Search results for: esophageal
#32619832 2020/06/27 To Up
Definitive chemoradiotherapy plus cetuximab for cancer in the oesophagus or gastro-oesophageal junction.Chemoradiotherapy is standard treatment for localized oesophageal cancer unsuitable for surgery. We aimed to evaluate the efficacy of cetuximab in combination with chemoradiotherapy.
Gabriella Alexandersson von Döbeln, Gunnar Wagenius, Eva Holtved, Anne-Birgitte Jacobsen, Magnus Nilsson, Jingru Yu, Lene Baeksgaard
2423 related Products with: Definitive chemoradiotherapy plus cetuximab for cancer in the oesophagus or gastro-oesophageal junction.
#32619460 2020/06/30 To Up
TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines.We investigated the transcriptome of esophageal squamous cell carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and the effects of blocking epigenetic regulatory proteins.
Yan-Yi Jiang, Yuan Jiang, Chun-Quan Li, Ying Zhang, Pushkar Dakle, Harvinder Kaur, Jian-Wen Deng, Ruby Yu-Tong Lin, Lin Han, Jian-Jun Xie, Yiwu Yan, Ngan Doan, Yueyuan Zheng, Anand Mayakonda, Masaharu Hazawa, Liang Xu, YanYu Li, Luay Aswad, Maya Jeitany, Deepika Kanojia, Xin-Yuan Guan, Jonathan W Said, Wei Yang, Melissa J Fullwood, De-Chen Lin, H Phillip Koeffler
1697 related Products with: TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines.
#32619324 2020/07/03 To Up
Prevalence of Synchronous ESCN in Head and Neck Cancer: A Single-Institution Perspective.The primary objective was to determine the prevalence of synchronous esophageal squamous cell carcinoma in head and neck squamous cell carcinoma (HNSCC) patients. The secondary objective was to determine risk factors for the development of synchronous esophageal squamous cell carcinoma (ESCN).
Kuldeep Thakur, Chirom A Singh, Alok Thakar, Aanchal Kakkar, Kapil Sikka, Rajeev Kumar, Suresh C Sharma
1423 related Products with: Prevalence of Synchronous ESCN in Head and Neck Cancer: A Single-Institution Perspective.
#32619021 2020/07/03 To Up
A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results in hypersensitivity to a variety of stressors, whereas its aberrant activation contributes to several cancer types, most commonly squamous cell carcinomas of the esophagus, oral cavity, bladder, and lung. Between 10 and 35% of patients with squamous cell carcinomas display hyperactive NRF2 signaling, harboring activating mutations and copy number amplifications of the NFE2L2 oncogene or inactivating mutations or deletions of KEAP1 or CUL3, the proteins of which co-complex to ubiquitylate and degrade NRF2 protein. To better understand the role of NRF2 in tumorigenesis and more broadly in development, we engineered the endogenous Nfe2l2 genomic locus to create a conditional mutant LSL-Nrf2 mouse model. The E79Q mutation, one of the most commonly observed NRF2-activating mutations in human squamous cancers, codes for a mutant protein that does not undergo KEAP1/CUL3-dependent degradation, resulting in its constitutive activity. Expression of NRF2 E79Q protein in keratin 14 (KRT14)-positive murine tissues resulted in hyperplasia of squamous cell tissues of the tongue, forestomach, and esophagus, a stunted body axis, decreased weight, and decreased visceral adipose depots. RNAseq profiling and follow-up validation studies of cultured NRF2 murine esophageal epithelial cells revealed known and novel NRF2-regulated transcriptional programs, including genes associated with squamous cell carcinoma (e.g. Myc), lipid and cellular metabolism (Hk2, Ppard), and growth factors (Areg, Bmp6, Vegfa). These data suggest that in addition to decreasing adipogenesis, KRT14-restricted NRF2 activation drives hyperplasia of the esophagus, forestomach, and tongue, but not formation of squamous cell carcinoma. This article is protected by copyright. All rights reserved.
Brittany M Bowman, Stephanie A Montgomery, Travis P Schrank, Jeremy M Simon, Travis S Ptacek, Tigist Y Tamir, Kathleen M Muvlaney, Seth J Weir, Tuong T Nguyen, Ryan M Murphy, Liza Makowski, D Neil Hayes, Xiaoxin L Chen, Scott H Randell, Bernard E Weissman, Michael B Major
2070 related Products with: A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.100.00 ug
#32618664 // To Up
Opioids Interfere With Deglutitive Inhibition Assessed by Response to Multiple Rapid Swallows During High-Resolution Esophageal Manometry.Normal response to multiple rapid swallows (MRS) during high-resolution esophageal manometry is deglutitive inhibition; opioids may interfere with this. The aim of this study was to evaluate the response to MRS in patients on opioids, not on opioids, and healthy controls.
Diana L Snyder, Luis R Valdovinos, Jennifer Horsley-Silva, Michael D Crowell, Miguel A Valdovinos, Marcelo F Vela
2994 related Products with: Opioids Interfere With Deglutitive Inhibition Assessed by Response to Multiple Rapid Swallows During High-Resolution Esophageal Manometry.400Tests
#32618654 // To Up
Esophageal Histological Precursor Lesions and Subsequent 8.5-Year Cancer Risk in a Population-Based Prospective Study in China.Data on the associations between esophageal histological lesions and risk of esophageal squamous cell carcinoma (ESCC) in general populations are limited. We aimed to investigate these associations in a large Chinese general population to inform future Chinese ESCC screening guidelines.
Wen-Qiang Wei, Chang-Qing Hao, Chen-Tao Guan, Guo-Hui Song, Meng Wang, De-Li Zhao, Bian-Yun Li, Wen-Long Bai, Pei-Yong Hou, Jin-Wu Wang, Guo-Liang Jin, Fu-Hua Lei, Xin-Qing Li, Li-Yan Xue, Guo-Qing Wang, Christian C Abnet, Philip R Taylor, Sanford M Dawsey, You-Lin Qiao
2142 related Products with: Esophageal Histological Precursor Lesions and Subsequent 8.5-Year Cancer Risk in a Population-Based Prospective Study in China.
#32618653 // To Up
The Impact of the Policy-Practice Gap on Costs and Benefits of Barrett's Esophagus Management.Clinical guidelines recommend surveillance of patients with Barrett's esophagus (BE). However, the surveillance intervals in practice are shorter than policy recommendations. We aimed to determine how this policy-practice gap affects the costs and benefits of BE surveillance.
Amir-Houshang Omidvari, Carlijn A M Roumans, Steffie K Naber, Sonja Kroep, Bas P L Wijnhoven, Ate van der Gaast, Pieter-Jan de Jonge, Manon C W Spaander, Iris Lansdorp-Vogelaar
1364 related Products with: The Impact of the Policy-Practice Gap on Costs and Benefits of Barrett's Esophagus Management.1 100ul
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#32618650 // To Up
Overutilization of Endoscopic Surveillance in Barrett's Esophagus: The Perils of Too Much of a Good Thing.A cost-utility analysis in the current issue of AJG examines the ramifications of the overuse of surveillance endoscopy in Barrett's esophagus (BE). This study suggests that excess surveillance is expensive, increasing costs by 50% or more, with only nominal increases in quality-adjusted life expectancy. This study joins a growing literature of cost-utility analyses that suggest that more is not likely better when it comes to surveillance endoscopy. Given the plentiful literature showing overutilization of surveillance endoscopy in BE, the authors argue for a focus on the quality of endoscopy rather than increased frequency of surveillance to improve returns on our healthcare investment.
Cary C Cotton, Nicholas J Shaheen
2940 related Products with: Overutilization of Endoscopic Surveillance in Barrett's Esophagus: The Perils of Too Much of a Good Thing.
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#32618401 2020/07/03 To Up
Upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitis.Chronic idiopathic lymphoplasmacytic rhinitis (CILPR) is a common inflammatory disorder of unknown etiology affecting the nasal cavity of dogs. The diagnosis is made by exclusion of other causes of nasal disease and specific therapeutic protocols are lacking. In human medicine, a relationship between CILPR and gastrointestinal clinical signs has been postulated, and remission of respiratory signs after clinical trials with medications for gastrointestinal disorders has been observed.
Paola Gianella, Silvia Roncone, Ugo Ala, Enrico Bottero, Federica Cagnasso, Giulia Cagnotti, Claudio Bellino
1553 related Products with: Upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitis.50 UG50ug100 μg1 mg100ug100 μg100ug100ug Lyophilized
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