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#32770824   2020/08/08 To Up

Adenoid cystic carcinoma of the salivary gland metastasizing to the pericardium and diaphragm: Report of a rare case.

Adenoid cystic carcinoma (AdCC) is an uncommon malignancy of the salivary gland characterized by slow growth, increased risk of recurrence and poor prognosis. The annual incidence in the United States is approximately 1200 cases per year and rarely involves the body cavities.
Nadia Nasir, Cara E Monroe, Brendan L Hagerty, Martha M Quezado, Mark J Roth, David S Schrump, Armando C Filie, Tanupriya Agrawal

1399 related Products with: Adenoid cystic carcinoma of the salivary gland metastasizing to the pericardium and diaphragm: Report of a rare case.

100.00 ul1 ml 100ul100.00 ul1 ml100

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#32770776   2020/08/08 To Up

Competing-risks model for prediction of small-for-gestational-age neonates from maternal characteristics and serum pregnancy-associated plasma protein-A at 11-13 weeks' gestation.

To develop a continuous likelihood model for the pregnancy associated plasma protein - A (PAPP-A), in the context of a new competing risks model for small for gestational age (SGA) neonates. To compare the predictive performance of the new model for SGA to that of previous methods.
I Papastefanou, D Wright, A Syngelaki, M Lolos, K Anampousi, K H Nicolaides

2265 related Products with: Competing-risks model for prediction of small-for-gestational-age neonates from maternal characteristics and serum pregnancy-associated plasma protein-A at 11-13 weeks' gestation.

96T96T96T96T1 kit96T96T10reactions 1 kit(96 Wells)0.1 mg1 kit(96 Wells)

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#32770769   2020/08/08 To Up

Under pressure: A cohort analysis of elevated intraocular pressure in long-term vascular endothelial growth factor inhibitor treatment.


Matthew McCartney, Beverley Curry, Paul Sanfilippo, Nitin Verma

2080 related Products with: Under pressure: A cohort analysis of elevated intraocular pressure in long-term vascular endothelial growth factor inhibitor treatment.

100 μg100.00 ug100.00 ug0.1ml (1mg/ml)2ug x 205ug100.00 ug100 μg2ug2ug100.00 ug100 ug

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#32770754   2020/08/08 To Up

IRONing out stress problems in crops: a homeostatic perspective.

Iron (Fe) is essential for plant growth and therefore plays a key role in influencing crop productivity worldwide. Apart from its central role in chlorophyll biosynthesis and oxidative phosphorylation (electron transfer), it is an important constituent of many enzymes involved in primary metabolism. Fe has different accessibilities to the roots in the rhizosphere depending upon whether it is ferrous (soluble) or ferric (insoluble) oxidation stages, which in turn, determine two kinds of Fe uptake strategies employed by the plants. The reduction strategy is exclusively found in non-graminaceous plants wherein the ferrous Fe absorbed and translocated from the soil through specialized transporters. In contrast, the chelation strategy (widespread in graminaceous plants) relies on the formation of Fe (III)-chelate complex as the necessary requirement of Fe uptake. Once inside the cell, Fe is translocated, compartmentalized and stored through a common set of physiological processes involving many transporters and enzymes whose functions are controlled by underlying genetic components, so that a fine balance of Fe homeostasis is maintained. Recently, molecular and mechanistic aspects of the process involving the role of transcription factors, signalling components, and cis-acting elements have been obtained, which has enabled a much better understanding of its ecophysiology. This mini-review summarizes recent developments in our understanding of Fe transport in higher plants with particular emphasis on crops in the context of major agronomically important abiotic stresses. It also highlights outstanding questions on the regulation of Fe homeostasis and lists potentially useful genes/regulatory pathways that may be useful for subsequent crop improvement under the stresses discussed through either conventional or transgenic approaches. This article is protected by copyright. All rights reserved.
Tirthankar Bandyopadhyay, Manoj Prasad

2391 related Products with: IRONing out stress problems in crops: a homeostatic perspective.

100 UG100 ul (2 mM)100 μg100 μg100 μg100 μg100ug Lyophilized100 μg100ug Lyophilized0.1mg100 μg1 Set

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#32770753   2020/08/08 To Up

Synergistic effect on anti-methicillin-resistant Staphylococcus aureus among combinations of α-mangostin-rich extract, lawsone methyl ether and ampicillin.

α-Mangostin rich extract (AME) exhibited satisfactory inhibitory activities against all tested MRSA strains, with minimum inhibitory concentrations (MICs) of 7.8-31.25 µg/mL, while lawsone methyl ether (LME) and ampicillin revealed weak antibacterial activity with MICs of 62.5-125 µg/mL. However, the combination of AME and LME showed synergistic effects against all tested MRSA strains with fractional inhibitory concentration index (FICI) values of 0.008-0.009, while the combination of AME and ampicillin, as well as LME and ampicillin produced synergistic effects with FICIs of 0.016-0.257. A time-kill assay against MRSA (DMST 20654 strain) revealed a 6-log reduction in CFU/mL, which completely inhibited bacterial growth for the combinations of AME and LME, AME and ampicillin, and LME and ampicillin at a 8 h incubation, while those against MRSA (2468 strain) were at 10 h incubation. The combination of α-mangostin and LME as well as the combinations of each compound with ampicillin synergized the alteration of membrane permeability. In addition, α-mangostin, LME and ampicillin inhibited the biofilm formation of MRSA. These findings indicated that the combinations AME and LME or each of them in combination with ampicillin had enhanced antibacterial activity against MRSA. Therefore, these compounds might be used as the antibacterial cocktails for treatment of MRSA.
Mohammed Sohel Meah, Monthon Lertcanawanichakul, Patchara Pedpradab, Wenhan Lin, Kui Zhu, Guoqiang Li, Pharkphoom Panichayupakaranant

1306 related Products with: Synergistic effect on anti-methicillin-resistant Staphylococcus aureus among combinations of α-mangostin-rich extract, lawsone methyl ether and ampicillin.

500 200 1 mL200 200 0.1 ml10 mg1000 5 mg1 mg1 ml

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#32770746   2020/08/08 To Up

An In situ Collagen-HA Hydrogel System Promotes Survival and Preserves the Proangiogenic Secretion of hiPSC-derived Vascular Smooth Muscle Cells.

Human induced pluripotent stem cell-derived vascular smooth muscle cells (hiPSC-VSMCs) with proangiogenic properties have huge therapeutic potential. While hiPSC-VSMCs have already been utilized for wound healing using a biomimetic collagen scaffold, an in situ forming hydrogel mimicking the native environment of skin offers the promise of hiPSC-VSMC mediated repair and regeneration. Herein, the impact of a collagen type-I-hyaluronic acid (HA) in situ hydrogel cross-linked using a PEG-based cross-linker on hiPSC-VSMCs viability and proangiogenic paracrine secretion was investigated. Our study demonstrated increases in cell viability, maintenance of phenotype and proangiogenic growth factor secretion, and proangiogenic activity in response to the conditioned medium. The optimally cross-linked and functionalized collagen type-I/HA hydrogel system developed in this study shows promise as an in situ hiPSC-VSMC carrier system for wound regeneration. This article is protected by copyright. All rights reserved.
Biraja C Dash, Kaiti Duan, Hao Xing, Themis R Kyriakides, Henry C Hsia

1455 related Products with: An In situ Collagen-HA Hydrogel System Promotes Survival and Preserves the Proangiogenic Secretion of hiPSC-derived Vascular Smooth Muscle Cells.

100ul0.1ml (1mg/ml)100ul100ul100 μg1 mg100ul100 μg100ul100 μg

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#32770713   2020/08/08 To Up

Whole genome analyses revealed genomic difference between European taurine and East Asian taurine.

European taurine and East Asian taurine are two main clades in Bos taurus, but their genomic differences are not clearly elucidated. Here, we sequenced 16 Mongolian cattle genomes and compared them to the 92 genomes of 10 representative breeds worldwide. We found the highest LD level in Mishima cattle and the fastest LD decay in European taurine. Phylogenetic analysis revealed that Mongolian, Hanwoo and Mishima cattle were clustered into East Asian taurine. From selective sweep, gene annotation, functional enrichment and differential expression analysis, we identified selective signals including genes and/or pathways related to rapid growth and large body size in European taurine, and superior meat quality in East Asian taurine. Our findings will help us understand the evolutionary history and formation process of the breeds and provide theoretical materials regarding the genetic mechanism underlying breed characteristics and molecular breeding programmes of the taurine clades in the future.
Qiuming Chen, Jiafei Shen, Quratulain Hanif, Ningbo Chen, Yongzhen Huang, Ruihua Dang, Xianyong Lan, Hong Chen, Chuzhao Lei

1144 related Products with: Whole genome analyses revealed genomic difference between European taurine and East Asian taurine.

500 G100ug300 units1 g0.1 mg96 wells (1 kit)10, 10ml whole blood 100ug200ul10 mg50 mg

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#32770666   2020/08/07 To Up

Update on the developmental consequences of cannabis use during pregnancy and lactation.

There is a strong increase in prevalence trends for cannabis use during pregnancy and lactation as more states legalize use of this drug. Information on the teratogenic risk of cannabis is limited but some important themes can be gleaned. Studies have not found a unique phenotypic signature of prenatal exposure but an increased risk of congenital anomalies, particularly gastroschisis, has been reported. Changes in fetal growth have been described in some epidemiological studies but long-term patterns of physical growth appear unaffected. Prenatzith reductions in global IQ but specific cognitive skills, especially attention and memory, can be negatively impacted. Long-term impacts on psychological health include increased rates of depressive symptoms and anxiety as well as delinquency. Relatively little is known about the risk of maternal cannabis use during lactation but data suggest that infant exposure is relatively low compared to maternal exposure. As delta-9-tetrahydrocannabinol (THC) levels increase to meet consumer demand and routes of exposure diversify, there is a strong need for prospective birth-cohort studies that collect biological samples to quantify exposure. Data from such studies will be critical to overcoming the weaknesses of past cannabis research and are essential to establishing reliable information on the risks of maternal use. Until that time, health care providers should be encouraged to talk about the risks and benefits associated with cannabis use during pregnancy and lactation with their patients, emphasizing that fetal and neonatal risks cannot be excluded at this time.
Kimberly S Grant, Elizabeth Conover, Christina D Chambers

2330 related Products with: Update on the developmental consequences of cannabis use during pregnancy and lactation.

100 mg200 units0.2 mg1000 tests11 ml2.5 mg100ug1100ug 6 ml Ready-to-use 25 mg

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#32770664   2020/08/08 To Up

The Un Oeuf study: Design, methods and baseline data from a cluster randomised controlled trial to increase child egg consumption in Burkina Faso.

In many low-income countries, such as Burkina Faso, rates of malnutrition are high among children. Research indicates that animal source foods may provide important elements to improve growth and development of young children, especially during periods of rapid development, such as the first 1,000 days of life. The Un Oeuf study is designed to test an innovative behaviour change communication strategy to increase egg consumption in children 6-24 months in Burkina Faso, thereby improving dietary diversity and nutritional outcomes. This 1-year cluster randomised controlled trial tests whether the gifting of chickens by a community champion directly to a child, combined with a behaviour change package of integrated poultry management and human nutrition trainings, can significantly increase egg consumption among children under 2 years in rural communities where egg consumption is very low. The nutrition-sensitive behaviour change package is designed to increase egg consumption through improving livestock production, women's empowerment and food security at the household level. This paper presents a detailed account of the study design and protocol for the Un Oeuf study, alongside a description of the study population. Baseline data show a study population with high rates of malnutrition (stunting 21.6%, wasting 10.8% and underweight 20.4%) and a very low rate of egg consumption-less than 10% among children. Although poultry production is quite common, egg consumption is low reportedly because of cultural norms, including widespread practice of allowing eggs to hatch and a lack of knowledge about the nutritional benefits of egg consumption.
Heather Stark, Anteneh Omer, Aïssata Wereme N'Diaye, Amanda C Sapp, Emily V Moore, Sarah L McKune

2217 related Products with: The Un Oeuf study: Design, methods and baseline data from a cluster randomised controlled trial to increase child egg consumption in Burkina Faso.

100ug100ug100 100 μg100 μg

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#32770650   2020/08/07 To Up

Leukoencephalopathy in Al-Raqad syndrome: Expanding the clinical and neuroimaging features caused by a biallelic novel missense variant in DCPS.

Al-Raqad syndrome (ARS) is a rare autosomal recessive congenital disorder, associated mainly with developmental delay, and intellectual disability. This syndrome is caused by mutations in DCPS, encoding scavenger mRNA decapping enzyme, which plays a role in the 3-prime-end mRNA decay pathway. Whole-exome sequencing was performed on an offspring of a consanguineous family presenting with developmental delay, intellectual disability, growth retardation, mild craniofacial abnormalities, cerebral and cerebellar atrophy, and white matter diffuse hypomyelination pattern. A novel biallelic missense variant, c.918G>C p. (Glu306Asp), in the DCPS gene was identified which was confirmed by sanger sequencing and segregation analysis subsequently. Few cases of ARS have been described up to now, and this study represents a 7-years-old boy presenting with central and peripheral nervous system impaired myelination in addition to ocular and dental manifestation, therefore outstretch both neuroimaging and clinical findings of this ultra-rare syndrome.
Maryam Masoudi, Ali Hosseini Bereshneh, Maryam Rasoulinezhad, Mahmoud Reza Ashrafi, Masoud Garshasbi, Ali Reza Tavasoli

2832 related Products with: Leukoencephalopathy in Al-Raqad syndrome: Expanding the clinical and neuroimaging features caused by a biallelic novel missense variant in DCPS.

100ug

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