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#32791557   2020/08/13 To Up

[Unexpected increase in extravascular lung water after acute lung injury].

 We report on a 27-year-old female patient presenting with pneumonia and developing acute respiratory distress syndrome. Using transpulmonary thermodilution, an elevated extravascular lung water was detected (17 ml/kg). Patient required lung-protective mechanical ventilation and received antibiotic therapy. Negative fluid balance was targeted. Under this treatment, respiratory function improved, inflammation parameters declined, and extravascular lung water was recurrent (10 ml/kg). Subsequently, extravascular lung water increased to 29 ml/kg.
Veit-Simon Eckle, Martin Witzenrath, Holger Müller-Redetzky

2106 related Products with: [Unexpected increase in extravascular lung water after acute lung injury].



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#32791555   2020/08/13 To Up

[Occupational medical pneumology - what's new?]

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Dennis Nowak, Caroline Quartucci, Stefan Karrasch

1078 related Products with: [Occupational medical pneumology - what's new?]

50ul50 ug 1100 G1 mg100ug Lyophilized 1250 Slides 1 mg 100ul96T1 L5.0 g

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#32791550   2020/08/13 To Up

[Nontuberculous mycobacterial pulmonary disease - The new ATS/ERS/ESCMID/IDSA Guideline].

The new ATS/ERS/ESCMID/IDSA guideline answers 22 PICO questions on the treatment of lung diseases caused by complex (MAC), and .
Dirk Wagner, Christoph Lange

1858 related Products with: [Nontuberculous mycobacterial pulmonary disease - The new ATS/ERS/ESCMID/IDSA Guideline].

25200 1 mg96 tests

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#32791506   2020/08/13 To Up

The Effect of Bronchoconstriction by Methacholine Inhalation in a Murine Model of Asthma.

Bronchoconstriction was recently shown to cause airway remodeling and induce allergic airway inflammation in asthma. However, the mechanisms how mechanical stress via bronchoconstriction could induce airway inflammation and remodeling remain unclear.
Yoshito Miyata, Shin Ohta, Akihiko Tanaka, Ayaka Kashima, Hiromitsu Suganuma, Tomoki Uno, Haruna Sato, Hitomi Ida, Tomoyuki Kimura, Megumi Jinno, Kuniaki Hirai, Tetsuya Homma, Mayumi Yamamoto, Yoshio Watanabe, Shintaro Suzuki, Hironori Sagara

1434 related Products with: The Effect of Bronchoconstriction by Methacholine Inhalation in a Murine Model of Asthma.

18 kgs1100ug100ug

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#32791503   2020/08/13 To Up

Immune Modulation in Chronic Respiratory Diseases: The Path to Precision Medicine.


Marek Lommatzsch, Stephan F van Eeden

1581 related Products with: Immune Modulation in Chronic Respiratory Diseases: The Path to Precision Medicine.

500 tests

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#32791502   2020/08/13 To Up

Genetic Variants in One-Carbon Metabolism Pathway Predict Survival Outcomes of Early-Stage Non-Small Cell Lung Cancer.

This study was conducted to investigate the association between genetic variants in one-carbon metabolism and survival outcomes of surgically resected non-small cell lung cancer (NSCLC).
Sook Kyung Do, Sun Ha Choi, Shin Yup Lee, Jin Eun Choi, Hyo-Gyoung Kang, Mi Jeong Hong, Ji Hyun Kim, Sun Ah Baek, Jang Hyuck Lee, Won Kee Lee, Young Woo Do, Eung Bae Lee, Kyung Min Shin, Ji Yun Jeong, Yong Hoon Lee, Hyewon Seo, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Yangki Seok, Sukki Cho, Sanghoon Jheon, Jae Yong Park

1298 related Products with: Genetic Variants in One-Carbon Metabolism Pathway Predict Survival Outcomes of Early-Stage Non-Small Cell Lung Cancer.



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#32791489   2020/08/10 To Up

Screening and identification of key regulatory connections and immune cell infiltration characteristics for lung transplant rejection using mucosal biopsies.

This study aimed to explore key regulatory connections underlying lung transplant rejection. The differentially expressed genes (DEGs) between rejection and stable lung transplantation (LTx) samples were screened using R package limma, followed by functional enrichment analysis and protein-protein interaction network construction. Subsequently, a global triple network, including miRNAs, mRNAs, and transcription factors (TFs), was constructed. Furthermore, immune cell infiltration characteristics were analyzed to investigate the molecular immunology of lung transplant rejection. Finally, potential drug-target interactions were generated. In brief, 739 DEGs were found between rejection and stable LTx samples. PTPRC, IL-6, ITGAM, CD86, TLR8, TYROBP, CXCL10, ITGB2, and CCR5 were defined as hub genes. Eight TFs, including STAT1, SPIB, NFKB1, SPI1, STAT5A, RUNX1, VENTX, and BATF, and five miRNAs, including miR-335-5p, miR-26b-5p, miR-124-3p, miR-1-3p, and miR-155-5p, were involved in regulating hub genes. The immune cell infiltration analysis revealed higher proportions of activated memory CD4 T cells, follicular helper T cells, γδ T cells, monocytes, M1 and M2 macrophages, and eosinophils in rejection samples, besides lower proportions of resting memory CD4 T cells, regulatory T cells, activated NK cells, M0 macrophages, and resting mast cells. This study provided a comprehensive perspective of the molecular co-regulatory network underlying lung transplant rejection.
Meng-Xi Xiu, Zu-Ting Liu, Jian Tang

1868 related Products with: Screening and identification of key regulatory connections and immune cell infiltration characteristics for lung transplant rejection using mucosal biopsies.

10 mg5mg1000 tests100ul50 ml

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#32791452   2020/07/10 To Up

lncRNA LCPAT1 Upregulation Promotes Breast Cancer Progression via Enhancing MFAP2 Transcription.

The importance of long noncoding RNA (lncRNA) in tumorigenesis has been supported by increasing evidence in recent years. However, the mechanism linking lncRNA function with cancer progression remains poorly understood. lncRNA LCPAT1 plays a role in lung cancer. However, how it works in breast cancer (BC) is largely unclear. In this study, we found that LCPAT1 was highly expressed in BC tissues and cell lines. High LCPAT1 expression predicted a low survival rate in BC patients. LCPAT1 promoted BC cell proliferation, migration, and invasion while inhibiting apoptosis in vitro. LCPAT1 knockdown suppressed BC growth in vivo and vice versa. LCPAT1 interacted with RBBP4 and recruited it to the MFAP2 (microfibril-associated protein 2) promoter and then activated MFAP2 transcription. Restoration of MFAP2 rescued the effects of LCPAT1 knockdown in BC cells. In sum, LCPAT1 promotes BC progression through recruiting RBBP4 to initiate MFAP2 transcription.
Xue Gong, Tuozhou Dong, Ming Niu, Xiaoshuan Liang, Shanshan Sun, Youxue Zhang, Yue Li, Dalin Li

1541 related Products with: lncRNA LCPAT1 Upregulation Promotes Breast Cancer Progression via Enhancing MFAP2 Transcription.

96T

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#32791343   2020/06/11 To Up

Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma.

Reasons why pancreatic ductal adenocarcinoma (PDAC) continues to have poor survival are only partly known. No previous studies have analyzed the combined influence of KRAS mutations, persistent organic pollutants (POPs), and trace elements upon survival in PDAC or in any other human cancer.
Miquel Porta, José Pumarega, André F S Amaral, Jeanine M Genkinger, Judit Camargo, Lorelei Mucci, Juan Alguacil, Magda Gasull, Xuehong Zhang, Eva Morales, Mar Iglesias, Shuji Ogino, Lawrence S Engel,

1467 related Products with: Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma.

500 MG3x 500 mlEach25 mg100ug Lyophilized

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#32791248   2020/08/10 To Up

Multidimensional assessment of asthma identifies clinically relevant phenotype overlap: a cross-sectional study.

Asthma is a heterogenous disease with multiple phenotypes; however, the relevance of phenotype overlap remains largely unexplored.
Yu Yu Han, Xin Zhang, Ji Wang, Gang Wang, Brian G Oliver, Hong Ping Zhang, De Ying Kang, Lei Wang, Zhi Xin Qiu, Wei Min Li, Gang Wang

1797 related Products with: Multidimensional assessment of asthma identifies clinically relevant phenotype overlap: a cross-sectional study.

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