Only in Titles

Search results for: metastatic

paperclip

#33098716   2020/10/24 To Up

Risk factors associated with rhinitis, allergic conjunctivitis and eczema among schoolchildren in Uganda.

The prevalence of allergy-related diseases (ARDs), including rhinitis, allergic conjunctivitis and eczema, is on the increase globally. The causes of this increase are not well established.
Harriet Mpairwe

1311 related Products with: Risk factors associated with rhinitis, allergic conjunctivitis and eczema among schoolchildren in Uganda.

100 units100ug Lyophilized100ug5 g100 μg1 Set 100 G100 μg1 Set

Related Pathways

paperclip

#33098702   2020/10/24 To Up

Recurrence patterns in patients with Stage II melanoma: The evolving role of routine imaging for surveillance.

The relatively recent availability of effective systemic therapies for metastatic melanoma necessitates reconsideration of current surveillance patterns. Evidence supporting surveillance guidelines for resected Stage II melanoma is lacking. Prior reports note routine imaging detects only 21% of recurrent disease. This study aims to define recurrence patterns for Stage II melanoma to inform future surveillance guidelines.
Josh Bleicher, Douglas S Swords, Meghan E Mali, Lauren McGuire, Maranda K Pahlkotter, Elliot A Asare, Tawnya L Bowles, John R Hyngstrom

1310 related Products with: Recurrence patterns in patients with Stage II melanoma: The evolving role of routine imaging for surveillance.



Related Pathways

paperclip

#33098699   2020/10/24 To Up

The significance of acute kidney injury in Clostridioides difficile infection.

Clostridioides difficile infection (CDI) may present as sepsis with acute kidney injury (AKI). Herein, we aimed to evaluate the clinical outcomes of patients with AKI complicating CDI.
T Avni, H Hammud, O Itzhaki, A Gafter-Gvili, B Rozen-Zvi, H Ben-Zvi, J Bishara, A Atamna

1597 related Products with: The significance of acute kidney injury in Clostridioides difficile infection.

96T

Related Pathways

paperclip

#33098641   2020/10/24 To Up

Chronic Lymphocytic Leukemia Concomitant with COVID 19: A Case Report.

BACKGROUND COVID-19 is a newly emerging disease that is not yet fully understood. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that is easily transmitted from human to human through the respiratory route. Usually, it presents with fever, headache, fatigue accompanied by respiratory symptoms like cough and dyspnea, and other systemic involvements. Chronic lymphocytic leukemia (CLL) is a common lymphoproliferative neoplasm characterized by absolute lymphocytosis and demonstration of clonality unlike other causes of lymphocytosis. Patients with CLL are considered immunocompromised because of impaired humoral immunity (mainly) and cellular immunity. Therefore, they are vulnerable to various infections including COVID-19. Little is known about the COVID-19 infection when it unmasks CLL. CASE REPORT A 49-year-old man with no significant previous illnesses, and an unremarkable family history, presented with a moderate COVID-19 infection. He initially presented to the emergency department with fever and mild shortness of breath. A complete blood count showed a high white blood cell count with absolute lymphocytosis. Flow cytometry revealed the clonality of the lymphocytes confirming the diagnosis of CLL. Despite having CLL, he developed a moderate COVID-19 infection and recovered in a few days. To the best of our knowledge, this is the first report of CLL, which presented with a COVID-19 infection as the initial presentation. CONCLUSIONS Lymphocytosis is an unexpected finding in patients diagnosed with COVID-19 infection and the elevated lymphocytes may be indicative of other conditions. Secondary causes of lymphocytosis like malignancy or other infections should be considered in these cases.
Elrazi Ali, Mohamed Badawi, Elabbass Abdelmahmuod, Samah Kohla, Mohamed A Yassin

1529 related Products with: Chronic Lymphocytic Leukemia Concomitant with COVID 19: A Case Report.



Related Pathways

paperclip

#33098620   2020/10/24 To Up

Characterization of Telehealth Use in Veterans with Spinal Cord Injuries and Disorders.

Individuals with spinal cord injuries and disorders (SCI/D) require frequent interdisciplinary health care to address impairments in mobility, autonomic functions, and secondary complications. Telehealth has the capacity to substantially transform healthcare delivery and improve care by increasing access and communication. However, relatively little is known about telehealth use in this specific population. Here, we attempt to fill part of this gap.
Maya N Hatch, Rachael N Martinez, Bella Etingen, Bridget Cotner, Timothy P Hogan, Itala M Wickremasinghe, Jennifer Sippel, Bridget M Smith

1358 related Products with: Characterization of Telehealth Use in Veterans with Spinal Cord Injuries and Disorders.

130 reactions1 kit(96 Wells)100.00 ug 5 G

Related Pathways

paperclip

#33098613   2020/10/24 To Up

Prevalence of gastro-esophageal reflux symptoms: an Italian cross-sectional survey focusing on knowledge and attitudes towards lifestyle and nutrition.

The gastro-esophageal reflux disease (GERD) is a public health issue for its prevalence and association with low life quality and substantial costs. Since most of Italian data refer to over a decade ago, the aim was to provide an updated estimate of GERD symptoms prevalence. Knowledge about appropriate nutrition and behaviours in presence of GERD was assessed. Predictors for symptoms presence and knowledge were explored.
Fabrizio Bert, Erika Pompili, Giuseppina Lo Moro, Alessio Corradi, Angelica Sagrawa Caro, Maria Rosaria Gualano, Roberta Siliquini

2089 related Products with: Prevalence of gastro-esophageal reflux symptoms: an Italian cross-sectional survey focusing on knowledge and attitudes towards lifestyle and nutrition.

10 mg100ug1 ml200ug25 mg1000 tests200ul10 mg100 mg50 ug 10 mg

Related Pathways

paperclip

#33098601   2020/10/24 To Up

Comprehensive phenotyping of peripheral blood T lymphocytes in healthy mice.

T lymphocytes play a central role in antigen-specific immune responses. They modulate the function of different immune cells both through a direct contact (receptor binding) and through the secretion of cytokines. At the same time, they are deeply involved in the direct killing of aberrant target cells. T lymphocytes derive from a bone marrow precursor that migrates in the thymus where the main differentiation steps take place. Mature CD4 and CD8 single-positive cells, then, leave the thymus to reach the secondary lymphoid organs. T cell subsets and their maturation steps can be identified mainly based on the expression of extracellular markers, intracellular transcription factors and cytokine production profiles. In this review, we report, from a cytometric point of view, an overview of the most important T cell subpopulations and their differentiation state.
Genny Del Zotto, Elisa Principi, Francesca Antonini, Serena Baratto, Chiara Panicucci, Claudio Bruno, Lizzia Raffaghello

2553 related Products with: Comprehensive phenotyping of peripheral blood T lymphocytes in healthy mice.

100 extractions96 tests100 μg1 kit251mg1 Set

Related Pathways

paperclip

#33098594   2020/07/19 To Up

Abemaciclib-induced reversible grade 4 nephrotoxicity.


Angélique Da Silva, Basile Chretien, Joachim Alexandre, George Emile

1813 related Products with: Abemaciclib-induced reversible grade 4 nephrotoxicity.

100 G 500 G50gm2.5 lt100 mg40ug10mg 25 G

Related Pathways

    No related Items
paperclip

#33098588   2020/10/24 To Up

Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma.

Neuroinflammation leads to neurodegeneration, cognitive defects, and neurodegenerative disorders. Neurotrauma/traumatic brain injury (TBI) can cause activation of glial cells, neurons, and neuroimmune cells in the brain to release neuroinflammatory mediators. Neurotrauma leads to immediate primary brain damage (direct damage), neuroinflammatory responses, neuroinflammation, and late secondary brain damage (indirect) through neuroinflammatory mechanism. Secondary brain damage leads to chronic inflammation and the onset and progression of neurodegenerative diseases. Currently, there are no effective and specific therapeutic options to treat these brain damages or neurodegenerative diseases. Flavone luteolin is an important natural polyphenol present in several plants that show anti-inflammatory, antioxidant, anticancer, cytoprotective, and macrophage polarization effects. In this short review article, we have reviewed the neuroprotective effects of luteolin in neurotrauma and neurodegenerative disorders and pathways involved in this mechanism. We have collected data for this study from publications in the PubMed using the keywords luteolin and mast cells, neuroinflammation, neurodegenerative diseases, and TBI. Recent reports suggest that luteolin suppresses systemic and neuroinflammatory responses in Coronavirus disease 2019 (COVID-19). Studies have shown that luteolin exhibits neuroprotective effects through various mechanisms, including suppressing immune cell activation, such as mast cells, and inflammatory mediators released from these cells. In addition, luteolin can suppress neuroinflammatory response, activation of microglia and astrocytes, oxidative stress, neuroinflammation, and the severity of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and TBI pathogenesis. In conclusion, luteolin can improve cognitive decline and enhance neuroprotection in neurodegenerative diseases, TBI, and stroke.
Duraisamy Kempuraj, Ramasamy Thangavel, Deepak D Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P Raikwar, Smita A Zaheer, Shankar S Iyer, Raghav Govindarajan, Premkumar Nattanmai Chandrasekaran, Asgar Zaheer

2248 related Products with: Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma.

100 assays100 μg100 MG100 μg100ug100ug4 Arrays/Slide100ug1 Set1 Set

Related Pathways

paperclip

#33098586   2020/10/24 To Up

Beyond the patch-clamp resolution:functional activity of non-electrogenic vacuolar NHX proton/potassium antiporters and inhibition by phosphoinositides.

We combined the patch-clamp technique with ratiometric fluorescence imaging using the proton-responsive BCECF dye as a luminal probe. Upon application of a steep cytosol-directed K gradient in Arabidopsis mesophyll vacuoles, a strong and reversible acidification of the vacuolar lumen was detected, while no associated electrical currents were observed, in agreement with electroneutral cation/H exchange. Our data show that this acidification was generated by NHX antiport activity, since: it did not distinguish between K and Na ions; it was sensitive to the NHX inhibitor benzamil; and it was completely absent in vacuoles from nhx1 nhx2 double knockout plants. Our data further show that NHX activity could be reversed, was voltage independent and specifically impaired by the low-abundance signaling lipid PI(3,5)P , which may regulate salt accumulation in plants by acting as a common messenger to coordinately shut down secondary active carriers responsible for cation and anion uptake inside the vacuole. Finally, we developed a theory based on thermodynamics, which supports the data obtained by our novel experimental approach. This work, therefore, represents a proof of principle that can be applied to the study of proton-dependent exchangers from plants and animals, which are barely detectable using conventional techniques.
Antonella Gradogna, Joachim Scholz-Starke, José M Pardo, Armando Carpaneto

2521 related Products with: Beyond the patch-clamp resolution:functional activity of non-electrogenic vacuolar NHX proton/potassium antiporters and inhibition by phosphoinositides.

48 assays 96 assays 0.1ml (1mg/ml)48 assays 96 assays 48 assays48 assays 96 assays

Related Pathways