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#34128366   2021/05/14 To Up

A Nationwide Study on the Incidence of Breast Cancer in Korean Women with Osteoporosis Receiving Raloxifene Treatment.

Raloxifene is a selective estrogen receptor modulator (SERM), and raloxifene treatment for osteoporosis is reimbursable under the Korean National Health Insurance. Evidence suggests that SERMs use reduces the risk of breast cancer in Asian population. Herein, we retrospectively investigated the protective effect of raloxifene on breast cancer rates in Korean population.
Jihyoun Lee, Ji Sung Lee, Jong Eun Lee, Zisun Kim, Sun Wook Han, Sung Mo Hur, Young Jin Choi, Sungmin Park

1187 related Products with: A Nationwide Study on the Incidence of Breast Cancer in Korean Women with Osteoporosis Receiving Raloxifene Treatment.



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#34128200   2021/06/14 To Up

Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model.

Anaphylactic shock is a serious adverse drug reaction that can occur in response to contrast media used during coronary computed tomography angiography. The imaging quality of coronary computed tomography angiography is improved by β-blockers, which decrease heart rate. In this study, we sought to analyze anaphylactic shock treatment in patients receiving short-acting β1-blockers.
Masaharu Hirano, Tatsuaki Okamura, Tetsuji Nagano, Shigeyuki Nonaka, Tsutomu Shiroya

2796 related Products with: Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model.

100ug100 ul100ug100ug100 ul50 ul50 ul18 kgs96 assays 100ul100 μg1 Set

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#34128146   2021/06/14 To Up

Preferential Oxycodone Loss of Physically Manipulated Abuse Deterrent Oxycodone HCl Extended Release Tablets Prepared for Nasal Insufflation Studies.

A method to reproducibly mill abuse deterrent oxycodone hydrochloride (HCl) extended release (ER) tablets was developed for a nasal insufflation pharmacokinetic (PK) study. Several comminution methods were explored before determining that a conical mill resulted in controlled milling of tablets to a size range equal to or below 1000 μm. However, milling resulted in significant loss of oxycodone from abuse deterrent oxycodone HCl ER tablets compared to minimal oxycodone loss from oxycodone HCl immediate release (IR) tablets. Characterization of milled tablet powder showed that loss of oxycodone was not attributed to analytical procedures or oxycodone phase change during high intensity milling processes. The content uniformity of oxycodone in the milled tablet powder varied when ER and IR tablets were milled to a particle size distribution equal to or below 500 μm but did not vary when particles were sized above 500 µm to equal to or below 1000 μm. In addition, the initial excipient weight to drug substance weight ratio impacted the amount of oxycodone lost from the respective formulation. However, dissolution demonstrated that when oxycodone HCl ER tablets are milled, differences in excipient weight to drug substance weight ratio and particle size distribution of milled tablets did not result in significantly different release of oxycodone.
Zhengjie Meng, Heather J Boyce, Dajun Sun, Minori Kinjo, Saeid Raofi, Tonglei Li

1344 related Products with: Preferential Oxycodone Loss of Physically Manipulated Abuse Deterrent Oxycodone HCl Extended Release Tablets Prepared for Nasal Insufflation Studies.

1 mg100ug100μg0.1 mg 25 ea. 10 mg 500 ml 1.0 mg10 Tablets250 mg0.1 ml

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#34127228   2021/05/27 To Up

Hyaluronic acid-based nanogels derived from multicomponent self-assembly for imaging-guided chemo-photodynamic cancer therapy.

Multifunctional theranostic nanoplatforms integrated of imaging function, multi-modality therapy, stimuli-responsiveness, and targeted delivery are of highly desirable attributes in achieving precise medicine. However, preparation of multifunctional nanoplatforms often involves laborious, multiple steps and inevitably utilizes low-biocompatible or non-functional components. Herein we report a facile, one-step self-assembly strategy to fabricate hyaluronic acid (HA)-based multifunctional tumor theranostic nanoplatform by employing magnetic resonance imaging (MRI) agent Mn as a reversible crosslink agent for histidine-grafted HA, along with simultaneously loading chemotherapeutic agent doxorubicin hydrochloride (DOX) and photodynamic therapy agent chlorin e6, to realize MRI-guided targeted chemo-photodynamic cancer therapy. The targeted delivery and stimuli-responsive payload release were demonstrated in vitro and in vivo. Furthermore, the combined chemo-photodynamic therapy of the nanoassembly dramatically improved the cancer therapeutic outcome, in comparison with that of free DOX and nanoplatform solely loaded DOX in a melanoma bearing mice. Our one step assemble strategy is of great potential in clinic transformation.
Ya-Ting Pan, Yuan-Fu Ding, Zhi-Hao Han, Lihui Yuwen, Zhan Ye, Greta S P Mok, Shengke Li, Lian-Hui Wang

1931 related Products with: Hyaluronic acid-based nanogels derived from multicomponent self-assembly for imaging-guided chemo-photodynamic cancer therapy.

100 G 1 G5 g 1 G10 mg 1 G 500 G1 ml 1 G 1 G 1 G50 ug

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#34126913   2021/06/11 To Up

Potential Drugs for the Treatment of COVID-19: Synthesis, Brief History and Application.

Coronaviruses (CoVs) belonging to the Betacoronavirus group, an unusually large RNA genome, are characterized by club-like spikes that project from their surface. An outbreak of a novel coronavirus 2019 (nCOVID-19) showing a unique replication strategy and infection has posed a significant threat to international health and the economy around the globe. Scientists around the world are investigating few previously used clinical drugs for the treatment of COVID-19. This review provides synthesis and mode of action of recently investigated drugs like Chloroquine, Hydroxychloroquine, Ivermectin, Selamectin, Remdesivir, Baricitinib, Darunavir, Favipiravir, Lopinavir/ritonavir and Mefloquine hydrochloride that constitute an option for COVID-19 treatment.
Ekhlass Uddin, Raisul Islam, Ashrafuzzaman, Nur Amin Bitu, Md Saddam Hossain, Abm Nazmul Islam, Ali Asraf, Faruk Hossen, Ranjan K Mohapatra, Md Kudrat-E-Zahan

2370 related Products with: Potential Drugs for the Treatment of COVID-19: Synthesis, Brief History and Application.

100ul 100ul 100ul 100ul0.1ml (1mg/ml)0.1ml 100ul2000 IU 100ul 100 G 100ul 100ul

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#34123305   2020/01/13 To Up

Coordinating bioorthogonal reactions with two tumor-microenvironment-responsive nanovehicles for spatiotemporally controlled prodrug activation.

Precise activation of prodrugs in tumor tissues is critical to ensuring specific antitumor efficacy, meanwhile reducing the serious adverse effects. Here, a spatiotemporally controlled prodrug activation strategy was provided by integrating the inverse electron demand Diels-Alder (IEDDA) reaction with two tumor-microenvironment-responsive nanovehicles. The prodrug (Dox-TCO) and [4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methanamine (Tz) were separately camouflaged into low pH and matrix metalloproteinase 2 (MMP-2) sensitive micellar nanoparticles. After systemic administration, only in the tumor tissues could both the nanovehicles dissociate responding to two special tumor microenvironments, with Dox-TCO and Tz released and then immediately triggering the prodrug activation through the IEDDA reaction. The hierarchically regulated and locally confined Dox liberation led to dramatically decreased side-effects that were much lower than those of the clinical Doxorubicin Hydrochloride Liposomal Injection (Doxil), while the antitumor therapeutic effect was potent.
Liping Zuo, Jingjing Ding, Changkun Li, Feng Lin, Peng R Chen, Peilin Wang, Guihong Lu, Jinfeng Zhang, Li-Li Huang, Hai-Yan Xie

2539 related Products with: Coordinating bioorthogonal reactions with two tumor-microenvironment-responsive nanovehicles for spatiotemporally controlled prodrug activation.

125 ml 96 reactions25 reactions 96T/Kit 1 mg24 reactions

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#34124588   2021/03/09 To Up

Effects of voluntary removal of ractopamine hydrochloride (Optaflexx) on live performance and carcass characteristics of beef steers.

There is a lack of consistency across the globe in how countries establish tissue ractopamine residue limits and which residue limits are applied to various tissues, particularly for edible noncarcass tissues. Therefore, some U.S. beef slaughter organizations have recommended a 48-h voluntary removal of ractopamine before slaughter to meet residue requirements of specific export countries and maintain international trade. Our objective was to assess the impact of voluntary removal of ractopamine hydrochloride (Optaflexx; Elanco, Greenfield, IN) up to 8 d before slaughter on growth performance and carcass characteristics. Crossbred beef steers (60 pens of 10 animals/pen) with an initial shrunk body weight () of 611.8 ± 10 kg SEM were fed one of six treatments over 42 d. Treatments included a control that did not receive ractopamine, on-label use of ractopamine (0-d withdrawal), and 2, 4, 6, or 8 d of voluntary removal of ractopamine from feed before slaughter. The start of ractopamine feeding (30.1 mg/kg of diet dry matter for 32 d) was staggered, so that blocks could be slaughtered on the same day. Dry matter intake was decreased by 0.5 kg/d when ractopamine was fed with a 0-d withdrawal ( = 0.04) compared with the control, but was not altered ( = 0.56) as the duration of ractopamine removal increased from 0 to 8 d. Final BW, total BW gain, and average daily BW gain were increased by feeding ractopamine with a 0-d withdrawal ( = 0.09) compared with the control, but these variables decreased in a linear manner ( = 0.10) as the duration of removal increased from 0 to 8 d. Gain efficiency was improved by 15% ( < 0.01) by feeding ractopamine with a 0-d withdrawal compared with the control, and gain efficiency decreased linearly ( = 0.06) as the duration of ractopamine removal increased. Approximately 2/3 of the increase in gain efficiency remained after 8 d of removal. Hot carcass weight was increased by 6 kg ( = 0.02) by feeding ractopamine with a 0-d withdrawal compared to the control. Measured carcass characteristics were not altered by ractopamine feeding or by removal before slaughter ( ≥ 0.24). The consequences of voluntary removal of ractopamine up to 8 d before slaughter were a linear decrease in live BW gain (0.64 kg/d), poorer gain efficiency, and numerically lighter carcass weight.
Phillip J Rincker, Janet B Allen, Matt Edmonds, Michael S Brown, John C Kube

2789 related Products with: Effects of voluntary removal of ractopamine hydrochloride (Optaflexx) on live performance and carcass characteristics of beef steers.

5 G 25 MG 25 MG 5 G 500 G250 mg25 mg 500 G 5 G1 mg50 ug

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#34122783   2021/06/01 To Up

Clinical Observation of Intraosseous Anesthesia in Percutaneous Kyphoplasty.

Percutaneous kyphoplasty (PKP) is an effective minimally invasive technique in spine surgery in recent years. General anesthesia and local anesthesia are the main ways of anesthesia in PKP, and epidural anesthesia is also applied to PKP to some extent. However, all these three anesthetic methods have their respective advantages and disadvantages. It is essential to compare and evaluate the effects of different anesthesia methods on PKP for treating spinal fractures.
Li-Shuai Bao, Wei Wu, Xin Wang, Xi-Hong Zhong, Lin-Xiu Wang, Hong Wang

1474 related Products with: Clinical Observation of Intraosseous Anesthesia in Percutaneous Kyphoplasty.



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#34121212   2021/06/13 To Up

Determination of bupivacaine tissue concentration in human biopsy samples using high-performance liquid chromatography with mass spectrometry.

In the present study, we developed a simple and rapid analytical method for the quantification of bupivacaine hydrochloride in human biopsy samples of adipose, muscle, neural, connective and cartilage tissue using liquid chromatography-mass spectrometry. Anaesthetics were extracted from the tissue samples using 0.1% formic acid in acetonitrile for protein denaturation and hexane for lipophilic impurities removal. Analytes were separated adequately on Phenomenex Luna® Omega polar C18 column using gradient mobile phase 0.1% formic acid in water and 0.1% formic acid in acetonitrile. The lower limits of quantification were ≤ 97 ng g tissue for all studied tissues. Intra-day recoveries were between 48.2-82.1% with relative standard deviations (RSDs) between 1.47-14.28%, while inter-day recoveries were between 52.2-77.6% with RSDs between 2.98-14.79%. The calibration curve showed linear fit with R higher than 0.99 in concentration range from 0.16-100 μg g . Lidocaine hydrochloride was tested as internal standard because its recoveries and matrix-effects were comparable to bupivacaine hydrochloride. Post analytical corrections of measured bupivacaine tissue concentrations can accordingly be made based on recovery of lidocaine as internal standard, with recoveries between 51.2-86.9% and RSDs between 1.99-16.88%. The developed method could be used to study time-dependent spread of bupivacaine locally or to more distant locations across tissue barriers.
Simon Istenič, Erika Cvetko, Joži Zabret, Tatjana Stopar Pintarič, Nejc Umek

2730 related Products with: Determination of bupivacaine tissue concentration in human biopsy samples using high-performance liquid chromatography with mass spectrometry.

96 wells (1 kit)16 Arrays/Slide96T96 wells (1 kit)

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