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#33249793   // To Up

Immune-Mediated Fetal Complete Atrioventricular Block: Can Dexamethasone Therapy Revert the Process?

Fetal complete atrioventricular block (CAVB) is usually autoimmune mediated. The risk of developing CAVB is 2% to 3% in anti-Ro/SS-A seropositive pregnancies and it increases 10 times after previous CAVB in siblings. Despite being a rare complication, CAVB carries a 20% mortality rate and substantial morbidity, as about 65% of newborns will eventually need life-long pacing. Once found, fetal CAVB is almost always irreversible, despite aggressive immunotherapy. This poor outcome prompted some research groups to address this situation. All groups followed anti-Ro/SS-A seropositive pregnancies on a weekly basis during the second trimester of pregnancy and tried to detect first degree atrioventricular block (AVB) using accurate echocardiographic tools, assuming they may characterize the initiation of the immune damage to the A-V conduction system, at which point the process might still be reversible. Some of the groups treated fetuses with first degree AVB with maternal oral fluorinated steroids. We summarized the results of all groups, including our group. We describe a case of a fetus that developed CAVB 6 days after normal sinus rhythm (NSR), who under aggressive dexamethasone therapy gradually reverted to NSR. This fetus had a previous sibling with CAVB. We assumed the immune damage to the conduction system in this small group of fetuses with a previous CAVB sibling may have occurred more quickly than usual. We therefore recommend a twice-weekly follow-up with these fetuses.
Zeev Perles, Yuval Ishay, Amiram Nir, Sagui Gavri, Julius Golender, Asaf Ta-Shma, Ibrahim Abu-Zahira, Juma Natsheh, Uriel Elchalal, Dror Mevorach, Azaria Jjt Rein

1883 related Products with: Immune-Mediated Fetal Complete Atrioventricular Block: Can Dexamethasone Therapy Revert the Process?

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#33249789   // To Up

Re-Appraisal of Echocardiographic Assessment in Patients with Pulmonary Embolism: Prospective Blinded Long-Term Follow-Up.

Acute pulmonary embolism (PE) is considered to be one of the most common cardiovascular diseases with considerable mortality. Conflicting data imply possible role for echocardiography in assessing this disease.
Hezzy Shmueli, Arie Steinvil, Galit Aviram, Sileman Moaad, Adam Sharon, Achiude Bendet, Simon Biner, Yacov Shacham, Jack Sherez, Ricki Megidish, Yifat Hasin, Ester Elazar, Sevan Letourneau-Shesaf, Gad Keren, Shlomo Berliner, Yan Topilsky

1527 related Products with: Re-Appraisal of Echocardiographic Assessment in Patients with Pulmonary Embolism: Prospective Blinded Long-Term Follow-Up.

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#33249785   // To Up

The Impact of the COVID-19 Pandemic on General Surgery Acute Admissions and Urgent Operations: A Comparative Prospective Study.

As part of the effort to control the coronavirus disease-19 (COVID-19) outbreak, strict emergency measures, including prolonged national curfews, have been imposed. Even in countries where healthcare systems still functioned, patients avoided visiting emergency departments (EDs) because of fears of exposure to COVID-19.
Eyal Aviran, Shachar Laks, Haggai Benvenisti, Saed Khalilieh, Dan Assaf, Nimrod Aviran, David Hazzan, Yoram Klein, Amir Cohen, Mordechai Gutman, Aviram Nissan, Lior Segev

1616 related Products with: The Impact of the COVID-19 Pandemic on General Surgery Acute Admissions and Urgent Operations: A Comparative Prospective Study.

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#33249779   2020/11/29 To Up

Association of immune responses of Zebu and Holstein-Friesian cattle and resistance to mycobacteria in a BCG challenge model.

Mycobacterium bovis is the main cause of bovine tuberculosis (BTB) in cattle and can also infect humans. Zebu cattle are considered more resistant to some infectious diseases compared to Holstein-Friesian (HF) cattle, including BTB. However, epidemiological studies may not take into account usage differences of the two types of cattle. HF cattle may suffer greater metabolic stress due to their more or less exclusive dairy use, whereas Zebu cattle are mainly used for beef production. In experiments conducted so far, the number of animals has been too small to draw statistically robust conclusions on the resistance differences between these cattle breeds. Here, we used a BCG challenge model to compare the ability of naïve and vaccinated Zebu and HF cattle to control/kill mycobacteria. Young cattle of both breeds with similar ages were housed in the same accommodation for the duration of the experiment. After correcting for multiple comparisons, we found no difference between naïve HF and Zebu (ρ = 0.862) cattle. However, there was a trend for vaccinated HF cattle to have lower cfu numbers than non-vaccinated HF cattle (ρ = 0.057); no such trend was observed between vaccinated and non-vaccinated Zebu cattle (ρ = 0.560). Evaluation of antigen-specific IFNγ secretion by PBMC indicated that Zebu and HF cattle differed in their response to mycobacteria. Thus, whilst there may be difference in immune responses, our data indicate that with the number of animals included in the study and under the conditions used in this work, we were unable to measure any differences between Zebu and HF cattle in the overall control of mycobacteria. Whilst determination of different susceptibilities between Zebu and HF cattle using the BCG challenge model will require larger numbers of animals than the number of animals used in this experiment, these data should inform future experiments.
Omar Antonio Alcaraz-López, Susana Flores-Villalva, Omar Cortéz-Hernández, Guadalupe Vigueras-Meneses, Jacobo Carrisoza-Urbina, Alejandro Benítez-Guzmán, Hugo Esquivel-Solís, Dirk Werling, Francisco J Salguero Bodes, Martin Vordemeier, Bernardo Villarreal-Ramos, José A Gutiérrez-Pabello

1079 related Products with: Association of immune responses of Zebu and Holstein-Friesian cattle and resistance to mycobacteria in a BCG challenge model.

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#33249775   2020/11/28 To Up

Admission hyperglycemia as an independent predictor of long-term prognosis in non-diabetic patients with acute myocardial infarction: a retrospective study.

The predictive value of admission hyperglycemia in the long-term prognosis of AMI patients is still controversial. We aim to investigate this value based on the diabetic status.
Cai-Yan Cui, Ming-Gang Zhou, Lian-Chao Cheng, Tao Ye, Yu-Mei Zhang, Feng Zhu, Si-Yi Li, Xing-Lin Jiang, Qiang Chen, Ling-Yao Qi, Xu Chen, Si-Qi Yang, Lin Cai

1440 related Products with: Admission hyperglycemia as an independent predictor of long-term prognosis in non-diabetic patients with acute myocardial infarction: a retrospective study.

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#33249774   2020/11/29 To Up

The impact of ferritin on the disassociation of HbA1c and mean plasma glucose.

To explore the impact of ferritin level on the disassociation of glycated hemoglobin A1c (HbA1c) and mean plasma glucose (MPG).
Yufeng Li, Fang Zhang, Xiuying Zhang, Zuodi Fu, Lianying Wang, Cuiling Zhao, Guangxia Guo, Xianghai Zhou, Linong Ji

1943 related Products with: The impact of ferritin on the disassociation of HbA1c and mean plasma glucose.

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#33249768   2020/11/29 To Up

Toxoplasma gondii infection in Colombia with a review of hosts and their ecogeographic distribution.

Toxoplasma gondii is one of the most prevalent zoonotic protozoan parasites among warm-blooded animal populations (humans included) around the world, causing multiple clinic manifestations including death in the most severe cases of infection. Due to the versatile life cycle of T. gondii and its diversity of potential hosts, there is a common perception that natural areas and wildlife are highly prevalent reservoirs for the parasite; however, information and reports of the parasite on wildlife populations in Colombia are scarce. Using PRC-based detection analyses of the B1 gene, we evaluated the presence of T. gondii in 49 native small mammal species (10% of the mammal species of Colombia) from 4 different undisturbed natural habitats. Additionally, to understand the ecogeographical distribution of the parasite in Colombia, we developed a literature search of infection reports including information on the host species, density of records and occurrence patterns (using landcover and ecoregions) in natural, rural and urban areas. Our literature review showed a total of 8,103 reports of T. gondii for Colombia of which 86% were related to humans, and 14% to non-human mammals and other categories, with just a single report associated to wildlife; additionally, 82% of all reports were associated to urban areas whereas only 18% to rural sites. Based on the negative results for the presence of T. gondii in our PCR-based analyses and our literature search, we suggest that T. gondii has a synanthropic distribution in Colombia occurring in ecoregions as variable as the xeric scrubs in the northern lowlands and humid montane Andean forests, also we show a lack of information on the parasite relationship with wildlife, a concerning fact given that zoonoses are the leading mechanism for the emergence of infectious diseases.
Luis Javier Pérez-Grisales, Mariana Cruz-Moncada, Ronald Peláez-Sánchez, Juan Fernando Díaz-Nieto

1784 related Products with: Toxoplasma gondii infection in Colombia with a review of hosts and their ecogeographic distribution.

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#33249760   2020/11/28 To Up

Machine learning models predict coagulopathy in spontaneous intracerebral hemorrhage patients in ER.

Coagulation abnormality is one of the primary concerns for patients with spontaneous intracerebral hemorrhage admitted to ER. Conventional laboratory indicators require hours for coagulopathy diagnosis, which brings difficulties for appropriate intervention within the optimal window. This study evaluates the possibility of building efficient coagulopathy prediction models using data mining and machine learning algorithms.
Fengping Zhu, Zhiguang Pan, Ying Tang, Pengfei Fu, Sijie Cheng, Wenzhong Hou, Qi Zhang, Hong Huang, Yirui Sun

2327 related Products with: Machine learning models predict coagulopathy in spontaneous intracerebral hemorrhage patients in ER.

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#33249751   2020/11/28 To Up

The regulation of gastric ghrelin secretion.

Ghrelin is a gastric hormone with multiple physiological functions, including the stimulation of food intake and adiposity. It is well established that circulating ghrelin levels are closely associated with feeding patterns, rising strongly before a meal, and lowering upon food intake. However, the mechanisms underlying the modulation of ghrelin secretion are not fully understood. The purpose of this review is to discuss current knowledge on the circadian oscillation of circulating ghrelin levels, the neural mechanisms stimulating fasting ghrelin levels, and peripheral mechanisms modulating postprandial ghrelin levels. Furthermore, the therapeutic potential of targeting the ghrelin pathway is discussed in the context of the treatment of various metabolic disorders, including obesity, type 2 diabetes, diabetic gastroparesis and Prader-Willi syndrome. Moreover, eating disorders, including anorexia nervosa, bulimia nervosa and binge-eating disorder are also discussed.
Maria Nunez-Salces, Hui Li, Christine Feinle-Bisset, Richard L Young, Amanda J Page

2346 related Products with: The regulation of gastric ghrelin secretion.

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#33249748   2020/11/29 To Up

Beyond energy storage: roles of glycogen metabolism in health and disease.

Beyond storing and supplying energy in the liver and muscles, glycogen also plays critical roles in cell differentiation, signaling, redox regulation and stemness under various physiological and pathophysiological conditions. Such versatile functions have been revealed by various forms of glycogen storage diseases. Here, we outline the source of carbon flux in glycogen metabolism and discuss how glycogen metabolism guides CD8 T cell memory formation and maintenance. Likewise, we review how this affects macrophage polarization and inflammatory responses. Furthermore, we dissect how glycogen metabolism supports tumor development by promoting tumor-repopulating cell growth in hypoxic tumor microenvironments. This review highlights the essential role of the gluconeogenesis-glycogenesis-glycogenolysis-PPP metabolic chain in redox homeostasis, thus providing insights into potential therapeutic strategies against major chronic diseases including cancer.
Huafeng Zhang, Jingwei Ma, Ke Tang, Bo Huang

1795 related Products with: Beyond energy storage: roles of glycogen metabolism in health and disease.

96 tests96 tests1-99 mg/ml/ea price x 2

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