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#33086451   // To Up

[Diagnosis and treatment of gastric cancer with immediate double primary carcinoma].

To investigate the clinical characteristics, treatment and prognosis of gastric cancer complicated with immediate double primary cancer. The clinical data of patients who met the diagnostic criteria of gastric cancer with immediate double primary cancer from January 2016 to June 2019 were analyzed retrospectively. There were 29 cases of gastric cancer with immediate double primary carcinoma, accounting for 1.7% of the 1 741 patients with gastric cancer in the same period. Of these, 17 (58.6%) were more than 70 years of age. 25 cases (86.2%) were male. The postoperative pathological staging was mainly for early gastric cancer (63.2%). Colorectal cancer accounted for 8 cases (27.6%), followed by esophageal cancer in 7 cases (24.1%). The others included 6 cases of lung cancer (20.7%), 2 cases of pancreatic cancer (6.9%), 2 cases of prostate cancer (6.9%), 1 case of non-Hodgkin's lymphoma (3.4%), 1 case of ampullary tumor (3.4%), 1 case of bile duct carcinoma (3.4%) and 1 case of laryngeal carcinoma (3.4%). The prognosis of the surgical treatment group was significantly better than that of the non-surgical treatment group (median survival time: 21.0 months vs 13.0 months, 0.014). Gastric cancer complicated with immediate double primary cancer mostly occurs in elderly men and early gastric cancer patients. In the complicated tumor, colorectal cancer is the main cause, so we should pay attention to the screening of digestive system. Radical surgery should be performed as far as possible for each primary tumor.
H B Yao, R C Zhang, J F Hu, Z K Zhao, Q S Shao

1170 related Products with: [Diagnosis and treatment of gastric cancer with immediate double primary carcinoma].

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#33086402   2020/10/21 To Up

Sulodexide versus Control and the Risk of Thrombotic and Hemorrhagic Events: Meta-Analysis of Randomized Trials.

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Behnood Bikdeli, Saurav Chatterjee, Ajay J Kirtane, Sahil A Parikh, Giuseppe M Andreozzi, Nihar R Desai, Dominic P Francese, C Michael Gibson, Gregory Piazza, Samuel Z Goldhaber, John W Eikelboom, Harlan M Krumholz, Gregg W Stone

1834 related Products with: Sulodexide versus Control and the Risk of Thrombotic and Hemorrhagic Events: Meta-Analysis of Randomized Trials.

1 mg100ul100ul1,000 tests50 ug 25 mg1000 tests100ug 5 G100ug2.5 mg

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#33086384   2020/10/15 To Up

Driver mutations in major lung cancer oncogenes can be analyzed in Drosophila models.

Lung cancer remains the leading cause of cancer-associated mortality. Despite recent promising achievements, the overall prognosis remains very poor. In order to integrate the advantages of adapted, transgenic animal models with a high-throughput procedure on the one hand and compliance with the 3Rs principles on the other hand, we have established and evaluated appropriate Drosophila models. To achieve this goal, we ectopically expressed oncogenes representing the most important driver mutations exclusively in the airway system. These oncogenes were either the human oncogenes or the corresponding Drosophila orthologs. We have concentrated on two complementary read-out systems, 1) early larval lethality and 2) quantification of concurrently expressed GFP as a proxy for tumor mass. We could show that ectopic expression of EgfrCA, RasV12, Raf, Rolled (MAPK), PI3K92E, Alk, Akt and Arm can induce early lethality. Thus, they can be used in a straight-forward high-throughput screening approach and can replace mouse models to a considerable extent. Moreover, we could also show that measurement of tumor mass by a concurrently expressed marker (GFP) can be used to detect positive treatment results. Our results show that our Drosophila system provides a superb in vivo screening system amenable to high-throughput approaches, and thus effectively complements the toolbox for development of novel anti-lung cancer treatments, while complying with the 3R principles.
Judith Bossen, Karin Uliczka, Line Steen, Pia Neugebauer, Mandy Mong-Quyen Mai, Christine Fink, Frank Stracke, Holger Heine, Thomas Roeder

2090 related Products with: Driver mutations in major lung cancer oncogenes can be analyzed in Drosophila models.



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#33086321   2020/10/19 To Up

Results of COVID-Minimal Surgical Pathway During Surge-Phase of COVID-19 Pandemic.

The outcomes of patients treated on the COVID-minimal pathway were evaluated during a period of surging COVID-19 hospital admissions, to determine the safety of continuing to perform urgent operations during the pandemic.
Daniel J Boffa, Benjamin L Judson, Kevin G Billingsley, Erin Del Rossi, Kasey Hindinger, Samantha Walters, Theresa Ermer, Elena Ratner, Marci R Mitchell, Maxwell S Laurans, Dirk C Johnson, Peter S Yoo, John M Morton, Holly B Zurich, Kimberly Davis, Nita Ahuja

1533 related Products with: Results of COVID-Minimal Surgical Pathway During Surge-Phase of COVID-19 Pandemic.

5 G1 mg10 g25 g100 mg2 Pieces/Box100 mg 5 G2 Pieces/Box 25 G

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#33086278   2020/10/20 To Up

Elevated 68Ga-FAPI Accumulation in a Recurrent Angiomyolipoma.

Ga-FAPI (Ga-labeled fibroblast activation protein inhibitor) PET imaging has been recently introduced for the diagnosis and staging in various malignant tumors. However, the reports about the utility of FAPI imaging in benign tumor are relatively rare. Here we report a case of pathologically proven recurrent angiomyolipoma in the left retroperitoneal area with low F-FDG uptake but diffuse heterogeneous intense Ga-FAPI uptake together with suspected lung metastases in a 53-year-old woman. Our case illustrates FAPI imaging could be helpful not only for detecting various malignant tumors but also for benign tumor like this case due to fibrotic activity in the disease.
Chunxia Qin, Yongkang Gai, Qingyao Liu, Fuqiang Shao, Xiaoli Lan

2349 related Products with: Elevated 68Ga-FAPI Accumulation in a Recurrent Angiomyolipoma.

100 μg100 μg96T100 μg100 μg100 μg100 μg

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#33086222   2020/10/20 To Up

Identification of Immunohistochemical Reagents for In Situ Protein Expression Analysis of Coronavirus-associated Changes in Human Tissues.

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Matthias Szabolcs, Jennifer L Sauter, Denise Frosina, Jerica A Geronimo, Enmily Hernandez, Elena Selbs, Amy V Rapkiewicz, Natasha Rekhtman, Marina K Baine, Elke Jäger, William D Travis, Achim A Jungbluth

2332 related Products with: Identification of Immunohistochemical Reagents for In Situ Protein Expression Analysis of Coronavirus-associated Changes in Human Tissues.

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#33086147   2020/10/18 To Up

Gustave Roussy Immune Score based on a three-category risk assessment scale serves as a novel and effective prognostic indicator for surgically resectable early-stage non-small-cell lung cancer: A propensity score matching retrospective cohort study.

The Gustave Roussy Immune score (GRIm-Score) emerges as a novel prognostic scoring system for patient selection in phase I trials testing targeted immunotherapy for advanced-stage cancer. We tried to assess potential prognostic roles of preoperative GRIm-Score in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for stage I-II non-small-cell lung cancer (NSCLC) by propensity score-matching (PSM) analysis.
Shuang-Jiang Li, Liang Zhao, Hong-Yu Wang, Hai-Ning Zhou, Juan Ju, Heng Du, Guo-Wei Che

2807 related Products with: Gustave Roussy Immune Score based on a three-category risk assessment scale serves as a novel and effective prognostic indicator for surgically resectable early-stage non-small-cell lung cancer: A propensity score matching retrospective cohort study.



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