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#32746384   2020/07/30 To Up

How the Mechanical Properties and Thickness of Glass Affect TPaD Performance.

One well-known class of surface haptic devices that we have called TPaDs (Tactile Pattern Displays) uses ultrasonic transverse vibrations of a touch surface to modulate fingertip friction. This paper addresses the power consumption of glass TPaDs, which is an important consideration in the context of mobile touchscreens. In particular, based on existing ultrasonic friction reduction models, we consider how the mechanical properties (density and Young's modulus) and thickness of commonly-used glass formulations affect TPaD performance, namely the relation between its friction reduction ability and its real power consumption. Experiments performed with eight types of TPaDs and an electromechanical model for the fingertip-TPaD system indicate: 1) TPaD performance decreases as glass thickness increases; 2) TPaD performance increases as the Young's modulus and density of glass decrease; 3) real power consumption of a TPaD decreases as the contact force increases. Proper applications of these results can lead to significant increases in TPaD performance.
Heng Xu, Michael A Peshkin, Edward Colgate

2932 related Products with: How the Mechanical Properties and Thickness of Glass Affect TPaD Performance.

1 ml6/12 Packing /sleeve/box100ug4 Arrays/Slide10 mg2000 IU4 Sample Kit1000 tests100.00 ul100ug

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#32746353   2020/07/10 To Up

Fully Integrated Time-Gated 3D Fluorescence Imager for Deep Neural Imaging.

This paper presents a device for time-gated fluorescence imaging in the deep brain, consisting of two on-chip laser diodes and 512 single-photon avalanche diodes (SPADs). The edge-emitting laser diodes deliver fluorescence excitation above the SPAD array, parallel to the imager. In the time domain, laser diode illumination is pulsed and the SPAD is time-gated, allowing a fluorescence excitation rejection up to O.D. 3 at 1 ns of time-gate delay. Each SPAD array is masked with Talbot gratings to enable the mapping of 2D array photon counts into a 3D image. The 3D image achieves a resolution of 40, 35, and 73 m in the x, y, z directions, respectively, in a noiseless environment, with a maximum frame rate of 50 kilo-frames-per-second. We present measurement results of the spatial and temporal profiles of the dual-pulsed laser diode illumination and of the photon detection characteristics of the SPAD array. Finally, we show the imager's ability to resolve a glass micropipette filled with red fluorescent microspheres. The system's 420 m-wide cross section allows it to be inserted at arbitrary depths of the brain while achieving a field of view four times larger than fiber endoscopes of equal diameter.
Jaebin Choi, Adriaan J Taal, William L Meng, Eric H Pollmann, John W Stanton, Changhuk Lee, Sajjad Moazeni, Laurent C Moreaux, Michael Roukes, Kenneth Shepard

1125 related Products with: Fully Integrated Time-Gated 3D Fluorescence Imager for Deep Neural Imaging.

1 kit200 Tests1 kit1 kit1 kit1 kit1 kit1 kit100 mg

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#32746074   2020/07/29 To Up

A long-term cranial window for high-resolution Photoacoustic imaging.

In this study, we introduce the design, fabrication, and assessment of an optically and acoustically transparent, long-term and biocompatible cranial window for high-resolution photoacoustic microscopy of rat cerebral cortex.
Yongchao Wang, Guangru Liang, Fei Liu, Qian Chen, Lei Xi

2280 related Products with: A long-term cranial window for high-resolution Photoacoustic imaging.

100μg100μg100μg100ug100μg0.2 mg50 100 μg0.5mg1 mg

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#32745895   2020/07/29 To Up

Role of computed tomography in predicting critical disease in patients with covid-19 pneumonia: A retrospective study using a semiautomatic quantitative method.

So far, only a few studies evaluated the correlation between CT features and clinical outcome in patients with COVID-19 pneumonia.
Andrea Leonardi, Roberto Scipione, Giulia Alfieri, Roberta Petrillo, Miriam Dolciami, Fabio Ciccarelli, Stefano Perotti, Gaia Cartocci, Annarita Scala, Carmela Imperiale, Franco Iafrate, Marco Francone, Carlo Catalano, Paolo Ricci

1243 related Products with: Role of computed tomography in predicting critical disease in patients with covid-19 pneumonia: A retrospective study using a semiautomatic quantitative method.

100 96 tests500 tests1-99 mg/ml/ea price x 216 Arrays/Slide1 mg96 tests

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#32745797   2020/07/26 To Up

Modeling variable density flow in subsurface and surface water in the vicinity of the boundary between a surface water-atmosphere system and the subsurface.

When seawater intrudes into a subterranean estuary, there is interaction between groundwater and surface water, and ocean tides and waves can influence the salt concentration distribution in subsurface of the estuary. However, numerical simulations of seawater intrusion into a subterranean estuary often neglect the atmosphere and surface water and simply specify hydrostatic pressure and a constant seawater salt concentration. This study examined the influence of fluid flow and pressure in a surface water-atmosphere system consisting of both atmosphere and surface water on the salt distribution in subsurface and in the surface water by a numerical simulation that couples fluid flows in the surface water-atmosphere system and groundwater. This study first confirmed the precision of the simulation method by comparing experimentally determined salt concentration distributions in silica beads unsaturated with water. This study then conducted an experiment in a two-dimensional tank filled with seawater and glass beads (mean diameter 0.2 mm) and carried out two simulations of this tank experiment: one of a limited system consisting of the porous medium and surface water only, and the other of a full system, consisting of the porous medium, surface water, and atmosphere. Darcy's law has frequently been applied in limited system simulations by assigning extremely high permeability to the surface water. This study therefore also conducted a third, simpler numerical simulation of the limited system that used only Darcy's law. The salt concentration distribution obtained by the full system simulation was closer to the experimental distribution than that obtained by the limited system simulation. This result implies that fluid flow and pressure in both the atmosphere and surface water influence water flow and water pressure in the porous medium. Furthermore, the third simulation using Darcy's law only could not precisely reproduce flow in the surface water. Therefore, when variable-density flow in surface water and a shallow subsurface are numerically simulated, the simulation system needs to include atmosphere and surface water to take account of the influence of fluid flow and fluid pressure in both the atmosphere and surface water on the fluid flow and transport of salt in a shallow subsurface.
Yoshihiko Hibi

2000 related Products with: Modeling variable density flow in subsurface and surface water in the vicinity of the boundary between a surface water-atmosphere system and the subsurface.

150μl100ug Lyophilized

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#32745484   2020/07/31 To Up

Impacts of trehalose and l-proline on the thermodynamic nonequilibrium phase change and thermal properties of normal saline.

Understanding the phase change behavior and thermal properties of cryoprotective agents (CPAs) in biological solutions is essential for enhancing the success of cryopreservation and biobanking. In this study, the phase change behavior and thermal properties of normal saline added with trehalose or l-proline were investigated using differential scanning calorimeter (DSC) and cryomicroscope during freezing and warming. The addition of trehalose or l-proline can eliminate the eutectic formation in normal saline. Trehalose had significantly lower latent heat release than l-proline does at a high concentration of 1 M (P < 0.05), while unfrozen water content of trehalose is significantly lower than that of l-proline at all the concentrations (P < 0.05). It was also found that addition of 0.2 M, 0.3 M and 1 M trehalose can achieve partial vitrification in normal saline and that the glass transition temperature rises along with the increase in concentrations of trehalose. However, no vitrification was observed in normal saline with l-proline at any concentrations. Besides, rates of ice crystal growth in normal saline added with trehalose are slower than those in normal saline with l-proline at the same concentrations. These results suggest that both trehalose and l-proline can act as CPAs by avoiding eutectic formation and inhibiting ice formation in normal saline for cell cryopreservation. It could be useful for CPA selection and designing in the future.
Wei Liu, Zhiyong Huang, Xiaowen He, Pei Jiang, Xiaoyue Huo, Zekang Lu, Baolin Liu

1940 related Products with: Impacts of trehalose and l-proline on the thermodynamic nonequilibrium phase change and thermal properties of normal saline.

100ug50 ug 1000 TESTS/0.65ml10 mg1000 tests500 mg 5 G25 mg10 mg100ug25 mg

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#32745423   // To Up

Solid-Liquid Transition of Deformable and Overlapping Active Particles.

Experiments and theory have shown that cell monolayers and epithelial tissues exhibit solid-liquid and glass-liquid transitions. These transitions are biologically relevant to our understanding of embryonic development, wound healing, and cancer. Current models of confluent epithelia have focused on the role of cell shape, with less attention paid to cell extrusion, which is key for maintaining homeostasis in biological tissue. Here, we use a multiphase field model to study the solid-liquid transition in a confluent monolayer of deformable cells. Cell overlap is allowed and provides a way for modeling the precursor for extrusion. When cells overlap rather than deform, we find that the melting transition changes from continuous to first order like, and that there is an intermittent regime close to the transition, where solid and liquid states alternate over time. By studying the dynamics of five- and sevenfold disclinations in the hexagonal lattice formed by the cell centers, we observe that these correlate with spatial fluctuations in the cellular overlap, and that cell extrusion tends to initiate near fivefold disclinations.
Benjamin Loewe, Michael Chiang, Davide Marenduzzo, M Cristina Marchetti

2988 related Products with: Solid-Liquid Transition of Deformable and Overlapping Active Particles.

50 g5 mg50 ug5 ug100 assays1 g100 mg5 mg50 ug100 μg

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#32744516   2020/07/14 To Up

Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium.

The retinal pigment epithelium (RPE) is a specialized monolayer of cells strategically located between the retina and the choriocapillaris that maintain the overall health and structural integrity of the photoreceptors. The RPE is polarized, exhibiting apically and basally located receptors or channels, and performs vectoral transport of water, ions, metabolites, and secretes several cytokines. In vivo noninvasive measurements of RPE function can be made using direct-coupled ERGs (DC-ERGs). The methodology behind the DC-ERG was pioneered by Marmorstein, Peachey, and colleagues using a custom-built stimulation recording system and later demonstrated using a commercially available system. The DC-ERG technique uses glass capillaries filled with Hank's buffered salt solution (HBSS) to measure the slower electrical responses of the RPE elicited from light-evoked concentration changes in the subretinal space due to photoreceptor activity. The prolonged light stimulus and length of the DC-ERG recording make it vulnerable to drift and noise resulting in a low yield of useable recordings. Here, we present a fast, reliable method for improving the stability of the recordings while reducing noise by using vacuum pressure to reduce/eliminate bubbles that result from outgassing of the HBSS and electrode holder. Additionally, power line artifacts are attenuated using a voltage regulator/power conditioner. We include the necessary light stimulation protocols for a commercially available ERG system as well as scripts for analysis of the DC-ERG components: c-wave, fast oscillation, light peak, and off response. Due to the improved ease of recordings and rapid analysis workflow, this simplified protocol is particularly useful in measuring age-related changes in RPE function, disease progression, and in the assessment of pharmacological intervention.
Kiyoharu J Miyagishima, Congxiao Zhang, Volha V Malechka, Kapil Bharti, Wei Li

2477 related Products with: Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium.

100 21 ml1.5 mg110.1ml (1mg/ml)100.00 ul200

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#32744514   2020/06/16 To Up

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease.

Early diagnosis of systemic sclerosis-related interstitial lung disease (SSc-ILD) is important to enable treatment to be administered with minimal delay. However, diagnosing SSc-ILD is challenging because key symptoms are non-specific. High-resolution computed tomography (HRCT) of the chest is recognized as a sensitive imaging method for diagnosing and assessing SSc-ILD. Exposure of patients to ionizing radiation may be considered as a limitation, although methodological steps may be taken to moderate this. We present practical recommendations for performing HRCT scans and interpreting the results. Key features of SSc-ILD on HRCT include a non-specific interstitial pneumonia (NSIP) pattern with peripheral ground-glass opacities and extensive traction bronchiectasis. Despite similarities between SSc-ILD and idiopathic pulmonary fibrosis (IPF), HRCT can be used to differentiate between these conditions: in SSc-ILD compared with IPF, there is a greater proportion of ground-glass opacity and fibrosis is less coarse. A dilated, air-filled esophagus with diameter >10 mm, suggestive of esophageal dysmotility is commonly seen in SSc-ILD. Pulmonary artery size greater than the adjacent ascending aorta suggests coexistent pulmonary hypertension. Nodules must be monitored due to the increased risk of lung cancer. A large extent of disease on HRCT (≥20%) or a high fibrosis score suggests an increased risk of mortality. HRCT is central to diagnosing SSc-ILD, and serial assessments can be helpful in monitoring disease progression or treatment response.
Jonathan H Chung, Christopher M Walker, Stephen Hobbs

2125 related Products with: Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease.

1 kit(s)

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#32743957   2020/08/02 To Up

An Integrated Microfluidic Probe for Mass Spectrometry Imaging of Biological Samples.

Ambient ionization based on liquid extraction is widely used in mass spectrometry imaging (MSI) of molecules in biological samples. The development of nanospray desorption electrospray ionization (nano-DESI) has enabled the robust imaging of tissue sections with high spatial resolution. However, the fabrication of the nano-DESI probe is challenging, which limits its dissemination to the broader scientific community. Herein, we describe the design and performance of an integrated microfluidic probe (iMFP) for nano-DESI MSI. The glass iMFP fabricated using photolithography, wet etching, and polishing shows comparable performance to the capillary-based nano-DESI MSI in terms of stability and sensitivity; the spatial resolution of better than 25 µm was obtained in these first proof-of-principle experiments. The iMFP is easy to operate and align in front of a mass spectrometer, which will facilitate broader use of liquid extraction-based MSI in biological research, drug discovery, and clinical studies.
Xiangtang Li, Ruichuan Yin, Hang Hu, Yingju Li, Xiaofei Sun, Sudhansu K Dey, Julia Laskin

2294 related Products with: An Integrated Microfluidic Probe for Mass Spectrometry Imaging of Biological Samples.

100 TESTS 100ul1 ml1 kit16 Arrays/SlideFor 2 miRNA probes, each 16 Arrays/Slide100μg16 Arrays/Slide0.25 mg16 Arrays/Slide16 Arrays/Slide

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