Search results for: metastasize
#32619622 2020/06/30 To Up
Characteristics and risk differences of different tumor sizes on distant metastases of hepatocellular carcinoma: A retrospective cohort study in the SEER database.A typical feature of hepatocellular carcinoma (HCC) is growth with metastasis to distant organs, which is associated with poor survival. Whether tumor size can predict distant metastases in HCC remains unclear.
Bing Yan, Dou-Sheng Bai, Chi Zhang, Jian-Jun Qian, Sheng-Jie Jin, Guo-Qing Jiang
1271 related Products with: Characteristics and risk differences of different tumor sizes on distant metastases of hepatocellular carcinoma: A retrospective cohort study in the SEER database.
#32617667 2020/07/02 To Up
Neoadjuvant chemotherapy plus surgery for high-risk advanced gastric cancer: long-term results of KDOG1001 trial.The purpose of this study is to evaluate the long-term survival outcomes of KDOG1001 trial after a minimum follow-up of 3 years.
Kei Hosoda, Chikatoshi Katada, Kenji Ishido, Masahiro Niihara, Hideki Ushiku, Mikiko Sakuraya, Marie Washio, Takuya Wada, Akinori Watanabe, Hiroki Harada, Takeo Sato, Hiroshi Tajima, Takashi Kaizu, Yoshimasa Kosaka, Hiroshi Kato, Norihiko Sengoku, Kiyoshi Tanaka, Takeshi Naito, Yusuke Kumamoto, Takafumi Sangai, Satoshi Tanabe, Wasaburo Koizumi, Keishi Yamashita, Naoki Hiki
2177 related Products with: Neoadjuvant chemotherapy plus surgery for high-risk advanced gastric cancer: long-term results of KDOG1001 trial.25
#32617300 // To Up
Should the left gastric artery lymph node be considered as the predictive lymph node for extra-gastric lymph node metastases?To validate the prognostic impacts of the left gastric artery lymph node (No. 7 LN) metastasis and investigate whether the No. 7 LN metastasis should be considered as the predictive LN for extra-gastric LN metastases.
Weilin Sun, Jingyu Deng, Wenting He, Jinyuan Liu, Shiwei Guo, Pengfei Gu, Zizhen Wu, Han Liang
2712 related Products with: Should the left gastric artery lymph node be considered as the predictive lymph node for extra-gastric lymph node metastases?5 Pieces/Box
#32617128 2020/06/25 To Up
Incidental primary breast cancer detected on surveillance Ga-DOTATATE PET/CT in a patient with metastatic neuroendocrine carcinoma.We present a case of a 53-year-old woman with metastatic neuroendocrine tumor, presumed primary in the small intestine with metastases to the liver and mesenteric lymph nodes. The patient was being treated with lanreotide and followed with somatostatin receptor (SSTR)-targeted 68Ga-labeled 1,4,7,10-tetraazacyclododecane-', '','''-tetraacetic acid-d-Phe(1)-Tyr(3)-octreotate (Ga-DOTATATE) positron emission tomography - computed tomography (PET/CT). On a follow-up exam, the patient's primary and metastatic disease had improved but she had new Ga-DOTATATE-avid lesions in the right breast and right axilla. Subsequent breast imaging workup and biopsy demonstrated a primary breast cancer and axillary lymph node metastasis.
Emily B Ambinder, Rudolf A Werner, Steven P Rowe
1579 related Products with: Incidental primary breast cancer detected on surveillance Ga-DOTATATE PET/CT in a patient with metastatic neuroendocrine carcinoma.
#32612483 // To Up
Pulmonary Adenocarcinoma Presenting as a Pineal Gland Mass With Obstructive Hydrocephalus.Adenocarcinoma is the most prevalent type of non-small cell carcinoma of the lungs. Patients with lung adenocarcinoma often present with cough, dyspnea, pain, and weight loss. They can also present with signs and symptoms of brain metastasis because the lungs are one of the most common origins of metastatic brain cancer. We describe a rare case of adenocarcinoma of the lungs presenting with pineal region metastasis. A 61-year-old male presented to the emergency department with dizzy spells and gait disturbance. Magnetic resonance imaging of the brain demonstrated a solitary mass in the pineal region with marked obstructive hydrocephalus. A stereotactic biopsy was performed, and metastatic adenocarcinoma consistent with pulmonary origin was diagnosed. Computed tomography scan of the chest revealed a spiculated mass. The patient died shortly after the diagnosis was made. The pineal region is an unusual site for brain metastasis. Although such metastasis has rarely been described, it should be considered in the differential diagnosis of pineal region tumors, especially for patients with suggestive clinical or histopathologic features of primary malignancy elsewhere.
Mohamed A Abdallah, Mahum Shahid, Moataz Ellithi, Ahmed Yeddi, Arwyn Cunningham, Ryan Askeland, Jamal Dodin
1307 related Products with: Pulmonary Adenocarcinoma Presenting as a Pineal Gland Mass With Obstructive Hydrocephalus.100ug Lyophilized100 mg1 kit1 kit1001000 assays1 kit(96 Wells)25 assays100 assays96 assays 100μg
#32612476 // To Up
Cholangiocarcinoma Metastasis to the Spine and Cranium.Cholangiocarcinoma (CCC), a rare tumor arising from the viscera, has a poor prognosis. Although CCC is prone to metastasis, spread to the cranium and spine is exceedingly rare. Treatment for metastatic disease is palliative, with total resection of the primary lesion the only cure. We describe a case of metastatic CCC to the spine and cranium treated with surgical resection. A 61-year-old male with a history of hepatitis C with liver transplant and incidental discovery of CCC presented with gradually increasing back pain. Physical examination revealed a palpable nontender mass in the parieto-occipital area. Computed tomography survey of the spine and head revealed mixed sclerotic and lytic lesions of the T9, T11, L2, and L5 vertebral bodies, a lytic lesion on the T6 vertebral body, and a 1.4-cm lesion in the right occipital calvarium. The patient underwent right occipital craniotomy for excisional biopsy of the calvarial mass with gross total resection and immunohistochemical confirmation of CCC. The patient was started on gemcitabine chemotherapy and radiation therapy for spinal metastases. Three months later, the patient died from metastatic disease complications. To our knowledge, only 6 cases of cranial CCC have been reported, and only 2 reported mixed cranial/spinal involvement. We report a rare case of CCC metastasis to the spine and cranium that was treated with surgery, chemotherapy, and radiotherapy. CCC should be considered an exceedingly rare etiology with treatment options aimed solely at palliation. This case supplements the existing literature to inform medical and surgical decision-making.
Joshua A Hanna, Mansour Mathkour, Edna E Gouveia, Ryan Glynn, Adhira Divagaran, JonMark B Lane, Cuong J Bui, Olawale A Sulaiman, Roger D Smith11 module100ug1 module1 mg100 g
#32612366 2020/06/24 To Up
Primary Urothelium Carcinoma of the Distal Urethra in a Male: Case Report and Literature Review.Male primary urethral urothelium carcinoma is a rare clinical case. Here, we detail a case of a 58-year-old man with primary urothelium carcinoma of the distal urethra treated in our hospital. The patient with a neoplasm inside the external urethral orifice for 2 years, which was previously diagnosed as condyloma acuminata, had received photodynamic therapy for 3 times, with initial symptoms of urinary stream bifurcation and dysuria. The exfoliative urine cytology showed negative. Cystoscopy showed a tumor growing around the distal urethra. Biopsy and immunohistochemistry revealed high-grade papillary urothelium carcinoma. The patient received partial urethrectomy, followed by urinary bladder irrigation chemotherapy with epirubicin postoperatively. The corpus spongiosum was invaded while the corpus cavernosa were not. Postoperative pathological examination showed high-grade invasive urothelium carcinoma. There is no evidence of tumor recurrence, metastasis or surgical complications during a 61-month follow-up period. Male primary urethral urothelium carcinoma is a rare clinical case with particular clinical and pathological characteristics. There are still no established treatment guidelines and should be studied further.
Ning Wang, Jingxian Min, Qiang Wei, Wanlong Tan, Qiang Dang
1110 related Products with: Primary Urothelium Carcinoma of the Distal Urethra in a Male: Case Report and Literature Review.
#32612211 2020/07/01 To Up
Molecular dissection of CRC primary tumors and their matched liver metastases reveals critical role of immune microenvironment, EMT and angiogenesis in cancer metastasis.Metastasis is the primary cause of cancer mortality. The primary tumors of colorectal cancer (CRC) often metastasize to the liver. In this study, we have collected 122 samples from 45 CRC patients. Among them, 32 patients have primary tumors, adjacent normal tissues, and matched liver metastases. Thirteen patients have primary tumors without distant metastasis and matched normal tissues. Characterization of these samples was conducted by whole-exome and RNA sequencing and SNP6.0 analysis. Our results revealed no significant difference in genetic alterations including common oncogenic mutations, whole genome mutations and copy number variations between primary and metastatic tumors. We then assembled gene co-expression networks and identified metastasis-correlated gene networks of immune-suppression, epithelial-mesenchymal transition (EMT) and angiogenesis as the key events and potentially synergistic drivers associated with CRC metastasis. Further independent cohort validation using published datasets has verified that these specific gene networks are up regulated throughout the tumor progression. The gene networks of EMT, angiogenesis, immune-suppression and T cell exhaustion are closely correlated with the poor patient outcome and intrinsic anti-PD-1 resistance. These results offer insights of combinational strategy for the treatment of metastatic CRC.
Jiangang Liu, Yong Beom Cho, Hye Kyung Hong, Song Wu, Philip J Ebert, Steven M Bray, Swee Seong Wong, Jason C Ting, John N Calley, Catherine F Whittington, Shripad V Bhagwat, Christoph Reinhard, Robert Wild, Do-Hyun Nam, Amit Aggarwal, Woo Yong Lee, Sheng-Bin Peng
2138 related Products with: Molecular dissection of CRC primary tumors and their matched liver metastases reveals critical role of immune microenvironment, EMT and angiogenesis in cancer metastasis.
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Newer Concepts in the Classification of Pituitary Adenomas.The classification of tumors of the pituitary gland has seen several changes in recent years. The 4 edition of the World Health Organization Classification of Tumours of Endocrine Organs, published in 2017, saw the introduction of a classification based on cell lineage using immunohistochemistry for both pituitary specific hormones as well as pituitary specific transcription factors. The term "hormone-producing" was thus replaced by "-troph." The other major change was that the entity of "atypical adenoma," which was introduced in the 2004 classification, to identify tumors with a poor prognosis, was removed as it failed to identify aggressive tumors. Instead, assessment of markers of proliferation, clinical parameters, such as invasive status and histological subtypes were recommended to identify tumors with aggressive potential. The diagnostic criteria for pituitary carcinoma, however, remained unchanged and continued to be defined as a tumor of adenohypophyseal cells that metastasize craniospinally or systemically. Null cell adenomas were more clearly defined as tumors that did not show any cell-type differentiation, lacking immunoexpression of hormones as well as transcription factors. Since 2017, the classification has continued to evolve with the identification of aggressive histological variants. There is more recently a proposal to change the terminology from pituitary adenoma to pituitary neuroendocrine tumor (PitNET). This review summarizes the recent advances in the classification of pituitary adenomas.
Rima Sathyakumar, Geeta Chacko1100 assays250ul10 ml
#32610423 // To Up
[Clinical diagnosis and treatment characteristics of pancreatic cystic neoplasms in pediatric patients: a report of 13 cases].To investigate the clinical characteristics of pancreatic cystic neoplasms in pediatric patients. The clinical data of 13 patients with pancreatic cystic neoplasm at Wuhan Children's Hospital from July 2007 to November 2019 were collected.There were 5 males and 8 females, with a mean age of 133 months(range: 9 to 170 months). Eleven patients presented with abdominal pain, vomiting, and a palpable mass. Tumors were located in the pancreatic head(7), body(2) and tail(4), respectively. The preoperative diagnosis was confirmed by imaging examination in 11 patients, CT and MRI was significantly superior to ultrasound in the exact diagnosis of the tumor types. In this group, surgical methods mainly included pancreaticoduodenectomy(3), pylorus-preserving pancreatoduodenectomy(1), duodenum-preserving pancreas head resection(3), spleen-preserving distal pancreatectomy (3), distal pancreatectomy plus splenectomy(2), and tumor enucleation(1). Postoperative complications including biochemical leakage(1), delayed gastric emptying(grade A) (1), adhesive intestinal obstruction(1), transient elevation of platelet count(2), all were cured by conservative treatment. In one patient biliary leakage occurred and later developed into biliary stricture, this patient underwent the second operation 6 weeks later and recovered smoothly. All patients were diagnosed by postoperative pathology, including solid pseudopapillary neoplasm(10), serous cystadenoma(1), mucinous cystadenoma(1) and cystic lymphangiom(1). Three cases were lost in this group, the rest of patients were all accepted outpatient or telephones follow-up. There was no evidence of recurrence or metastasis during 3 to 92 months follow-up. The incidence of pancreatic cystic neoplasm is low in the pediatric patients. Symptomatic patients should receive surgical treatment timely. It's safe and effective to choose the organs and functions-preserving surgical method.
H F Kuang, X Q Yan, X F Duan, H Q Bian, J Yang, Z C Zhu
1724 related Products with: [Clinical diagnosis and treatment characteristics of pancreatic cystic neoplasms in pediatric patients: a report of 13 cases].
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