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#32791578   2020/08/14 To Up

Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease.

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder and is associated with various metabolic diseases, including type 2 diabetes mellitus. There are no approved drugs for NAFLD, and the only approved treatment option is weight reduction. As insulin resistance plays an important role in the development of NAFLD, many anti-diabetic drugs have been evaluated for the treatment of NAFLD. Improvement of liver enzymes has been demonstrated by many anti-diabetic drugs, but histological assessment still remains insufficient. Pioglitazone could become the first-line therapy for T2DM patients with NAFLD, based on evidence of histological improvement in patients with biopsy-proven nonalcoholic steatohepatitis (NASH). Liraglutide, another promising alternative, is not yet recommended in patients with NAFLD/NASH due to limited evidence. Therefore, well-designed randomized controlled trials should be performed in the near future to demonstrate if and how anti-diabetic drugs can play a role in the treatment of NAFLD.
Kyung-Soo Kim, Byung-Wan Lee

2824 related Products with: Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease.

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#32791559   2020/08/13 To Up

Identifying mismatch repair deficient colon cancer: near perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series.

Establishing mismatch repair (MMR) status of colorectal cancers is important to enable detection of underlying Lynch syndrome and inform prognosis and therapy. Current testing typically involves either PCR-based microsatellite (MSI) testing or MMR protein immunohistochemistry (IHC). We aimed to compare these two approaches in a large, population-based cohort of stage 2 and 3 colon cancer cases in Northern Ireland.
Maurice B Loughrey, Jason McGrath, Helen G Coleman, Peter Bankhead, Perry Maxwell, Claire McGready, Victoria Bingham, Matthew P Humphries, Stephanie G Craig, Stephen McQuaid, Manuel Salto-Tellez, Jacqueline A James

1204 related Products with: Identifying mismatch repair deficient colon cancer: near perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series.



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#32791513   2020/08/13 To Up

Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.

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Wenqiang Li, Xin Cai, Hui-Juan Li, Meng Song, Chu-Yi Zhang, Yongfeng Yang, Luwen Zhang, Lijuan Zhao, Weipeng Liu, Lu Wang, Minglong Shao, Yan Zhang, Chen Zhang, Jun Cai, Dong-Sheng Zhou, Xingxing Li, Li Hui, Qiu-Fang Jia, Na Qu, Bao-Liang Zhong, Shu-Fang Zhang, Jing Chen, Bin Xia, Yi Li, Xueqin Song, Weixing Fan, Wei Tang, Wenxin Tang, Jinsong Tang, Xiaogang Chen, Weihua Yue, Dai Zhang, Yiru Fang, Xiao Xiao, Ming Li, Luxian Lv, Hong Chang

1132 related Products with: Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.

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#32791462   2020/06/26 To Up

Telling their story: A qualitative descriptive study of the lived experience of expatriate palliative care nurses in the United Arab Emirates.

To explore the experiences of expatriate nurses caring for Muslim patients near end-of-life in a palliative care unit in the United Arab Emirates.
Suzanne Oakley, Laurie Grealish, Elisabeth Coyne

2410 related Products with: Telling their story: A qualitative descriptive study of the lived experience of expatriate palliative care nurses in the United Arab Emirates.

1100.00 ul0.1 mg

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#32791343   2020/06/11 To Up

Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma.

Reasons why pancreatic ductal adenocarcinoma (PDAC) continues to have poor survival are only partly known. No previous studies have analyzed the combined influence of KRAS mutations, persistent organic pollutants (POPs), and trace elements upon survival in PDAC or in any other human cancer.
Miquel Porta, José Pumarega, André F S Amaral, Jeanine M Genkinger, Judit Camargo, Lorelei Mucci, Juan Alguacil, Magda Gasull, Xuehong Zhang, Eva Morales, Mar Iglesias, Shuji Ogino, Lawrence S Engel,

2810 related Products with: Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma.

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#32791227   2020/08/10 To Up

Contralateral transfalcine approach to deep parasagittal AVMs - technical note.

Resection of deep medial frontal and parietal arterio-venous malformations (AVM) is often challenging due to a tangential angle of attack, deep and narrow working corridor. Adequate visualization of the AVM and its feeding arteries without brain retraction is of particular importance when operating in or near eloquent cortical areas, where brain manipulation could inadvertently result in neurological deficits. The aim of this paper is to provide a step by step description of surgical approach and report our experience with the contralateral transfalcine approach for resection of deep seated parasagittal AVMs.
Ivo Peto, Mohsen Nouri, Jeffrey Katz, Henry Woo, Amir R Dehdashti

1279 related Products with: Contralateral transfalcine approach to deep parasagittal AVMs - technical note.

1x96 well plate1 g100 MG100 1 kit1 module100 ug10 25 G480/kit

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#32791064   2020/08/10 To Up

Well-differentiated liposarcoma primary from thymic stroma: Case report and literature review.

Primary liposarcoma of thymic stroma is an exceptionally rare tumor. Histological findings are usually sufficient for diagnosis, however due to the variable amount of atypia and the overlapping with other adipocytic tumors, ancillary techniques are helpful as confirmatory tools. Currently, Fluorescent in situ hybridization for MDM2 is the gold standard for diagnosis of well-differentiated and dedifferentiated liposarcomas, however a panel of immunohistochemical stainings, including MDM2, CDK4 and p16 is available as alternative and useful method, helping to distinguish liposarcoma from its benign counterpart lipoma, especially in borderline cases. We describe the case of a young female diagnosed with a well-differentiated lipomatous tumor primary of thymic stroma with near cut-off result for MDM2-FISH, but positive immunohistochemical staining for the panel described above. We discuss the challenges in the diagnosis of this rare entity and a present a literature review.
Karina Furlan, Ira Miller, Prih Rohra, Fatima Mir, Fernando A Ocampo Gonzales, Paolo Gattuso

2650 related Products with: Well-differentiated liposarcoma primary from thymic stroma: Case report and literature review.



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#32790995   2020/08/13 To Up

Three Reversible Redox States of Thiolate-Bridged Dirhodium Complexes without Metal-Metal Bonds.

An unusual dinuclear rhodium complex with the anionic 2-mercapto-6-methylpyridinate (mmp) bridging ligand is reported which is capable of undergoing significant variations in its structural and coordination environments as a result of two reversible redox events at accessible potentials (E1/2 = 0.014, 0.52 V vs. Ag/AgCl). The large degree of separation between these redox states (ΔE = 0.51 V, KC = 4.17x108) allows for the chemical isolation of three distinct complexes 1, 2, and 3, in which the oxidation states of each Rh center are described as Rh2I,I, Rh2I,II, and Rh2II,II, respectively, and whose structures were elucidated by single crystal X-ray diffraction studies. Complex 2 is an unprecedented type of mixed valence dirhodium species whose EPR spectrum revealed a delocalization of the unpaired electron through the thiolate bridging ligand. Intervalence charge transfer (IVCT) occurs between the Rh centers as evidenced by a broad absorption in the near-infrared region (λmax¬=1187 nm). The structure of 3 is quite rare in that it lacks the typical RhII-RhII σ bond but significant orbital overlap between the Rh 4dz2 and S 3pz orbitals results in strong antiferromagnetic coupling (computed J = -1516.9 cm-1). Complex 3 also absorbs low energy light (λmax¬ = 779 nm) and spectroscopic and magnetic measurements are supported by DFT methods which further elucidate the nature of the ground state energies, frontier orbital characters, excitated state transitions, and the presence of weak Rh-Rh NBO interactions.
Ryan Patrick Coll, Kim R Dunbar

2089 related Products with: Three Reversible Redox States of Thiolate-Bridged Dirhodium Complexes without Metal-Metal Bonds.

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#32790849   // To Up

Perceptual Learning of Appendicitis Diagnosis in Radiological Images.

A sizeable body of work has demonstrated that participants have the capacity to show substantial increases in performance on perceptual tasks given appropriate practice. This has resulted in significant interest in the use of such perceptual learning techniques to positively impact performance in real-world domains where the extraction of perceptual information in the service of guiding decisions is at a premium. Radiological training is one clear example of such a domain. Here we examine a number of basic science questions related to the use of perceptual learning techniques in the context of a radiology-inspired task. On each trial of this task, participants were presented with a single axial slice from a CT image of the abdomen. They were then asked to indicate whether or not the image was consistent with appendicitis. We first demonstrate that, although the task differs in many ways from standard radiological practice, it nonetheless makes use of expert knowledge, as trained radiologists who underwent the task showed high (near ceiling) levels of performance. Then, in a series of four studies we show that (1) performance on this task does improve significantly over a reasonably short period of training (on the scale of a few hours); (2) the learning transfers to previously unseen images and to untrained image orientations; (3) purely correct/incorrect feedback produces weak learning compared to more informative feedback where the spatial position of the appendix is indicated in each image; and (4) there was little benefit seen from purposefully structuring the learning experience by starting with easier images and then moving on to more difficulty images (as compared to simply presenting all images in a random order). The implications for these various findings with respect to the use of perceptual learning techniques as part of radiological training are then discussed.
Ian Andrew Johnston, Mohan Ji, Aaron Cochrane, Zachary Demko, Jessica B Robbins, Jason W Stephenson, C Shawn Green

1216 related Products with: Perceptual Learning of Appendicitis Diagnosis in Radiological Images.

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#32790810   2020/07/30 To Up

Large-area periodic arrays of gold nanostars derived from HEPES-, DMF-, and ascorbic-acid-driven syntheses.

With arms radiating from a central core, gold nanostars represent a unique and fascinating class of nanomaterials from which extraordinary plasmonic properties are derived. Despite their relevance to sensing applications, methods for fabricating homogeneous populations of nanostars on large-area planar surfaces in truly periodic arrays is lacking. Herein, the fabrication of nanostar arrays is demonstrated through the formation of hexagonal patterns of near-hemispherical gold seeds and their subsequent exposure to a liquid-state chemical environment that is conducive to colloidal nanostar formation. Three different colloidal nanostar protocols were targeted where HEPES, DMF, and ascorbic acid represent a key reagent in their respective redox chemistries. Only the DMF-driven synthesis proved readily adaptable to the substrate-based platform but nanostar-like structures emerged from the other protocols when synthetic controls such as reaction kinetics, the addition of Ag ions, and pH adjustments were applied. Because the nanostars were derived from near-hemispherical seeds, they acquired a unique geometry that resembles a conventional nanostar that has been truncated near its midsection. Simulations of plasmonic properties of this geometry reveal that such structures can exhibit maximum near-field intensities that are as much as seven-times greater than the standard nanostar geometry, a finding that is corroborated by surface-enhanced Raman scattering (SERS) measurements showing large enhancement factors. The study adds nanostars to the library of nanostructure geometries that are amenable to large-area periodic arrays and provides a potential pathway for the nanofabrication of SERS substrates with even greater enhancements.
Trevor B Demille, Robert A Hughes, Nathaniel Dominique, Jacob E Olson, Sergei Rouvimov, Jon P Camden, Svetlana Neretina

2602 related Products with: Large-area periodic arrays of gold nanostars derived from HEPES-, DMF-, and ascorbic-acid-driven syntheses.

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