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#33080658 2020/10/20 To Up
[Equine chorionic gonadotrophin: Biology and veterinary use].T
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#33080614 2020/10/20 To Up
Do Alzheimer's Disease Patients Appear Younger than Their Real Age?The most prominent risk factor of Alzheimer's disease (AD) is aging. Aging also influences the physical appearance. Our clinical experience suggests that patients with AD may appear younger than their actual age. Based on this empirical observation, we set forth to test the hypothesis with human and computer-based estimation systems.
Zeynep Tufekcioglu, Başar Bilgic, Abdullah Emir Zeylan, Albert Ali Salah, Hamdi Dibeklioglu, Murat Emre5 mg25 mg96 tests96 tests1ml96 tests1ml96 tests50 ug25 100ul5 mg
#33080611 2020/10/20 To Up
The Protective Effects of Helicobacter pylori Infection on Allergic Asthma.As an ancient Gram-negative bacterium, Helicobacter pylori has settled in human stomach. Eradicating H. pylori increases the morbidities of asthma and other allergic diseases. Therefore, H. pylori might play a protective role against asthma. The "disappearing microbiota" hypothesis suggests that the absence of certain types of the ancestral microbiota could change the development of immunology, metabolism, and cognitive ability in our early life, contributing to the development of some diseases. And the Hygiene Hypothesis links early environmental and microbial exposure to the prevalence of atopic allergies and asthma. Exposure to the environment and microbes can influence the growing immune system and protect subsequent immune-mediated diseases. H. pylori can inhibit allergic asthma by regulating the ratio of helper T cells 1/2 (Th1/Th2), Th17/regulatory T cells (Tregs), etc. H. pylori can also target dendritic cells to promote immune tolerance and enhance the protective effect on allergic asthma, and this effect relies on highly suppressed Tregs. The remote regulation of lung immune function by H. pylori is consistent with the gut-lung axis theory. Perhaps, H. pylori also protects against asthma by altering levels of stomach hormones, affecting the autonomic nervous system and lowering the expression of heat shock protein 70. Therapeutic products from H. pylori may be used to prevent and treat asthma. This paper reviews the possible protective influence of H. pylori on allergic asthma and the possible application of H. pylori in treating asthma.
Zhi Tong Zuo, Ya Ma, Yan Sun, Cui Qing Bai, Chun Hua Ling, Feng Lai Yuan
2307 related Products with: The Protective Effects of Helicobacter pylori Infection on Allergic Asthma.96 tests96 tests1 mg1 mg96/kit96T96T200 units 2 ml 1 kit(s) 1 100 G
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#33080584 2020/10/20 To Up
In vivo neutron activation assembly design for quantification of trace elements using MCNP.Trace and essential elements both play a crucial role in maintaining normal cellular and organ functions in human, while abnormal exposure to some of them are also potentially related to diseases, e.g., manganism. To study the association between elemental intake and health outcomes, accurate assessment of elemental uptake and storage in the human body is essential.
Sana Tabbassum, Linda Huiling Nie
1240 related Products with: In vivo neutron activation assembly design for quantification of trace elements using MCNP.100μg 1 G96 tests 5 G25 Bags/Unit100ug500 MG2 mg10ml
#33080582 2020/10/20 To Up
Nitric oxide's physiologic effects and potential as a therapeutic agent against Covid-19.The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for COVID-19 pneumonia, a pandemic that precipitates huge pressures on the world's social and economic systems. Disease severity varies among individuals. SARS-CoV-2 infection can be associated with e.g. flu-like symptoms, dyspnoea, severe interstitial pneumonia, acute respiratory distress syndrome, multiorgan dysfunction, and generalized coagulopathy. Nitric oxide (NO), is a small signal molecule that impacts pleiotropic functions in human physiology, which can be involved in the significant effects of COVID-19 infection. NO is a neurotransmitter involved in the neural olfactory processes in the central nervous system, and some infected patients have reported anosmia as a symptom. Additionally, NO is a well-known vasodilator, important coagulation mediator, anti-microbial effector and inhibitor of SARS-CoV replication. Exhaled NO is strongly related to the type-2 inflammatory response found in asthma, which has been suggested to be protective against SARS-CoV-2 infection. Several reports indicate that the use of inhaled NO has been an effective therapy during this pandemic since the ventilation-perfusion ratio in COVID-19 patients improved afterwards and they did not require mechanical ventilation. The aim of this mini-review is to summarize relevant actions of NO that could be beneficial in the treatment of COVID-19.
Fabio Luigi Massimo Ricciardolo, Francesca Bertolini, Vitina Carriero, Marieann Högman
2731 related Products with: Nitric oxide's physiologic effects and potential as a therapeutic agent against Covid-19.10010 plates100 100 100Tests100 plates100 200 assays10010 plates2 x 96 assays100 plates
#33080579 2020/10/20 To Up
Combination therapy of biogenic C-dots and lysozyme for enhanced antibacterial and antibiofilm activity.Nearly 80% of human chronic infections are caused due to bacterial biofilm formation. The increased resistance against the conventional antimicrobial agents makes it difficult to treat the biofilm-related infections. The antibiotics resistance developed by planktonic cells has also become a major threat for human. Therefore, we have attempted here to develop an effective alternative strategy to overcome the issues of antibiotics resistance of bacteria. Upon synthesis, biogenic C-dots were combined with lysozymes which were further encapsulated into chitosan nanocarrier to form C-dots carrier (CDC). The as-synthesized C-dots were found irregular shaped and the average size of C-dots and CDC were 8 ± 2 nm and 450± 50 nm, respectively. To ensure secure and targeted delivery of C-dots and lysozyme we have employed chitosan, a biodegradable and natural biopolymer, as a delivery system. The study of time-dependent bacterial growth and flow cytometry analysis demonstrated that CDC can exhibit a synergistic bactericidal activity against the antibiotics resistant recombinant E. coli cells. Further, we have shown that the CDC could be a potent agent for both prevention of biofilm formation and eradication of preformed biofilm. In addition, we have observed that our drug delivery system is hemocompatible in nature making it suitable for in vivo applications. Therefore, we believe that the combination therapy of C-dots and lysozyme may be used as an excellent antibacterial and antibiofilm strategy.
Anirudh Singh, Arushi Verma, Ruhar Singh, Amaresh Sahoo, Sintu Samanta
1693 related Products with: Combination therapy of biogenic C-dots and lysozyme for enhanced antibacterial and antibiofilm activity.100ul1 mg1,000 tests100ug200 100 mg1000 tests100ug500 MG25 mg10 mg
#33080570 2020/10/20 To Up
LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2.In this study, we investigated the functional and clinical significance of the long non-coding RNA (lncRNA) in human gliomas. TCGA, GTEx and CGGA database analyses showed that high expression correlates with advanced tumor stage and poor survival of glioma patients. expression is higher in glioma cell lines compared to normal human astrocytes (NHA). CCK-8, EdU, and colony formation assays show that knockdown decreases proliferation and colony formation in glioma cells, whereas, overexpression reverses these effects. Bioinformatics analysis showed that miR-129-5p is a potential target of MiR-129-5p expression negatively correlates with expression in glioma patients. Dual luciferase reporter assays confirmed that miR-129-5p binds directly to in glioma cells. RNA immunoprecipitation (RIP) assays using anti-Ago2 antibody pulled down with miR-129-5p. Bioinformatics analysis identified as a potential miR-129-5p target gene. Dual luciferase reporter assays confirmed that miR-129-5p binds directly to the 3'-UTR of 2 mRNA. Furthermore, miR-129-5p overexpression or knockdown reduces proliferation and colony formation of overexpressing glioma cells. These findings show that promotes gliomagenesis by enhancing ZRANB2 expression by sponging of miR-129-5p.
Xin Jiang, Dong Chen
1252 related Products with: LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2.100ug10 mg 25UG1000 tests100ul100ug500 mg25 mg50 ug 10 mg 5 G100ul
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