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#32746507   2020/08/03 To Up

Effects of aging on gene expression in blood of captive Tibetan macaques ( ) and comparisons with expression in humans.

Changes in gene expression occur as animals, including primates, age. Macaques have long been used as a model species for primate evolution and biomedical studies. Here, to study gene expression in Tibetan macaques (, TM) and its differences to humans, we applied RNA-Seq to obtain the blood transcriptomes of 24 TMs. In total, 2 523 age-associated differentially expressed genes (DEGs) were identified. Several pathways and processes that regulate aging, including the FoxO signaling pathway, autophagy, and platelet activation, were significantly enriched in the up-regulated DEGs. Two significantly age-related modules were identified by weighted gene co-expression network analysis (WGCNA). The TMs and humans shared 279 common DEGs, including 111 up-regulated and 141 down-regulated genes with advancing age in the same expression direction. However, 27 age-related DEGs presented the opposite expression direction in TMs as that in humans. For example, , with inhibitory effects on the B cell receptor signaling pathway, was up-regulated in humans but down-regulated in TMs. In general, our study suggests that aging is a critical factor affecting gene expression in the captive TM population. The similarities and differences in gene expression patterns between TMs and humans could provide new insights into primate evolution and benefit TM model development.
Chao-Chao Yan, Xin-Shang Zhang, Liang Zhou, Qiao Yang, Min Zhou, Lin-Wan Zhang, Jin-Chuan Xing, Zhi-Feng Yan, Megan Price, Jing Li, Bi-Song Yue, Zhen-Xin Fan

2945 related Products with: Effects of aging on gene expression in blood of captive Tibetan macaques ( ) and comparisons with expression in humans.

300 units96T100ug5 μg2ug96 tests

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#32746497   2020/08/03 To Up

Modulation of NADPH oxidase and Nrf2/HO-1 pathway by vanillin in cisplatin-induced nephrotoxicity in rats.

To investigate the protective effect of vanillin in cisplatin (CP)-induced nephrotoxicity in rats and elucidate the role of nrf-2 and its downstream antioxidant molecules.
Nahla N Younis, Nehal M Elsherbiny, Mohamed A Shaheen, Mohamed M Elseweidy

1363 related Products with: Modulation of NADPH oxidase and Nrf2/HO-1 pathway by vanillin in cisplatin-induced nephrotoxicity in rats.

100ug100ug 100ul10ug2 Pieces/Box7 inhibitors100ug Lyophilized100ug Lyophilized100ug100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#32746489   2020/08/03 To Up

"Quod licet Chefarzt …": The Impact of Perceived Hierarchy on Working Atmosphere and Quality of Work in Orthopaedic and Trauma Surgery. Results of a Survey Among 799 Orthopaedic and Trauma Surgeons in Germany.

Surgical departments are discredited as guardians of traditional structures of hierarchy. Hierarchy and working climate have a large share in human factor, being made responsible for 70% of avoidable errors in medicine. Aim of this study was the assessment of these topics amongst physicians in the field of orthopedics and traumatology.
Ricarda Johanna Seemann, Matthias Münzberg, Manuel Mutschler, Jasmina Sterz, Reinhard Hoffmann, Miriam Ruesseler

1023 related Products with: "Quod licet Chefarzt …": The Impact of Perceived Hierarchy on Working Atmosphere and Quality of Work in Orthopaedic and Trauma Surgery. Results of a Survey Among 799 Orthopaedic and Trauma Surgeons in Germany.

50 ul100 ul100 ul50 ul100ug10 mg25 mg

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#32746481   2020/08/03 To Up

Coronavirus Disease-2019 (COVID-19): An Updated Review.

The current outbreak of novel Coronavirus Disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major pandemic situation and a catastrophe for humans. COVID-19 is a severe infectious disease particularly of the respiratory system characterized by fatal complications such as severe acute respiratory distress syndrome (SARS), pneumonia, cardiac arrhythmia, kidney failure/ multiple organ failure and even death. Since its discovery, the SARS-CoV-2 has spread across 213 countries or territories, causing more than 8.5 million people with a rising death toll over 5.5 million people (as of June 2020, WHO). In fact, the current looming crisis of COVID-19 has become an increasingly serious concern to public health. It has affected lives of millions of people with severe impact on health systems and economies globally. Since there are no specific drugs and/or vaccines available so far, combating COVID-19 remains to be a major challenging task. Therefore, development of potential and effective treatment regimens (prophylactic/therapeutic) is urgently required which could resolve the issue. In this review, we summarize the current knowledge about the coronavirus, disease epidemiology, clinical manifestations and risk factors, replication of the virus, pathophysiology and host immune responses of SARS-CoV-2 infection. The therapeutic interventions and prophylactic measures along with precautionary measures are the frontline approaches that could be undertaken in order to control and prevent the spread of the deadly and highly contagious COVID-19 are also detailed herein.
Mithun Rudrapal, Shubham J Khairnar, Laxmikant B Borse, Anil G Jadhav

2672 related Products with: Coronavirus Disease-2019 (COVID-19): An Updated Review.

1 mg100 ug/vial100 100 µg200 1 mg200 200 50ug 1mg

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#32746472   2020/08/03 To Up

Diterpenoids from Leaves of Cultivated Plectranthus ornatus.

Two new diterpenoid derivatives 7,12,17-triacetoxy-619-dihydroxy-13,16-spirocicloabiet-8-ene-11,14-dione (1: ) and 6-acetoxy-3,7,12-trihydroxy-13,16-spirocicloabiet-8-ene-11,14-dione (2: ) along with 11 (3: -13: ) miscellaneous compounds were isolated from the leaves of Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6: and 9: were moderately cytotoxic against HL-60, whereas 6: and 13: were more active on SF-295 and HCT-116.
Lidivânia Silva Freitas Mesquita, Taynara Simão Matos, Fábio do Nascimento Ávila, Alison da Silva Batista, Andréa Felinto Moura, Manoel Odorico de Moraes, Matheus Carlos Matos da Silva, Talles Luann Abrantes Ferreira, Nilberto Robson Falcão Nascimento, Norberto Kássio Vieira Monteiro, Otília Deusdênia Loiola Pessoa

1377 related Products with: Diterpenoids from Leaves of Cultivated Plectranthus ornatus.

5 G

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#32746445   2020/08/03 To Up

Advancing equity, diversity, and inclusion in the American College of Neuropsychopharmacology (ACNP): advances, challenges, and opportunities to accelerate progress.


Jack E Henningfield, Sherecce Fields, James C Anthony, Lawrence S Brown, Carlos A Bolaños-Guzmán, Sandra D Comer, Richard De La Garza, Debra Furr-Holden, Albert Garcia-Romeu, Dorothy Hatsukami, Armin Raznahan, Carlos A Zarate

2977 related Products with: Advancing equity, diversity, and inclusion in the American College of Neuropsychopharmacology (ACNP): advances, challenges, and opportunities to accelerate progress.

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#32746378   2020/06/25 To Up

Vibrotactile Alphabets: Time and Frequency Patterns to Encode Information.

Although many tactual communication methods have been developed over the past decades, few of them have been widely adopted in everyday lives. In this paper, we investigate the ability to deliver text messages using patterns of vibrations. By manipulating the duration and frequency of vibrations, we designed two vibrotactile alphabets, i.e. 3F Vibraille and 2F Vibraille, along with their corresponding numbers and symbols. The main difference between 3F Vibraille and 2F Vibraille is the number of frequency levels utilised. Both alphabets were evaluated through human experiments in terms of training time, learning process and recognition accuracy of words and symbols. For both alphabets, the results demonstrated that participants were able to recognise words and symbols at an accuracy of over 90% after 6-8 hours of training. The main difference between the alphabets was that 3F Vibraille achieved a higher transmission rate while 2F Vibraille required less training time.
Xun Liu, Mischa Dohler

1553 related Products with: Vibrotactile Alphabets: Time and Frequency Patterns to Encode Information.

96 wells1 mL 25 G 5 G1 mg251 module50 mg25One 96-Well Strip Micropl200

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#32746377   2020/06/24 To Up

Synthesizing the Roughness of Textured Surfaces for an Encountered-type Haptic Display using Spatiotemporal Encoding.

Encountered-type haptic rendering provides realistic, free-to-touch, and move-and-collide haptic sensation to a user. However, inducing haptic-texture sensation without complicated tactile actuators is challenging for encountered-type haptic rendering. In this paper, we propose a novel texture synthesizing method for an encountered-type haptic display using spatial and temporal encoding of roughness, which provides both active and passive touch sensation requiring no complicated tactile actuation. Focused on macro-scale roughness perception, we geometrically model the textured surface with a grid of hemiellipsoidal bumps, which can provide a variety of perceived roughness as the user explores the surface with one's bare hand. Our texture synthesis method is based on two important hypotheses. First, we assume that perceptual roughness can be spatially encoded along the radial direction of a textured surface with hemiellipsoidal bumps. Second, perceptual roughness temporally varies with the relative velocity of a scanning human hand with respect to the surface. To validate these hypotheses on our spatiotemporal encoding method, we implemented an encountered-type haptic texture rendering system using an off-the-shelf collaborative robot that can also track the user's hand using IR sensors.
Yaesol Kim, Siyeon Kim, Uran Oh, Young J Kim

1151 related Products with: Synthesizing the Roughness of Textured Surfaces for an Encountered-type Haptic Display using Spatiotemporal Encoding.

0.2 mg25 µg25 µg0.25 mg100 TESTS0.2 mg1 ml0.1 ml100μg

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#32746376   2020/06/23 To Up

Haptic and Visual Feedback Assistance for Dual-Arm Robot Teleoperation in Surface Conditioning Tasks.

Contact driven tasks, such as surface conditioning operations (wiping, polishing, sanding, etc.), are difficult to program in advance to be performed autonomously by a robotic system, specially when the objects involved are moving. In many applications, human-robot physical interaction can be used for the teaching, specially in learning from demonstrations frameworks, but this solution is not always available. Robot teleoperation is very useful when user and robot cannot share the same workspace due to hazardous environments, inaccessible locations, or because of ergonomic issues. In this sense, this paper introduces a novel dual-arm teleoperation architecture with haptic and visual feedback to enhance the operator immersion in surface treatment tasks. Two task-based assistance systems are also proposed to control each robotic manipulator individually. To validate the remote assisted control, some usability tests have been carried out using Baxter, a dual-arm collaborative robot. After analysing several benchmark metrics, the results show that the proposed assistance method helps to reduce the task duration and improves the overall performance of the teleoperation.
Vicent Girbes-Juan, Vinicius Schettino, Yiannis Demiris, Josep Tornero

1668 related Products with: Haptic and Visual Feedback Assistance for Dual-Arm Robot Teleoperation in Surface Conditioning Tasks.

250 mg 1 G100 μg 1 G100 μg 5 G500 MG 100 G100 μg

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