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Search results for: iodide

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#34520798   2021/09/11 To Up

A Straightforward One-Pot Two-Step Conversion of Bile Acids into Dehomologated Alcohols.

Irradiation of dichloroethane solutions of different bile acids with diacetoxy(iodobenzene) and iodine followed by treatment of the resulting raw mixture with MCPBA led to the 41-50% yields of the corresponding dehomologated alcohols in an uncomplicated one-pot protocol that can be completed in less than one day of work.
Eduardo Hernández-Huerta, Marcos Flores-Álamo, Martín A Iglesias-Arteaga

1798 related Products with: A Straightforward One-Pot Two-Step Conversion of Bile Acids into Dehomologated Alcohols.

600 Tests / Kit430 Tests / Kit430 tests1 kit720/kit100ug Lyophilized100ug Lyophilized1 g100 plates 1KG100 ug

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#34520744   2021/09/11 To Up

Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter.

The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells. Approaches to bolster NIS function and diminish recurrence post-radioiodide therapy are impeded by oncogenic pathways that suppress NIS, as well as the inherent complexity of NIS regulation. Here, we utilize NIS in high-throughput drug screening and undertake rigorous evaluation of lead compounds to identify and target key processes underpinning NIS function. We find that multiple proteostasis pathways, including proteasomal degradation and autophagy, are central to the cellular processing of NIS. Utilizing inhibitors targeting distinct molecular processes, we pinpoint combinatorial drug strategies giving robust >5-fold increases in radioiodide uptake. We also reveal significant dysregulation of core proteostasis genes in human tumors, identifying a 13-gene risk score classifier as an independent predictor of recurrence in radioiodide-treated patients. We thus propose and discuss a model for targetable steps of intracellular processing of NIS function.
Martin L Read, Katie Brookes, Caitlin E M Thornton, Alice Fletcher, Hannah R Nieto, Mohammed Alshahrani, Rashida Khan, Patricia Borges de Souza, Ling Zha, Jamie R M Webster, Luke J Alderwick, Moray J Campbell, Kristien Boelaert, Vicki E Smith, Christopher J McCabe

1112 related Products with: Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter.

100 assays1 kit(96 Wells)1 kit(96 Wells)430 tests1 kit(96 Wells)100 assays1 kit(96 Wells)1 kit

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#34520586   2021/09/14 To Up

Halogen Bonding Heteroditopic Materials for Cooperative Sodium Iodide Binding and Extraction.

A series of novel heteroditopic halogen bonding (XB) receptor functionalised silica based materials, containing mono- and bis-iodotriazole benzo-15-crown-5 groups are investigated for the cooperative binding and extraction of sodium halide ion-pair species from aqueous solution. Characterisation of the XB materials by CHN elemental analysis, 13 C CP/MAS-NMR and ATR-FTIR spectroscopies confirms and quantifies the successful incorporation of the ion-pair receptor frameworks to the silica material. ICP-MS solid-liquid extraction studies demonstrate the bidentate XB functionalised material is capable of NaI extraction from water. Importantly, cooperative XB-mediated sodium halide ion-pair binding is determined to be crucial to the material's extraction capabilities, impressively demonstrating a two-fold enhancement in sodium iodide extraction efficiency relative to a heteroditopic hydrogen bonding receptor functionalised silica material analogue.
Andrew Docker, James G Stevens, Paul D Beer

2719 related Products with: Halogen Bonding Heteroditopic Materials for Cooperative Sodium Iodide Binding and Extraction.

1000 TESTS/0.65ml96 Well 100 G96 wells (1 kit) 1 G1 umole5.0 g 25 G 100 G100 ml2.5 mg

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#34519212   2021/09/14 To Up

Direct Synthesis of 4-Aryl-1,2,3-triazoles via I-Promoted Cyclization under Metal- and Azide-Free Conditions.

We herein report an iodine-mediated formal [2 + 2 + 1] cyclization of methyl ketones, -toluenesulfonyl hydrazines, and 1-aminopyridinium iodide for preparation of 4-aryl--1,2,3-triazoles under metal- and azide-free conditions. Notably, this is achieved using -toluenesulfonyl hydrazines and 1-aminopyridinium iodide as azide surrogates, providing a novel route to-1,2,3-triazoles. Furthermore, this approach provides rapid and practical access to potent inhibitors of indoleamine 2,3-dioxygenase (IDO).
Chun Huang, Xiao Geng, Peng Zhao, You Zhou, Xiao-Xiao Yu, Li-Sheng Wang, Yan-Dong Wu, An-Xin Wu

1089 related Products with: Direct Synthesis of 4-Aryl-1,2,3-triazoles via I-Promoted Cyclization under Metal- and Azide-Free Conditions.

1 mg1 mg1 mg1 mg100 1 mg0.25 mg1 mg500 1 mg1 mg1 mg

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#34519147   2021/09/14 To Up

Chiral Indoline-2-carboxylic Acid Enables Highly Enantioselective Catellani-type Annulation with 4-(bromomethyl)cyclohexanone.

Chiral indoline-2-carboxylic acid has been identified to enable the first highly enantioselective Catellani-type annulation of (hetero)aryl, alkenyl triflate and conjugated vinyl iodides with 4-(bromomethyl)cyclohexanone, directly assembling a diverse range of chiral all-carbon bridged ring systems. Control experiments and DFT calculations suggest that the coordinating orientation of the chiral amino acid to the arylpalladium(II) center allows for high levels of stereochemical control.
Liuzhu Gong, Xin-Meng Chen, Ling Zhu, Dian-Feng Chen

1765 related Products with: Chiral Indoline-2-carboxylic Acid Enables Highly Enantioselective Catellani-type Annulation with 4-(bromomethyl)cyclohexanone.

5 G 1 G10 mg 1 G 100 G25 mg100 mg 5 G100 mg1 g1 g

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#34517596   2021/07/22 To Up

Iodide-modified Ag nanoparticles coupled with DSN-Assisted cycling amplification for label-free and ultrasensitive SERS detection of MicroRNA-21.

With the emergence of microRNA (miRNA) as a key player in early clinical disease diagnosis, development of rapidly sensitive and quantitative miRNA detection methods are imperative. Herein, a label-free SERS assay coupled with duplex-specific nuclease (DSN) signal amplification strategy was proposed for facilely ultrasensitive and quantitative analysis of miRNA-21. Firstly, magnetic beads assembled with excessive capture DNA were utilized to hybridize the target miRNA-21. These DNA-RNA heteroduplexes were cleaved by DSN to generate small nucleotide fragments into the supernatant and the miRNA-21 released and rehybridized another DNA, going to the next DSN cycle. Consequently, numerous of small nucleotide fragments of capture DNA were released from magnetic beads and the miRNA-21 signal was transferred and amplified by the SERS signals of total phosphate backbones which are abundant in nucleotide. Furthermore, iodide-modified Ag nanoparticles (AgINPs) was employed to generate a strong and reproducible SERS signal. The proposed method displayed excellent performance for miRNA-21 detection with the linear range from 0.33 fM to 3.3 pM, and a lower detection limit of 42 aM. Moreover, this strategy exhibited effectively base discrimination capability and was successfully applied for monitoring the expression levels of miRNA-21 in different cancer cell lines and human serum.
Yuanyuan Yao, Hongding Zhang, Tongtong Tian, Yixin Liu, Rendan Zhu, Ji Ji, Baohong Liu

1440 related Products with: Iodide-modified Ag nanoparticles coupled with DSN-Assisted cycling amplification for label-free and ultrasensitive SERS detection of MicroRNA-21.

100 ul10 reactions100tests100 ul2x96 well plate5L50 ul30 Samples50 ul10 reactions

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#34517583   2021/07/13 To Up

Electrocolorimetric gel-based sensing approach for simultaneous extraction, preconcentration, and detection of iodide and chromium (VI) ions.

A total integrated electrocolorimetric sensing approach consisting of gel-based electromembrane extraction and colorimetric detection in a one-step process was developed. This system was designed using colorimetric reagents preadded to the agarose gel for the determination of the following two model analytes: iodide and hexavalent chromium [Cr(VI)]. In this system, when a voltage was applied, the analytes were extracted and transferred from the sample solution (donor phase) to the gel (acceptor phase). The analytes then simultaneously reacted with the colorimetric reagents inside the gel, yielding blue and violet colors for iodide and Cr(VI), respectively. These colors were then analyzed using a portable spectrometer and could also be distinguished with the naked eye. Parameters affecting the extraction efficiency were studied and optimized for both analytes. The gel composition for iodide detection was 4% (w/v) agarose, 5% (v/v) HO, and 1% (w/v) starch in 2 mM HCl. The gel composition for Cr(VI) detection was 2% (w/v) agarose and 1% (w/v) DPC in 0.5 mM HNO. Both analytes were extracted at an applied potential of 50 V, an extraction time of 15 min and a stirring rate of 600 rpm. Under the optimized conditions, the developed systems provided linear responses within 15 min for iodide concentrations ranging from 50 to 250 μg L with a detection limit of 18 μg L and for Cr(VI) concentrations ranging from 30 to 125 μg L with a detection limit of 5 μg L. Finally, these systems were successfully applied to the determination of iodide in iodide food supplement samples and Cr(VI) in drinking water samples, showing a negligible matrix effect. This integration could also be extended to other analytes and detection systems to develop sensitive, on-site, and environmentally friendly sensing approaches.
Ali Sahragard, Waleed Alahmad, Pakorn Varanusupakul

1542 related Products with: Electrocolorimetric gel-based sensing approach for simultaneous extraction, preconcentration, and detection of iodide and chromium (VI) ions.

100ug100ug100 mg1000 tests50 ug 500 MG25 mg1 ml100.00 ul10 mg96T

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#34517264   2021/08/14 To Up

Combination of curcumin with N-n-butyl haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncRNA H19 to silence Wnt/β-catenin signaling.

Hepatocellular carcinoma (HCC) is one of the most common cause of cancer-related death worldwide. Curcumin (C) has been extensively investigated in different types of malignancies, including hepatocellular carcinoma, but its physicochemical properties have significantly influenced its clinical use. Several approaches are being explored to enhance curcumin's therapeutic response, including its combination with various drugs.
Hanif Khan, Zhengzhong Ni, Hai Feng, Yaqi Xing, Xuejun Wu, Danmei Huang, Ling Chen, Yongdong Niu, Ganggang Shi

1613 related Products with: Combination of curcumin with N-n-butyl haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncRNA H19 to silence Wnt/β-catenin signaling.

5 G200ul96T5 g200ul2500 Tests10 mg

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#34517219   2021/08/24 To Up

SERS liquid biopsy: An emerging tool for medical diagnosis.

Surface-enhanced Raman scattering (SERS) is emerging as a novel strategy for biofluid analysis. In this review, we delineate four experimental SERS protocols that are frequently used for the profiling of biofluids: 1) liquid SERS for the detection of purine metabolites; 2) iodide-modified liquid SERS for the detection of proteins; 3) dried SERS for the detection of both purine metabolites and proteins; 4) resonant Raman for the detection of carotenoids. To explain the selectivity of each experimental SERS protocol, we introduce a heuristic model for the chemisorption of analytes mediated by adsorbed ions (adions) onto the SERS substrate. Next, we show that the promising results of SERS liquid biopsy stem from the fact that the concentration levels of purine metabolites, proteins and carotenoids are informative of the cellular turnover rate, inflammation, and oxidative stress, respectively. These processes are perturbed in virtually every disease, from cancer to autoimmune maladies. Finally, we review recent SERS liquid biopsy studies and discuss future steps that are required for translating SERS in the clinical setting.
Vlad Moisoiu, Stefania D Iancu, Andrei Stefancu, Tudor Moisoiu, Barbara Pardini, Mihnea P Dragomir, Nicolae Crisan, Lucretia Avram, Dana Crisan, Iulia Andras, Daniela Fodor, Loredana F Leopold, Carmen Socaciu, Zoltán Bálint, Ciprian Tomuleasa, Florin Elec, Nicolae Leopold

2459 related Products with: SERS liquid biopsy: An emerging tool for medical diagnosis.

1 module1 module1 module0.25 mg1 module1 module0.2 mg1 module0.2 mg1 module1 module100μg

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#34517030   2021/09/10 To Up

Functionalization of nanocellulose to quaternized nanocellulose tri-iodide and its evaluation as an antimicrobial agent.

The reported research involves formation of quaternized nanocellulose triiodide for use as an agent for controlled release of iodine. Nanocellulose was extracted from bagasse and the extracted cellulose nanofibers (CNFs) were quaternized with 3-chloro-2-hydroxypropyltrimethyl ammonium chloride (CHPTAC) in NaOH/urea solution. This was followed by exchange of Cl with I by reaction with KI/I. Nanofibers having I anions were characterized by SEM, TEM, XRD, XRF and FTIR spectroscopy. The iodine content was estimated to be 33.42% and the fibers showed no leaching of molecular I in detectable amounts. The fibers showed a maximum activity of 94.73% and 99.86% against E. coli and S. aureus, respectively. These are capable of sustaining 100% antimicrobial activity over a period of six months. These fibers can thus find potential applications as a disinfectant agent in biomedical and water purification processes.
Monica Bansal, Dharmender, Ghanshyam S Chauhan, Anupama Kaushik, Gagandeep Kaur

1161 related Products with: Functionalization of nanocellulose to quaternized nanocellulose tri-iodide and its evaluation as an antimicrobial agent.

961 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)100 assays1 kit(96 Wells)1 kit(96 Wells)1 kit(96 Wells)100 assays1 kit(96 Wells)1 kit(96 Wells)

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