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Incomplete Hydrolysis of Curcumin Conjugates by β-Glucuronidase: Detection of Complex Conjugates in Plasma.The diphenol curcumin from turmeric is rapidly metabolized into phase II conjugates following oral administration, resulting in negligible plasma concentration of the free compound which is considered the bioactive form. Total plasma concentration of curcumin is often quantified after treatment with β-glucuronidase to hydrolyze curcumin-glucuronide, the most abundant conjugate in vivo. The efficiency of enzymatic hydrolysis has not been tested.
1594 related Products with: Incomplete Hydrolysis of Curcumin Conjugates by β-Glucuronidase: Detection of Complex Conjugates in Plasma.MarkerGene™ Biotin Dete Anti Avidin peroxidase co Plasma Proteins: Corn Try MarkerGeneTM in vivo lacZ Anti Bordetella pertussis Anti AGO2 Human, Monoclon Prolactin-Inducible Prote Rabbit Plasma US Origin I Rabbit Plasma US Origin I Rabbit Plasma US Origin I 5HT1B, FITC conjugates Human interleukin 2(IL-2)
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The Putative Caloric Restriction Mimetic Resveratrol has Moderate Impact on Insulin Sensitivity, Body Composition and the Metabolome in Mice.Data on resveratrol-(trans-3,5,4'-trihydroxystilbene)-induced caloric-restriction-(CR)-mimicking effects in mice receiving a high-fat diet (HFD) are contradictory. We hypothesized that this could possibly stem from different bioactivities of resveratrol (RSV) microbial metabolites.
1196 related Products with: The Putative Caloric Restriction Mimetic Resveratrol has Moderate Impact on Insulin Sensitivity, Body Composition and the Metabolome in Mice.FDA Standard Frozen Tissu Multiple organ tumor tiss FDA Standard Frozen Tissu Thermal Shaker with cooli FDA Standard Frozen Tissu MultiGene Gradient therm FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu Rabbit Anti-Insulin Polyc Insulin Receptor Phospho- CSL Thermal Cycler with C
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Ulinastatin Inhibits the Formation and Progression of Experimental Abdominal Aortic Aneurysms.Aortic mural inflammatory damage takes a vital part in abdominal aortic aneurysm (AAA). Recently, ulinastatin (UTI) has attracted attention for its anti-inflammatory function. Our study aimed to evaluate potential influences of UTI on experimental AAA.
2564 related Products with: Ulinastatin Inhibits the Formation and Progression of Experimental Abdominal Aortic Aneurysms.Parotid gland disease spe Rabbit anti PKC theta (Ab Bovine Androstenedione,AS Sheep Anti-Theophylline 3 Endometrial disease spect FDA Standard Frozen Tissu Androgen Receptor (Ab-650 cell cycle progression 2 MyGenie 32 Thermal Block Anti-Abdominal-B Monoclon Rabbit Anti-Human Androge Penis disease spectrum (p
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Membranous Nephropathy Due to Anti-GBM Antibodies of Mice and Men.
Goat Anti- TOX3, (N Termi Rabbit Anti-Human TOSO (C Rabbit Anti-Human Toll-Li Mouse Anti-Diphtheria Tox Goat Anti-Clostridium tet Mouse Anti-C. difficile T Mouse Anti-E. coli Labile Rabbit Anti-Toxic Shock S Mouse Anti-Clostridium di Rabbit Anti-Staphylococca Goat Anti-Diphtheria Toxi Mouse Anti-Cholera Toxin
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Simultaneous determination of a promising anti-brain tumor agent CAT3 and its two major metabolites in mouse plasma and brain by a LC-MS/MS method.A rapid and reproducible method with high selectivity was developed for simultaneous determination of a promising anti-brain tumor agent CAT3 and its two metabolites PF403 and GLU-PF403 in mouse plasma and brain. An economic deproteinization with septuple acetonitrile (v/v) was applied to pretreat the samples in this study. All analytes were well retained and separated on a CAPCELL CORE PC (2.7 μm, 2.1 mm I.D. × 150 mm, SHISEIDO Technologies) column with an eluting solvent of acetonitrile /water containing 0.1 % formic acid (v/v) at the flow rate of 0.2 mL per minute. The detection was carried out on a Q Exactive high resolution mass spectrometer equipped with a HESI ion source in parallel reaction monitoring (PRM) mode. The corresponding transitions for quantitation were 434.23→ 70.07 for CAT3, 350.17→70.07 for PF403, 526.21→70.07 for GLU-PF403, 364.19→70.07 for IS-1 and 625.18→317.07 for IS-2, respectively. A well-linear fit curve was achieved among the range of 0.1∼50 ng/mL for CAT3, 0.2∼100 ng/mL for PF403 and 2.5∼600 ng/mL for GLU-PF403 both in mouse plasma and brain homogenate. The intra-/inter-day accuracies of three analytes were within ±14.5 % and precisions were below to 13.44 %. The mean values of recovery of three compounds in mouse plasma and brain homogenate were among 98.06 ∼ 118.63 % and 81.04∼108.69 %. The analytes in NaF-treated ice cold blood of mouse was stable within tested 30 min. Plasma and brain homogenate samples had no obvious changes during all storage, sample treatment and analytic process of mouse plasma sample. The reproducible and reliable method was well employed to the research of CAT3 pharmacokinetic characteristics in mouse plasma and brain after a single intragastric administration at dose of 10 mg/kg.
1808 related Products with: Simultaneous determination of a promising anti-brain tumor agent CAT3 and its two major metabolites in mouse plasma and brain by a LC-MS/MS method.Brain tumor tissue array, Brain tumor tissue array Brain tumor tissue array, Brain tumor tissue array Brain tumor and adjacent Brain tumor tissue array Mid advanced stage brain Brain tumor test tissue a Brain tumor and normal ti Monoclonal Anti Brain der Goat Anti-Human CKB Brain Anti 3 DG imidazolone Mon
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Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1.Macrophages play a dynamic role in tissue repair following injury. Here we found that following streptozotocin (STZ)-induced beta-cell death, mouse islet macrophages had increased Igf1 expression, decreased proinflammatory cytokine expression, and transcriptome changes consistent with macrophages undergoing efferocytosis and having an enhanced state of metabolism. Macrophages were the major, if not sole, contributors to islet insulin-like growth factor-1 (IGF-1) production. Adoptive transfer experiments showed that macrophages can maintain insulin secretion in vivo following beta-cell death with no effects on islet cell turnover. IGF-1 neutralization during STZ treatment decreased insulin secretion without affecting islet cell apoptosis or proliferation. Interestingly, high-fat diet (HFD) combined with STZ further skewed islet macrophages to a reparative state. Finally, islet macrophages from db/db mice also expressed decreased proinflammatory cytokines and increased Igf1 mRNA. These data have important implications for islet biology and pathology and show that islet macrophages preserve their reparative state following beta-cell death even during HFD feeding and severe hyperglycemia.
1002 related Products with: Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1.Epidermal Growth Factor ( Rat monoclonal anti mouse ELISA Human , 2 Screen Is IGF-1R Signaling Phospho- thymic dendritic cell-der Rat monoclonal anti mouse RABBIT ANTI HUMAN SDF-1 A Epidermal Growth Factor ( Rat monoclonal anti mouse Growth Differentiation Fa Rat monoclonal anti mouse Mouse Anti-Insulin-Like G
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Spermidine Suppresses Inflammatory DC Function by Activating the FOXO3 Pathway and Counteracts Autoimmunity.Dendritic cells (DCs) function is intimately linked to microenvironment and metabolism. Type I interferons (IFNs) condition dendritic cells to respond to weak self-signals, leading to autoimmunity. However, the metabolic adaption in the process is unclear. Here, we identified spermidine as a critical metabolite impacting the metabolic fitness of DC. First, dynamic metabolome screening indicated that spermidine decreased during IFN priming and following TLR7 ligand stimulation, accompanied by metabolic change from oxidative phosphorylation to glycolysis. Second, spermidine supplement restrained the glycolysis and prevented the overactivation of IFN-α primed DC both in vivo and in vitro. Third, mechanism study uncovered that the activity of FOXO3 adapted to the metabolic change, mediating the anti-inflammatory effect of spermidine. More importantly, addition of spermidine in vivo greatly alleviated the development of psoriasis-like symptom in mice. Thus, our studies revealed metabolic changes boosting DC responses and identified spermidine as a potential therapeutic agent for autoimmune diseases.
1502 related Products with: Spermidine Suppresses Inflammatory DC Function by Activating the FOXO3 Pathway and Counteracts Autoimmunity.∆2-Androstene-1α,17β- DCUN1D1 Jak Stat Phospho-Specific FDA Standard Frozen Tissu Androgen Receptor (Ab 650 Androstenedione 19 T-Cell Receptor Signaling Normal rat multiple organ Androgen Receptor Ab-1 An Anti-DCL1 (phospho-Ser431 Rabbit Anti-FLAP 5-lipoxy CSL Gradient Thermal Cycl
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Glycine transporter type 1 (GlyT1) inhibition improves conspecific-provoked immobility in Balb/c mice: Analysis of corticosterone response and glucocorticoid gene expression in cortex and hippocampus.Stress reactivity and glucocorticoid signaling alterations are reported in mouse models of autism spectrum disorder (ASD). Balb/c mice display decreased locomotor activity in the presence of stimulus mice and spend less time exploring enclosed stimulus mice; this mouse strain has been validated as an ASD model. VU0410120, a glycine type 1 transporter (GlyT1) inhibitor, improved sociability in Balb/c mice, consistent with data that NMDA Receptor (NMDAR) activation regulates sociability, and the endogenous tone of NMDAR-mediated neurotransmission is altered in this strain. Effects of a prosocial dose of VU0410120 on conspecific-provoked immobility, and relationships between conspecific-provoked immobility and corticosterone response were explored. VU0410120-treated Balb/c mice showed reduced immobility in the presence of conspecifics and increased the conspecific-provoked corticosterone response. However, the intensity of conspecific-provoked immobility in VU0410120-treated Balb/c mice did not differ as a function of corticosterone response. Expression profiles of 88 glucocorticoid signaling associated genes within frontal cortex and hippocampus were examined. Balb/c mice resistant to prosocial effects of VU0410120 had increased mRNA expression of Ddit4, a negative regulator of mTOR signaling. Dysregulated mTOR signaling activity is a convergent finding in several monogenic syndromic forms of ASD. Prosocial effects of VU0410120 in the Balb/c strain may be related to regulatory influences of NMDAR-activation on mTOR signaling activity. Because corticosterone response is a marker of social stress, the current data suggest that the stressfulness of a social encounter alone may not be the sole determinant of increased immobility in Balb/c mice; this strain may also display an element of social disinterest.
2834 related Products with: Glycine transporter type 1 (GlyT1) inhibition improves conspecific-provoked immobility in Balb/c mice: Analysis of corticosterone response and glucocorticoid gene expression in cortex and hippocampus.DNA (cytosine 5) methyltr Rabbit Anti-Integrin alph Rabbit Anti-Integrin alph CELLKINES INTERLEUKIN 2 ( Rabbit Anti-NOS-2 iNOS Po Rabbit Anti-APIP Apaf1 In Rabbit Anti-Insulin Recep Rabbit Anti-TNIP2 ABIN2 T Rabbit Anti-Integrin beta Rabbit Anti-Integrin alph Rabbit Anti-Integrin alph Rabbit Anti-NOS-2 iNOS Po
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