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#32770869   // To Up

[Association between delayed diagnosis and breast cancer in advanced clinical stage at the time of consultation in four oncology centers in Medellin- Colombia, 2017. Cross-sectional study].

To determine the association between delayed diagnosis and advanced clinical stage breast cancer, and to explore the factors that influence this delay.
Diana Cristina Martínez-Pérez, Luis Rodolfo Gómez-Wolff, Carlos Andrés Ossa-Gómez, Gilma Norela Hernández-Herrera, Yamile Rivas-Bedoya, Héctor Iván García-García

1226 related Products with: [Association between delayed diagnosis and breast cancer in advanced clinical stage at the time of consultation in four oncology centers in Medellin- Colombia, 2017. Cross-sectional study].



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#32770857   2020/04/18 To Up

Inhibition of histone deacetylases is the major pathway mediated by astaxanthin to antagonize LPS-induced inflammatory responses in mammary epithelial cells.

Mastitis is a major inflammatory response of the mammary gland due to various pathogenic invasions and is a serious disease that affects the production yield and health status of cows. Astaxanthin (AST), a xanthophyll carotenoid, is a secondary metabolite synthesized by microalgae and yeasts that has been reported to suppress various inflammatory responses. However, the protective effect of AST on lipopolysaccharide (LPS)-induced mammary epithelial cells has not yet been reported. The present study results indicated that AST treatment markedly attenuated the oxidative stress markers and nitric oxide (NO) while improving the anti-oxidant enzymes in LPS exposed cells. On the other hand, LPS-exposed cells showed nuclear translocation of nuclear factor-κB (NF-κB) with the activation of inflammatory cytokines such as monocyte chemoattractant protein-1, tumor necrosis factor-α, interferon-γ, and interleukin-6 (IL-6). In addition, mRNA expression analysis revealed that the histone deacetylase (HDAC) -1, -2, -3, -6, -7 and pentraxin 3 (PTX3) expressions were increased in the LPS group. Furthermore, the activity of HDAC was increased to 2-fold with a significant reduction in the histone acetyltransferase activity in cells exposed to LPS. However, AST was able to inhibit the nuclear translocation of NF-κB with attenuated HDAC activity. Intriguingly, HDAC inhibition studies demonstrated that the cytokines such as IL-4, IL-8, granulocyte-mcrophage colony stimulating factor, C-reactive protein, IL-17A, and IL-22 were significantly suppressed which were upregulated in LPS treatment; while AST was found acting by improving the anti-inflammatory cytokine IL-10, and thioredoxin reductase levels. Collectively, these findings provide novel insights into the role of HDACs in regulating cellular processes involved in the pathogenesis of LPS-induced mastitis as well as the potential use of AST as a therapeutic in treatment for controlling disease progression.
Baskar Venkidasamy, Muthu Thiruvengadam, Prabhu Thirupathi, Umadevi Subramanian

2648 related Products with: Inhibition of histone deacetylases is the major pathway mediated by astaxanthin to antagonize LPS-induced inflammatory responses in mammary epithelial cells.

48 assays 0.1ml (1mg/ml)96 assays 1.00 flask48 assays 100 ul96 assays 100 ul1.5x10(6) cells

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#32770844   2020/08/08 To Up

Metabolomics signature of the seminal plasma in men with severe oligoasthenospermia.

Male factor is incriminated in approximately 50% of cases of infertility. The metabolomics approach has recently been used in the assessment of sperm quality and male fertility.
Magalie Boguenet, Cinzia Bocca, Pierre-Emmanuel Bouet, Orianne Serri, Stéphanie Chupin, Lydie Tessier, Odile Blanchet, Hady El Hachem, Juan Manuel Chao de la Barca, Pascal Reynier, Pascale MayPanloup

2545 related Products with: Metabolomics signature of the seminal plasma in men with severe oligoasthenospermia.

0.05 mg1 mg96T0.05 mg96T

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#32770815   2020/08/08 To Up

Grip on Life as a possible antecedent for self-control beliefs interacts with well-being and perceived stress.

Self-control has been established as an important factor in various domains of life, significant for general well-being; thus, a self-induced lack of self-control may prove detrimental for well-being. Self-induced lack of self-control may stem from implicit beliefs about self-control as a limited resource, but research has shown this belief to be unwarranted. Furthermore, it has been shown that a belief about self-control resources as unlimited has a positive effect on many domains in life and ultimately on well-being. This study addresses the question of antecedent beliefs about self-control resources and proposes personal Grip on Life, defined as skill-based goal setting and goal approaches, as a possible antecedent. This points to development of interventions altering a limited belief to an unlimited belief based on empowerment of one's Grip on Life.
Preben Bertelsen, Simon Ozer

2242 related Products with: Grip on Life as a possible antecedent for self-control beliefs interacts with well-being and perceived stress.

10 assays100tests96 Tests10 assays100tests1,000 tests250tests100tests150 assays

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#32770808   2020/08/08 To Up

Modification and utility of a rat burn wound model.

This study aimed to improve the conventional rat burn wound model and to validate its utility. In total, 60 Sprague-Dawley rats were divided equally into the control and experimental groups. Altogether, 60 burn wound models with zones of stasis were created in each group. Gross visual assessments of the burn wounds were performed at 0 h, 24 h, and 48 h after burn creation. The rates of necrosis in the zones of stasis were calculated, and the blood flow from the wounds was examined. Wound tissues were collected 48 h after the burn and subjected to hematoxylin and eosin staining to determine whether the models were successfully established. The model success rates were calculated. The success rate of the burn wound models was significantly different between the control group and the experimental group (93.33% [56/60] vs. 100%; P=0.042). The Cronbach's alpha values and the respective correlation coefficients indicated that the stability of the zones of stasis in the models on the 2 sides of the spine was higher in the experimental group than in the control group. The standard deviations of the rate of necrosis, blood flow, and density of necrotic cells and apoptosis cell density, and inflammatory factor content in the zones of stasis were smaller in the experimental group than in the control group at 48 h after model construction. This suggested that the stability of repeated procedures was higher in the experimental group than in the control group. The novel device for creating burns in animal models facilitated the effective creation of zones of stasis for rat burn wound models. Both the model success rate and stability were higher compared with the conventional model construction method. In addition, the use of the novel device can better align with the requirements of self-controlled studies. This article is protected by copyright. All rights reserved.
Xiaoyan Hu, Xingxia Wang, Xudong Hong, Hao Fan, Xudong Zhang, Aifen Chen, Guangyi Wang, Jian Jin, Zhaofan Xia

1292 related Products with: Modification and utility of a rat burn wound model.

50 ug 10 mg10 mg100ul1 kit200ul100 ul25 mg5mg100 mg

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#32770769   2020/08/08 To Up

Under pressure: A cohort analysis of elevated intraocular pressure in long-term vascular endothelial growth factor inhibitor treatment.


Matthew McCartney, Beverley Curry, Paul Sanfilippo, Nitin Verma

1808 related Products with: Under pressure: A cohort analysis of elevated intraocular pressure in long-term vascular endothelial growth factor inhibitor treatment.

100 μg100.00 ug100.00 ug0.1ml (1mg/ml)2ug x 205ug100.00 ug100 μg2ug2ug100.00 ug100 ug

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#32770767   2020/08/08 To Up

Irisin ameliorates high glucose-induced cardiomyocytes injury via AMPK/mTOR signal pathway.

High glucose (HG)-induced cardiomyocytes (CMs) injury is a leading cause of diabetic cardiomyopathy with little treatment options. Irisin, a new myokine, which is cleaved from its precursor fibronectin type III domain-containing protein 5 (FNDC5), has aroused great attentions as an essential cardioprotective factor and glucose metabolism regulator but little was known on diabetic cardiomyopathy yet. Here, we aim to clarify the role of irisin in the HG-induced CMs injury. Neonatal Sprague-Dawley (SD) rat CMs were cultured in a normal or high glucose medium for 12, 24 and 48 h respectively before exposing to irisin. The apoptosis level was determined by Terminal-deoxynucleotidyl transferase mediated-dUTP Nick End Labeling (TUNEL) assay. Cell viability was measured with the conventional methylthiazolyl tetrazolium (MTT) assay. Moreover, reactive oxygen species (ROS) production was evaluated by dihydroethidium (DHE) staining. Inflammatory factors, namely TNF-ɑ, IL-6, IL-1β were determined by enzyme-linked immunosorbent assay (ELISA) kits. Furthermore, protein and mRNA expressions were measured by Western blot and qRT-PCR respectively. HG increases the apoptosis of CMs and activated the inflammatory responses and oxidative stress in CMs. Meanwhile, the mRNA and protein expressions of FNDC5 are decreased after HG exposure. Nevertheless, the increased apoptosis is alleviated by irisin treatment. Notably, irisn suppresses the inflammatory responses and oxidative stress in injured CMs. Mechanically, after administration of Compound C, AMPK inhibitor, these cardioprotective effects resulting from irisin are reversed. Irisin plays a significant role in anti-apoptosis, anti-inflammation, anti-oxidative stress in HG-induced CMs via AMPK/mTOR signaling pathway. This article is protected by copyright. All rights reserved.
Jingyu Deng, Ning Zhang, Feng Chen, Chao Yang, Hongjuan Ning, Chun Xiao, Ke Sun, Yongfei Liu, Ming Yang, Taohong Hu, Zheng Zhang, Wei Jiang

1950 related Products with: Irisin ameliorates high glucose-induced cardiomyocytes injury via AMPK/mTOR signal pathway.

2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box

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#32770756   2020/08/08 To Up

Cognitive and motor function in developmental coordination disorder.

To analyse the development of motor skill and executive function in school-aged children with and without developmental coordination disorder (DCD).
Peter Wilson, Scott Ruddock, Shahin Rahimi-Golkhandan, Jan Piek, David Sugden, Dido Green, Bert Steenbergen

2057 related Products with: Cognitive and motor function in developmental coordination disorder.

100ug Lyophilized50ul100ug100ug Lyophilized100ug1 Set

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#32770746   2020/08/08 To Up

An In situ Collagen-HA Hydrogel System Promotes Survival and Preserves the Proangiogenic Secretion of hiPSC-derived Vascular Smooth Muscle Cells.

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Biraja C Dash, Kaiti Duan, Hao Xing, Themis R Kyriakides, Henry C Hsia

1824 related Products with: An In situ Collagen-HA Hydrogel System Promotes Survival and Preserves the Proangiogenic Secretion of hiPSC-derived Vascular Smooth Muscle Cells.

100ul0.1ml (1mg/ml)100ul100ul100 μg1 mg100ul100 μg100ul100 μg

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#32770745   2020/08/08 To Up

Ion Homeostasis for Salinity Tolerance in Plants: A Molecular Approach.

Soil salinity is one of the major environmental stresses faced by the plants. Sodium chloride is the most important salt responsible for inducing salt stress by disrupting the osmotic potential. Due to various innate mechanisms, plants adapt to the sodic niche around them. Genes and transcription factors regulating ion transport and exclusion like Salt Overly Sensitive (SOS), Na /H Exchangers (NHXs), High Sodium Affinity Transporter (HKT) and Plasma membrane protein (PMP) are activated during salinity stress and help in alleviating cells of ion toxicity. For salt tolerance in plants signal transduction and gene expression is regulated via transcription factors such as NAM (no apical meristem), ATAF (Arabidopsis transcription activation factor), CUC (cup-shaped cotyledon), Apetala 2/Ethylene Responsive Factor (AP2/ERF), W-box binding factor (WRKY) and Basic Leucine Zipper Domain (bZIP).Crosstalk between all these transcription factors and genes aid in developing the tolerance mechanisms adopted by plants against salt stress. These genes and transcription factors regulate the movement of ions out of the cells by opening various membrane ion channels. Mutants or knockouts of all these genes are known to be less salt-tolerant compared to wild types. Using novel molecular techniques like analysis of genome, transcriptome, ionome and metabolome of a plant, can help in expanding the understanding of salt tolerance mechanism in plants. In this review, we discuss the genes responsible for imparting salt tolerance under salinity stress through transport dynamics of ion balance and need to integrate high-throughput molecular biology techniques to delineate the issue. This article is protected by copyright. All rights reserved.
Insha Amin, Saiema Rasool, Mudasir A Mir, Wasia Wani, Khalid Z Masoodi, Parvaiz Ahmad

2124 related Products with: Ion Homeostasis for Salinity Tolerance in Plants: A Molecular Approach.

20 ug100ug Lyophilized100 μg100ug100 μg100ug

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