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#35045491   // To Up

[A Case of Spindle Cell Tumor in the Gastric Mucosa Treated with Laparoscopic Local Gastrectomy].

The patient was a 43-year-old man. An upper gastrointestinal endoscopic examination revealed a gastric submucosal tumor(SMT)-like, elevated 8-mm lesion in the greater curvature of the upper body of the stomach. It was diagnosed as spindle cell tumor on the basis of biopsy findings, and a gastrointestinal stromal tumor(GIST)was suspected. Various immunohistochemical staining techniques were used; however, a definitive diagnosis could not be achieved. There was no evidence of distant metastasis even on thoracoabdominal computed tomography imaging; thus, the patient was referred to our department for definitive diagnosis and surgical treatment. Laparoscopic local gastrectomy with concomitant intraoperative gastroscopy was performed. Pathological examination of the resected specimen showed a type Ⅱc-like lesion with a maximum diameter of 6 mm in the mucosal layer along with spindle cell proliferation. Immunostaining was negative for c- kit, DOG1, CD34, S-100, SMA, WT-1, desmin(N), EMA, and keratin(pan)and positive for β-catenin, Bcl-2, and vimentin; furthermore, low Ki-67(MIB-1)expression was detected. Therefore, GIST, solitary fibrous tumor, leiomyoma, leiomyosarcoma, desmoid tumor, spindle cell carcinoma, and synovial sarcoma were excluded, and an unclassifiable spindle cell tumor arising from the gastric mucosa was diagnosed. The patient has remained recurrence-free for 1 year and 8 months post-operatively and is currently under careful outpatient follow-up.
Hidemasa Tamai, Sumi Kobayashi, Hirofumi Suzuki, Tomoya Hatakeyama, Kazuki Sakai, Sosuke Komiyama, Shiro Ogino, Toshikazu Akami, Yuji Ueda, Takeshi Mazaki

2227 related Products with: [A Case of Spindle Cell Tumor in the Gastric Mucosa Treated with Laparoscopic Local Gastrectomy].



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#35045486   // To Up

[Mediastinoscope-Assisted Transhiatal Esophagectomy for Esophageal Gastrointestinal Stromal Tumor(GIST)-A Case Report].

A 71-year-old woman was referred to our hospital because of an esophageal submucosal tumor. Esophagogastroduodenoscopy revealed a submucosal tumor of 40×25 mm with ulceration in the lower thoracic esophagus and endoscopic ultrasonographic fine needle aspiration histology showed KIT(+), CD34(+), DOG-1(+), desmin(-), S-100 protein(-). We diagnosed esophageal GIST and performed mediastinoscope-assisted transhiatal esophagectomy with gastric tube reconstruction. Histopathological findings showed c-kit(+), Ki-67 index of 8%, and middle-risk GIST by the modified- Fletcher classification. Mediastinoscope-assisted transhiatal esophagectomy is useful in terms of shortening total operative time and preventing respiratory complications because it does not require thoracic operation, one-lung ventilation, or repositioning. Subtotal esophagectomy under a mediastinal approach could secure a margin for resection, which may reduce the risk of recurrence, and could be one of the surgical procedures for esophageal GIST.
Mizuki Tamai, Atsushi Shiozaki, Hitoshi Fujiwara, Hirotaka Konishi, Jun Kiuchi, Takuma Ohashi, Hiroki Shimizu, Tomohiro Arita, Yusuke Yamamoto, Ryo Morimura, Yoshiaki Kuriu, Hisashi Ikoma, Takeshi Kubota, Kazuma Okamoto, Eigo Otsuji

1377 related Products with: [Mediastinoscope-Assisted Transhiatal Esophagectomy for Esophageal Gastrointestinal Stromal Tumor(GIST)-A Case Report].



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#35045471   // To Up

[A Case of Gastrointestinal Stromal Tumor(GIST)of the Sigmoid Colon with Early Colon Cancer].

A 67-year-old male patient was referred to our department for fecal occult blood in March 2019. In April, lower intestinal endoscopic examination revealed a 25-mm pedunculated polyp in the sigmoid colon. Endoscopic mucosal resection was then performed. The pathological diagnosis was tub1-tub2 with an invasion depth of pT1b 3,000 μm, and ly0 and v1 vascular invasion. The tumor marker levels were normal, with CEA of 1.1 ng/mL and CA19-9 of 13.9 U/mL. An additional laparoscopic low anterior resection and D2 dissection were performed in June. After the endoscopic mucosal resection, pathologic examination revealed densely hyperplastic spindle cells arranged in bundles at the proper muscular layer of the scar site. There was no lymph node metastasis. On immunostaining, the lesion tested positive for c-kit, CD34, and DOG1, but negative for desmin, SMA, and S-100, with a MIB-1 index of 2%. The patient was diagnosed with very low risk gastrointestinal stromal tumor(GIST). We encountered a rare case of early sigmoid colon cancer, complicated by sigmoid colon GIST.
Tomohisa Nomura, Kenji Katsumata, Tomoya Tago, Kenta Kasahara, Junichi Mazaki, Hiroshi Kuwabara, Masatoshi Shigoka, Masanobu Enomoto, Tetsuo Ishizaki, Hiroo Shobu, Atsushi Uehara, Yuichi Nagakawa, Akihiko Tsuchida

3000 related Products with: [A Case of Gastrointestinal Stromal Tumor(GIST)of the Sigmoid Colon with Early Colon Cancer].



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[A Case of Giant Intestinal GIST That Was Resected Just after TAE].

A 42-year-old woman visited our hospital complaining of fever and diarrhea. She had abdominal swelling and muscular defense. CT revealed a lobulated tumor occupying the lower abdomen. The tumor contained solid and cystic areas. The main artery vascularizing the tumor was the ileocecal artery, so we considered the tumor to be derived from the intestine or mesentery. We anticipated massive bleeding due to resection, and immediately after the embolization of the artery just before the operation. A vascular bundle from the terminal ileum and mesentery was found on the dorsal side of the tumor, and an outflow from the inferior mesenteric vein was also observed. We ligated each vessel and performed ileocecal resection. The operation lasted 4 hours and 18 minutes, with an estimated blood loss of 2,585 mL, requiring the transfusion of 6 units of concentrated red blood cells. According to histopathological findings, tumor cells with spindle-shaped to ellipsoidal nuclei proliferated in bundles and intricately, and immunostaining was positive for c-kit and DOG-1. We identified the tumor as high-risk GIST. The clinical course after the operation was uneventful. She continued to take imatinib for 3 years and is currently alive and without recurrence for 6 years after the operation.
Naoko Sekiguchi, Masakazu Ikenaga, Masahiro Koh, Kiyotsugu Iede, Masami Ueda, Yujiro Tsuda, Shinsuke Nakashima, Tsukasa Tanida, Jin Matsuyama, Terumasa Yamada

1101 related Products with: [A Case of Giant Intestinal GIST That Was Resected Just after TAE].



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#35045360   2022/01/16 To Up

Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit.

Ubiquitin-specific proteases (USPs) act as proto-oncogenes or tumor suppressors in a wide variety of cancers. In this study, we intended to explore the role of USP1 in hepatocellular carcinoma (HCC).
Zhangbin Chen, Yifei Ma, Zhitang Guo, Dingyuan Song, Zili Chen, Min Sun

1124 related Products with: Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit.

100ul100ug100ug Lyophilized100ug Lyophilized100μg100ug Lyophilized100ug100ug100ug Lyophilized100ug100ug

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#35045172   2022/01/19 To Up

Hybrid machine learning to localize atrial flutter substrates using the surface 12-lead electrocardiogram.

Atrial flutter (AFlut) is a common re-entrant atrial tachycardia driven by self-sustainable mechanisms that cause excitations to propagate along pathways different from sinus rhythm. Intra-cardiac electrophysiological mapping and catheter ablation are often performed without detailed prior knowledge of the mechanism perpetuating AFlut, likely prolonging the procedure time of these invasive interventions. We sought to discriminate the AFlut location [cavotricuspid isthmus-dependent (CTI), peri-mitral, and other left atrium (LA) AFlut classes] with a machine learning-based algorithm using only the non-invasive signals from the 12-lead electrocardiogram (ECG).
Giorgio Luongo, Gaetano Vacanti, Vincent Nitzke, Deborah Nairn, Claudia Nagel, Diba Kabiri, Tiago P Almeida, Diogo C Soriano, Massimo W Rivolta, Ghulam André Ng, Olaf Dössel, Armin Luik, Roberto Sassi, Claus Schmitt, Axel Loewe

1008 related Products with: Hybrid machine learning to localize atrial flutter substrates using the surface 12-lead electrocardiogram.

96T51 mL1 moduleOne 96-Well Strip Micropl

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#35045162   2022/01/19 To Up

Effects of tenofovir on telomeres, telomerase and T cell maturational subset distribution in long-term aviraemic HIV-infected adults.

To evaluate whether the negative impact of tenofovir on telomere length (TL) is due to immune reconstitution interference or inhibition of telomerase.
Javier Rodríguez-Centeno, Andrés Esteban-Cantos, Rocío Montejano, Natalia Stella-Ascariz, Rosa De Miguel, Beatriz Mena-Garay, Gabriel Saiz-Medrano, Belén Alejos, María Jiménez-González, Jose I Bernardino, Julen Cadiñanos, Juan M Castro-Alvarez, Berta Rodés, Jose R Arribas

1989 related Products with: Effects of tenofovir on telomeres, telomerase and T cell maturational subset distribution in long-term aviraemic HIV-infected adults.

100 ug 0.1 mg 100 μg100 μg100 μg100 μg1 mg100 μg

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#35044989   2022/01/18 To Up

A Peer-Led Online Community to Increase HIV Self-Testing among African American and Latinx MSM: A Randomized Controlled Trial.

We sought to assess the effectiveness of using a peer-led online community to increase HIV self-testing among Latinx and African American men who have sex with men (MSM).
Sean D Young, William G Cumberland, Parvati Singh, Thomas Coates, William G Cumberland

1268 related Products with: A Peer-Led Online Community to Increase HIV Self-Testing among African American and Latinx MSM: A Randomized Controlled Trial.

0.1 mg100 1 module100 µg961 mL430 tests25 mg1 module

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