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#38625704   2024/04/01 To Up

Colorectal Cancer Screening After Sequential Outreach Components in a Demographically Diverse Cohort.

Organized screening outreach can reduce differences in colorectal cancer (CRC) incidence and mortality between demographic subgroups. Outcomes associated with additional outreach, beyond universal outreach, are not well known.
Clara Podmore, Kevin Selby, Christopher D Jensen, Wei K Zhao, Noel S Weiss, Theodore R Levin, Joanne Schottinger, Chyke A Doubeni, Douglas A Corley

1215 related Products with: Colorectal Cancer Screening After Sequential Outreach Components in a Demographically Diverse Cohort.



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#38625505   2024/04/16 To Up

Cancer-associated fibroblasts-derived exosomal METTL3 promotes the proliferation, invasion, stemness and glutaminolysis in non-small cell lung cancer cells by eliciting SLC7A5 m6A modification.

Cancer-associated fibroblasts (CAFs) can promote the crosstalk between cancer cells and tumor microenvironment by exosomes. METTL3-mediated N6-methyladenine (m6A) modification has been proved to promote the progression of non-small cell lung cancer (NSCLC). Here, we focused on the impacts of CAFs-derived exosomes and METTL3-mediated m6A modification on NSCLC progression. Functional analyses were conducted using Cell Counting Kit-8, EdU, colony formation, sphere formation and transwell assays, respectively. Glutamine metabolism was evaluated by detecting glutamate consumption, and the production of intercellular glutamate and α-ketoglutarate (α-KG). qRT-PCR and western blotting analyses were utilized to measure the levels of genes and proteins. Exosomes were isolated by kits. The methylated RNA immunoprecipitation assay detected the m6A modification profile of Amino acid transporter LAT1 (SLC7A5) mRNA. The NSCLC mouse model was established to conduct in vivo experiments. We found that CAFs promoted the proliferation, invasion, stemness and glutaminolysis in NSCLC cells. METTL3 was enriched in CAFs and was packaged into exosomes. After knockdown of METTL3 in CAF exosomes, it was found the oncogenic effects of CAFs on NSCLC cells were suppressed. CAFs elevated m6A levels in NSCLC cells. Mechanistically, exosomal METTL3-induced m6A modification in SLC7A5 mRNA and stabilized its expression in NSCLC cells. Moreover, SLC7A5 overexpression abolished the inhibitory effects of exosomal METTL3-decreased CAFs on NSCLC cells. In addition, METTL3 inhibition in CAF exosomes impeded NSCLC growth in vivo. In all, CAFs-derived exosomal METTL3 promoted the proliferation, invasion, stemness and glutaminolysis in NSCLC cells by inducing SLC7A5 m6A modification.
Yafeng Fan, Yanling Yu

1603 related Products with: Cancer-associated fibroblasts-derived exosomal METTL3 promotes the proliferation, invasion, stemness and glutaminolysis in non-small cell lung cancer cells by eliciting SLC7A5 m6A modification.

1.00 flask

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#38624981   2022/02/21 To Up

At-home medical student simulation: achieving knot-tying proficiency using video-based assessment.

Due to the pandemic, we restructured our medical student knot-tying simulation to a virtual format. This study evaluated curriculum feasibility and effectiveness.
Madhuri B Nagaraj, Krystle K Campbell, Robert V Rege, Angela P Mihalic, Daniel J Scott

2652 related Products with: At-home medical student simulation: achieving knot-tying proficiency using video-based assessment.

250ul500 testsOne 96-Well Microplate Ki100ug Lyophilized100ug Lyophilized20One 96-Well Microplate Ki2T100 μgOne 96-Well Microplate Ki100ug Lyophilized100ug

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#38624934   2022/01/03 To Up

Mechanism design for pandemics.

Under normal circumstances, competitive markets do an excellent job of supplying the goods that members of society want and need. But in an emergency like a pandemic, unassisted markets may not suffice. Imagine, for example, that society suddenly needs to obtain tens (or even hundreds) of millions of COVID-19 virus test kits a week. Test kits for this virus are a new product, and so it may not even be clear who the relevant set of manufacturers are. If we had the luxury of time, a laissez-faire market might identify these manufacturers: the price of test kits would adjust until supply matched demand. But getting a new market of this size to equilibrate quickly is unrealistic. Furthermore, markets don't work well when there are concentrations of power on either the buying or selling side, as there might well be here. Finally, a test is, in part, a good (its benefits go not just to the person being tested, but everyone he might come in contact with), and markets do not usually provide public goods adequately. Fortunately, mechanism design can be enlisted to help.
Eric Maskin

2946 related Products with: Mechanism design for pandemics.

1 Kit5mg5mg10 lt100 ug 1000 ml 1,000 tests5mg1 g50mg0.2 mg

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#38624614   2021/02/20 To Up

Environmental impact of COVID-19 pandemic: more negatives than positives.

Coronaviruses are the well-known cause of severe respiratory, enteric and systemic infections in a wide range of animal hosts including man. The scientific interest on coronaviruses has increased since the outbreak of COVID-19 (SARS-CoV-2) that initiated in Wuhan, China. This was soon declared a 'Public Health Emergency of International Concern' by World Health Organisation (WHO). Presently, the best strategy against this pandemic is prevention through regular hand and face washes, use of masks, gloves and personal protective equipment and social distancing. At the government level, the task is to perform as many tests as possible to identify coronavirus infected people and to isolate them to avoid the uncontrollable spread of the virus. The ongoing and future strategies against coronavirus ensue that huge quantity of masks, plastic products (personal protective equipment (PPE) kits, face shields, etc.) and chemicals (chloroxylenol, chlorine, HO, etc.) would be generated as waste in near future. Further, the amount of water consumption per person shall also increase. These effects can have unforeseen impacts on the environment. Apart from this, the ecological impacts on human-animal interactions can also be seen, such as people avoiding pets in coming future as a health and safety measure. The present review gives an overview of coronavirus, its current state of spread and environmental and ecological risks ensuing from the pandemic.
Ankit, Amit Kumar, Vartika Jain, Ankit Deovanshi, Ayush Lepcha, Chandan Das, Kuldeep Bauddh, Sudhakar Srivastava

1970 related Products with: Environmental impact of COVID-19 pandemic: more negatives than positives.

25 g 1 G 1 G 25 G5 g10 g1 g50 ug25 mg 1 G1 g

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#38624418   2020/07/04 To Up

Mobile Virology Research and Diagnostic Laboratory (MVRDL: BSL-3) for COVID-19 Screening, Virus Culturing and Vaccine Development.

In order to prevent spread of COVID-19, World Health Organization (WHO) has specified that measures such as cleaning hands regularly with alcohol-based hand sanitizer or washing with soap and water, avoiding touching nose, eyes, mouth and social distancing should be followed by people. Another important measure for containing spread is by - By testing, patients affected by COVID-19 can be isolated and further spread from them can be prevented. For testing, clinical specimen inactivation should be performed in a bio-safety level-3 (BSL-3) laboratory and after this step, routine testing can be performed in a bio-safety level-2 laboratory. Based on the infection and death rates in the current pandemic situation, few high-level bio-safety facilities are required to handle this deadly virus associated with potential exposure risks. It would take a long time, a large staff and many resources to construct a new fixed bio-safety facility, thus delaying the prevention and control of the pandemic. Therefore, a mobile BSL-3 laboratory with both bio-safety and flexibility is urgently needed to manage the pandemic and emergent public health incidents. To meet this requirement, the author has designed a mobile virology research and diagnostic laboratory with inputs from ESIC Medical College, Hyderabad, identified two companies which specialize in fabrication of shelters and containment facilities, realized and installed it within 15 days of time. This state-of-the-art, one of its kind laboratory was inaugurated by Hon'ble Raksha Mantri on 23 April, 2020. The MVRDL developed as per WHO and ICMR bio-safety standard (BSL-3) can be used:To conduct real-time reverse transcription polymerase chain reaction (rRT-PCR) test for diagnosing COVID-19. Possibility to test up to 2000 samples per day.For virus culturing for drug screening, convalescent plasma-derived therapy.To aid in the development of vaccine and development of diagnostic kits.
Yellamanchali Sreenivas Rao

1113 related Products with: Mobile Virology Research and Diagnostic Laboratory (MVRDL: BSL-3) for COVID-19 Screening, Virus Culturing and Vaccine Development.

100ug1 ml2.5 mg200ug0.25 mg10 mg 5 G100ug1000 TESTS/0.65ml1,000 tests100ul1 mg

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#38624404   2020/06/13 To Up

A Molecularly Imprinted Polymer-Based Technology for Rapid Testing of COVID-19.

The outbreak of COVID-19 has taken a large number of lives since 2019 and the death toll continues to increase all over the world. Recent data reports that about 27 lacs of people are infected with this virus till date and around 2 lacs are dead due to this pandemic. The situation in India is no way better. In India, almost all the states have become victim of this deadly pandemic. Considering the enormous population in India, citizens here are facing acute shortage of detection kits and many are dying even before the knowledge of their infection. The present treatise proposes a molecularly imprinted polymer (MIP) based technique for simple and rapid detection of COVID-19. The technique will be inexpensive, selective, reusable and easy to handle. It has been already implemented in our laboratory in order to detect the taste contributing agents found in tea. This article discusses the detailed methodology and the resultant analytical characteristic of the sensors developed so far and also outlines the suitability of the MIP technique towards fabrication of testing kits for rapid detection of COVID-19.
Trisita Nandy Chatterjee, Rajib Bandyopadhyay

2567 related Products with: A Molecularly Imprinted Polymer-Based Technology for Rapid Testing of COVID-19.

500 G 96 Tests 96 Tests20 ug250 mg1 mg 1 G0.1 mg 1000 ml

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#38624317   2020/05/19 To Up

Monitoring Novel Corona Virus (COVID-19) Infections in India by Cluster Analysis.

It is a great challenge of identification as well as formation of groups of infectious disease data set. Data mining, a process of uncovering silent characteristics of big data is one of such techniques which have nowadays become more popular for treating massive volume of infectious disease data set. In the current study, we apply cluster analysis, one of the data mining techniques to classify real groups of infectious disease "novel corona virus disease (COVID-19)" data set of different states and union territories (UTs) in India according to their high similarity to each other. The results obtained permit us to have a sense of clusters of affected Indian states and UTs. The main objective of clustering in this study is to optimize monitoring techniques in affected states and UTs in India which will be very valuable to the government, doctors, the police and others involved in understanding seriousness of the spread of novel coronavirus (COVID-19) to improve government policies, decisions, medical facilities (ventilators, testing kits, masks etc.), treatment etc. to reduce number of infected and deceased persons.
Sanjay Kumar

2165 related Products with: Monitoring Novel Corona Virus (COVID-19) Infections in India by Cluster Analysis.

50 100 1 mg1 mL1 mg50 1 mg1 mL1025100200

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#38624027   2024/04/15 To Up

Specialty-Specific Trends in Surgery for Apical Pelvic Organ Prolapse Post Vaginal Mesh.

Since transvaginal mesh (VM) kits for apical pelvic organ prolapse (APOP) were labeled "high-risk" in 2016 and subsequently banned in 2019 by the U.S. Food and Drug Administration, the most common remaining surgical options include abdominal mesh-augmented sacrocolpopexy (AS) and transvaginal native tissue suspension (VN).
Rahul Dutta, Raymond Xu, Dylan Thomas Wolff, Gopal Hariram Badlani, Catherine Ann Matthews

1986 related Products with: Specialty-Specific Trends in Surgery for Apical Pelvic Organ Prolapse Post Vaginal Mesh.

0.1 mg4 Membranes/Box2 Pieces/Box4 Membranes/Box4 Arrays/Slide2.50 nmol4 Arrays/Slide2 Pieces/Box

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#38623684   // To Up

Sensitivity, Specificity, Positive Rate and Consistency of Two Kits in SARS-CoV-2 Nucleic Acid Detection.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was a highly transmissible and pathogenic coronavirus and it emerged in late 2019. SARS-CoV-2 had caused a pandemic of acute respiratory disease and its name was coronavirus disease 2019 (COVID-19). It threatened human health and public safety. This study would analyze and evaluate two different kinds of SARS-CoV-2 nucleic acid detection reagents which could provide value for accurate detection.
Xiangyun Li, Juan Xu

2937 related Products with: Sensitivity, Specificity, Positive Rate and Consistency of Two Kits in SARS-CoV-2 Nucleic Acid Detection.

1 G 500 G 1 G96 tests100ug Lyophilized10mg100ug Lyophilized500 mg 5 G100 MG200ug

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