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#32791570   2020/08/13 To Up

Impact of obstructive sleep apnoea on cognitive function in multiple sclerosis: A longitudinal study.

Cognitive impairment (CI) and fatigue are common in people with multiple sclerosis (MS), with well-known profound effects on quality of life. Sleep disorders, including obstructive sleep apnoea (OSA), are also common in MS patients. The presence of CI has previously been shown to strongly correlate with OSA diagnosed using polysomnography in MS. Treatment of OSA has not previously been investigated as a potential modality to improve cognition in MS patients. Therefore, we sought to investigate the potential effects of OSA treatment on both cognitive function and fatigue in MS patients. Twenty-three participants with MS reporting significant fatigue were enrolled. CI was assessed by the Brief International Cognitive Assessment in MS and the 3-second Paced Auditory Serial Addition Test. All participants underwent overnight polysomnography to assess for possible OSA. Cognitive and fatigue measures were repeated in those subsequently treated for OSA and in a comparative untreated sample. Seven participants (30%) had a diagnosis of OSA based on an apnoea-hypopnea index greater than 5 per hour, with no correlation between the presence of CI and OSA. Verbal learning at follow-up assessment was seen to improve significantly in those treated for OSA, compared with those who were not treated for a sleep disorder. This small study demonstrates the potential for OSA treatment to improve verbal learning in people with MS, larger studies are indicated to further investigate the potential for cognitive and fatigue improvement in people with MS through treatment of comorbid OSA.
Nuala McNicholas, Audrey Russell, Geraldine Nolan, Niall Tubridy, Michael Hutchinson, John Francis Garvey, Christopher McGuigan

2691 related Products with: Impact of obstructive sleep apnoea on cognitive function in multiple sclerosis: A longitudinal study.

16 Arrays/Slide16 Arrays/Slide

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#32791568   2020/08/13 To Up

Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protection.

The potential for a rapid increase in severity is among the most frightening aspects of severe acute respiratory syndrome coronavirus 2 infection. Evidence increasingly suggests that the symptoms of coronavirus disease-2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) differ from those of classic ARDS. Recently, the severity of COVID-19 has been attributed to a systemic, thrombotic, and inflammatory disease that damages not only the lungs but multiple organs, including the heart, brain, toes, and liver. This systemic form of COVID-19 may be due to inflammation and vascular endothelial cell injury. The vascular endothelial glycocalyx comprises glycoproteins, and plays an important role in systemic capillary homeostasis maintenance. The glycocalyx covers the entire vascular endothelium, and its thickness varies among organs. The endothelial glycocalyx is very thin in the pulmonary capillaries, where it is affected by gaseous exchange with the alveoli and the low intravascular pressure in the pulmonary circulation. Despite the clearly important roles of the glycocalyx in vascular endothelial injury, thrombosis, vasculitis, and inflammation, the link between this structure and vascular endothelial cell dysfunction in COVID-19 remains unclear. In this prospective review, we summarize the importance of the glycocalyx and its potential as a therapeutic target in cases of systemic COVID-19.
Hideshi Okada, Shozo Yoshida, Akira Hara, Shinji Ogura, Hiroyuki Tomita

2225 related Products with: Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protection.

2ug96T5ug2ug x 202ug2ug2ug2ug1.00 flask1.00 flask50 ug 6 ml Ready-to-use

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#32791565   2020/08/13 To Up

CARDIAC chronotropic effects of sleep-disordered breathing in patients with heart failure.

It is still not known whether the oscillation in heart rate (HR) induced by sleep-disordered breathing (SDB) in patients with heart failure entails significant chronotropic effects. We hypothesised that since cyclical changes in ventilation and arterial blood gases during SDB affect HR through multiple and complexly interacting mechanisms characterised by large inter-subject variability, chronotropic effects may change from patient to patient. A total of 42 patients with moderate-to-severe chronic heart failure with systolic dysfunction underwent an in-hospital sleep study. Chronotropic effects of SDB were quantified by comparing the distribution of instantaneous HR during SDB with that during periods without SDB (noSDB) within the same night in each patient. Based on distribution changes from noSDB to SDB, 12, nine, 11, and 10 patients showed a significant tachycardic, bradycardic, tachycardic and bradycardic, and neither significant tachycardic nor significant bradycardic effect, respectively. Tachycardic and bradycardic effects were primarily due to an increase in the rate rather than in the magnitude of cyclical HR elevations and reductions, and were more prevalent and severe in patients with dominant obstructive and central events, respectively. The apnea-hypopnea index did not differ between groups. Conversely, the time spent with an oxygen saturation of <90% was greater in the tachycardic and tachycardic-bradycardic groups compared to the bradycardic group. These findings indicate that HR distribution changes induced by SDB can vary from patient to patient revealing four distinct and well-characterised chronotropic effects. These effects are related to the degree of hypoxic burden brought about by SDB and are affected by the type of sleep apnea (central/obstructive).
Gian Domenico Pinna, Maria Teresa La Rovere, Elena Robbi, Luigi Tavazzi, Roberto Maestri

1962 related Products with: CARDIAC chronotropic effects of sleep-disordered breathing in patients with heart failure.

100 UG100ug Lyophilized100 μg100ug Lyophilized100ug Lyophilized

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#32791552   2020/08/13 To Up

[COVID-19 and the impact of cardiovascular comorbidities].

Since its outbreak, coronavirus disease 2019 (COVID-19) has rapidly resulted in a global pandemic. Underlying cardiovascular disease (CVD) is associated with severe COVID-19 infection and adverse clinical outcomes. While COVID-19 predominantly causes respiratory symptoms, a substantial number of patients eventually develop an acute cardiovascular syndrome associated with an excessive risk of mortality. While the exact mechanisms remain uncertain, angiotensin-converting enzyme 2 plays a pivotal role as a link between COVID-19 and the cardiovascular system. As there is no evidence that inhibition of the renin-angiotensin-aldosterone-system is harmful in COVID-19, therapy should be continued as indicated in hypertension or heart failure patients. As multiple drugs are being investigated in ongoing clinical trials, potential cardiotoxicity remains an important issue. In times of rigorous public health measures such as social distancing, efforts should be undertaken to ensure timely treatment of acute CVD and continuation of guideline-directed treatment in order to avoid an increase in morbidity and mortality. In addition to its acute complications, COVID-19 is likely to be associated with long-term cardiovascular damage. Consequently, for a subgroup of patients a long-term management strategy is needed.
Hatim Seoudy, Norbert Frey

1771 related Products with: [COVID-19 and the impact of cardiovascular comorbidities].

2.5 mg25 mg100 ug2.5 mg500 Units5 g 1 G10 mg 1 G100ug1 g

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#32791528   2020/08/13 To Up

Flexural Strength of Different Monolithic Computer-Assisted Design and Computer-Assisted Manufacturing Ceramic Materials upon Different Thermal Tempering Processes.

 Strength of ceramics related with sintering procedure. This study investigated the influence of different tempering processes on flexural strength of three monolithic ceramic materials.
Niwut Juntavee, Pithiwat Uasuwan

1726 related Products with: Flexural Strength of Different Monolithic Computer-Assisted Design and Computer-Assisted Manufacturing Ceramic Materials upon Different Thermal Tempering Processes.

5 x 50 ug3x 500 ml100ug Lyophilized10ug100ug Lyophilized 1000 ml 100ug Lyophilized100 μg100.00 ug50 ug100ug Lyophilized

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#32791524   2020/08/13 To Up

Introduction to the Special Issue: Addressing Health Disparities in Pediatric Psychology.

This introduction to the special issue on Addressing Health Disparities in Pediatric Psychology provides context for why this special issue is needed, reviews key findings of the accepted articles, and discusses future directions for advancing the field. This special issue, one of three on this topic area that has been put forth in the history of this journal, comes at a critical point in our world. This is a time when the COVID-19 pandemic is systematically infecting Black, Indigenous, and People of Color and when there has been increased attention to systemic racism and intersecting violence inherent in multiple systems, including the justice, health, and educational systems. Using Kilbourne et al. (2016) framework, this special issue focuses on Phase 2 and Phase 3 research. Rather than only identifying health disparities (Phase 1), this issue focuses on understanding mechanisms and translating such understanding into interventions and policy changes. The accepted articles span a wide gamut from obesity to autism to rural populations. Furthermore, the articles provide methods for advancing the field beyond simply noting that systematic differences exist toward strategies to address these inequities. We conclude this introduction by discussing next steps for future research, with hopes that it inspires the next generation to study issues of disparities and inequity in deeper, more meaningful, and impactful ways.
Cecelia Valrie, Idia Thurston, Melissa Santos

1746 related Products with: Introduction to the Special Issue: Addressing Health Disparities in Pediatric Psychology.

96 wells (1 kit)1 mg100 1 G1mg1 mg

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#32791505   2020/08/13 To Up

Relative Cerebellum Size Is Not Sexually Dimorphic across Primates.

Substantive sex differences in behavior and cognition are found in humans and other primates. However, potential sex differences in primate neuroanatomy remain largely unexplored. Here, we investigate sex differences in the relative size of the cerebellum, a region that has played a major role in primate brain evolution and that has been associated with cognitive abilities that may be subject to sexual selection in primates.
Alex R DeCasien, James P Higham

1983 related Products with: Relative Cerebellum Size Is Not Sexually Dimorphic across Primates.

10 mg100ug Lyophilized100ug Lyophilized100 ul100ug Lyophilized100ug Lyophilized100ug Lyophilized1 mg100ug Lyophilized100ug Lyophilized 100 G100ug Lyophilized

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#32791490   2020/08/07 To Up

A temporal analysis of bilateral gait coordination in people with multiple sclerosis.

Gait performance often dictates an individual's ability to navigate the dynamic environments of everyday living. With each stride, the lower extremities move through phases of stance, swing, and double support. Coordinating these motions with high accuracy and consistency is imperative to constraining the center of mass within the base of support, thereby maintaining balance. Gait abnormalities accompany neurodegeneration, impeding stride to stride cohesion and increasing the likelihood of a fall. This study sought to identify the temporal actions underlying bilateral coordination in people with multiple sclerosis (PwMS) and furthermore, how bilateral coordination is affected by gait speed augmentation in these individuals.
Sutton B Richmond, Clayton W Swanson, Daniel S Peterson, Brett W Fling

1706 related Products with: A temporal analysis of bilateral gait coordination in people with multiple sclerosis.

16 Arrays/Slide

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#32791478   2020/08/01 To Up

Polyvinylidene fluoride nanocomposite super hydrophilic membrane integrated with Polyaniline-Graphene oxide nano fillers for treatment of textile effluents.

Water pollution from the fashion industries containing dyes has become a major source of water pollution. These anthropogenic contaminated waters directly enter irrigation and drinking water systems, causing irreversible environmental damage to human health. Nanomembrane technology has attracted extensive attention to remove these toxic chemicals but new approaches are still required for improving removal efficiency and control the channel size. The work deals with the fabrication of a novel hybrid polyvinylidene fluoride (PVDF)-polyaniline (PANI) membrane with graphene oxide (GO). Incorporation of PANI-GO as a nanofiller has significantly improved antifouling properties and a solvent content of the fabricated membrane. Besides, pure water flux also increases from 112 to 454 L m h indicating the hydrophilic nature of the nanocomposite membrane. Among various compositions, the nanocomposites membrane with 0.1 %w/v GO demonstrated a maximum of 98 % dye rejection at 0.1 MPa operating pressure. After multiple testing of the membrane, the flux recovery ratio reached about 94 % and dyes rejection improved with the addition of PANI-GO. The removal efficiency of the composite membrane for Allura red is 98 % and for methyl orange is 95 %. Based on the above results the PVDF/PANI/GO membranes are recommended for practical use in wastewater treatment, particularly for anionic dyes removal from textile effluents.
Hifza Nawaz, Muhammad Umar, Azeem Ullah, Humaira Razzaq, Khalid Mahmood Zia, Xuqing Liu

1591 related Products with: Polyvinylidene fluoride nanocomposite super hydrophilic membrane integrated with Polyaniline-Graphene oxide nano fillers for treatment of textile effluents.

KIT100 mg25 mg1 kit0.2 mg4 Membranes/Box 1 G0,61 kit8250 mg

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