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#33096445   2020/10/16 To Up

Laparoscopic bile duct resection with lymph node dissection for gallbladder cancer diagnosed after laparoscopic cholecystectomy.

Laparoscopic reoperation of postoperatively diagnosed gallbladder cancer is a technically challenging procedure due to inflammatory adhesion or fibrosis around the hepatoduodenal ligament and gallbladder bed [1,2]. Here we describe a technique for laparoscopic bile duct resection with lymph node dissection in a patient with cystic duct cancer diagnosed after laparoscopic cholecystectomy.
Sunjong Han, Yoo-Seok Yoon, Ho-Seong Han, Jun Suh Lee

2256 related Products with: Laparoscopic bile duct resection with lymph node dissection for gallbladder cancer diagnosed after laparoscopic cholecystectomy.



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#33096418   2020/10/20 To Up

eXaSkin: A novel high-density bolus for 6MV X-rays radiotherapy.

To evaluate eXaSkin, a novel high-density bolus alternative to commercial tissue-equivalent Superflab, for 6MV photon-beam radiotherapy.
Taghreed A Al-Sudani, Giordano Biasi, Dean Wilkinson, Jeremy A Davis, Royce Kearnan, Fatima S Matar, Dean L Cutajar, Peter Metcalfe, Anatoly B Rosenfeld

1819 related Products with: eXaSkin: A novel high-density bolus for 6MV X-rays radiotherapy.

100ug Lyophilized100ug Lyophilized2 Sample Kit

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#33095875   // To Up

ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells.

The treatment of advanced-stage cutaneous T-cell lymphoma (CTCL) remains an unmet medical need. Mogamulizumab, anti-KIR3DL2, and brentuximab vedotin (BV), an anti-CD30 antibody-drug conjugate (ADC) coupled with monomethyl-auristatin-E (MMAE), provided encouraging results, but new targeted therapies are needed. Inducible T-cell costimulator (ICOS), a T-cell costimulatory receptor, is a promising therapeutic target, not only because it is expressed by malignant T cells in CTCL but also because of its connection with the suppressive activity of regulatory T (Treg) cells. Immunohistochemical analysis revealed that ICOS was widely expressed by malignant cells in skin biopsy specimens from 52 patients with mycosis fungoides and Sézary syndrome (SS), as well as in involved node biopsy specimens from patients with SS. Furthermore, flow cytometry demonstrated its strong expression by circulating tumor cells in all our patients with SS. Percentages of ICOS+ Treg cells were significantly higher in patients with SS than in healthy donors. We then investigated the preclinical efficacy of anti-ICOS ADCs generated by coupling murine anti-ICOS monoclonal antibodies with MMAE and pyrrolobenzodiazepine. In 3 CTCL cell lines (Myla, MJ, and HUT78), we observed a significant dose-dependent decrease in cell viability in the presence of anti-ICOS ADCs. In addition, anti-ICOS-MMAE ADCs had an in vitro and in vivo efficacy superior to BV in a mouse xenograft model (MyLa). Finally, we assessed the efficacy of anti-ICOS ADCs in ICOS+ patient-derived xenografts from patients with SS and angioimmunoblastic T-cell lymphoma. Collectively, our findings provide the preliminary basis for a therapeutic trial.
Florent Amatore, Nicolas Ortonne, Marc Lopez, Florence Orlanducci, Rémy Castellano, Saskia Ingen-Housz-Oro, Amandine De Croos, Clémentine Salvado, Laurent Gorvel, Armelle Goubard, Yves Collette, Réda Bouabdallah, Jean-Marc Schiano, Nathalie Bonnet, Jean-Jacques Grob, Philippe Gaulard, Martine Bagot, Armand Bensussan, Philippe Berbis, Daniel Olive

2769 related Products with: ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells.

100.00 ug1x10e7 cells100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100.00 ug96 tests1x10e7 cells

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#33095806   2020/10/23 To Up

Potential association of LOXL1 with peritoneal dissemination in gastric cancer possibly via promotion of EMT.

Peritoneal dissemination (PD) frequently occurs in gastric cancer (GC) and is incurable. In this study, we aimed to identify novel PD-associated genes and clarify their clinical and biological significance in GC.
Qingjiang Hu, Takaaki Masuda, Shotaro Kuramitsu, Taro Tobo, Kuniaki Sato, Shinya Kidogami, Sho Nambara, Masami Ueda, Yusuke Tsuruda, Yosuke Kuroda, Shuhei Ito, Eiji Oki, Masaki Mori, Koshi Mimori

2315 related Products with: Potential association of LOXL1 with peritoneal dissemination in gastric cancer possibly via promotion of EMT.



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#33095362   2020/10/23 To Up

Oncologic Safety of Sentinel Lymph Node Biopsy Alone After Neoadjuvant Chemotherapy for Breast Cancer.

The oncologic safety of sentinel lymph node biopsy (SLNB) alone for clinically node-positive (cN1-2) patients who convert to pathologic node-negativity (ypN0) after neoadjuvant chemotherapy (NAC) is not well established.
Stephanie M Wong, Mark Basik, Livia Florianova, Richard Margolese, Sinziana Dumitra, Thierry Muanza, Annie Carbonneau, Cristiano Ferrario, Jean Francois Boileau

2198 related Products with: Oncologic Safety of Sentinel Lymph Node Biopsy Alone After Neoadjuvant Chemotherapy for Breast Cancer.



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#33095359   2020/10/23 To Up

Utility of Intraoperative Fluorescence Imaging in Gynecologic Surgery: Systematic Review and Consensus Statement.

This study aimed to review the current knowledge on the utility of intraoperative fluorescence imaging in gynecologic surgery and to give evidence-based recommendations to improve the quality of care for women who undergo gynecologic surgery.
Ignacio Zapardiel, Julio Alvarez, Manel Barahona, Pere Barri, Ana Boldo, Pera Bresco, Isabel Gasca, Ibon Jaunarena, Ali Kucukmetin, Gloria Mancebo, Borja Otero, Fernando Roldan, Ramón Rovira, Enma Suarez, Alvaro Tejerizo, Anna Torrent, Mikel Gorostidi

1528 related Products with: Utility of Intraoperative Fluorescence Imaging in Gynecologic Surgery: Systematic Review and Consensus Statement.

1 kit1 kit1 kit1 kit1 kit1 kit1 Set100 μg 1 kit(s)

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#33095298   2020/10/23 To Up

Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking.

The hyperpolarization-activated cation current I is a key determinant for cardiac pacemaker activity. It is conducted by subunits of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel family, of which HCN4 is predominant in mammalian heart. Both loss-of-function and gain-of-function mutations of the HCN4 gene are associated with sinus node dysfunction in humans; however, their functional impact is not fully understood yet. Here, we sought to characterize a HCN4 V759I variant detected in a patient with a family history of sick sinus syndrome. The genomic analysis yielded a mono-allelic HCN4 V759I variant in a 49-year-old woman presenting with a family history of sick sinus syndrome. This HCN4 variant was previously classified as putatively pathogenic because genetically linked to sudden infant death syndrome and malignant epilepsy. However, detailed electrophysiological and cell biological characterization of HCN4 V759I in Xenopus laevis oocytes and embryonic rat cardiomyocytes, respectively, did not reveal any obvious abnormality. Voltage dependence and kinetics of mutant channel activation, modulation of cAMP-gating by the neuronal HCN channel auxiliary subunit PEX5R, and cell surface expression were indistinguishable from wild-type HCN4. In good agreement, the clinically likewise affected mother of the patient does not exhibit the reported HCN4 variance. HCN4 V759I resembles an innocuous genetic HCN channel variant, which is not sufficient to disturb cardiac pacemaking. Once more, our work emphasizes the importance of careful functional interpretation of genetic findings not only in the context of hereditary cardiac arrhythmias.
Nadine Erlenhardt, Olaf Kletke, Franziska Wohlfarth, Marlene A Komadowski, Lukas Clasen, Hisaki Makimoto, Susanne Rinné, Malte Kelm, Christiane Jungen, Niels Decher, Christian Meyer, Nikolaj Klöcker

2293 related Products with: Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking.

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#33095194   // To Up

An investigation of the possible scenarios for the optimal locating of quality sensors in the water distribution networks with uncertain contamination.

One of the ways to reduce the risk of contaminated water consumption is to optimally locate the quality sensors. These sensors warn users in the case of contamination detection. Analyzing the actual conditions of the contamination which enters the network is faced with many uncertainties. These uncertainties include the dose of contamination, time and location of its entry which have received less attention. Also, the uncertainty in the nodes' water demand causes changes in the distribution and contamination diffusion within the network. The main impetus of the present study is to determine the optimal quality sensor locations in the water distribution network in order to reduce the damage caused by contaminated water consumption prior to the contamination event detection. For this purpose, a parameter is defined as the maximum possible damage for calculating which the vulnerability and importance of the nodes have been considered in addition to the uncertainties in the location and time of the contamination entry. The importance of each node differs from that of other ones. Ranking the importance of the nodes is influenced by both land use and covered population ratio. In this study, six scenarios are defined for the contamination event in the water distribution network. These scenarios consider the effects of varying pollutant dose and the contamination input from nodes which are prone to its entry. Also, the NSGA-II has been utilized in order to minimize the damage with minimum number of sensors. The proposed model is evaluated on a real network in Iran. The results indicate that adding only one or two contamination warning sensors to the proposed locations can lead to the decreasing damage caused by the contaminated water consumption from 54 to 82%. According to the proposed method, the best answer for scenarios 1-6 was obtained for 7, 6, 6, 2, 2 and 2 sensors, respectively. The results showed that the slope of the pollution rate diagram does not change much from 6 sensors upwards in the first three scenarios, and from 4 sensors upwards in the second three scenarios. In scenarios 1-3, with 7, 6 and 6 sensors, respectively, in different nodes, the best placement is for 203-224 equivalent attack population, and in scenarios 4-6, with sensors in nodes 4 and 43, the best placement is for 225-279 equivalent attack population.
Hamideh Jafari, Taher Rajaee, Sara Nazif

2656 related Products with: An investigation of the possible scenarios for the optimal locating of quality sensors in the water distribution networks with uncertain contamination.

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