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#32455435   // To Up

Polarized Expression of Ion Channels and Solute Carrier Family Transporters on Heterogeneous Cultured Human Corneal Endothelial Cells.

To clarify the expression profiles of ion channels and transporters of metabolic substrates among heterogeneous cultured human corneal endothelial cells (cHCECs) distinct in their effectiveness in reconstituting the corneal endothelium.
Junji Hamuro, Hideto Deguchi, Tomoko Fujita, Koji Ueda, Yuichi Tokuda, Nao Hiramoto, Kohsaku Numa, Masakazu Nakano, John Bush, Morio Ueno, Chie Sotozono, Shigeru Kinoshita

1796 related Products with: Polarized Expression of Ion Channels and Solute Carrier Family Transporters on Heterogeneous Cultured Human Corneal Endothelial Cells.

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#32455427   2020/05/26 To Up

Pro-inflammatory Cytokine Interleukin 1β Disrupts β cell Circadian Clock Function and Regulation of Insulin Secretion.

Intrinsic β cell circadian clocks are important regulators of insulin secretion and overall glucose homeostasis. Whether the circadian clock in β cells is perturbed following exposure to pro-diabetogenic stressors such as pro-inflammatory cytokines, and whether these perturbations are featured during the development of diabetes, remains unknown. To address this, we examined the effects of cytokine-mediated inflammation common to the pathophysiology of diabetes, on the physiological and molecular regulation of the β cell circadian clock. Specifically, we provide evidence that the key diabetogenic cytokine IL-1β disrupts functionality of the β cell circadian clock and impairs circadian regulation of glucose-stimulated insulin secretion. The deleterious effects of IL-1β on the circadian clock were attributed to impaired expression of key circadian transcription factor Bmal1, and its regulator, the NAD-dependent deacetylase, Sirtuin 1 (Sirt1). Moreover, we also identified that Type 2 diabetes in humans is associated with reduced immunoreactivity of β cell BMAL1 and SIRT1, suggestive of a potential causative link between islet inflammation, circadian clock disruption, and β cell failure. These data suggest that the circadian clock in β cells is perturbed following exposure to pro-inflammatory stressors and highlights the potential for therapeutic targeting of the circadian system for treatment β cell failure in diabetes.
Naureen Javeed, Matthew R Brown, Kuntol Rakshit, Tracy Her, Satish K Sen, Aleksey V Matveyenko

2785 related Products with: Pro-inflammatory Cytokine Interleukin 1β Disrupts β cell Circadian Clock Function and Regulation of Insulin Secretion.

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#32455337   2019/10/07 To Up

Conceptual Organization is Revealed by Consumer Activity Patterns.

Computational models using text corpora have proved useful in understanding the nature of language and human concepts. One appeal of this work is that text, such as from newspaper articles, should reflect human behaviour and conceptual organization outside the laboratory. However, texts do not directly reflect human activity, but instead serve a communicative function and are highly curated or edited to suit an audience. Here, we apply methods devised for text to a data source that directly reflects thousands of individuals' activity patterns. Using product co-occurrence data from nearly 1.3-m supermarket shopping baskets, we trained a topic model to learn 25 high-level concepts (or ). These topics were found to be comprehensible and coherent by both retail experts and consumers. The topics indicated that human concepts are primarily organized around goals and interactions (e.g. tomatoes go well with vegetables in a salad), rather than their intrinsic features (e.g. defining a tomato by the fact that it has seeds and is fleshy). These results are consistent with the notion that human conceptual knowledge is tailored to support action. Individual differences in the topics sampled predicted basic demographic characteristics. Our findings suggest that human activity patterns can reveal conceptual organization and may give rise to it.
Adam N Hornsby, Thomas Evans, Peter S Riefer, Rosie Prior, Bradley C Love

1913 related Products with: Conceptual Organization is Revealed by Consumer Activity Patterns.

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#32455252   2020/05/05 To Up

Cell shape, and not 2D migration, predicts extracellular matrix-driven 3D cell invasion in breast cancer.

Metastasis, the leading cause of death in cancer patients, requires the invasion of tumor cells through the stroma in response to migratory cues, in part provided by the extracellular matrix (ECM). Recent advances in proteomics have led to the identification of hundreds of ECM proteins, which are more abundant in tumors relative to healthy tissue. Our goal was to develop a pipeline to easily predict which ECM proteins are more likely to have an effect on cancer invasion and metastasis. We evaluated the effect of four ECM proteins upregulated in breast tumor tissue in multiple human breast cancer cell lines in three assays. There was no linear relationship between cell adhesion to ECM proteins and ECM-driven 2D cell migration speed, persistence, or 3D invasion. We then used classifiers and partial-least squares regression analysis to identify which metrics best predicted ECM-driven 2D migration and 3D invasion responses. We find that ECM-driven 2D cell migration speed or persistence did not predict 3D invasion in response to the same cue. However, cell adhesion, and in particular cell elongation and shape irregularity, accurately predicted the magnitude of ECM-driven 2D migration and 3D invasion. Our models successfully predicted the effect of novel ECM proteins in a cell-line specific manner. Overall, our studies identify the cell morphological features that determine 3D invasion responses to individual ECM proteins. This platform will help provide insight into the functional role of ECM proteins abundant in tumor tissue and help prioritize strategies for targeting tumor-ECM interactions to treat metastasis.
Janani P Baskaran, Anna Weldy, Justinne Guarin, Gabrielle Munoz, Polina H Shpilker, Michael Kotlik, Nandita Subbiah, Andrew Wishart, Yifan Peng, Miles A Miller, Lenore Cowen, Madeleine J Oudin

2657 related Products with: Cell shape, and not 2D migration, predicts extracellular matrix-driven 3D cell invasion in breast cancer.

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