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Probiotics for people with cystic fibrosis.Cystic fibrosis (CF) is a multisystem disease and the importance of growth and nutrition has been well established, given its implications for lung function and overall survival. It has been established that intestinal dysbiosis (i.e. microbial imbalance) and inflammation is present in people with CF. Probiotics are commercially available (over-the-counter) and may improve both intestinal and overall health.
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[Quo vadis 116117? Nationwide Overview of the Status Quo and Current Changes].The on-call service (emergency service) has been reachable under 116117 in Germany since 2012. Nevertheless, this number is almost unknown to most Germans. A literature review of emergency service has shown that information which can be found is often incomplete and unclear. Thus, the aim of this study was to cover the status quo regarding 116117 at the federal level in Germany.
1085 related Products with: [Quo vadis 116117? Nationwide Overview of the Status Quo and Current Changes].19 Hydroxy 4 androstene 3 Recombinant Human PKC the BACTERIOLOGY BACTEROIDES Andarine C19H18F3N3O6� Androgen Receptor Goat Anti-Human Androgen Androgen Receptor Theophylline CAS Number [ 5α-N-Acetyl-2'H-androst- Normal mouse multiple org 3β-O-Acetyl-androsta-5,1 MyGenie 96 Gradient Therm
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Lifecycle management in pharmaceutical analysis: How to establish an efficient and relevant continued performance monitoring program.It is the objective of a systematic and holistic Quality-by-Design approach to demonstrate and ensure that an analytical procedure is fit for its intended purpose over its entire lifecycle. Such a lifecycle approach, as proposed for a new USP General Information Chapter includes the three stages Procedure Design and Development, Procedure Performance Qualification, and Continued Procedure Performance Verification, in alignment to manufacturing process validation. A decisive component of this approach is the Analytical Target Profile, which defines the performance requirements for the measurement of a Quality Attribute as the target for selection, development and optimization of the respective analytical procedures. Although the most benefit can be gained by a comprehensive Quality-by-Design approach establishing the Analytical Target Profile in the very beginning of a drug development project, it may also be established retrospectively for analytical procedures long in routine use, in order to facilitate future lifecycle activities such as continual improvements, transfers, monitoring and periodic performance evaluations. In contrast to the first two stages of the analytical lifecycle with usually limited amount of data, the Continued Procedure Performance Verification stage offers the possibility to utilize a much more reliable data base to collect, analyze, and evaluate data that relate to analytical procedure performance. This monitoring program should be aligned as far as possible with other quality systems already in place and may include performance indicators such as Conformity (i.e. out-of specification test results with analytical root-cause), Validity (i.e. failure to meet method acceptance criteria, e.g. system suitability tests), and (numerical) analytical performance parameters (e.g. ranges for replicate determinations, control sample results, etc). In addition to the monitoring of analytical control parameters by means of control charts, average (pooled) performance parameters can be calculated. Over time, a large number of data can be included and thus the reliability of these estimates is increased tremendously. Such reliable estimates for the true performance parameters, e.g. repeatability or intermediate precision are essential to identify systematic effects (also called special cause variation) with good confidence. The intent of the analytical procedure performance evaluation is to identify substandard performance, identify root cause through investigations, and determine when additional activities are required to improve it. Examples are provided for the monitoring and evaluation of performance parameters for the compendial drug substance Furosemide and for biopharmaceutical applications.
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Mass spectrometry based proteomics and metabolomics in personalized oncology.Precision medicine (PM) means the customization of healthcare with decisions and practices adjusted to the individual patient. It includes personalized diagnostics, patients' sub-classification, individual treatment selection and the monitoring of its effectiveness. Currently, in oncology, PM is based on the molecular and cellular features of a tumor, its microenvironment and the patient's genetics and lifestyle. Surprisingly, the available targeted therapies were found effective only in a subset of patients. An in-depth understanding of tumor biology is crucial to improve their effectiveness and develop new therapeutic targets. Completion of genetic information with proteomics and metabolomics can give broader knowledge about tumor biology which consequently provides novel biomarkers and indicates new therapeutic targets. Recently, metabolomics and proteomics have extensively been applied in the field of oncology. In the context of PM, human studies, with the use of mass spectrometry (MS) which allows the detection of thousands of molecules in a large number of samples, are the most valuable. Such studies, focused on cancer biomarkers discovery or patients' stratification, are presented in this review. Moreover, the technical aspects of MS-based clinical proteomics and metabolomics are described.
2584 related Products with: Mass spectrometry based proteomics and metabolomics in personalized oncology.Androstadienone C19H26O C Goat Anti-Mouse Dcdc2a, ( Goat Anti-Influenza A H3N Goat Anti-Human GPR142, ( FAAH Inhibitor, PF-622; A RXRA & CTNNB1 Protein Pro CREB Phospho-Specific Arr Rabbit Anti-Insulin Recep MAP3K3 & FLNA Protein Pro Multiple organ tumor tiss Interleukins Recombinant 9-(4’-Aminophenyl)-9H-p
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Immunoinformatics guided rational design of a next generation multi epitope based peptide (MEBP) vaccine by exploring Zika virus proteome.Zika virus (ZIKV) is an RNA virus that has spread through mosquito sting. Currently, no vaccine and antiviral medication available so far against ZIKV. Therefore, it has fostered a study to design MEBP vaccine enabling effective prevention against the ZIKV infection. In this study combination of immuno-informatics and molecular docking approach was used to constitute a MEBP vaccine. The ZIKV proteome was used for prediction of B-cell, T-cell (HTL & CTL) and IFN-γ epitopes. After prediction, highly antigenic and overlapping epitopes have been shortlisted which includes 14 CTL and 11 HTL epitopes that have been linked to the final peptide through AAY and GPGPG linkers respectively. An adjuvant at the N-end of the vaccine was added to improve the immunogenicity of the vaccine through the EAAAK linker. The final construct constitutes 435 amino acids after the addition of linkers and adjuvant. The existence of B-cell and IFN-γ epitopes affirms the humoral and cell-mediated immune responses acquired by the construct. Allergenicity, antigenicity and different physiochemical attributes of the vaccine were evaluated to assure its safety and immunogenicity profile. In fact, the construct was antigenic and non-allergenic. Docking was performed among vaccine and TLR-3 to evaluate the binding affinity and the molecular interaction. Finally, the construct was subjected to In silico cloning to confers the authenticity of its expression efficiency. However, the proposed construct need to be validate experimentally to ensure its safety and immunogenic profile.
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Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data.The surveillance of drug resistance among tuberculosis (TB) patients is central to combatting the global TB epidemic and preventing the spread of antimicrobial resistance. Isoniazid and rifampicin are two of the most powerful first-line anti-TB medicines, and resistance to either of them increases the risk of treatment failure, relapse, or acquisition of resistance to other drugs. The global prevalence of rifampicin resistance is well documented, occurring in 3.4% (95% CI 2.5%-4.4%) of new TB patients and 18% (95% CI 7.6%-31%) of previously treated TB patients in 2018, whereas the prevalence of isoniazid resistance at global and regional levels is less understood. In 2018, the World Health Organization (WHO) recommended a modified 6-month treatment regimen for people with isoniazid-resistant, rifampicin-susceptible TB (Hr-TB), which includes rifampicin, pyrazinamide, ethambutol, and levofloxacin. We estimated the global prevalence of Hr-TB among TB patients and investigated associated phenotypic and genotypic drug resistance patterns.
2252 related Products with: Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data.High density breast invas Small intestine disease s Prostate cancer, PIN (pro Advanced module Infinicyt High density larynx and p Rectum adenocarcinoma tis Goat Anti- NBL4, (interna Rabbit Anti-TNIP2 ABIN2 T APC & CTNNA1 Protein Prot Rat Anti-Mouse Interleuki Breast invasive ductal ca Goat Anti- HOXB4, (intern
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ICTV Virus Taxonomy Profile: .The family includes viruses that replicate in hyperthermophilic archaea from the genus . The non-enveloped, hollow, cylindrical virions are formed from a coiling fibre that consists of two intertwining halves of a single circular nucleoprotein filament. A short appendage protrudes from each end of the cylindrical virion. The genome is circular, positive-sense, single-stranded DNA of 24 893 nucleotides. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) report on the family , which is available at ictv.global/report/spiraviridae.
Recombinant SARS Virus Nu Rabbit Anti-polyprotein[C Mouse Anti-Rubella Virus Goat Anti-Rubella Virus A Adeno Associated Virus (A Recombinant Dengue Virus Recombinant SARS Virus Nu Rabbit Anti-Hepatitis C V ENA 6 parameters profile Rabbit Anti-SARS Virus Sp Adeno Associated Virus VP Recombinant Dengue Virus
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Bladder preservation in muscle-invasive bladder cancer: a comprehensive review.Standard management of muscle-invasive bladder cancer involves radical cystectomy with pelvic lymph node dissection. However, patients may be ineligible for surgery or may wish to avoid the morbidity of cystectomy due to quality of life concerns. Bladder preservation therapies have emerged as alternatives treatment options that can provide comparable oncologic outcomes while maintaining patients' quality of life.
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Conversion of FACIT-F to PROMIS® Fatigue Scores in Two Phase 3 Baricitinib Rheumatoid Arthritis Trials.The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) is validated for measuring fatigue in rheumatoid arthritis (RA). However, 10 of 13 FACIT-F items are identified as relevant to RA patients. The Patient-Reported Outcomes Measurement Information System (PROMIS ) uses an item response theory (IRT)-calibrated T-score metric. The PROMIS Fatigue item bank includes the FACIT-F items, enabling score conversion. Converted PROMIS Fatigue scores' performance has not been evaluated in RA populations or clinical trials. We assessed converted PROMIS Fatigue scores' performance in 2 RA clinical trials of baricitinib.
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Fear driven compulsive behaviour is associated with worse long-term outcome in obsessive-compulsive disorder.In this retrospective study of patients with obsessive-compulsive disorder (OCD), we assessed the relationship between different motivational drivers of compulsive behaviours and the response to naturalistic treatments (based mostly on high dose serotonin reuptake inhibitors [SRIs]).
2511 related Products with: Fear driven compulsive behaviour is associated with worse long-term outcome in obsessive-compulsive disorder.Interleukin-34 IL34 (N-t Hamster AntiSerine Protea Rabbit Anti-APIP Apaf1 In Goat Anti-Human PI31 PSMF Rabbit Anti-intestinal FA Rabbit Anti-Integrin beta Rabbit Anti-Tenascin C (C Rabbit Anti-Phospho-INPPL Mouse Anti-Insulin(1D4:) Rabbit Anti-APIP Apaf1 In Goat Anti-Human TSPO PBR Rabbit Anti-Insulin Polyc
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