao, Danni Liu, Xiarong Huang, Jinling Wang, Jun Zhou

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1 mg8 Sample Kit16-22 Sample Kit2ug

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#34130334   2021/06/15 To Up

Drug-Induced Vanishing Bile Duct Syndrome: From Pathogenesis to Diagnosis and Therapeutics.

The most concerned issue in the context of drug/herb-induced chronic cholestasis is vanishing bile duct syndrome. The progressive destruction of intrahepatic bile ducts leading to ductopenia is usually not dose dependent, and has a delayed onset that should be suspected when abnormal serum cholestasis enzyme levels persist despite drug withdrawal. Immune-mediated cholangiocyte injury, direct cholangiocyte damage by drugs or their metabolites once in bile, and sustained exposure to toxic bile salts when biliary epithelium protective defenses are impaired are the main mechanisms of cholangiolar damage. Current therapeutic alternatives are scarce and have not shown consistent beneficial effects so far. This review will summarize the current literature on the main diagnostic tools of ductopenia and its histological features, and the differential diagnostic with other ductopenic diseases. In addition, pathomechanisms will be addressed, as well as the connection between them and the supportive and curative strategies for ductopenia management.
Fernando Bessone, Nidia Hernández, Mario Tanno, Marcelo G Roma

2544 related Products with: Drug-Induced Vanishing Bile Duct Syndrome: From Pathogenesis to Diagnosis and Therapeutics.

1 mg430 tests600 Tests / Kit1 mL430 Tests / Kit0.1 mg 2 ml Ready-to-use 100 MG1 module250ug50 ul

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#34130232   2021/06/10 To Up

Promoting corn stover degradation via sequential processing of steam explosion and cellulase/lactic acid bacteria-assisted ensilage.

To improve the utilization efficiency of corn stover , steam explosion pretreatment and cellulase/lactic acid bacteria-assisted ensilage storage were conducted in sequence, mainly focusing on morphological structure, lignocellulose fraction, cellulose accessibility and degradation profile. The results showed that there was a synergistic effect of steam explosion and ensilage storage, where hemicellulose of corn stover was partly degraded during steam explosion processing (70%) or ensilage storage (20-40%). Meanwhile, its morphological structure was apparently broken, increasing cellulose accessibility (2.44, 2.83, 4.08-4.33 mg/g), where enzyme YDL and inoculant QZB were the two most effective additives. Furthermore, rumen effective degradability of corn stover (39.25%, 48.33%, 52.57-54.07%) were increased along with greater rapid degradation fraction (0, 1.67%, 9.16-11.62%) and degradation rate of slow degradation fraction (0.020, 0.034, 0.039-0.048 h) . In conclusions, it is suggested that treating corn stover with steam explosion processing and ensilage storage is a feasible way to improve its utilization efficiency.
Dechao Nie, Lingyun Yao, Xiaokai Xu, Zhuo Zhang, Yanling Li

2606 related Products with: Promoting corn stover degradation via sequential processing of steam explosion and cellulase/lactic acid bacteria-assisted ensilage.

100 G 100 Slides 100tests10 mg 1 kit(s) 100Tests100 MG1 kg 1 G100 ug/vial25 mg1 mg

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#34130222   2021/05/28 To Up

Lipolytic enzymes and free fatty acids at the endothelial interface.

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Ira J Goldberg, Ainara G Cabodevilla, Dmitri Samovski, Vincenza Cifarelli, Debapriya Basu, Nada A Abumrad

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1,000 tests500gm1kg100100gm500g50gm100g

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#34130217   2021/06/07 To Up

"Clicking" fragment leads to novel dual-binding cholinesterase inhibitors.

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Zuzanna Molęda, Anna Zawadzka, Zbigniew Czarnocki, Leticia Monjas, Anna K H Hirsch, Armand Budzianowski, Jan K Maurin

2417 related Products with: "Clicking" fragment leads to novel dual-binding cholinesterase inhibitors.

1 ml100 µg5 g1 kit(96 Wells)1000 100 ml0.1 mg 2 ml Ready-to-use 0.2 mg1x96 well plate1 module50ug

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#34130214   2021/06/08 To Up

Lectins: Biological significance to biotechnological application.

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Dixita Chettri, Manswama Boro, Lija Sarkar, Anil Kumar Verma

2316 related Products with: Lectins: Biological significance to biotechnological application.

0.1ml (1.3mg/ml) 100ul 100ul50ul25 mg0.5mg50ul 100ul 100ul 100ul 100ul 100ul

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#34130189   2021/06/10 To Up

Study on the influence of advanced treatment processes on the surface properties of polylactic acid for a bio-based circular economy for plastics.

New biotechnological processes using microorganisms and/or enzymes to convert carbonaceous resources, either biomass or depolymerized plastics into a broad range of different bioproducts are recognized for their high potential for reduced energy consumption and reduced GHG emissions. However, the hydrophobicity, high molecular weight, chemical and structural composition of most of them hinders their biodegradation. A solution to reduce the impact of non-biodegradable polymers spread in the environment would be to make them biodegradable. Different approaches are evaluated for enhancing their biodegradation. The aim of this work is to develop and optimize the ultrasonication (US) and UV photodegradation and their combination as well as dielectric barrier discharge (DBD) plasma as pre-treatment technologies, which change surface properties and enhance the biodegradation of plastic by surface oxidation and thus helping bacteria to dock on them. Polylactic acid (PLA) has been chosen as a model polymer to investigate its surface degradation by US, UV, and DBD plasma using surface characterization methods like X-ray Photoelectron Spectroscopy (XPS) and Confocal Laser Microscopy (CLSM), Atomic Force Microscopy (AFM) as well as FT-IR and drop contour analysis. Both US and UV affect the surface properties substantially by eliminating the oxygen content of the polymer but in a different way, while plasma oxidizes the surface.
Georgia Sourkouni, Charalampia Kalogirou, Philipp Moritz, Anna Gödde, Pavlos K Pandis, Oliver Höfft, Stamatina Vouyiouka, Antonis A Zorpas, Christos Argirusis

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